Serum levels of interleukin-1 beta and interleukin-6 in patients with chronic pancreatitis.

Abstract:

:To investigate the role played by cytokines in chronic pancreatitis, we examined serum levels of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) in 33 patients with definitively diagnosed chronic pancreatitis. All the patients, who had received either no treatment or only digestive enzyme products for their chronic pancreatitis, had significantly elevated serum IL-1 beta levels (38.5 +/- 28.8 pg/ml, mean +/- SD), compared to normal controls (16.0 +/- 6.7 pg/ml; P < 0.01); however they showed no changes in serum IL-6 levels. Changes in IL-1 beta and IL-6 serum levels were not correlated with the etiological features of pancreatitis or with complications due to liver diseases. Serum IL-1 beta and IL-6 levels were also not correlated with the activity of any pancreatic enzymes in blood or urine. However, in the patients with chronic pancreatitis, serum IL-6 levels were correlated with C-reactive protein (CRP), whereas serum IL-1 beta levels were not correlated with CRP or with erythrocyte sedimentation rate. These results suggest that serum IL-1 beta is involved in the progression and reduction of chronic inflammation of the pancreas, and that the serum IL-1 beta level may be useful as a marker for chronic pancreatitis.

journal_name

J Gastroenterol

authors

Bamba T,Yoshioka U,Inoue H,Iwasaki Y,Hosoda S

doi

10.1007/BF02358371

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

314-9

issue

3

eissn

0944-1174

issn

1435-5922

journal_volume

29

pub_type

杂志文章
  • Solving the questions regarding 5-aminosalitylate formulation in the treatment of ulcerative colitis.

    abstract::5-aminosalicylate is a fundamental treatment for patients with ulcerative colitis with mild-to-moderate disease; however, evidence for 5-aminosalicylate treatment is unclear in some situations. This review discusses the clinical guidelines and previous studies, and highlights the following points: (1) Although rectal ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-020-01713-8

    authors: Naganuma M

    更新日期:2020-11-01 00:00:00

  • Effect of erythromycin on gastric emptying in healthy individuals assessed by radio-opaque markers and plasma acetaminophen levels.

    abstract::We simultaneously recorded gastric emptying of radio-opaque markers (ROMs) and monitored serial changes in plasma acetaminophen (AAP) levels to demonstrate the relationship between the ROM and the AAP methods, and we investigated the effect of a single intravenous dose of erythromycin (EM) on gastric emptying in healt...

    journal_title:Journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02936948

    authors: Park HJ,Jung JK,Song KS,Lee SI,Itoh Z,Park IS

    更新日期:1997-12-01 00:00:00

  • Nationwide epidemiological survey of chronic pancreatitis in Japan: introduction and validation of the new Japanese diagnostic criteria 2019.

    abstract:OBJECTIVES:To provide updated clinico-epidemiological information on chronic pancreatitis (CP) in Japan. METHODS:We conducted a two-stage nationwide epidemiological survey; the number of CP patients was estimated in the first-stage survey, and their clinical features were examined in the second-stage survey. We survey...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-020-01704-9

    authors: Masamune A,Kikuta K,Kume K,Hamada S,Tsuji I,Takeyama Y,Shimosegawa T,Okazaki K,Japan Pancreas Society.

    更新日期:2020-11-01 00:00:00

  • Gastric mucosa: long-term outcome after cure of Helicobacter pylori infection.

    abstract::The histopathological changes due to chronic Helicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication of H. pylori on nonulcer dyspepsia, the long-term ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02990094

    authors: Franceschi F,Genta RM,Sepulveda AR

    更新日期:2002-01-01 00:00:00

  • Ileal varices associated with recurrent bleeding in a patient with liver cirrhosis.

    abstract::We report a rare case of massive and recurrent bleeding from ileal varices in a patient with hepatitis C virus-positive liver cirrhosis. A 66-year old woman, who had undergone laparotomy and blood transfusion 36 years before (because of an extrauterine pregnancy) and endoscopic sclerotherapy for esophageal varices 1 y...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s005350050255

    authors: Ohtani T,Kajiwara E,Suzuki N,Kawasaki A,Sadoshima S,Sakata H,Sasaguri Y,Onoyama K

    更新日期:1999-04-01 00:00:00

  • An expert review on the use of tenofovir alafenamide for the treatment of chronic hepatitis B virus infection in Asia.

    abstract::Asia has intermediate-to-high prevalence and high morbidity of hepatitis B virus (HBV) infection. The use of guideline-recommended nucleos(t)ide analogs with high barrier to resistance, such as entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF), is one of the key interventions for cu...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-020-01698-4

    authors: Charlton MR,Alam A,Shukla A,Dashtseren B,Lesmana CRA,Duger D,Payawal DA,Duy Cuong D,Jargalsaikhan G,Cua IHY,Sollano JD,Singh KR,Madan K,Win KM,Kyi KP,Tun KS,Salih M,Rastogi M,Saraf N,Thuy PTT,Hien PTD,Gani RA,

    更新日期:2020-09-01 00:00:00

  • The effect of etanercept on hepatic fibrosis risk in patients with non-alcoholic fatty liver disease, metabolic syndrome, and psoriasis.

    abstract:BACKGROUND:Patients with psoriasis show a greater prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome than the general population. Moreover, patients with NAFLD and psoriasis are at higher risk of severe liver fibrosis than their counterparts with NAFLD and without psoriasis. The link between...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-012-0678-9

    authors: Campanati A,Ganzetti G,Di Sario A,Damiani A,Sandroni L,Rosa L,Benedetti A,Offidani A

    更新日期:2013-07-01 00:00:00

  • Recurrence of hepatocellular carcinoma 102 months after successful eradication and removal of membranous obstruction of the inferior vena cava.

    abstract::We report a 54-year-old Japanese woman who developed liver tumors 102 months after hepatic resection for hepatocellular carcinoma (HCC) and percutaneous transluminal angioplasty (PTA) for membranous obstruction of the inferior vena cava (MOVC), which is one form of Budd-Chiari syndrome. In the present admission workup...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-004-1365-2

    authors: Takamura M,Ichida T,Yokoyama J,Matsuda Y,Nomoto M,Aoyagi Y

    更新日期:2004-07-01 00:00:00

  • Prognostic impact of primary tumor location in Stage III colorectal cancer-right-sided colon versus left-sided colon versus rectum: a nationwide multicenter retrospective study.

    abstract:BACKGROUND:Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. left-sided colon,' 'colon vs. rectum,' and 'right-sided (right-sided colon) vs. left-sided (left-sided colon and rectum).' This nationwide multicenter ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-020-01706-7

    authors: Shida D,Inoue M,Tanabe T,Moritani K,Tsukamoto S,Yamauchi S,Sugihara K,Kanemitsu Y

    更新日期:2020-10-01 00:00:00

  • CagA positivity and its association with gastroduodenal disease in Turkish children undergoing endoscopic investigation.

    abstract:BACKGROUND:Cytotoxin-associated gene A (CagA) product is a bacterial virulence factor contributing to the pathogenicity of Helicobacter pylori (HP) infection in humans. Host factors, which vary in different countries, interact with bacterial factors to determine the disease state. Our objective was to investigate the f...

    journal_title:Journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00535-006-1788-z

    authors: Sökücü S,Ozden AT,Süoğlu OD,Elkabes B,Demir F,Cevikbaş U,Gökçe S,Saner G

    更新日期:2006-06-01 00:00:00

  • Phospholipid turnover in the inflamed intestinal mucosa: arachidonic acid-rich phosphatidyl/plasmenyl-ethanolamine in the mucosa in inflammatory bowel disease.

    abstract::Cytosolic phospholipase A2 (PLase A2) is activated by low Ca2+ concentrations and translocates from the cytosol to the cell membrane, releasing arachidonic acid; the arachidonic acid cascade then leads to the production of many inflammatory mediators. The aim of this study, accordingly, was to investigate the role of ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050215

    authors: Morita H,Nakanishi K,Dohi T,Yasugi E,Oshima M

    更新日期:1999-02-01 00:00:00

  • Noninvasive diagnostic criteria for nonalcoholic steatohepatitis based on gene expression levels in peripheral blood mononuclear cells.

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) consists of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH); the latter progresses to liver cirrhosis and hepatocellular carcinoma. Discriminating NASH from NAFL typically involves liver biopsy. The mechanism of NASH progression is unclear but ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-019-01565-x

    authors: Kado A,Tsutsumi T,Enooku K,Fujinaga H,Ikeuchi K,Okushin K,Moriya K,Yotsuyanagi H,Koike K

    更新日期:2019-08-01 00:00:00

  • Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease.

    abstract:BACKGROUND:Abrogating tolerance is a critical step in the pathogenesis of Crohn's disease (CD). T cell-anergy is one of the main mechanisms of tolerance and is regulated by the gene related to anergy in lymphocytes (GRAIL). This study investigated the expressions and regulation of GRAIL in CD and murine colitis models....

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-013-0923-x

    authors: Mukai A,Iijima H,Hiyama S,Fujii H,Shinzaki S,Inoue T,Shiraishi E,Kawai S,Araki M,Hayashi Y,Kondo J,Mizushima T,Kanto T,Egawa S,Nishida T,Tsujii M,Takehara T

    更新日期:2014-12-01 00:00:00

  • Role of extravariceal collateral channels in the development of portal-hypertensive gastropathy before and after sclerotherapy.

    abstract::We investigated whether extravariceal collateral pattern contributed to the development of portal-hypertensive gastropathy (PHG) before and after sclerotherapy. Ninety-nine patients with cirrhosis and large esophageal varices were examined in this retrospective study. They were divided into four groups according to tr...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050061

    authors: Nakayama M,Iwao T,Oho K,Toyonaga A,Tanikawa K

    更新日期:1998-04-01 00:00:00

  • The pathogenesis of Crohn's disease.

    abstract::This paper describes a program of research undertaken by the Inflammatory Bowel Disease Study Group at the Royal Free Hospital School of Medicine. The Group has tested the hypothesis that the primary pathological abnormality in Crohn's disease is in the mesenteric blood supply. The first experiments involved microcorr...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Pounder RE

    更新日期:1994-07-01 00:00:00

  • Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study.

    abstract:BACKGROUND:Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use. METHODS:Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for mo...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00535-011-0410-1

    authors: Endo H,Higurashi T,Hosono K,Sakai E,Sekino Y,Iida H,Sakamoto Y,Koide T,Takahashi H,Yoneda M,Tokoro C,Inamori M,Abe Y,Nakajima A

    更新日期:2011-07-01 00:00:00

  • Gastric sensitivity and reflexes: basic mechanisms underlying clinical problems.

    abstract::Both reflex and sensory mechanisms control the function of the stomach, and disturbances in these mechanisms may explain the pathophysiology of disorders of gastric function. The objective of this report is to perform a literature-based critical analysis of new, relevant or conflicting information on gastric sensitivi...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-013-0917-8

    authors: Azpiroz F,Feinle-Bisset C,Grundy D,Tack J

    更新日期:2014-02-01 00:00:00

  • Malignant lymphoma in the ileocecal region causing intussusception.

    abstract::A 67-year-old female was admitted with diarrhea. Preoperatively, we diagnosed intussusception due to malignant lymphoma in the ileocecal region by image and colonoscopic examinations. We resected the right hemicolon for the tumor, which was located mainly in the cecum, causing intussusception. The stenotic terminal il...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02358684

    authors: Matsushita M,Hajiro K,Kajiyama T,Ohana M,Konishi Y,Kusumi F,Matsubayashi Y,Sawami H,Narusawa H,Takahashi Y

    更新日期:1994-04-01 00:00:00

  • NSAID enteropathy and bacteria: a complicated relationship.

    abstract::The clinical significance of small intestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains under-appreciated. It occurs with greater frequency than the damage caused by these drugs in the upper gastrointestinal tract, but is much more difficult to diagnose and treat. Although the pathogenesis...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-014-1032-1

    authors: Syer SD,Blackler RW,Martin R,de Palma G,Rossi L,Verdu E,Bercik P,Surette MG,Aucouturier A,Langella P,Wallace JL

    更新日期:2015-04-01 00:00:00

  • Nonrotation of the midgut with appendiceal mucocele in an adult.

    abstract::Nonrotation of the midgut in adults and appendiceal mucocele are both rare pathological conditions. We report here the first case of nonrotation of the midgut associated with appendiceal mucocele. The patient was a 51-year-old man admitted to hospital with ileus. An upper gastrointestinal series and a barium enema rev...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350170153

    authors: Kawashima K,Ishihara S,Amano K,Hirakawa K,Adachi K,Fukuda R,Sumi S,Watanabe M,Kinoshita Y

    更新日期:2001-01-01 00:00:00

  • The efficacy of nocturnal administration of branched-chain amino acid granules to improve quality of life in patients with cirrhosis.

    abstract:BACKGROUND:Nocturnal administration of branched-chain amino acid (BCAA) granules improves serum albumin levels in patients with cirrhosis. However, it is unclear whether or not this administration method can improve the patients' quality of life (QOL). In this study, we aimed to investigate the efficacy of BCAA granule...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00535-012-0632-x

    authors: Hidaka H,Nakazawa T,Kutsukake S,Yamazaki Y,Aoki I,Nakano S,Asaba N,Minamino T,Takada J,Tanaka Y,Okuwaki Y,Watanabe M,Shibuya A,Koizumi W

    更新日期:2013-02-01 00:00:00

  • Inhibitory effects of n-3 polyunsaturated fatty acids on sigmoid colon cancer transformants.

    abstract::Various types of polyunsaturated fatty acids (PUFAs) have been suggested to exert different effects on the colon in terms of promotion or inhibition of tumor development. Results of in vitro and in vivo studies are, however, inconsistent and it remains unclear whether or not the cellular effects of PUFAs change along ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050071

    authors: Tsai WS,Nagawa H,Kaizaki S,Tsuruo T,Muto T

    更新日期:1998-04-01 00:00:00

  • Sex differences in relation to serum hepatitis B e antigen and alanine aminotransferase levels among asymptomatic hepatitis B surface antigen carriers.

    abstract::This study aimed to investigate sex differences in relation to hepatitis B e antigen (HBeAg) and serum alanine aminotransferase (ALT) levels in chronic asymptomatic hepatitis B virus (HBV) infection. HBeAg and ALT level were determined in 636 asymptomatic hepatitis B surface antigen carriers. There was no significant ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350070048

    authors: Tsai JF,Chuang LY,Jeng JE,Ho MS,Lin ZY,Hsieh MY,Wang LY,Tsai JH

    更新日期:2000-01-01 00:00:00

  • Pu'erh tea extract-mediated protection against hepatosteatosis and insulin resistance in mice with diet-induced obesity is associated with the induction of de novo lipogenesis in visceral adipose tissue.

    abstract:BACKGROUND:White adipose tissue (WAT) is important for the maintenance of metabolic homeostasis, and metabolic syndrome is sometimes associated with WAT dysfunction in humans and animals. WAT reportedly plays a key, beneficial role in the maintenance of glucose and lipid homeostasis during de novo lipogenesis (DNL). Pu...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-017-1332-3

    authors: Cai X,Hayashi S,Fang C,Hao S,Wang X,Nishiguchi S,Tsutsui H,Sheng J

    更新日期:2017-12-01 00:00:00

  • Strangulation ileus resulting from encasement of a loop of the small intestine by the great omentum, caused by abnormal adhesion.

    abstract::We treated a patient with a mechanical ileus resulting from encasement of a loop of the small intestine by the great omentum, caused by abnormal adhesion. Apart from its occurrence postoperatively with laparotomy, strangulation of small intestine into the omentum is very rare, and its occurrence without underlying dis...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02347622

    authors: Kimura H,Earashi M,Konishi K,Tsuneda A,Tazawa K,Inoue T,Maeda K,Yabushita K,Kuroda Y,Tsuji M,Miwa A

    更新日期:1996-10-01 00:00:00

  • Hepatitis C virus core protein inhibits deoxycholic acid-mediated apoptosis despite generating mitochondrial reactive oxygen species.

    abstract:BACKGROUND:Hepatitis C virus (HCV) core protein is known to cause oxidative stress and alter apoptosis pathways. However, the apoptosis results are inconsistent, and the real significance of oxidative stress is not well known. The aim of this study was twofold. First, we wanted to confirm whether core-induced oxidative...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-005-1738-1

    authors: Hara Y,Hino K,Okuda M,Furutani T,Hidaka I,Yamaguchi Y,Korenaga M,Li K,Weinman SA,Lemon SM,Okita K

    更新日期:2006-03-01 00:00:00

  • Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.

    abstract:BACKGROUND:Neutrophil elastase (NE) is a major secretory product from activated neutrophils and a major contributor to tissue destruction. However, little is known about the pathogenic contribution of NE to ulcerative colitis (UC). This study was designed to investigate the contribution of NE by measuring NE activity i...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-005-1768-8

    authors: Morohoshi Y,Matsuoka K,Chinen H,Kamada N,Sato T,Hisamatsu T,Okamoto S,Inoue N,Takaishi H,Ogata H,Iwao Y,Hibi T

    更新日期:2006-04-01 00:00:00

  • Primary diaphragmatic schwannoma with a typical target appearance: correlation of CT and MR imagings and histologic findings.

    abstract::A rare case of benign diaphragmatic schwannoma in a 38-year-old female is reported. Precontrast computed tomography (CT) showed an encapsulated well-defined round homogeneous tumor with central calcification, measuring approximately 5 cm in diameter, arising from the left diaphragm. Contrast-enhanced CT and gadolinium...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02389529

    authors: Koyama S,Araki M,Suzuki K,Fukutomi H,Maruyama T,Mun Y,Otsuka M,Fukao K

    更新日期:1996-04-01 00:00:00

  • Serum metabolomics analysis for early detection of colorectal cancer.

    abstract:BACKGROUND:Although colorectal cancer (CRC) is one of the most common causes of cancer mortality, early-stage detection improves survival rates dramatically. Because cancer impacts important metabolic pathways, the alteration of metabolite levels as a potential biomarker of early-stage cancer has been the focus of many...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-016-1261-6

    authors: Uchiyama K,Yagi N,Mizushima K,Higashimura Y,Hirai Y,Okayama T,Yoshida N,Katada K,Kamada K,Handa O,Ishikawa T,Takagi T,Konishi H,Kuriu Y,Nakanishi M,Otsuji E,Itoh Y,Naito Y

    更新日期:2017-06-01 00:00:00

  • Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan.

    abstract:BACKGROUND:Fulminant non-A, non-B, non-C hepatitis has a high mortality rate, making the identification of its causative agent imperative. Cytomegalovirus, Epstein-Barr virus, human herpesvirus-6, and herpes simplex virus are all members of the herpesviridae family that are associated with fatal hepatic failure. We inv...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350200081

    authors: Ishikawa K,Hasegawa K,Naritomi T,Kanai N,Ogawa M,Kato Y,Kobayashi M,Torii N,Hayashi N

    更新日期:2002-01-01 00:00:00