Abstract:
:In this issue of Blood, Doyle et al provide evidence that knockout of the genes encoding the two most abundant eosinophil secondary granule proteins disrupts the normal differentiation of eosinophils from progenitors in the bone marrow, providing a novel strain of mice with a highly specific deficiency in eosinophilopoiesis and, therefore, eosinophils. This strain is likely to be used by investigators to elaborate the normal vs pathogenic roles of eosinophils in health and disease.
journal_name
Bloodjournal_title
Bloodauthors
Ackerman SJdoi
10.1182/blood-2013-06-508507subject
Has Abstractpub_date
2013-08-01 00:00:00pages
621-3issue
5eissn
0006-4971issn
1528-0020pii
122/5/621journal_volume
122pub_type
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