Cyclooxygenase, NSAIDs, and colorectal cancer.

abstract：:We assessed the influence of epidermal growth factor (EGF) and insulin on gastric epithelial restoration in vitro. Rabbit gastric epithelial cells were cultured and formed a complete monolayer cell sheet in 2 days. We created a wound (1.8 +/- 0.05 mm2) by denuding an area of cells, and EGF (0.1-30 ng/ml) and/or insuli...

journal_title：Journal of gastroenterology

authors： Maehiro K,Watanabe S,Hirose M,Iwazaki R,Miwa H,Sato N

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Cytotoxin-associated gene A (CagA) product is a bacterial virulence factor contributing to the pathogenicity of Helicobacter pylori (HP) infection in humans. Host factors, which vary in different countries, interact with bacterial factors to determine the disease state. Our objective was to investigate the f...

journal_title：Journal of gastroenterology

authors： Sökücü S,Ozden AT,Süoğlu OD,Elkabes B,Demir F,Cevikbaş U,Gökçe S,Saner G

更新日期：2006-06-01 00:00:00

abstract：:A 67-year-old female was admitted with diarrhea. Preoperatively, we diagnosed intussusception due to malignant lymphoma in the ileocecal region by image and colonoscopic examinations. We resected the right hemicolon for the tumor, which was located mainly in the cecum, causing intussusception. The stenotic terminal il...

journal_title：Journal of gastroenterology

authors： Matsushita M,Hajiro K,Kajiyama T,Ohana M,Konishi Y,Kusumi F,Matsubayashi Y,Sawami H,Narusawa H,Takahashi Y

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to elucidate the role of nuclear factor kappaB (NF-kappaB) in the development of gastric ischemia-reperfusion (GI-R) injury and in mediating the effects of angiotensin II (Ang II) in the paraventricular nucleus (PVN) on GI-R injury. METHODS:GI-R injury was induced in rats by cl...

journal_title：Journal of gastroenterology

authors： Zhang YM,Wei EQ,Hu X,Qiao WL,Shi Y,Xu M,Zhang JF

更新日期：2008-01-01 00:00:00

abstract：:An extremely rare case of malignant schwannoma of the esophagus with lymph node metastasis is reported. A 49-year-old woman was found to have an abnormal shadow on a chest X-ray film taken during an annual checkup. Upper gastrointestinal series showed extrinsic pressure on the middle thoracic esophagus, without a muco...

journal_title：Journal of gastroenterology

authors： Murase K,Hino A,Ozeki Y,Karagiri Y,Onitsuka A,Sugie S

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Subunit A of coagulation factor XIII (FXIII-A) is important for clot stability and acts in the subsequent wound healing process. Loss of plasma FXIII-A has been reported after surgery, sepsis, and inflammatory conditions. In the intestinal mucosa, FXIII-A is expressed by macrophages and cellular FXIII-A has ...

journal_title：Journal of gastroenterology

authors： Soendergaard C,Kvist PH,Seidelin JB,Pelzer H,Nielsen OH

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The endoscopic abnormalities present in the small bowel (SB) of patients with portal hypertension (PH) are not well understood. This study sought to evaluate endoscopic findings of the SB in patients with PH by double balloon endoscopy (DBE). METHODS:We evaluated the endoscopic findings of SB in 15 patients...

journal_title：Journal of gastroenterology

authors： Kodama M,Uto H,Numata M,Hori T,Murayama T,Sasaki F,Tsubouchi N,Ido A,Shimoda K,Tsubouchi H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Angiogenesis is essential for gastric ulcer healing. Recent results suggest that vascular endothelial growth factor receptor 1 (VEGFR1), which binds to VEGF, promotes angiogenesis. In the present study, we investigated the role of VEGFR1 signaling in gastric ulcer healing and angiogenesis. METHODS:Gastric u...

journal_title：Journal of gastroenterology

authors： Sato T,Amano H,Ito Y,Eshima K,Minamino T,Ae T,Katada C,Ohno T,Hosono K,Suzuki T,Shibuya M,Koizumi W,Majima M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Recently, the novel gene DOG1 has been found to be overexpressed in most gastrointestinal stromal tumors (GISTs) specifically within the field of soft tissue tumors. DOG1 might play a role in development of GISTs and have potential as a diagnostic marker and therapeutic target, but the biological function an...

journal_title：Journal of gastroenterology

authors： Miwa S,Nakajima T,Murai Y,Takano Y,Sugiyama T

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV) often recurs after surgical or medical treatment. METHODS:Eighty consecutive patients with HBV-positive cirrhosis and HCC who underwent potentially curative ablation for HCC were analyzed. Eleven patients received long-term interferon (IFN) th...

journal_title：Journal of gastroenterology

authors： Someya T,Ikeda K,Saitoh S,Kobayashi M,Hosaka T,Sezaki H,Akuta N,Suzuki F,Suzuki Y,Arase Y,Kumada H

更新日期：2006-12-01 00:00:00

abstract：:Changes of hepatic sinusoids are crucial in the pathogenesis of liver cirrhosis and portal hypertension. Liver injury leads to distinct morphological abnormalities such as loss of sinusoidal fenestration, vasoconstriction, and angiogenesis as well as molecular changes. Communication between the two key cells in this h...

journal_title：Journal of gastroenterology

authors： Greuter T,Shah VH

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:White adipose tissue (WAT) is important for the maintenance of metabolic homeostasis, and metabolic syndrome is sometimes associated with WAT dysfunction in humans and animals. WAT reportedly plays a key, beneficial role in the maintenance of glucose and lipid homeostasis during de novo lipogenesis (DNL). Pu...

journal_title：Journal of gastroenterology

authors： Cai X,Hayashi S,Fang C,Hao S,Wang X,Nishiguchi S,Tsutsui H,Sheng J

更新日期：2017-12-01 00:00:00

abstract：:We investigated the effect of intravenous infusions of the therapeutically available amino acid solutions Moripron and Morihepamin (Roussel Morishita, Osaka, Japan) on gallbladder contraction and cholecystokinin (CCK) release in healthy male volunteers. Plasma CCK levels were measured by radioimmunoassay, using the an...

journal_title：Journal of gastroenterology

authors： Shirohara H,Tabaru A,Otsuki M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Fatty liver is an important clinical feature not only in alcoholic and non-alcoholic fatty liver diseases, but in other chronic liver diseases as well. Our aim was to elucidate the effect and relationship between habitual alcohol intake and obesity in the development of fatty liver disease. METHODS:We enrol...

journal_title：Journal of gastroenterology

authors： Takahashi H,Ono M,Hyogo H,Tsuji C,Kitajima Y,Ono N,Eguchi T,Fujimoto K,Chayama K,Saibara T,Anzai K,Eguchi Y

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Loss of imprinting (LOI) of the insulin-like growth factor 2 (IGF2) is an early event in the development of colorectal cancer (CRC). Whether LOI of IGF2 denotes a molecular or clinical cancer subgroup is currently unknown. METHODS:Tumor biopsies and paired normal mucosa from 399 patients with extensive clin...

journal_title：Journal of gastroenterology

authors： Belharazem D,Magdeburg J,Berton AK,Beissbarth L,Sauer C,Sticht C,Marx A,Hofheinz R,Post S,Kienle P,Ströbel P

更新日期：2016-10-01 00:00:00

abstract：:An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all were involved in the fina...

journal_title：Journal of gastroenterology

authors： Unge P

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Photodynamic therapy (PDT) has not been reported for human hepatoma, because cancer cells only weakly take up the photosensitizer. Indocyanine green (ICG) is a photosensitizer normally excreted into the bile, and bile excretion is impaired in human hepatomas. We examined whether human hepatoma cell lines pre...

journal_title：Journal of gastroenterology

authors： Kaneko J,Inagaki Y,Ishizawa T,Gao J,Tang W,Aoki T,Sakamoto Y,Hasegawa K,Sugawara Y,Kokudo N

更新日期：2014-01-01 00:00:00

abstract：:A 60-year-old woman was admitted to our department for detailed examination of a polypoid lesions of the gallbladder detected at the time of a mass survey by ultrasound. Endoscopic ultrasonography (EUS) demonstrated a broad-based mass lesion, about 10 mm in size, with an irregular surface, at the peritoneal side of th...

journal_title：Journal of gastroenterology

authors： Fujita N,Noda Y,Kobayashi G,Kimura K,Yago A,Okaniwa S

更新日期：1997-08-01 00:00:00

abstract：:We report a patient who survived total colonic type ulcerative colitis (UC) complicated by toxic megacolon (TM), disseminated intravascular coagulation (DIC), methicillin-resistant Staphylococcus aureus infection, and phlebothrombosis. A 69-year-old man was treated for about 4 months under the diagnosis of ischemic co...

journal_title：Journal of gastroenterology

authors： Arai H,Hanai H,Furuta T,Sato Y,Yamada M,Kaneko E,Baba S,Sugimura H

更新日期：1999-06-01 00:00:00

abstract：:We report a case of living-related partial liver transplantation for decompensated hepatitis B without reactivation of hepatitis B in the following 30 months, and we analyze the factors that indicate a favorable prognosis for transplantation. The 42-year-old female patient received continuously administered lamivudine...

journal_title：Journal of gastroenterology

authors： Hasegawa K,Hashimoto E,Kanai N,Ogawa M,Naritomi T,Taniai M,Takasaki K,Hayashi N

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The introduction of capsule endoscopy (CE) has facilitated the detection of mucosal changes in the small bowel, and such mucosal changes have been noted in cirrhotic patients with portal hypertension; these changes are described as portal hypertensive enteropathy. The aim of this study was to assess the effe...

journal_title：Journal of gastroenterology

authors： Matsushita Y,Narahara Y,Fujimori S,Kanazawa H,Itokawa N,Fukuda T,Takahashi Y,Kondo C,Kidokoro H,Atsukawa M,Nakatsuka K,Sakamoto C

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The clinicopathologic features of cystic neoplasms of the liver, such as cystadenoma and cystadenocarcinoma, are poorly defined because these lesions are extremely rare. METHODS:Clinicopathologic findings in six patients who underwent surgery for a cystic hepatic neoplasm were reviewed retrospectively to de...

journal_title：Journal of gastroenterology

authors： Hai S,Hirohashi K,Uenishi T,Yamamoto T,Shuto T,Tanaka H,Kubo S,Tanaka S,Kinoshita H

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Dual oral therapy with daclatasvir plus asunaprevir yielded an SVR rate of 85% among patients with genotype 1b HCV. Treatment failure mainly occurred in patients with pre-existing HCV with NS5A-Y93H mutation. The significance of the mutation was evaluated. METHODS:The percent of serum NS5A-Y93H strains rela...

journal_title：Journal of gastroenterology

authors： Uchida Y,Kouyama J,Naiki K,Sugawara K,Ando S,Nakao M,Motoya D,Inao M,Imai Y,Nakayama N,Mochida S

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Rice extract has been shown to protect gastric mucosa from stress-induced damage. In this study, the antibiotic effect and the anti-inflammatory effect of orally administered aqueous rice extract on Helicobacter pylori infection and H. pylori-induced gastritis, respectively, in Mongolian gerbils were investi...

journal_title：Journal of gastroenterology

authors： Murakami M,Ota H,Sugiyama A,Ishizone S,Maruta F,Akita N,Okimura Y,Kumagai T,Jo M,Tokuyama T

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Fulminant non-A, non-B, non-C hepatitis has a high mortality rate, making the identification of its causative agent imperative. Cytomegalovirus, Epstein-Barr virus, human herpesvirus-6, and herpes simplex virus are all members of the herpesviridae family that are associated with fatal hepatic failure. We inv...

journal_title：Journal of gastroenterology

authors： Ishikawa K,Hasegawa K,Naritomi T,Kanai N,Ogawa M,Kato Y,Kobayashi M,Torii N,Hayashi N

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The efficacy, safety, and pharmacokinetics of the combination of three direct-acting antiviral (DAA) agents (adafosbuvir [also known as AL-335], odalasvir, and simeprevir) were investigated in DAA treatment-naïve Japanese patients with genotype (GT)1 or GT2 chronic hepatitis C virus (HCV) infection, with or ...

journal_title：Journal of gastroenterology

authors： Takehara T,Chayama K,Kurosaki M,Yatsuhashi H,Tanaka Y,Hiramatsu N,Sakamoto N,Asahina Y,Nozaki A,Nakano T,Hagiwara Y,Shimizu H,Yoshida H,Huang Y,Biermer M,Vijgen L,Hayashi N

更新日期：2020-06-01 00:00:00

abstract：:We report a case of squamous cell carcinoma (SCC) of the gastric cardia showing submucosal progression with direct invasion of the liver. A 71-year-old man was admitted with dysphagia. Esophagogastroscopy showed a protruding tumor covered with normal gastric mucosa in the anterior wall of the gastric cardia, although ...

journal_title：Journal of gastroenterology

authors： Koide N,Hanazaki K,Kajikawa S,Adachi W,Hara E,Amano J

更新日期：2001-04-01 00:00:00

abstract：:The spontaneous passage of colon cast from a 76-year-old Japanese female patient is reported. Macroscopically, the colon case was shaped like the airbladder of a fish. Histopathologically, the cast consisted of degenerated colonal mucosa, including glands. No inflammatory reaction was apparent. The patient lacked any ...

journal_title：Journal of gastroenterology

authors： Yoshiji H,Nakae D,Sugiya R,Mizumoto Y,Tsutsumi M,Hiriguchi K,Yokose Y,Sakurai R,Fukui H,Tsujii T

更新日期：1994-02-01 00:00:00

abstract：:A patient with hepatitis C virus (HCV)-related liver cirrhosis and hepatocellular carcinoma (HCC) was treated successfully with an orthotopic liver transplantation (OLT) followed by interferon therapy. The 36-year-old Japanese man was diagnosed as having liver cirrhosis in 1983. HCC was detected in 1991, and by 1994, ...

journal_title：Journal of gastroenterology

authors： Shibata M,Yanaga K,Morizane T,Yanagawa T,Hirakawa M,Ueno Y,Esquivel CO,Mitamura K

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Hypersensitive esophagus (HE) is defined by endoscopy-negative heartburn with a normal acid exposure time but positive symptom association probability (SAP) and/or symptom index (SI) on impedance-pH monitoring, and proton pump inhibitor (PPI) responsiveness. Functional heartburn (FH) is distinguished by nega...

journal_title：Journal of gastroenterology

authors： Frazzoni M,de Bortoli N,Frazzoni L,Furnari M,Martinucci I,Tolone S,Farioli A,Marchi S,Fuccio L,Savarino V,Savarino E

更新日期：2017-04-01 00:00:00