Abstract:
BACKGROUND:Experimental evidence and clinical studies suggest that the renin-angiotensin system and its inhibitors may play a role in regulating the mechanisms of liver fibrosis development. The present study aimed to verify whether carriage of specific angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) allelic variants, modulating angiotensin II generation, could affect the outcome of recurrent hepatitis C after liver transplantation, via several metabolic pathways.
METHODS:Forty-five (29 men) recipients, with a median histological follow-up of 60 months after orthotopic liver transplantation (OLT), were studied. ACE gene I/D polymorphism was assessed by means of a polymerase chain reaction procedure. Fibrosis progression was evaluated annually during the follow-up.
RESULTS:Weight gain 1 year post-OLT (defined as an increase in body mass index, BMI, of >0.5 kg/m(2)) was significantly more common among D/ carriers (22/22 vs. 16/23, P < 0.005); patients who 1 year after OLT had an increase in their BMI value of >0.5 kg/m(2) more frequently had a triglycerides/cholesterol ratio of journal_name journal_title authors doi subject pub_date pages issue eissn issn journal_volume pub_type
abstract:BACKGROUND:The clinical utility of relative and absolute grading criteria for submucosal invasion in T1 colorectal carcinomas has been controversial. METHODS:In 51 T1 colorectal carcinomas, depth of submucosal invasion was graded either according to a modified Haggitt's classification (a relative criterion) or by dire...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350300004
更新日期:2003-01-01 00:00:00
abstract::Soft drinks containing dietary fiber are popular in Japan. There seem to be two types, one containing polydextrose and the other, oligosaccharide. These beverages are claimed to be useful for constipation or obesity, but data are scanty. We examined four such fiber-containing beverages [Fibe-mini Otsuka Pharmaceutical...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02347612
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Although it is less frequently encountered, mesenteric vein occlusion poses as important a problem as mesenteric artery occlusion. The energy metabolism of intestinal tissue during venous occlusion and reperfusion was studied. METHODS:Male Wistar rats were studied in four groups of 17 animals each. Intestin...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1160-5
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Acute liver failure is a potentially fatal disease of various etiologies for which liver transplantation is the only known curative treatment. Although the decision-making on transplantation is largely dependent on the severity of liver injury (based on predicting a fatal outcome), a statistical analysis to ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-017-1421-3
更新日期:2018-07-01 00:00:00
abstract::We estimated the levels of free sialic acid and sialylated oligosaccharides excreted in the urine of normal donors (n = 10) and patients with gastric cancer (n = 6) and colorectal cancer (n = 4). The total sialic acid level in cancer patients was similar to that in normal donors. However, the ratios of glycosidically ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF01211370
更新日期:1995-02-01 00:00:00
abstract::In this study, we used magnetic resonance (MR) imaging to measure portal blood flow in 12 healthy controls and 17 cirrhotics while they were breath-holding after inspiration and after expiration. We then compared the results with measurements made during normal respiration in the healthy controls and cirrhotics. Blood...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050381
更新日期:1999-10-01 00:00:00
abstract::Combined hepatocellular (HCC) and cholangiocellular carcinoma (CCC) (mixed carcinoma) is a rare subtype of primary hepatic carcinoma. We report a case of mixed carcinoma that developed in a non-cirrhotic liver, in a patient who was serologically negative for both hepatitis B and C viruses. A 65-year-old Japanese woman...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050140
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:A new capsule endoscope has been developed by Olympus Medical Systems. The visualization and usefulness of its real-time image viewer for gastric transit abnormality were evaluated by using this new device. METHODS:Thirty-seven consecutive patients were enrolled. In cases of gastric transit abnormality (gas...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1007/s00535-007-2140-y
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The search is on to find more effective drug regimens for patients with severe ulcerative colitis, as conventional drugs such as sulfasalazine and its congeners fail to prevent relapse in a significant number of patients. Azathioprine has also been reported to be useful as a steroid-sparing drug in patients ...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s005350200034
更新日期:2002-01-01 00:00:00
abstract::To investigate the role played by cytokines in chronic pancreatitis, we examined serum levels of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) in 33 patients with definitively diagnosed chronic pancreatitis. All the patients, who had rec...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02358371
更新日期:1994-06-01 00:00:00
abstract::We simultaneously recorded gastric emptying of radio-opaque markers (ROMs) and monitored serial changes in plasma acetaminophen (AAP) levels to demonstrate the relationship between the ROM and the AAP methods, and we investigated the effect of a single intravenous dose of erythromycin (EM) on gastric emptying in healt...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02936948
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Ulcerative colitis (UC) is characterized by chronic inflammation in the colon and epigenetic factors underlying the occurrence. Circular RNAs (circRNAs) have been under intensive focus due to the circular construct and gene-regulating functions. However, the changes and roles of circRNAs in UC remain unknown...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-019-01585-7
更新日期:2019-09-01 00:00:00
abstract::In this study, we quantitatively measured glycogen levels in tissue samples obtained from tumors, regions adjacent to tumor, and regions of normal colorectum to determine whether the levels were related to cell cycle and cancer growth. Glycogen levels were analyzed in relation to histopathological factors, (tumor size...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050299
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Among the factors influencing variceal relapse after endoscopic treatment, portal hemodynamic changes, especially in portal systemic shunts, could be the most important factor because hemodynamics are directly related to the development of esophageal varices. We aimed to clarify the influence of endoscopic t...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-005-1730-9
更新日期:2006-02-01 00:00:00
abstract::Strain differences in the susceptibility of rats to induction of intestinal metaplasia by X-irradiation were examined. The gastric regions of 5-week-old males of five inbred strains of rats (F344/NSlc, Copenhagen, Buffalo/NacJcl, and ACI/NHos) and three strains of randomly bred rats (HOS:Donryu, Slc:Wistar, Slc:SD) we...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02934483
更新日期:1997-06-01 00:00:00
abstract::A rare case of simple ulcer of the colon in a 7-year-old girl is reported. Simple ulcer is clinically and pathologically recognized as a serious disease linked to intestinal Behcet's disease. Recently, some immunomodulators, such as thalidomide and antitumor necrosis factor monoclonal antibody, have been used to treat...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350200122
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. left-sided colon,' 'colon vs. rectum,' and 'right-sided (right-sided colon) vs. left-sided (left-sided colon and rectum).' This nationwide multicenter ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-020-01706-7
更新日期:2020-10-01 00:00:00
abstract::Eosinophilic esophagitis (EE) is a rarely diagnosed condition involving eosinophilic infiltration of the esophageal mucosa. Here we present a case of EE in a 69-year-old Japanese man, who presented with abdominal pain, appetite loss, and a history of bronchial asthma. Laboratory findings included peripheral eosinophil...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-006-1827-9
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Gastric cancer stem cells (CSCs), which require activation of Wnt signaling to maintain their self-renewal and tumorigenicity, are proposed to be critical targets for effective therapy of gastric carcinomas. Gene therapies that are delivered by adenovirus of serotype 5 (Ad5) or chimeric 5/35(Ad5/35) adenovir...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0711-z
更新日期:2013-07-01 00:00:00
abstract::A 27-year-old woman with a 9-year history of ulcerative colitis involving the entire colon was admitted to our hospital in August 1992 because of bloody stools and left lower abdominal pain. She had been treated with sulfasalazine since 1983 and the colitis had been clinically quiescent or mild for 7 years. She had al...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF01213301
更新日期:1997-02-01 00:00:00
abstract::The correct name of the last author should be. ...
journal_title:Journal of gastroenterology
pub_type: 已发布勘误
doi:10.1007/s00535-019-01646-x
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Obliterative phlebitis is a useful pathological finding for the diagnosis of lymphoplasmacytic sclerosing pancreatitis (LPSP), or type 1 autoimmune pancreatitis. The present study evaluated histological findings of obliterative phlebitis, including the significance of adding Elastica van Gieson stain (EVG) i...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-013-0818-x
更新日期:2014-04-01 00:00:00
abstract::Pyogenic granulomas represent the aquisition of vasodilative granulation tissue in the skin or mucosa. They are extremely rare in the alimentary tract, other than in the oral cavity. Here, we report a case of pyogenic granuloma arising from the gastric mucosa. An 82-year-old man was admitted to our hospital because of...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-004-1579-3
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use. METHODS:Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for mo...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00535-011-0410-1
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Although pancreatic duct guidewire placement (P-GW) for achieving selective biliary cannulation is reported to be effective in patients in whom endoscopic retrograde cholangiopancreatography (ERCP) is difficult, this technique entails a possible increased risk of post-ERCP pancreatitis. We conducted a prospe...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00535-010-0268-7
更新日期:2010-11-01 00:00:00
abstract::We aimed to determine the safety and feasibility of an alternative postoperative oral intake protocol for Japanese patients who had had oncological colorectal surgery, with the goal of shortening the length of postoperative stay to the same level as that in Western countries. The subjects of the study were 42 consecut...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350070075
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japan...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-015-1135-3
更新日期:2016-07-01 00:00:00
abstract::We investigated whether extravariceal collateral pattern contributed to the development of portal-hypertensive gastropathy (PHG) before and after sclerotherapy. Ninety-nine patients with cirrhosis and large esophageal varices were examined in this retrospective study. They were divided into four groups according to tr...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050061
更新日期:1998-04-01 00:00:00
abstract::In Japan, nutritional therapy as both a primary and as a secondary treatment is widely used for Crohn's disease (CD). The rationale for its use is based on a variety of reasons. The first is its ability to induce remission and to ameliorate the activity of intestinal lesions in the short term by enteral (EN) or by par...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/BF02990575
更新日期:2005-03-01 00:00:00
abstract::Black liver is a common finding in Dubin-Johnson syndrome (DJS), which is caused by the lack of multidrug resistance-associated protein 2 (MRP2). Impaired excretion of epinephrine metabolites is believed to be a cause of black liver in DJS. Recently, we experienced a patient with black liver whose serum bilirubin leve...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-004-1406-x
更新日期:2004-09-01 00:00:00