A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in Japan.

abstract：BACKGROUND:Polymorphisms in the gene for interleukin 1beta (IL-1B) have been found to increase the risks of gastric cancer and its precursors in response to Helicobacter pylori infection in white populations. however, there has been no independent confirmation of the role of IL-1B markers in gastric cancer patients fro...

journal_title：Journal of gastroenterology

authors： Lee KA,Ki CS,Kim HJ,Sohn KM,Kim JW,Kang WK,Rhee JC,Song SY,Sohn TS

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The ability of serum infliximab level to predict clinical outcome in infliximab therapy in Crohn's disease is unclear. Here, we aimed to clarify the correlation between the timing of loss of response (LOR) to treatment and a decrease in serum infliximab level, and, in addition, to identify an indicator of in...

journal_title：Journal of gastroenterology

authors： Hibi T,Sakuraba A,Watanabe M,Motoya S,Ito H,Sato N,Yoshinari T,Motegi K,Kinouchi Y,Takazoe M,Suzuki Y,Matsumoto T,Kawakami K,Matsumoto T,Hirata I,Tanaka S,Ashida T,Matsui T

更新日期：2014-02-01 00:00:00

abstract：:The clinical significance of small intestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains under-appreciated. It occurs with greater frequency than the damage caused by these drugs in the upper gastrointestinal tract, but is much more difficult to diagnose and treat. Although the pathogenesis...

journal_title：Journal of gastroenterology

authors： Syer SD,Blackler RW,Martin R,de Palma G,Rossi L,Verdu E,Bercik P,Surette MG,Aucouturier A,Langella P,Wallace JL

更新日期：2015-04-01 00:00:00

abstract：:Helicobacter pylori infection has been found to decrease the expression of antral somatostatin and to increase the release of the acid-stimulating hormone gastrin. The reversal of these changes in gut hormones by the eradication of H. pylori, and in-vivo and in-vitro studies in animals either infected with H. pylori o...

journal_title：Journal of gastroenterology

authors： Kaneko H,Konagaya T,Kusugami K

更新日期：2002-01-01 00:00:00

abstract：:The purpose of the present study was to elucidate the effect of hepatic reflow following ischemia on the remnant liver after hepatectomy with occluded hepatic blood inflow in dogs with obstructive jaundice. When 40% hepatectomy was performed with 10-min occlusion of hepatic blood inflow in dogs with obstructive jaundi...

journal_title：Journal of gastroenterology

authors： Ogura Y,Takagi K,Kawarada Y,Mizumoto R

更新日期：1996-06-01 00:00:00

abstract：:Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and non-lymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients wit...

journal_title：Journal of gastroenterology

authors： Malaguarnera M,Di Fazio I,Romeo MA,Restuccia S,Laurino A,Trovato BA

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Better diagnosis of metastatic disease has been pursued by oncologists: however, many of the tumor markers have been still controversial. Our purpose was to estimate the usefulness of soluble E-selectin and its ligand sialyl Lewis A for more accurate diagnosis as a combined tumor marker for metastases in col...

journal_title：Journal of gastroenterology

authors： Ito K,Ye CL,Hibi K,Mitsuoka C,Kannagi R,Hidemura K,Ando H,Kasai Y,Akiyama S,Nakao A

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) core protein is known to cause oxidative stress and alter apoptosis pathways. However, the apoptosis results are inconsistent, and the real significance of oxidative stress is not well known. The aim of this study was twofold. First, we wanted to confirm whether core-induced oxidative...

journal_title：Journal of gastroenterology

authors： Hara Y,Hino K,Okuda M,Furutani T,Hidaka I,Yamaguchi Y,Korenaga M,Li K,Weinman SA,Lemon SM,Okita K

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:It is suggested that nonalcoholic fatty liver disease (NAFLD), including nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH), can be associated with insomnia and gastro-esophageal reflux disease (GERD). The relationship between GERD and insomnia in subjects with biopsy-proven NAFLD was in...

journal_title：Journal of gastroenterology

authors： Taketani H,Sumida Y,Tanaka S,Imajo K,Yoneda M,Hyogo H,Ono M,Fujii H,Eguchi Y,Kanemasa K,Chayama K,Itoh Y,Yoshikawa T,Saibara T,Fujimoto K,Nakajima A,Japan Study Group of NAFLD.

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Cytotoxin-associated gene A (CagA) product is a bacterial virulence factor contributing to the pathogenicity of Helicobacter pylori (HP) infection in humans. Host factors, which vary in different countries, interact with bacterial factors to determine the disease state. Our objective was to investigate the f...

journal_title：Journal of gastroenterology

authors： Sökücü S,Ozden AT,Süoğlu OD,Elkabes B,Demir F,Cevikbaş U,Gökçe S,Saner G

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:At clinical scintigraphic examinations of the abdomen using single photon emission computed tomography (SPECT), we have observed a different distribution between the left and right main liver lobes of various radiopharmaceuticals. This was studied retrospectively in clinical patients. METHODS:Examinations w...

journal_title：Journal of gastroenterology

authors： Jacobsson H,Jonas E,Hellström PM,Larsson SA

更新日期：2005-07-01 00:00:00

abstract：:Although polycystic liver disease (PLD) is known to be associated with autosomal dominant polycystic kidney disease, a finding of PLD with pancreatic ductal adenocarcinoma is extremely rare. We have experienced one such case of a ductal adenocarcinoma of the pancreas in a patient with Potter type III cystic disease of...

journal_title：Journal of gastroenterology

authors： Sakurai Y,Shoji M,Matsubara T,Ochiai M,Funabiki T,Urano M,Mizoguchi Y,Fuwa N

更新日期：2001-06-01 00:00:00

abstract：:We investigated the effect of intravenous infusions of the therapeutically available amino acid solutions Moripron and Morihepamin (Roussel Morishita, Osaka, Japan) on gallbladder contraction and cholecystokinin (CCK) release in healthy male volunteers. Plasma CCK levels were measured by radioimmunoassay, using the an...

journal_title：Journal of gastroenterology

authors： Shirohara H,Tabaru A,Otsuki M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Given the well-documented adverse side effects of sorafenib, many sorafenib-treated patients may need the reduced initial dose of the compound, and an alternative sorafenib-based therapy, which exerts similar clinical benefit, is anticipated. An angiostatic therapy with sorafenib is considered one of the pro...

journal_title：Journal of gastroenterology

authors： Yoshiji H,Noguchi R,Namisaki T,Moriya K,Kitade M,Aihara Y,Douhara A,Kawaratani H,Nishimura N,Fukui H

更新日期：2014-10-01 00:00:00

abstract：:In Japan, nutritional therapy as both a primary and as a secondary treatment is widely used for Crohn's disease (CD). The rationale for its use is based on a variety of reasons. The first is its ability to induce remission and to ameliorate the activity of intestinal lesions in the short term by enteral (EN) or by par...

journal_title：Journal of gastroenterology

authors： Matsui T,Sakurai T,Yao T

更新日期：2005-03-01 00:00:00

abstract：:A 21-year-old man with diarrhea and edema was admitted to our hospital and diagnosed with protein-losing enteropathy caused by primary intestinal lymphangiectasia. He was placed, in turn, on a low-fat diet, an elemental diet, and, subsequently, fasting therapy with total parenteral nutrition (TPN) support. However, hi...

journal_title：Journal of gastroenterology

authors： Kuroiwa G,Takayama T,Sato Y,Takahashi Y,Fujita T,Nobuoka A,Kukitsu T,Kato J,Sakamaki S,Niitsu Y

更新日期：2001-02-01 00:00:00

abstract：:Prevention of human diseases has become a major focus of biomedical investigators around the world. Our current screening and treatment regimens for colorectal cancer are not effective, as indicated by the fact that this disease is the second leading cause of death from cancer in the United States. Recently published ...

journal_title：Journal of gastroenterology

authors： DuBois RN,Smalley WE

更新日期：1996-12-01 00:00:00

abstract：:In a pilot study of direct dissolution therapy of gallstones with methyl tert-butyl ether (MTBE), endoscopic transpapillary catheterization in the gallbladder (ETCG) was performed. Complete dissolution was seen in 8 out of 12 (66%) patients and partial dissolution was seen in 2 (16%) patients. In one of the 8 complete...

journal_title：Journal of gastroenterology

authors： Uchida N,Nakatsu T,Hirabayashi S,Minami A,Fukuma H,Ezaki T,Morshed SA,Fuke C,Ameno K,Ijiri I

更新日期：1994-08-01 00:00:00

abstract：:We report a case of primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap syndrome with concurrent idiopathic thrombocytopenic purpura (ITP) and Hashimoto's disease with positivity for anticentromere antibody. The patient was a 64-year-old woman with symptoms of jaundice and general fatigue. About 30 year...

journal_title：Journal of gastroenterology

authors： Arakawa Y,Amaki S,Miyakawa H,Sakai T,Gotou I,Tanaka N,Moriyama M,Iwasaki A,Sugitani M,Arakawa Y

更新日期：2004-01-01 00:00:00

abstract：:The tight junction of pancreatic exocrine cells is thought to regulate paracellular permeability, and is a possible reflux route of pancreatic juice into the blood flow. Morphological changes in the tight junction of canine pancreatic acinar cells following intraductal hypertension and secretin stimulation were morpho...

journal_title：Journal of gastroenterology

authors： Akao S,Oya M,Akiyama H,Ishikawa H

更新日期：2000-01-01 00:00:00

abstract：:This study was conducted to determine and compare serum trace metal levels in viral hepatitis-associated chronic liver disease. Of 98 patients aged 43 (+/- 13) [mean (+/- SD)] years, 83 (85%) were seropositive for hepatitis B surface antigen (HBsAg) and 15 (15%) were seropositive for anti-hepatitis C virus (HCV). Twen...

journal_title：Journal of gastroenterology

authors： Pramoolsinsap C,Promvanit N,Komindr S,Lerdverasirikul P,Srianujata S

更新日期：1994-10-01 00:00:00

abstract：:A 69-year-old woman was admitted to our hospital with fever and abdominal pain in the epigastric region. Abdominal ultrasonography demonstrated a well-defined hypoechoic mass in the epigastric region with encasement of the left hepatic lobe and stomach. Computed tomography confirmed a low-density mass, 20 cm in diamet...

journal_title：Journal of gastroenterology

authors： Kaibori M,Kawaguchi Y,Yokoigawa N,Yanagida H,Takai S,Kwon AH,Uemura Y,Kamiyama Y

更新日期：2003-01-01 00:00:00

abstract：:We report a 27-year-old male with Crohn's disease (CD) of the small and large intestine, whose peripheral blood lymphocytes (PBL) showed increased cell-mediated cytotoxicity (CTL). Autologous and allogeneic effector cells from PBL and intestinal lymph nodes (LN) were isolated on a Ficoll-Hypaque gradient. Colonic cell...

journal_title：Journal of gastroenterology

authors： Okazaki K,Yokoyama Y,Yamamoto Y,Kobayashi M,Araki K,Ogata T

更新日期：1994-08-01 00:00:00

abstract：:We report a case of pancreas head carcinoma associated with fat replacement of the body and tail. A 68-year-old man presented with obstructive jaundice and was admitted to our hospital. Ultrasonography and computed tomography showed pancreas head tumor with a neighboring cystic lesion and fatty replacement of parenchy...

journal_title：Journal of gastroenterology

authors： Toyama N,Kamiyama H,Suminaga Y,Namai K,Ota M,Konishi F

更新日期：2004-01-01 00:00:00

abstract：:Cholecystokinin (CCK) receptor antagonists have been reported on have an inhibitory effect on acute experimental pancreatitis, but their long-term administration is also reported to block pancreatic regeneration. We examined whether the short-term administration of KSG-504 (KSG), a synthetic CCK-A receptor antagonist,...

journal_title：Journal of gastroenterology

authors： Okumura Y,Inoue H,Fujiyama Y,Bamba T

更新日期：1995-08-01 00:00:00

abstract：:We report a 74-year-old man with triple synchronous cancers occurring in the gallbladder, common bile duct, and pancreas. The patient had consulted a nearby physician because of epigastralgia and icterus. On September 30, 1997, the patient was admitted to our department for further evaluation and treatment. Abdominal ...

journal_title：Journal of gastroenterology

authors： Sato K,Maekawa T,Yabuki K,Tamasaki Y,Maekawa H,Kudo K,Sengoku H,Kawa I,Wada R,Matsumoto M

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Autoimmune pancreatitis (AIP) is a unique form of pancreatitis and can be complicated with various extrapancreatic lesions. Little is known about the long-term clinical course of AIP. Here we aimed to document the clinical course of AIP. METHODS:For this study, we recruited 21 patients, averaging 66.5 years in...

journal_title：Journal of gastroenterology

authors： Uchida K,Yazumi S,Nishio A,Kusuda T,Koyabu M,Fukata M,Miyoshi H,Sakaguchi Y,Fukui T,Matsushita M,Takaoka M,Okazaki K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease affects the quality of a patient's life in many ways, but no validated instrument for measuring disease-specific quality of life in these patients is available in Japan. We developed a Japanese version of the Inflammatory Bowel Disease Questionnaire (IBDQ), together with the author...

journal_title：Journal of gastroenterology

authors： Hashimoto H,Green J,Iwao Y,Sakurai T,Hibi T,Fukuhara S

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Infection with Helicobacter pylori has been associated with chronic idiopathic urticaria (CIU). The aim of this study was to investigate the efficacy of H. pylori eradication in the treatment of patients with CIU. METHODS:Fifty patients with CIU (16 men and 34 women; age 25-75 years) and 100 sex- and age-ma...

journal_title：Journal of gastroenterology

authors： Fukuda S,Shimoyama T,Umegaki N,Mikami T,Nakano H,Munakata A

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Photodynamic therapy (PDT) has not been reported for human hepatoma, because cancer cells only weakly take up the photosensitizer. Indocyanine green (ICG) is a photosensitizer normally excreted into the bile, and bile excretion is impaired in human hepatomas. We examined whether human hepatoma cell lines pre...

journal_title：Journal of gastroenterology

authors： Kaneko J,Inagaki Y,Ishizawa T,Gao J,Tang W,Aoki T,Sakamoto Y,Hasegawa K,Sugawara Y,Kokudo N

更新日期：2014-01-01 00:00:00