Chronic pancreatitis in Japan: epidemiology, prognosis, diagnostic criteria, and future problems.

abstract：BACKGROUND:Recently, a significant relationship between gastric cancer and Helicobacter pylori infection has been proven. The purpose of this study was to elucidate the actual conditions of H. pylori infection in Japanese teenagers. METHODS:The study subjects were students at a certain high school between 2007 and 200...

journal_title：Journal of gastroenterology

authors： Akamatsu T,Ichikawa S,Okudaira S,Yokosawa S,Iwaya Y,Suga T,Ota H,Tanaka E

更新日期：2011-12-01 00:00:00

abstract：:Chronic inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer. However, the mechanism underlying the development of colorectal cancers through chronic inflammation is not known. Activation-induced cytidine deaminase (AID) was originally identified as an inducer of so...

journal_title：Journal of gastroenterology

authors： Endo Y,Marusawa H,Chiba T

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:There are substantial differences in inflammatory bowel disease (IBD) genetics depending on the populations examined. We aimed to identify Japanese population-specific or true culprit susceptibility genes through a meta-analysis of past genetic studies of Japanese IBD. METHODS:For this study, we reviewed 2,...

journal_title：Journal of gastroenterology

authors： Arimura Y,Isshiki H,Onodera K,Nagaishi K,Yamashita K,Sonoda T,Matsumoto T,Takahashi A,Takazoe M,Yamazaki K,Kubo M,Fujimiya M,Imai K,Shinomura Y

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy is the current standard of care for patients with chronic hepatitis C. Determining precisely the risk of serious adverse events (SAEs) and mortality from a single study is rather difficult because of the infrequency of such events. The aim of this s...

journal_title：Journal of gastroenterology

authors： Minami T,Kishikawa T,Sato M,Tateishi R,Yoshida H,Koike K

更新日期：2013-02-01 00:00:00

abstract：:A 27-year-old woman with a 9-year history of ulcerative colitis involving the entire colon was admitted to our hospital in August 1992 because of bloody stools and left lower abdominal pain. She had been treated with sulfasalazine since 1983 and the colitis had been clinically quiescent or mild for 7 years. She had al...

journal_title：Journal of gastroenterology

authors： Seo M,Okada M,Osamura S,Hara S,Umeno T,Maeshiro K,Yamada Y,Yuh K

更新日期：1997-02-01 00:00:00

abstract：:This study was designed to clarify what differences the last 25 years have made in surgical results for patients with hepatocellular carcinoma (HCC). We examined results for 716 hepatectomized patients in four treatment eras: first era (1973-1980; n = 58), second era (1981-1985; n = 155), third era (1986-1990; n = 243...

journal_title：Journal of gastroenterology

authors： Yamanaka N,Takata M,Tanaka T,Yamanaka J,Yasui C,Ando T,Kuroda N,Maeda S,Okamoto E

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:In patients with hepatitis C virus (HCV)-genotype 1b and a high virus load, of more than 1 Meq/ml by the DNA probe assay, the clearance of HCV-RNA was achieved in only 10% with a 6-month interferon (IFN) course. We therefore assessed the efficacy of prolonged IFN therapy in patients with HCV-genotype 1b and ...

journal_title：Journal of gastroenterology

authors： Arase Y,Ikeda K,Tsubota A,Suzuki Y,Saitoh S,Kobayashi M,Kobayashi M,Suzuki F,Akuta N,Someya T,Kumada H

更新日期：2003-01-01 00:00:00

abstract：:We simultaneously recorded gastric emptying of radio-opaque markers (ROMs) and monitored serial changes in plasma acetaminophen (AAP) levels to demonstrate the relationship between the ROM and the AAP methods, and we investigated the effect of a single intravenous dose of erythromycin (EM) on gastric emptying in healt...

journal_title：Journal of gastroenterology

authors： Park HJ,Jung JK,Song KS,Lee SI,Itoh Z,Park IS

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:Hepatic steatosis is frequently observed in subjects with metabolic syndrome (MS). In type 2 diabetics, it is independently associated with cardiovascular diseases. In order to confirm and extend this finding, a large group of patients with risk factors for atherosclerosis was studied. METHODS:Carotid atherosc...

journal_title：Journal of gastroenterology

authors： Carallo C,Mancuso G,Mauro G,Laghi F,Madafferi B,Irace C,Gnasso A,Scavelli F,Dell'Aquila F,Bartone M,Gullo F,Ferraro M,Spagnuolo V,Belmonte M,Ferrara A,Silvano Rotondaro A,Brandolino N,Parasporo F,Scopelliti F

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:King's College Hospital (KCH) criteria and the model for end-stage liver disease (MELD) score are useful and widely-employed prognostic markers for acute liver failure (ALF). We previously reported that liver atrophy is an important prognostic factor for ALF. The aim of the present study was to assess t...

journal_title：Journal of gastroenterology

authors： Yamagishi Y,Saito H,Ebinuma H,Kikuchi M,Ojiro K,Kanamori H,Tada S,Horie Y,Kato S,Hibi T

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) act as vital regulators of gene expression in a variety of cancers. However, the role of circRNAs in gastric cancer (GC) remains largely unexplored. Herein, we identified that circTMEM87A sponges miR-142-5p to promote GC progression through up-regulating ULK1 expression. METHODS:The...

journal_title：Journal of gastroenterology

authors： Wang H,Sun G,Xu P,Lv J,Zhang X,Zhang L,Wang S,Cao J,Xia Y,Xuan Z,Li B,Huang X,Jiang T,Fang L,Xu Z

更新日期：2020-11-06 00:00:00

abstract：:Magnetic resonance imaging (MRI) findings in three patients with primary anorectal malignant melanoma are described. Two patients had melanotic and one had amelanotic anorectal melanoma. The findings of MRI with a pelvic coil and an endorectal coil were consistent with pathologic findings. MRI with a pelvic coil demon...

journal_title：Journal of gastroenterology

authors： Matsuoka H,Nakamura A,Iwamoto K,Sugiyama M,Hachiya J,Atomi Y,Masaki T

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:There have only been a few prospective studies investigating risk factors associated with the development of hepatocellular carcinoma (HCC) among chronic hepatitis B patients all over the world, and no study has been conducted in Japanese population. METHODS:A population-based cohort consisting of 19393 sub...

journal_title：Journal of gastroenterology

authors： Kusakabe A,Tanaka Y,Inoue M,Kurbanov F,Tatematsu K,Nojiri S,Joh T,Tsugane S,Mizokami M

更新日期：2011-01-01 00:00:00

abstract：:Nonrotation of the midgut in adults and appendiceal mucocele are both rare pathological conditions. We report here the first case of nonrotation of the midgut associated with appendiceal mucocele. The patient was a 51-year-old man admitted to hospital with ileus. An upper gastrointestinal series and a barium enema rev...

journal_title：Journal of gastroenterology

authors： Kawashima K,Ishihara S,Amano K,Hirakawa K,Adachi K,Fukuda R,Sumi S,Watanabe M,Kinoshita Y

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is characterized by chronic inflammation in the colon and epigenetic factors underlying the occurrence. Circular RNAs (circRNAs) have been under intensive focus due to the circular construct and gene-regulating functions. However, the changes and roles of circRNAs in UC remain unknown...

journal_title：Journal of gastroenterology

authors： Wang T,Chen N,Ren W,Liu F,Gao F,Ye L,Han Y,Zhang Y,Liu Y

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Corticosteroid therapy has been commonly administered to patients with acute liver injury (ALI)/acute liver failure (ALF) in Japan to prevent the development of hepatic encephalopathy, but the appropriate timing to start corticosteroid therapy has not been determined and optimal response evaluation of the th...

journal_title：Journal of gastroenterology

authors： Kakisaka K,Kataoka K,Suzuki Y,Kuroda H,Takikawa Y

更新日期：2017-08-01 00:00:00

abstract：:Pyogenic granulomas represent the aquisition of vasodilative granulation tissue in the skin or mucosa. They are extremely rare in the alimentary tract, other than in the oral cavity. Here, we report a case of pyogenic granuloma arising from the gastric mucosa. An 82-year-old man was admitted to our hospital because of...

journal_title：Journal of gastroenterology

authors： Kusakabe A,Kato H,Hayashi K,Igami T,Hasegawa H,Tsuzuki T,Ueda R,Mizokami M

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:The virologic impact of adding interferon to antiviral nucleoside therapy was studied in Japanese patients having perinatally transmitted hepatitis B virus (HBV) genotype C. METHODS:Sixty-four patients including 41 positive for hepatitis B e antigen (HBeAg) were assigned to receive either (1) a combination ...

journal_title：Journal of gastroenterology

authors： Yuki N,Nagaoka T,Nukui K,Omura M,Hikiji K,Kato M

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to examine the diurnal variations in ornithine decarboxylase (ODC) activity and apoptosis in the small intestinal mucosa of Mongolian gerbils. First, the feeding, drinking, and ambulatory patterns of the gerbils were recorded. The results indicated that Mongolian gerbils lost diurnal cyclicit...

journal_title：Journal of gastroenterology

authors： Kashiwagi Y,Fujimoto K,Iwakiri R,Yoshida T,Noda T,Aw TY,Niho Y,Sakata T

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to examine the factors correlated with the progression of ribavirin-induced hemolytic anemia in patients with chronic hepatitis C treated by interferon and ribavirin combination therapy. METHODS:This study was conducted on 505 patients by the Osaka Liver Disease Study Group. A decl...

journal_title：Journal of gastroenterology

authors： Oze T,Hiramatsu N,Kurashige N,Tsuda N,Yakushijin T,Kanto T,Takehara T,Kasahara A,Kato M,Yoshihara H,Katayama K,Kubota S,Hijioka T,Ishibashi K,Oshita M,Hagiwara H,Haruna Y,Mita E,Tamura S,Hayashi N

更新日期：2006-09-01 00:00:00

abstract：:Depletion of goblet cells (the main mucin-producing cells in the colon) is one of the most reliable histological characteristics of ulcerative colitis, whereas a major symptom of this disease is bloody diarrhea containing a large amount of mucus. The discrepancy between these phenomena was investigated in a time-cours...

journal_title：Journal of gastroenterology

authors： Nakano S,Ohara S,Kubota T,Saigenji K,Hotta K

更新日期：1999-04-01 00:00:00

abstract：:In 1992, a seroepidemiologic study was carried out among hemodialysis patients and the general population in Fukuoka and Okinawa, Japan to determine the presence of hepatitis C virus (HCV) infection and HCV viremia. The markers used were antibody to HCV, determined by second-generation assay (anti-HCV), and HCV RNA, d...

journal_title：Journal of gastroenterology

authors： Hayashi J,Yoshimura E,Nabeshima A,Kishihara Y,Ikematsu H,Hirata M,Maeda Y,Kashiwagi S

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:In acute pancreatitis, pancreatic phospholipase A(2) (PLA2) in the circulating blood hydrolyzes phospholipids contained in plasma lipoproteins, liberating eicosanoid precursors that are subsequently converted to various eicosanoids. The pathophysiological significance of eicosanoid synthesis via this pathway...

journal_title：Journal of gastroenterology

authors： Motoyoshi M,Sugiyama M,Atomi Y,Kimura W,Nagawa H

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Given the well-documented adverse side effects of sorafenib, many sorafenib-treated patients may need the reduced initial dose of the compound, and an alternative sorafenib-based therapy, which exerts similar clinical benefit, is anticipated. An angiostatic therapy with sorafenib is considered one of the pro...

journal_title：Journal of gastroenterology

authors： Yoshiji H,Noguchi R,Namisaki T,Moriya K,Kitade M,Aihara Y,Douhara A,Kawaratani H,Nishimura N,Fukui H

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Only a few studies have longitudinally evaluated whether fatty pancreas increases the risk of type-2 diabetes (T2D), and their results were inconsistent. Fatty pancreas is closely linked to overweight and obesity, but previous studies did not exclude overweight or obese individuals. Therefore, in this cohort...

journal_title：Journal of gastroenterology

authors： Yamazaki H,Tauchi S,Wang J,Dohke M,Hanawa N,Kodama Y,Katanuma A,Saisho Y,Kamitani T,Fukuhara S,Yamamoto Y

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) core protein is known to cause oxidative stress and alter apoptosis pathways. However, the apoptosis results are inconsistent, and the real significance of oxidative stress is not well known. The aim of this study was twofold. First, we wanted to confirm whether core-induced oxidative...

journal_title：Journal of gastroenterology

authors： Hara Y,Hino K,Okuda M,Furutani T,Hidaka I,Yamaguchi Y,Korenaga M,Li K,Weinman SA,Lemon SM,Okita K

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Polymorphisms in the gene for interleukin 1beta (IL-1B) have been found to increase the risks of gastric cancer and its precursors in response to Helicobacter pylori infection in white populations. however, there has been no independent confirmation of the role of IL-1B markers in gastric cancer patients fro...

journal_title：Journal of gastroenterology

authors： Lee KA,Ki CS,Kim HJ,Sohn KM,Kim JW,Kang WK,Rhee JC,Song SY,Sohn TS

更新日期：2004-01-01 00:00:00

abstract：:We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in this country. Although the definition of GERD depends on the individual study, the prevalence of GERD has been increasing since the end of the 1990s. The reasons...

journal_title：Journal of gastroenterology

authors： Fujiwara Y,Arakawa T

更新日期：2009-01-01 00:00:00

abstract：:5-aminosalicylate is a fundamental treatment for patients with ulcerative colitis with mild-to-moderate disease; however, evidence for 5-aminosalicylate treatment is unclear in some situations. This review discusses the clinical guidelines and previous studies, and highlights the following points: (1) Although rectal ...

journal_title：Journal of gastroenterology

authors： Naganuma M

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Additional surgical treatment after non-curative endoscopic resection for superficial esophageal cancer should be considered unless the tumor is pathologically proven to be categorized within the absolute indication of endoscopic resection. However, the significance of this treatment strategy has been poorly...

journal_title：Journal of gastroenterology

authors： Saeki H,Watanabe M,Mine S,Shigaki H,Oya S,Ishiyama A,Tsuchida T,Fujisaki J,Baba H,Maehara Y,Sano T

更新日期：2015-04-01 00:00:00