当前位置： SCI文献检索 > JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Clinical utility of grading criteria for submucosal invasion in the prognosis of T1 colorectal carcinomas.

Clinical utility of grading criteria for submucosal invasion in the prognosis of T1 colorectal carcinomas.

Abstract：

BACKGROUND:The clinical utility of relative and absolute grading criteria for submucosal invasion in T1 colorectal carcinomas has been controversial. METHODS:In 51 T1 colorectal carcinomas, depth of submucosal invasion was graded either according to a modified Haggitt's classification (a relative criterion) or by direct measurement using a micrometer (an absolute criterion), and immunostaining for E-cadherin, alpha-catenin, beta-catenin, matrilysin, and CD44 variant 6 was performed on formalin-fixed, paraffin-embedded sections. The associations between lymph node metastasis or local recurrence (locoregional failure) and tumor budding, and clinicopathologic parameters and immunoreactivity were examined statistically. RESULTS:By univariate analysis, tumor budding, histology, and the co-expression pattern of nuclear beta-catenin and CD44 variant 6 were significantly associated with locoregional failure. The relative and absolute grading of submucosal invasion were not significantly associated with locoregional failure. Multivariate analysis showed that tumor budding alone was significantly associated with locoregional failure, and the association between the co-expression pattern of nuclear beta-catenin and CD44 variant 6, and locoregional failure was marginally significant ( P = 0.0502). Lymphatic invasion and absolute grading of depth and width of submucosal invasion were significantly associated with tumor budding, and the associations between tumor budding, and histologic differentiation and membranous alpha-catenin expression were marginally significant ( P = 0.06; P= 0.08), whereas, a relative grading of submucosal invasion was not significant ( P = 0.58). Analysis of variance showed that histologic differentiation and lymphatic invasion were independently and significantly associated with tumor budding ( P = 0.005; P < 0.001). CONCLUSIONS:These results suggest that the grading of submucosal invasion, either relative or absolute, may not be a useful risk factor for lymph node metastasis or local recurrence in T1 colorectal carcinomas.

journal_name

J Gastroenterol

journal_title

Journal of gastroenterology

authors

Masaki T,Sugiyama M,Matsuoka H,Abe N,Izumisato Y,Goto A,Sakamoto A,Atomi Y

doi

10.1007/s005350300004

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

37-44

issue

1

eissn

0944-1174

issn

1435-5922

journal_volume

38

pub_type

杂志文章

相关文献

JOURNAL OF GASTROENTEROLOGY文献大全
  • Sex differences in relation to serum hepatitis B e antigen and alanine aminotransferase levels among asymptomatic hepatitis B surface antigen carriers.

    abstract：:This study aimed to investigate sex differences in relation to hepatitis B e antigen (HBeAg) and serum alanine aminotransferase (ALT) levels in chronic asymptomatic hepatitis B virus (HBV) infection. HBeAg and ALT level were determined in 636 asymptomatic hepatitis B surface antigen carriers. There was no significant ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350070048

    authors： Tsai JF,Chuang LY,Jeng JE,Ho MS,Lin ZY,Hsieh MY,Wang LY,Tsai JH

    更新日期：2000-01-01 00:00:00

  • Nuclear cyclin D1 overexpression is a critical event associated with cell proliferation and invasive growth in gallbladder carcinogenesis.

    abstract：:Cyclin D1 overexpression is remarkably frequent in several human carcinomas and is believed to be a critical event in oncogenesis. We examined cyclin D1 expression, p53 expression, and the Ki-67 labeling index by immunostaining in human gallbladder mucosa in conditions varying from normal to malignant tissue. We also ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050027

    authors： Itoi T,Shinohara Y,Takeda K,Nakamura K,Takei K,Sanada J,Horibe T,Saito T,Kasuya K,Ebihara Y

    更新日期：2000-01-01 00:00:00

  • Gastric antral vascular ectasia successfully treated by endoscopic electrocoagulation.

    abstract：:We report two cirrhotic patients with gastric antral vascular ectasia (GAVE) in whom chronic blood loss presented a major problem. Case 1, a 69-year-old man, had alcoholic liver cirrhosis, and case 2, a 75-year-old woman, had liver cirrhosis associated with hepatitis C virus. The patients required repeated blood trans...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050130

    authors： Yamada M,Nishimura D,Hoshino H,Katada N,Sano H,Kato K

    更新日期：1998-08-01 00:00:00

  • Multiple focal nodular hyperplasia.

    abstract：:Focal nodular hyperplasia (FNH) is a benign lesion of the liver which usually presents with one or two localizations. We report a patient with history of resection of a biliary cyst, and who had been taking oral contraceptives for the past 18 years, who had multiple localizations of FNH (more than 30 lesions). The lar...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050198

    authors： Colle I,de Beeck BO,Hoorens A,Hautekeete M

    更新日期：1998-12-01 00:00:00

  • Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.

    abstract：BACKGROUND:Loss of imprinting (LOI) of the insulin-like growth factor 2 (IGF2) is an early event in the development of colorectal cancer (CRC). Whether LOI of IGF2 denotes a molecular or clinical cancer subgroup is currently unknown. METHODS:Tumor biopsies and paired normal mucosa from 399 patients with extensive clin...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-016-1181-5

    authors： Belharazem D,Magdeburg J,Berton AK,Beissbarth L,Sauer C,Sticht C,Marx A,Hofheinz R,Post S,Kienle P,Ströbel P

    更新日期：2016-10-01 00:00:00

  • Serum levels of interleukin-1 beta and interleukin-6 in patients with chronic pancreatitis.

    abstract：:To investigate the role played by cytokines in chronic pancreatitis, we examined serum levels of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) in 33 patients with definitively diagnosed chronic pancreatitis. All the patients, who had rec...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02358371

    authors： Bamba T,Yoshioka U,Inoue H,Iwasaki Y,Hosoda S

    更新日期：1994-06-01 00:00:00

  • Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival.

    abstract：BACKGROUND:EphA3, a member of the Eph receptor tyrosine kinases, plays important roles in tumor angiogenesis and progression. However, the function of EphA3 in solid tumors has not been widely studied. We aimed to explore EphA3 expression in gastric carcinoma and analyze its role as a potential prognostic factor. METH...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-012-0549-4

    authors： Xi HQ,Wu XS,Wei B,Chen L

    更新日期：2012-07-01 00:00:00

  • Primary sclerosing cholangitis in Japan--analysis of 192 cases.

    abstract：:Primary sclerosing cholangitis is very rare in Japan. The aim of the present study was to identify the characteristics of such patients in Japan. A questionnaire was sent to the members of the Japanese Society of Gastroenterology and responses for 192 cases were analyzed. There was male predominancy (61%), and two pea...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF01213311

    authors： Takikawa H,Manabe T

    更新日期：1997-02-01 00:00:00

  • Ciliated foregut cyst in cirrhotic liver.

    abstract：:We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonograp...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02355038

    authors： Murakami T,Imai A,Nakamura H,Tsuda K,Kanai T,Wakasa K

    更新日期：1996-06-01 00:00:00

  • Recent clinical features of Wilson's disease with hepatic presentation.

    abstract：BACKGROUND:We carried out this study to evaluate recent clinical features of Wilson's disease (WD) with hepatic presentation, especially in terms of age, degree of liver injury, and association with hepatocellular carcinoma (HCC). METHODS:Sixteen patients with hepatic manifestations were diagnosed with WD in the perio...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-004-1466-y

    authors： Kumagi T,Horiike N,Michitaka K,Hasebe A,Kawai K,Tokumoto Y,Nakanishi S,Furukawa S,Hiasa Y,Matsui H,Kurose K,Matsuura B,Onji M

    更新日期：2004-12-01 00:00:00

  • A proposed severity classification system for hepatolithiasis based on an analysis of prognostic factors in a Japanese patient cohort.

    abstract：BACKGROUND:Hepatolithiasis frequently results in severe complications. We conducted a cohort study to identify prognostic factors and to establish a hepatolithiasis severity classification system. METHODS:The study cohort comprised 396 patients who were identified through a 1998 nationwide survey and followed up for 1...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-017-1410-6

    authors： Suzuki Y,Mori T,Yokoyama M,Kim S,Momose H,Matsuki R,Kogure M,Abe N,Isayama H,Nakazawa T,Notohara K,Tanaka A,Tsuyuguchi T,Tazuma S,Takikawa H,Sugiyama M

    更新日期：2018-07-01 00:00:00

  • The protective effect of catechin on gastric mucosal lesions in rats, and its hormonal mechanisms.

    abstract：BACKGROUND:Catechin, a polyphenol contained in tea (a cup of tea contains approximately 0.1% [w/v] catechin), has various physiological effects. The aim of this study was to investigate the mechanism of the inhibitory effect of catechin on gastric mucosal lesions. METHODS:We studied the effect of catechin on gastric m...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350200004

    authors： Sato H,Matsui T,Arakawa Y

    更新日期：2002-01-01 00:00:00

  • Autoimmune pancreatitis: histo- and immunopathological features.

    abstract：:In recent years autoimmune pancreatitis (AIP) has been established as a special type of chronic pancreatitis. It is characterized by its histopathological and immunological features. The morphological hallmarks are periductal infiltration by lymphocytes and plasma cells, granulocytic epithelial lesions with focal dest...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s00535-007-2048-6

    authors： Klöppel G,Sipos B,Zamboni G,Kojima M,Morohoshi T

    更新日期：2007-05-01 00:00:00

  • Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus.

    abstract：BACKGROUND:Using cDNA microarray analysis that displays a total of 8734 mouse genes, we have identified 21 known and novel transcripts, including mouse expressed sequence tags (ESTs) that were consistently up- or downregulated in the fundus of wild-type mice and W/W(V) mice, where intramuscular interstitial cells of Ca...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-003-1283-8

    authors： Daigo Y,Takayama I,Ward SM,Sanders KM,Fujino MA

    更新日期：2004-01-01 00:00:00

  • Efficacy of oral adsorbent for treatment of peristomal fistula associated with Crohn's disease.

    abstract：:Perianal fistulae are frequently seen complications in Crohn's disease. Although surgical procedures such as Seton's method have been devised, many patients still suffer from fistulae that are resistant to conventional therapy. We administered oral adsorbent to a patient with disease Crohn's who had a complicated peri...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050349

    authors： Tsujikawa T,Araki Y,Makino J,Uda K,Ihara T,Sasaki M,Fujiyama Y,Bamba T

    更新日期：2000-01-01 00:00:00

  • Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p.

    abstract：BACKGROUND:Circular RNAs (circRNAs) act as vital regulators of gene expression in a variety of cancers. However, the role of circRNAs in gastric cancer (GC) remains largely unexplored. Herein, we identified that circTMEM87A sponges miR-142-5p to promote GC progression through up-regulating ULK1 expression. METHODS:The...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-020-01744-1

    authors： Wang H,Sun G,Xu P,Lv J,Zhang X,Zhang L,Wang S,Cao J,Xia Y,Xuan Z,Li B,Huang X,Jiang T,Fang L,Xu Z

    更新日期：2020-11-06 00:00:00

  • Characterization of polyethylene glycol-grafted polyethylenimine and superparamagnetic iron oxide nanoparticles (PEG-g-PEI-SPION) as an MRI-visible vector for siRNA delivery in gastric cancer in vitro and in vivo.

    abstract：BACKGROUND:Gene therapy is a promising therapeutic method but is severely hampered due to its lack of an ideal delivery system. Therefore, in this study, a nonviral and magnetic resonance imaging (MRI) visible vector, polyethylene glycol-grafted polyethylenimine and superparamagnetic iron oxide nanoparticles (PEG-g-PEI...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-012-0713-x

    authors： Chen Y,Lian G,Liao C,Wang W,Zeng L,Qian C,Huang K,Shuai X

    更新日期：2013-07-01 00:00:00

  • Endoscopic diagnosis and treatment of esophageal adenocarcinoma: introduction of Japan Esophageal Society classification of Barrett's esophagus.

    abstract：:Endoscopic surveillance of Barrett's esophagus has become a foundation of the management of esophageal adenocarcinoma (EAC). Surveillance for Barrett's esophagus commonly involves periodic upper endoscopy with biopsies of suspicious areas and random four-quadrant biopsies. However, targeted biopsies using narrow-band ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s00535-018-1491-x

    authors： Ishihara R,Goda K,Oyama T

    更新日期：2019-01-01 00:00:00

  • Breath hydrogen and methane excretion produced by commercial beverages containing dietary fiber.

    abstract：:Soft drinks containing dietary fiber are popular in Japan. There seem to be two types, one containing polydextrose and the other, oligosaccharide. These beverages are claimed to be useful for constipation or obesity, but data are scanty. We examined four such fiber-containing beverages [Fibe-mini Otsuka Pharmaceutical...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02347612

    authors： Kondo T,Nakae Y

    更新日期：1996-10-01 00:00:00

  • Early feeding after oncological colorectal surgery in Japanese patients.

    abstract：:We aimed to determine the safety and feasibility of an alternative postoperative oral intake protocol for Japanese patients who had had oncological colorectal surgery, with the goal of shortening the length of postoperative stay to the same level as that in Western countries. The subjects of the study were 42 consecut...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350070075

    authors： Kawamura YJ,Uchida H,Watanabe T,Nagawa H

    更新日期：2000-01-01 00:00:00

  • Suppressive effect of rice extract on Helicobacter pylori infection in a Mongolian gerbil model.

    abstract：BACKGROUND:Rice extract has been shown to protect gastric mucosa from stress-induced damage. In this study, the antibiotic effect and the anti-inflammatory effect of orally administered aqueous rice extract on Helicobacter pylori infection and H. pylori-induced gastritis, respectively, in Mongolian gerbils were investi...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-005-1570-7

    authors： Murakami M,Ota H,Sugiyama A,Ishizone S,Maruta F,Akita N,Okimura Y,Kumagai T,Jo M,Tokuyama T

    更新日期：2005-05-01 00:00:00

  • A new ABCB11 mutation in two Italian children with familial intrahepatic cholestasis.

    abstract：:Progressive familial intrahepatic cholestasis (PFIC) syndromes are characterized by defects in transporters of conjugated bile acids into the bile canaliculus. Three genes (ATP8B1, ABCB11, ABCB4) are associated with the different forms, but no easy genotype-phenotype correlations help in the prioritization for gene te...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-006-1816-z

    authors： Nobili V,Di Giandomenico S,Francalanci P,Callea F,Marcellini M,Santorelli FM

    更新日期：2006-06-01 00:00:00

  • Asymmetrical circumferential distribution of esophagogastric junctional lesions: anatomical and physiological considerations.

    abstract：:Several components of the gastrointestinal tract including the esophagogastric junction (EGJ) show circumferential asymmetry in the formation of pathological lesions, which is caused by the morphological and functional asymmetry of the gastrointestinal tract. Pressure in the lower esophageal sphincter (LES) is higher ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s00535-009-0092-0

    authors： Kinoshita Y,Furuta K,Adachi K,Amano Y

    更新日期：2009-01-01 00:00:00

  • Reliability, validity, and responsiveness of the Japanese version of the Inflammatory Bowel Disease Questionnaire.

    abstract：BACKGROUND:Inflammatory bowel disease affects the quality of a patient's life in many ways, but no validated instrument for measuring disease-specific quality of life in these patients is available in Japan. We developed a Japanese version of the Inflammatory Bowel Disease Questionnaire (IBDQ), together with the author...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-003-1220-x

    authors： Hashimoto H,Green J,Iwao Y,Sakurai T,Hibi T,Fukuhara S

    更新日期：2003-01-01 00:00:00

  • Positron emission tomography with 2-deoxy-2-[(18)F] fluoro- d-glucose for diagnosis of intraductal papillary mucinous tumor of the pancreas with parenchymal invasion.

    abstract：:We used positron emission tomography with 2-deoxy-2-[(18)F]fluoro- d-glucose (FDG-PET) in the diagnosis of two cases of malignant intraductal papillary mucinous tumor (IPMT) of the pancreas. A 56-year-old man and a 72-year-old man, both with tumors in the pancreatic head, were referred to Akita University Medical Cent...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-003-1230-8

    authors： Yoshioka M,Sato T,Furuya T,Shibata S,Andoh H,Asanuma Y,Hatazawa J,Koyama K

    更新日期：2003-01-01 00:00:00

  • Hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL) for pancreatic stones.

    abstract：:We present a patient with complication of huge hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL) for pancreatic lithotripsy. The hematoma measured 78-110mm. Angiography showed a subcapsular hematoma, rather than a hematoma in the liver. In the arterial phase, the distal end of the small v...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050325

    authors： Hirata N,Kushida Y,Ohguri T,Wakasugi S,Kojima T,Fujita R

    更新日期：1999-12-01 00:00:00

  • Effect of a selective thromboxane A2 synthetase inhibitor on the systemic changes induced by circulating pancreatic phospholipase A2.

    abstract：BACKGROUND:In acute pancreatitis, pancreatic phospholipase A(2) (PLA2) in the circulating blood hydrolyzes phospholipids contained in plasma lipoproteins, liberating eicosanoid precursors that are subsequently converted to various eicosanoids. The pathophysiological significance of eicosanoid synthesis via this pathway...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-006-1892-0

    authors： Motoyoshi M,Sugiyama M,Atomi Y,Kimura W,Nagawa H

    更新日期：2006-11-01 00:00:00

  • The effect of etanercept on hepatic fibrosis risk in patients with non-alcoholic fatty liver disease, metabolic syndrome, and psoriasis.

    abstract：BACKGROUND:Patients with psoriasis show a greater prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome than the general population. Moreover, patients with NAFLD and psoriasis are at higher risk of severe liver fibrosis than their counterparts with NAFLD and without psoriasis. The link between...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-012-0678-9

    authors： Campanati A,Ganzetti G,Di Sario A,Damiani A,Sandroni L,Rosa L,Benedetti A,Offidani A

    更新日期：2013-07-01 00:00:00

  • Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus.

    abstract：BACKGROUND:The Japan Society of Diabetes Mellitus reported that the leading cause of death in patients with diabetes mellitus (DM) was chronic liver disease; however, there are limited studies investigating the cause of liver injury in these patients. Our study aimed to clarify the clinicopathological features of liver...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00535-012-0653-5

    authors： Shima T,Uto H,Ueki K,Takamura T,Kohgo Y,Kawata S,Yasui K,Park H,Nakamura N,Nakatou T,Tanaka N,Umemura A,Mizuno M,Tanaka J,Okanoue T

    更新日期：2013-04-01 00:00:00

  • Aberrant methylation of p16 predicts candidates for 5-fluorouracil-based adjuvant therapy in gastric cancer patients.

    abstract：BACKGROUND:Aberrant methylation of some cancer-related genes has been reported to correlate with sensitivity to chemotherapeutic agents. The present study was designed to determine whether DNA methylation in six cancer-related genes affects recurrence of gastric cancer in patients who received 5-fluorouracil-based adju...

    journal_title：Journal of gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00535-007-2113-1

    authors： Mitsuno M,Kitajima Y,Ide T,Ohtaka K,Tanaka M,Satoh S,Miyazaki K

    更新日期：2007-11-01 00:00:00