High-dose cyclophosphamide, carmustine, and etoposide followed by autologous peripheral stem cell transplantation for patients with relapsed Hodgkin's disease.


:Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow abnormality, either hypocellularity or tumor involvement. At least 6.5 x 10(8) [corrected] mononuclear cells/kg patient weight were collected from the peripheral blood of each patient, cyropreserved, and returned intravenously following CBV administration. Three patients had an early death 2, 22, and 25 days after PSCT. The actuarial event-free survival for these 56 patients at 3 years was 37% and was at least as good as that reported for relapsed Hodgkin's disease patients treated with CBV and ABMT. The 30 patients who had no marrow metastases at the time of PSC harvesting had an actuarial event-free survival of 47%, while those 26 patients with marrow metastases had a significantly different actuarial event-free survival of 27% (P = .02). CBV and PSCT for patients with relapsed Hodgkin's diseases who have marrow hypocellularity in traditional harvest sites or histopathologic evidence of BM metastases can result in long-term event-free survival.






Kessinger A,Bierman PJ,Vose JM,Armitage JO


Has Abstract


1991-06-01 00:00:00














  • Endothelin-1 induces production of the neutrophil chemotactic factor interleukin-8 by human brain-derived endothelial cells.

    abstract::Increased levels of endothelin-1 (Et-1), a potent vasoconstrictor, have been correlated with hypertension and neuronal damage in ischemic/reperfusion injury. The presence of polymorphonuclear cells (PMNs) in the brain has been shown to be directly responsible for this observed pathology. To address the question of whe...


    pub_type: 杂志文章


    authors: Hofman FM,Chen P,Jeyaseelan R,Incardona F,Fisher M,Zidovetzki R

    更新日期:1998-11-01 00:00:00

  • Mutual inhibition of murine erythropoiesis and granulopoiesis during combined erythropoietin, granulocyte colony-stimulating factor, and stem cell factor administration: in vivo interactions and dose-response surfaces.

    abstract::We investigated the in vivo effects of erythropoietin (EPO) on granulopoiesis and, conversely, the effect of granulocyte colony-stimulating factor (G-CSF) treatment on erythropoiesis. Recombinant human EPO at four different doses in combination with recombinant human G-CSF also at four different doses was simultaneous...


    pub_type: 杂志文章


    authors: de Haan G,Engel C,Dontje B,Nijhof W,Loeffler M

    更新日期:1994-12-15 00:00:00

  • Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia.

    abstract::Derivative chromosome 9 deletions are seen in 10% to 15% of patients with chronic myelogenous leukemia and have been associated with a poor prognosis; however, no studies have been performed in the context of a randomized clinical trial. We developed a DNA-based deletion screen and investigated 339 chronic phase patie...


    pub_type: 杂志文章


    authors: Kreil S,Pfirrmann M,Haferlach C,Waghorn K,Chase A,Hehlmann R,Reiter A,Hochhaus A,Cross NC,German Chronic Myelogenous Leukemia (CML) Study Group.

    更新日期:2007-08-15 00:00:00

  • Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells.

    abstract::Although recent data suggests that osteoblasts play a key role within the hematopoietic stem cell (HSC) niche, the mechanisms underpinning this remain to be fully defined. The studies described herein examine the role in hematopoiesis of Osteopontin (Opn), a multidomain, phosphorylated glycoprotein, synthesized by ost...


    pub_type: 杂志文章


    authors: Nilsson SK,Johnston HM,Whitty GA,Williams B,Webb RJ,Denhardt DT,Bertoncello I,Bendall LJ,Simmons PJ,Haylock DN

    更新日期:2005-08-15 00:00:00

  • Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the i

    abstract::Anacardic acid (6-pentadecylsalicylic acid) is derived from traditional medicinal plants, such as cashew nuts, and has been linked to anticancer, anti-inflammatory, and radiosensitization activities through a mechanism that is not yet fully understood. Because of the role of nuclear factor-kappaB (NF-kappaB) activatio...


    pub_type: 杂志文章


    authors: Sung B,Pandey MK,Ahn KS,Yi T,Chaturvedi MM,Liu M,Aggarwal BB

    更新日期:2008-05-15 00:00:00

  • Gemtuzumab ozogamicin with or without interleukin 11 in patients 65 years of age or older with untreated acute myeloid leukemia and high-risk myelodysplastic syndrome: comparison with idarubicin plus continuous-infusion, high-dose cytosine arabinoside.

    abstract::We investigated treatment with gemtuzumab ozogamicin (GO) in 51 patients aged 65 years or older with newly diagnosed acute myeloid leukemia (AML), refectory anemia (RA) with excess of blasts in transformation, or RA with excess blasts. GO was given in doses of 9 mg/m(2) of body-surface area on days 1 and 8 or, therape...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Estey EH,Thall PF,Giles FJ,Wang XM,Cortes JE,Beran M,Pierce SA,Thomas DA,Kantarjian HM

    更新日期:2002-06-15 00:00:00

  • Effect of interleukin-1 beta converting enzyme inhibitor on acute myelogenous leukemia progenitor proliferation.

    abstract::Interleukin-1 beta (IL-1 beta) converting enzyme (ICE) is a cysteine protease that specifically cleaves precursor IL-1 beta to its biologically active form. Recent studies have also implicated ICE in the induction of apoptosis in vertebrate cells. Because IL-1 plays a major role in acute myelogenous leukemia (AML) bla...


    pub_type: 杂志文章


    authors: Estrov Z,Black RA,Sleath PR,Harris D,Van Q,LaPushin R,Estey EH,Talpaz M

    更新日期:1995-12-15 00:00:00

  • Cell interactions influencing murine marrow megakaryocytes: nature of the potentiator cell in bone marrow.

    abstract::Auxiliary bone marrow cells are required for optimal murine megakaryocyte colony formation in addition to progenitor cells and a colony stimulating activity (CSA) present in WEHI-3 cell conditioned medium. These auxiliary cells are adherent, with a sedimentation rate of 5.8 mm hr-1 and buoyant density of 1.065-1.078 g...


    pub_type: 杂志文章


    authors: Williams N,Jackson H,Ralph P,Nakoinz I

    更新日期:1981-01-01 00:00:00

  • High-dose etoposide and cyclophosphamide without bone marrow transplantation for resistant hematologic malignancy.

    abstract::Seventy-five patients with resistant acute leukemia or lymphoma received high-dose cyclophosphamide and etoposide to explore the activity of this combination in resistant hematologic malignancies, and to determine the maximum doses of these drugs that can be combined without bone marrow transplantation. Etoposide was ...


    pub_type: 杂志文章


    authors: Brown RA,Herzig RH,Wolff SN,Frei-Lahr D,Pineiro L,Bolwell BJ,Lowder JN,Harden EA,Hande KR,Herzig GP

    更新日期:1990-08-01 00:00:00

  • In vitro maturation of nascent reticulocytes to erythrocytes.

    abstract::Most studies of mammalian reticulocyte maturation have used blood reticulocytes. Nascent reticulocytes, as found in bone marrow, have not been available in developmentally synchronized populations. Nascent murine reticulocytes formed in vitro by enucleation of Friend virus-infected erythroblasts were purified and recu...


    pub_type: 杂志文章


    authors: Koury MJ,Koury ST,Kopsombut P,Bondurant MC

    更新日期:2005-03-01 00:00:00

  • Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel.

    abstract::Despite major improvements in outcome over the past decades, acute myeloid leukemia (AML) remains a life-threatening malignancy in children, with current survival rates of ∼70%. State-of-the-art recommendations in adult AML have recently been published in this journal by Döhner et al. The primary goal of an internatio...


    pub_type: 杂志文章,评审


    authors: Creutzig U,van den Heuvel-Eibrink MM,Gibson B,Dworzak MN,Adachi S,de Bont E,Harbott J,Hasle H,Johnston D,Kinoshita A,Lehrnbecher T,Leverger G,Mejstrikova E,Meshinchi S,Pession A,Raimondi SC,Sung L,Stary J,Zwaan CM,K

    更新日期:2012-10-18 00:00:00

  • Cell surface characterization of malignant T cells from lymphoblastic lymphoma using monoclonal antibodies: evidence for phenotypic differences between malignant T cells from patients with acute lymphoblastic leukemia and lymphoblastic lymphoma.

    abstract::A series of monoclonal antibodies was used for the characterization of malignant T cells from 21 patients with lymphoblastic lymphoma (LL). The tumor population from these patients showed a marked degree of phenotypic heterogeneity and a proportion (one-third) of patients had tumor cells that did not conform exactly w...


    pub_type: 杂志文章


    authors: Bernard A,Boumsell L,Reinherz EL,Nadler LM,Ritz J,Coppin H,Richard Y,Valensi F,Dausset J,Flandrin G,Lemerle J,Schlossman SF

    更新日期:1981-06-01 00:00:00

  • Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species.

    abstract::Lymphocytes bound at endothelial cell junctions extravasate within minutes. Lymphocyte-endothelial cell binding is mediated by receptors such as vascular cell adhesion molecule 1 (VCAM-1). VCAM-1 activates endothelial cell nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in minutes, and this activity is req...


    pub_type: 杂志文章


    authors: Deem TL,Cook-Mills JM

    更新日期:2004-10-15 00:00:00

  • Gemtuzumab ozogamicin (Mylotarg) as a single agent for molecularly relapsed acute promyelocytic leukemia.

    abstract::The anti-CD33 antibody calicheamicinconjugate gemtuzumab ozogamicin (GO) was used to treat 16 patients with acute promyelocytic leukemia (APL) who had relapsed at the molecular level. Of these patients, 8 were experiencing a first, 5 a second, 2 a third, and 1 a fourth relapse. GO was administered at 6 mg/m2 for 2 dos...


    pub_type: 临床试验,杂志文章


    authors: Lo-Coco F,Cimino G,Breccia M,Noguera NI,Diverio D,Finolezzi E,Pogliani EM,Di Bona E,Micalizzi C,Kropp M,Venditti A,Tafuri A,Mandelli F

    更新日期:2004-10-01 00:00:00

  • Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3.

    abstract::Activation of p38 MAP kinase (p38) as well as JNK/SAPK has been described as being induced by a variety of environmental stresses such as osmotic shock, ultraviolet radiation, and heat shock, or the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1 (IL-1). We found that the hematopoietic cytokine...


    pub_type: 杂志文章


    authors: Nagata Y,Moriguchi T,Nishida E,Todokoro K

    更新日期:1997-08-01 00:00:00

  • Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia.

    abstract::In this study, we randomly compared high doses of the tyrosine kinase inhibitor imatinib combined with reduced-intensity chemotherapy (arm A) to standard imatinib/hyperCVAD (cyclophosphamide/vincristine/doxorubicin/dexamethasone) therapy (arm B) in 268 adults (median age, 47 years) with Philadelphia chromosome-positiv...


    pub_type: 杂志文章,随机对照试验


    authors: Chalandon Y,Thomas X,Hayette S,Cayuela JM,Abbal C,Huguet F,Raffoux E,Leguay T,Rousselot P,Lepretre S,Escoffre-Barbe M,Maury S,Berthon C,Tavernier E,Lambert JF,Lafage-Pochitaloff M,Lhéritier V,Chevret S,Ifrah N,Dombr

    更新日期:2015-06-11 00:00:00

  • Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease.

    abstract::In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial ...


    pub_type: 杂志文章


    authors: Ertault-Daneshpouy M,Leboeuf C,Lemann M,Bouhidel F,Ades L,Gluckman E,Socié G,Janin A

    更新日期:2004-06-15 00:00:00

  • Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump.

    abstract::Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may lead to development of cellular resistance and subsequent treatment failure. Indee...


    pub_type: 杂志文章


    authors: Burger H,van Tol H,Boersma AW,Brok M,Wiemer EA,Stoter G,Nooter K

    更新日期:2004-11-01 00:00:00

  • Interleukin-23 acts as antitumor agent on childhood B-acute lymphoblastic leukemia cells.

    abstract::Interleukin (IL)-23 is a proinflammatory cytokine belonging to the IL-12 superfamily. The antitumor activity of IL-23 is controversial, and it is unknown whether or not the cytokine can act directly on tumor cells. The aim of this study was to investigate the potential direct antitumor activity of IL-23 in pediatric B...


    pub_type: 杂志文章


    authors: Cocco C,Canale S,Frasson C,Di Carlo E,Ognio E,Ribatti D,Prigione I,Basso G,Airoldi I

    更新日期:2010-11-11 00:00:00

  • Infectious mononucleosis: sequential immunologic, cytochemical, and cytokinetic studies on single lymphoid cells in peripheral blood.

    abstract::Sequential immunologic, cytochemical, and cytokinetic studies were done on single lymphoid cells in the peripheral blood of 6 children with infectious mononucleosis (IM) and 1 child with toxoplasmosis 1-2 wk after onset of symptomatology. The absolute number of AET-SRBC rosetting (E+) cells was increased in all patien...


    pub_type: 杂志文章


    authors: Hirt A,Imbach P,Morell A,Wagner HP

    更新日期:1981-09-01 00:00:00

  • Use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies.

    abstract::The use of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) following autologous marrow transplantation for lymphoid malignancies was explored in a phase I/II dose escalation study. rhGM-CSF given as a 2-hour infusion daily for 14 days was well tolerated at doses up to 240 micrograms/m2/da...


    pub_type: 杂志文章


    authors: Nemunaitis J,Singer JW,Buckner CD,Hill R,Storb R,Thomas ED,Appelbaum FR

    更新日期:1988-08-01 00:00:00

  • AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines.

    abstract::The PI3K/AKT signaling is activated in various hematologic malignancies. We evaluated the effect of a novel, pan-AKT kinase inhibitor, GSK690693, on the proliferation of 112 cell lines representing different hematologic neoplasia. Fifty-five percent of all cell lines tested were sensitive to AKT inhibitor (EC(50)<1 mi...


    pub_type: 杂志文章


    authors: Levy DS,Kahana JA,Kumar R

    更新日期:2009-02-19 00:00:00

  • An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation.

    abstract::Neutrophils recruited from the blood are key players in the innate immune response. Selectins play critical roles in neutrophil recruitment by mediating their tethering and rolling in inflamed venules. While the roles of P- and E-selectin in this process are well established, the mechanisms of L-selectin-mediated neut...


    pub_type: 杂志文章


    authors: Shigeta A,Matsumoto M,Tedder TF,Lowe JB,Miyasaka M,Hirata T

    更新日期:2008-12-15 00:00:00

  • Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow.

    abstract::The bone marrow plays a unique role within the immune system. We compared the phenotype and function of virus-specific CD8(+) T cells from matched samples of human peripheral blood and bone marrow. Analysis of virus-specific memory CD8(+) T cells showed widely divergent partition of antigen-specific populations betwee...


    pub_type: 杂志文章


    authors: Palendira U,Chinn R,Raza W,Piper K,Pratt G,Machado L,Bell A,Khan N,Hislop AD,Steyn R,Rickinson AB,Buckley CD,Moss P

    更新日期:2008-10-15 00:00:00

  • Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response.

    abstract::Stem cell factor (SCF) and interleukin-3 (IL-3) both act on several target hematopoietic populations, including mast cells. We have isolated a unique murine mast cell line, B6M, that is phenotypically similar to immature mast cells. For B6M cells, IL-3 is a survival factor and alone does not stimulate proliferation. S...


    pub_type: 杂志文章


    authors: O'Farrell AM,Ichihara M,Mui AL,Miyajima A

    更新日期:1996-05-01 00:00:00

  • Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB.

    abstract::Most bone marrow (BM) malignancies develop in association with an angiogenic phenotype and increased numbers of endothelial cells. The molecular mechanisms involved in the modulation and recruitment of BM endothelium are largely unknown and may provide novel therapeutic targets for neoplastic diseases. We observed tha...


    pub_type: 杂志文章


    authors: Costa LF,Balcells M,Edelman ER,Nadler LM,Cardoso AA

    更新日期:2006-01-01 00:00:00

  • Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.

    abstract:UNLABELLED:Polymorphonuclear neutrophil granulocytes (neutrophils) are tightly controlled by an incompletely understood homeostatic feedback loop adjusting the marrow's supply to peripheral needs. Although it has long been known that marrow cellularity is inversely correlated with G-CSF levels, the mechanism linking pe...


    pub_type: 杂志文章


    authors: Bugl S,Wirths S,Radsak MP,Schild H,Stein P,André MC,Müller MR,Malenke E,Wiesner T,Märklin M,Frick JS,Handgretinger R,Rammensee HG,Kanz L,Kopp HG

    更新日期:2013-01-31 00:00:00

  • Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.

    abstract::CTLA-4 inhibits T-cell activation and protects against the development of autoimmunity. We and others previously showed that the coreceptor can induce T-cell motility and shorten dwell times with dendritic cells (DCs). However, it has been unclear whether this property of CTLA-4 affects both conventional T cells (Tcon...


    pub_type: 杂志文章


    authors: Lu Y,Schneider H,Rudd CE

    更新日期:2012-11-29 00:00:00

  • Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes.

    abstract::CD8+CD25+ cells, which expressed high levels of Foxp3, glucocorticoid-induced tumor necrosis factor receptor (GITR), CCR8, tumor necrosis factor receptor 2 (TNFR2), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) mRNAs, were identified in the fibrous septa and medullary areas of human thymus. Activated CD8+CD...


    pub_type: 杂志文章


    authors: Cosmi L,Liotta F,Lazzeri E,Francalanci M,Angeli R,Mazzinghi B,Santarlasci V,Manetti R,Vanini V,Romagnani P,Maggi E,Romagnani S,Annunziato F

    更新日期:2003-12-01 00:00:00

  • Spontaneous generation and survival of blood dendritic cells in mononuclear cell culture without exogenous cytokines.

    abstract::Studies on purified blood dendritic cells (DCs) are hampered by poor viability in tissue culture. We, therefore, attempted to study some of the interactions/relationships between DCs and other blood cells by culturing unseparated peripheral blood mononuclear cell (PBMC) preparations in vitro. Flow cytometric technique...


    pub_type: 杂志文章


    authors: Ho CS,Munster D,Pyke CM,Hart DN,López JA

    更新日期:2002-04-15 00:00:00