Abstract:
:Asia has intermediate-to-high prevalence and high morbidity of hepatitis B virus (HBV) infection. The use of guideline-recommended nucleos(t)ide analogs with high barrier to resistance, such as entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF), is one of the key interventions for curbing HBV infection and associated morbidity in Asia. However, there are some challenges to the use of ETV and TDF; while ETV is associated with high resistance in lamivudine (LAM)-exposed (especially LAM-refractory) patients; bone and renal safety issues are a major concern with TDF. Hence, a panel of twenty-eight expert hepatologists from Asia convened, reviewed the literature, and developed the current expert opinion-based review article for the use of TAF in the resource-constrained settings in Asia. This article provides a comprehensive review of two large, phase 3, double-blind, randomized controlled trials of TAF versus TDF in HBeAg-negative (study 0108) and HBeAg-positive (study 0110) chronic HBV patients (> 70% Asians). These studies revealed as follows: (1) non-inferiority for the proportion of patients who had HBV DNA < 29 IU/mL; (2) significantly high rate of normalization of alanine aminotransferase levels; (3) no incidence of resistance; and (4) significantly better bone and renal safety, with TAF vs. TDF up to 144 weeks. Considering the benefits of TAF, the expert panel proposed recommendations for optimizing the use of TAF in Asia, along with guidance on specific patient groups at risk of renal or bone disease suitable for TAF therapy. The guidance provided in this article may help clinicians optimize the use of TAF in Asia.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Charlton MR,Alam A,Shukla A,Dashtseren B,Lesmana CRA,Duger D,Payawal DA,Duy Cuong D,Jargalsaikhan G,Cua IHY,Sollano JD,Singh KR,Madan K,Win KM,Kyi KP,Tun KS,Salih M,Rastogi M,Saraf N,Thuy PTT,Hien PTD,Gani RA,doi
10.1007/s00535-020-01698-4subject
Has Abstractpub_date
2020-09-01 00:00:00pages
811-823issue
9eissn
0944-1174issn
1435-5922pii
10.1007/s00535-020-01698-4journal_volume
55pub_type
杂志文章,评审abstract::Although esophageal candidiasis is the most common form of Candida infection in the gastro-intestinal tract, little attention has been directed toward determining the mechanism of its infection. We have already clarified the existence of four modes of adherence of Candida albicans to the esophagus; attachment, subepit...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF01229065
更新日期:1994-02-01 00:00:00
abstract::In vivo progression to malignancy is characterized by the switch to an angiogenic phenotype. The angiogenic switch is a critical control point for tumor expansion. The ability of a tumor to become neovascularized permits rapid expansion of tumor growth and increases the likelihood of metastases. The genetic alteration...
journal_title:Journal of gastroenterology
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doi:
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abstract:BACKGROUND:The aim of this study was to determine whether leptin and insulin resistance (IR) showed differences between steatotic patients with and without elevated serum transaminases. METHODS:The study included 32 patients with fatty liver and high serum transaminase level (group I), 31 patients with fatty liver and...
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doi:10.1007/s00535-002-1084-5
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Insufflation with carbon dioxide (CO(2)) in colonoscopy has not been widely adopted and, consequently, limited data are available on insufflated gas volume and blood pCO(2). The aim of this study was to compare CO(2) and air as an insufflation agent in patients undergoing colonoscopy without sedation in term...
journal_title:Journal of gastroenterology
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doi:10.1007/s00535-010-0286-5
更新日期:2010-12-01 00:00:00
abstract::IL-22 is a relatively new cytokine that is characterized by several unique biological properties. In the intestines, the effect of IL-22 is restricted mainly to non-lymphoid cells such as epithelial cells. Interestingly, the expression pattern and major cellular source of IL-22 have distinct difference between large a...
journal_title:Journal of gastroenterology
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doi:10.1007/s00535-017-1401-7
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abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a common cancer type in China. In this study, we aimed to develop aneuploidy markers for diagnosis and prognosis of ESCC. METHODS:Chromosomal aneuploidies were detected in 493 primary tumors and 61 precancerous lesions by fluorescence in situ hybridization with c...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-014-0961-z
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abstract::From its pattern of metastasis and recurrence, gastric carcinoma can be recognized as a slow-growing malignancy whose local control is still the most important part of treatment. With application of asymptomatic population screening and awareness of the high risk of this disease among the general population in Japan, ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The virologic impact of adding interferon to antiviral nucleoside therapy was studied in Japanese patients having perinatally transmitted hepatitis B virus (HBV) genotype C. METHODS:Sixty-four patients including 41 positive for hepatitis B e antigen (HBeAg) were assigned to receive either (1) a combination ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00535-008-2174-9
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The transcription factor nuclear factor-E2-related factor-2 (Nrf2) inhibits lipid accumulation and oxidative stress in the liver by interfering with lipogenic pathways and inducing antioxidative stress genes. METHODS:The involvement of Nrf2 in defense against the development of steatohepatitis was studied i...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0659-z
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Autoimmune pancreatitis (AIP) is considered to be a pancreatic lesion of IgG4-related systemic disease, but about 20% of AIP patients do not have elevated serum IgG4 levels. This study aimed to clarify the pathophysiology of AIP patients without elevated serum IgG4 levels. METHODS:Fifty-eight AIP patients w...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-010-0317-2
更新日期:2011-01-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1278-5
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use. METHODS:Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for mo...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00535-011-0410-1
更新日期:2011-07-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-005-1677-x
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Few studies have investigated the association between smoking and ultrasonographically diagnosed gallbladder (GB) disease, and their results were uncertain. This study was conducted to examine the association between smoking and drinking and GB diseases. METHODS:A total of 9,947 subjects (age, 30-69 years; ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350200066
更新日期:2002-01-01 00:00:00
abstract::We report a case of synchronous gas gangrene and spontaneous bacterial peritonitis associated with liver cirrhosis. The patient was a 52-year-old man who was being followed for decompensated liver cirrhosis. He experienced sudden onset lower abdominal pain with distension and pain in the left leg. A bullous lesion, wi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02936380
更新日期:1997-04-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050299
更新日期:1999-08-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-010-0289-2
更新日期:2011-01-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0542-y
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abstract::Small bowel transit time (SBTT) in 15 young and 13 elderly women was assessed by measuring breath hydrogen concentrations after they had consumed a solid test meal. The meal consisted of 200 g cooked rice, 50 ml miso (made from fermented soy bean curd) soup, a boiled egg, and 95.5 g of cooked soy beans with mixed vege...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02934082
更新日期:1997-08-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1230-8
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Journal of gastroenterology
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更新日期:1998-12-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
abstract::In recent years autoimmune pancreatitis (AIP) has been established as a special type of chronic pancreatitis. It is characterized by its histopathological and immunological features. The morphological hallmarks are periductal infiltration by lymphocytes and plasma cells, granulocytic epithelial lesions with focal dest...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-007-2048-6
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abstract::An association of hidradenitis suppurativa with Crohn's disease is supported by previous repent. We here report a patient with hidradenitis suppurativa who subsequently developed peripheral arthritis, sacroiliitis, and Crohn's disease. A significant attenuation of bowel, cutaneous, and joint symptoms was achieved afte...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1185-9
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Among the factors influencing variceal relapse after endoscopic treatment, portal hemodynamic changes, especially in portal systemic shunts, could be the most important factor because hemodynamics are directly related to the development of esophageal varices. We aimed to clarify the influence of endoscopic t...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
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更新日期:2006-02-01 00:00:00
abstract::Combined hepatocellular (HCC) and cholangiocellular carcinoma (CCC) (mixed carcinoma) is a rare subtype of primary hepatic carcinoma. We report a case of mixed carcinoma that developed in a non-cirrhotic liver, in a patient who was serologically negative for both hepatitis B and C viruses. A 65-year-old Japanese woman...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02365455
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Few epidemiologic studies have examined the role of nutrient intake in the development of pancreatic cancer in Japan. We addressed this association in a population-based case-control study. METHODS:The cases were 109 patients who were newly diagnosed with pancreatic cancer between January 2000 and March 200...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2005-03-01 00:00:00