Abstract：
:We report a case of squamous cell carcinoma (SCC) of the gastric cardia showing submucosal progression with direct invasion of the liver. A 71-year-old man was admitted with dysphagia. Esophagogastroscopy showed a protruding tumor covered with normal gastric mucosa in the anterior wall of the gastric cardia, although no abnormal findings were detected in the esophagus, including the esophagogastric junction. Serum SCC-related antigen level was elevated (6.6 ng/ml; normal level, less than 2.5 ng/ml). Endoscopic biopsy specimens taken from this tumor did not show malignant cells. Based on these findings, the preoperative diagnosis was a submucosal tumor of the stomach. Laparotomy was done; however, the tumor was not resected because it had direct invasion to the left lateral segment of the liver and adjacent tissues. As the tumor showed continuous bleeding from the stomach after surgery, total gastrectomy, combined with transhiatal lower esophagectomy, left lateral segmentectomy of the liver, splenectomy, and distal pancreatectomy was performed. Because histologic findings showed poorly or moderately differentiated SCC with direct invasion of the liver, the final diagnosis was SCC of the gastric cardia showing submucosal progression with hepatic invasion. Such a case of SCC of the gastric cardia showing submucosal progression is rare, and accurate preoperative diagnosis was very difficult. However, it may be important to consider SCC of the gastric cardia in such a situation.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Koide N,Hanazaki K,Kajikawa S,Adachi W,Hara E,Amano Jdoi
10.1007/s005350170113subject
Has Abstractpub_date
2001-04-01 00:00:00pages
259-63issue
4eissn
0944-1174issn
1435-5922journal_volume
36pub_type
杂志文章abstract：:Aberrant methylation of CpG islands in promoter regions can permanently inactivate tumor-suppressor genes, as mutations and chromosomal abnormalities do. In gastric cancers, CDKN2A, CDH1, and MLH1 are inactivated more frequently by aberrant methylation than by mutations, and novel tumor-suppressor genes inactivated by...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s00535-006-1846-6
更新日期：2006-05-01 00:00:00
abstract：:Electronic endoscopy, developed in 1983, enables the endoscopic image to be transmitted through electric signals that can be easily processed by computer. An electronic endoscope is composed of three vital parts, i.e., a charge-coupled device (CCD) that converts the image to electric signals, a video processor that co...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:Subepithelial myofibroblasts (SEMFs) play a role in extracellular matrix (ECM) metabolism in the colon. In this study, we investigated the effects of interleukin (IL)-17, IL-1beta, and tumor necrosis factor (TNF)-alpha on matrix metalloproteinase (MMP)-3 secretion in colonic SEMFs. METHODS:MMP-3 secretion a...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-002-1101-8
更新日期：2003-01-01 00:00:00
abstract：:Using commercial quantitative assays, quantitative hepatitis B surface antigen (qHBsAg) has improved our understanding and management of chronic hepatitis B (CHB). The HBsAg level is highest in the immune tolerance phase, starts to decline during the immune clearance phase, and decreases slowly but progressively after...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s00535-012-0668-y
更新日期：2013-01-01 00:00:00
abstract：:Black liver is a common finding in Dubin-Johnson syndrome (DJS), which is caused by the lack of multidrug resistance-associated protein 2 (MRP2). Impaired excretion of epinephrine metabolites is believed to be a cause of black liver in DJS. Recently, we experienced a patient with black liver whose serum bilirubin leve...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-004-1406-x
更新日期：2004-09-01 00:00:00
abstract：:An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all were involved in the fina...
journal_title：Journal of gastroenterology
pub_type：
doi：
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:An optimal surveillance program is important to prevent advanced colorectal neoplasm. In this context, we have evaluated the cumulative risk of high-risk adenoma (HRA) or colorectal cancer (CRC) according to surveillance interval time after polypectomy. In addition, we assessed risk factors for late surveill...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00535-016-1280-3
更新日期：2017-07-01 00:00:00
abstract：:Although polycystic liver disease (PLD) is known to be associated with autosomal dominant polycystic kidney disease, a finding of PLD with pancreatic ductal adenocarcinoma is extremely rare. We have experienced one such case of a ductal adenocarcinoma of the pancreas in a patient with Potter type III cystic disease of...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350170088
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Experimental evidence and clinical studies suggest that the renin-angiotensin system and its inhibitors may play a role in regulating the mechanisms of liver fibrosis development. The present study aimed to verify whether carriage of specific angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) all...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-007-2040-1
更新日期：2007-07-01 00:00:00
abstract：:A rare case of benign diaphragmatic schwannoma in a 38-year-old female is reported. Precontrast computed tomography (CT) showed an encapsulated well-defined round homogeneous tumor with central calcification, measuring approximately 5 cm in diameter, arising from the left diaphragm. Contrast-enhanced CT and gadolinium...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/BF02389529
更新日期：1996-04-01 00:00:00
abstract：:We report a case of gastric neuroendocrine (NE) carcinoma associated with chronic atrophic gastritis type A (CAG/A) or reversed atrophic type gastritis. A 9 x 6 cm tumor was resected from the stomach to control pain in a 55-year-old Japanese woman with peritoneal dissemination and metastatic tumors of the liver and ov...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02934114
更新日期：1997-10-01 00:00:00
abstract：:Class II antigens are strongly expressed on the inflamed colonic epithelium in inflammatory bowel disease. However, the mechanism of this epithelial class II antigen induction is not fully understood. Increased activities of interferon (IFN)gamma, tumor necrosis factor (TNF)alpha, and interleukin (IL)2 have been shown...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
abstract：:A patient with familial adenomatous polyposis (FAP) presented with a relapsing attack of acute pancreatitis. Evaluation using computed tomography, ultrasonography, and duodenoscopy revealed an ampullary adenoma, which was classified as Spigelman's stage III according to Spigelman's criteria. The patient underwent a py...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-006-1844-8
更新日期：2006-08-01 00:00:00
abstract：:We investigated the therapeutic effects of egualen sodium (KT1-32), a new antiulcer agent, on chronic erosive and atrophic gastritis induced by 5 months' administration of sodium taurocholate (TCA; 5 mM) in rats. The chronic gastritis was manifested by mucosal surface injuries (erosions), reduced mucosal thickness, re...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02358603
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:Efficacy and safety of interferon induction therapy alone or in combination with ribavirin or ribavirin plus amantadine were evaluated in chronic hepatitis C patients who were nonresponders to primary antiviral treatment. METHODS:The study was designed to have 225 HCV nonresponder patients, but at an interi...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00535-007-2006-3
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:Gene therapy is a promising therapeutic method but is severely hampered due to its lack of an ideal delivery system. Therefore, in this study, a nonviral and magnetic resonance imaging (MRI) visible vector, polyethylene glycol-grafted polyethylenimine and superparamagnetic iron oxide nanoparticles (PEG-g-PEI...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-012-0713-x
更新日期：2013-07-01 00:00:00
abstract：:We assessed the influence of epidermal growth factor (EGF) and insulin on gastric epithelial restoration in vitro. Rabbit gastric epithelial cells were cultured and formed a complete monolayer cell sheet in 2 days. We created a wound (1.8 +/- 0.05 mm2) by denuding an area of cells, and EGF (0.1-30 ng/ml) and/or insuli...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02934104
更新日期：1997-10-01 00:00:00
abstract：:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is the most frequent complication of ERCP. Several meta-analyses have examined the effects of protease inhibitors (gabexate mesilate, ulinastatin, and nafamostat mesilate) and non-steroidal anti-inflammatory drugs (NSAIDs) on post-ERCP pancreatiti...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00535-013-0834-x
更新日期：2014-03-01 00:00:00
abstract：:CYFRA 21-1 is a fragment of cytokeratin 19 (CK 19). Four patients with large intrahepatic (or peripheral) cholangiocarcinoma (CC) and high serum levels of CYFRA 21-1 (normal, < or = 2 ng/ml) are reported. CYFRA 21-1 levels exceeded 9 ng/ml in all 4 patients. Carcinoembryonic antigen (CEA), was high in 1 (CEA; normal r...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350050112
更新日期：1998-06-01 00:00:00
abstract：:We report the coexistence of symptomatic viral, bacterial, and fungal infection of the upper gastrointestinal tract in a heart transplant recipient. Endoscopic findings were normal at all levels but, because of severe symptoms and recent conversion to positive serology for Cytomegalovirus, biopsies were taken. These s...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02358613
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:Aberrant methylation of some cancer-related genes has been reported to correlate with sensitivity to chemotherapeutic agents. The present study was designed to determine whether DNA methylation in six cancer-related genes affects recurrence of gastric cancer in patients who received 5-fluorouracil-based adju...
journal_title：Journal of gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1007/s00535-007-2113-1
更新日期：2007-11-01 00:00:00
abstract：:We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonograp...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02355038
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:Subunit A of coagulation factor XIII (FXIII-A) is important for clot stability and acts in the subsequent wound healing process. Loss of plasma FXIII-A has been reported after surgery, sepsis, and inflammatory conditions. In the intestinal mucosa, FXIII-A is expressed by macrophages and cellular FXIII-A has ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-015-1152-2
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Ghrelin is a novel 28-amino-acid peptide isolated from rat and human stomach. This peptide is an endogenous ligand for the growth hormone secretagogue receptor and stimulates the release of growth hormones. Although the principal site of ghrelin synthesis has been reported to be in the stomach, there have be...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-004-1550-3
更新日期：2005-04-01 00:00:00
abstract：:Gastrointestinal symptoms such as abdominal pain, dyspepsia, and diarrhea are relatively nonspecific and a common cause for seeking medical attention. To date, it is challenging for physicians to differentiate between functional and organic gastrointestinal conditions and it involves the use of serological and endosco...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s00535-016-1182-4
更新日期：2016-05-01 00:00:00
abstract：:A 67-year-old female was admitted with diarrhea. Preoperatively, we diagnosed intussusception due to malignant lymphoma in the ileocecal region by image and colonoscopic examinations. We resected the right hemicolon for the tumor, which was located mainly in the cecum, causing intussusception. The stenotic terminal il...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/BF02358684
更新日期：1994-04-01 00:00:00
abstract：:Adult midgut rotational anomalies are difficult to diagnose. Any symptoms present in adults may be the result of intermittent volvulus of the midgut. Successful outcome of this clinical condition depends on prompt diagnosis and timely surgical intervention. Computed tomography (CT) is useful in early identification of...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s005350050052
更新日期：1998-02-01 00:00:00
abstract：:In this study, we quantitatively measured glycogen levels in tissue samples obtained from tumors, regions adjacent to tumor, and regions of normal colorectum to determine whether the levels were related to cell cycle and cancer growth. Glycogen levels were analyzed in relation to histopathological factors, (tumor size...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350050299
更新日期：1999-08-01 00:00:00
abstract：:In vivo progression to malignancy is characterized by the switch to an angiogenic phenotype. The angiogenic switch is a critical control point for tumor expansion. The ability of a tumor to become neovascularized permits rapid expansion of tumor growth and increases the likelihood of metastases. The genetic alteration...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：
更新日期：2003-03-01 00:00:00
abstract：:To evaluate the diagnostic utility of blood biochemical parameters in assessing degree of hepatic fibrosis, serum levels of aminoterminal type III procollagen peptide (P III P), type IV collagen (IV-collagen), 7S domain of type IV collagen (7S-collagen), and hyaluronan (HA) were measured in 54 patients with chronic vi...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02934493
更新日期：1997-06-01 00:00:00
