Abstract:
:The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for the test. The test meal for delaying gastric emptying was 100 ml fresh milk. Patients fasted for at least 6h. A baseline breath sample was collected 5 min after they had the test meal. Two other samples were collected at 15 and 30 min after the patients ingested the 13C-urea. The test was evaluated in 352 patients after routine upper gastrointestinal endoscopy, and the urease test, culture, and histopathology were taken as the gold standards for detecting H. pylori. According to the receiver operating characteristic (ROC) curves, we chose values of 2.8 and 4.2 excess delta 13CO2 per mil as the cut-off values for 15 and 30 min, respectively, post 13C-urea. The sensitivity and specificity of 13C-UBT were 99% and 93% at 15 min, and 98% and 93% at 30 min post 13C-urea, respectively. The 13C-UBT breath test is an efficient non-invasive method of high sensitivity and high specificity for detecting H. pylori infection. We suggest that the use of fresh milk as the test meal and the detection of excess delta 13CO2 15 min after the ingestion of 13C-urea are suitable for the clinical use of 13C-UBT. This test is simple and rapid.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Wang WM,Lee SC,Ding HJ,Jan CM,Chen LT,Wu DC,Liu CS,Peng CF,Chen YW,Huang YF,Chen CYdoi
10.1007/s005350050092subject
Has Abstractpub_date
1998-06-01 00:00:00pages
330-5issue
3eissn
0944-1174issn
1435-5922journal_volume
33pub_type
杂志文章abstract:BACKGROUND:Oropharyngeal dysphagia (OD) is a major gastrointestinal motility disorder that causes severe nutritional and respiratory complications in elderly and neurological patients. In an earlier study, we found that stimulation of pharyngeal sensory neurons by capsaicinoids acting on transient receptor potential va...
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/BF03326418
更新日期:2002-11-01 00:00:00
abstract::The present study was carried out to examine the effects of submucosal administration of endothelin on gastric mucosal integrity in rats. Injection of endothelin-3 into the submucosal space of the stomach induced gastric mucosal damage dose-dependently and site-specifically. The gastric injury was localized only at th...
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pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
abstract::To investigate the role played by cytokines in chronic pancreatitis, we examined serum levels of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) in 33 patients with definitively diagnosed chronic pancreatitis. All the patients, who had rec...
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doi:10.1007/BF02358371
更新日期:1994-06-01 00:00:00
abstract::In this study, we used magnetic resonance (MR) imaging to measure portal blood flow in 12 healthy controls and 17 cirrhotics while they were breath-holding after inspiration and after expiration. We then compared the results with measurements made during normal respiration in the healthy controls and cirrhotics. Blood...
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pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-015-1040-9
更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s00535-007-2048-6
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pub_type: 杂志文章,多中心研究
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更新日期:2004-06-01 00:00:00
abstract::Chronic pancreatitis is a chronic clinical disorder characterized by irreversible damage to the pancreas and the development of histologic evidence of inflammation and fibrosis, and eventually the destruction and permanent loss of exocrine and endocrine tissue. A nationwide survey in Japan revealed an increase in the ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of gastroenterology
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doi:10.1007/s00535-012-0723-8
更新日期:2013-08-01 00:00:00
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00535-011-0484-9
更新日期:2012-03-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00535-019-01583-9
更新日期:2019-10-01 00:00:00
abstract::A case of Dieulafoy's vascular malformation of the jejunum treated by laparoscopic surgery is described. The patient was a 31-year-old-woman who had complained of melena and had severe anemia needing blood transfusion. Angiography revealed microaneurysms and hypervascularity of the jejunum in the area between the firs...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-003-1305-6
更新日期:2004-01-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350300046
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Ulcerative colitis (UC) is characterized by chronic inflammation in the colon and epigenetic factors underlying the occurrence. Circular RNAs (circRNAs) have been under intensive focus due to the circular construct and gene-regulating functions. However, the changes and roles of circRNAs in UC remain unknown...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-019-01585-7
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doi:10.1007/s005350170103
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Evidence suggests that rates of gastroesophageal reflux disease are increasing in the Asia-Pacific region, where patients tend to have predominantly non-erosive reflux disease as opposed to erosive (reflux) esophagitis. At present, data for the responsiveness of non-erosive reflux disease to proton pump inhi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00535-011-0402-1
更新日期:2011-07-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02355018
更新日期:1996-06-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-015-1117-5
更新日期:2016-04-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-019-01625-2
更新日期:2020-02-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-015-1070-3
更新日期:2015-12-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050071
更新日期:1998-04-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-007-2111-3
更新日期:2008-01-01 00:00:00
abstract::Epidemiological studies of ulcerative colitis (UC) have been conducted once every year since 1973 in Japan. The number of participating hospitals in 1429 and they are distributed throughout Japan. A total number of 10819 patients diagnosed with UC have been registered, including 197 patients with a positive family his...
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pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00