Abstract:
BACKGROUND:Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. left-sided colon,' 'colon vs. rectum,' and 'right-sided (right-sided colon) vs. left-sided (left-sided colon and rectum).' This nationwide multicenter retrospective study aimed to clarify the prognostic impact of tumor location in patients with stage III colorectal cancer by classifying tumors into three groups: right-sided colon, left-sided colon, and rectum. METHODS:Subjects were 9194 patients with stage III colorectal cancer who underwent curative surgery from 1997 to 2012. Relapse-free survival (RFS) after primary surgery and overall survival (OS) after recurrence were examined. RESULTS:Rectal cancer (n = 2922) was associated with worse RFS compared to right-sided colon cancer (n = 2362) (hazard ratio (HR) 0.65; 95% CI 0.59-0.72; p < 0.001) and left-sided colon cancer (n = 3910) (HR 0.72; 95% CI 0.66-0.78; p < 0.001) after adjusting for key clinical factors (i.e., sex, age, histological type, CEA, adjuvant therapy, T category, and N category). Among patients with recurrence (n = 2823), rectal cancer was associated with better OS compared to right-sided colon cancer (HR 1.23; 95% CI 1.08-1.40; p = 0.002) and worse OS compared to left-sided colon cancer (HR 0.88; 95% CI 0.79-0.99; p = 0.029). Twenty percent of right-sided colon cancer recurrences exhibited peritoneal dissemination, 42% of left-sided colon cancer recurrences were liver metastases, and 33% of rectal cancer recurrences were local recurrences. CONCLUSIONS:The three tumor locations (right-sided colon, left-sided colon, rectum) had different prognostic implications for recurrence after curative resection and overall mortality, suggesting that tumor location serves as a prognostic biomarker in stage III colorectal cancer.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Shida D,Inoue M,Tanabe T,Moritani K,Tsukamoto S,Yamauchi S,Sugihara K,Kanemitsu Ydoi
10.1007/s00535-020-01706-7subject
Has Abstractpub_date
2020-10-01 00:00:00pages
958-968issue
10eissn
0944-1174issn
1435-5922pii
10.1007/s00535-020-01706-7journal_volume
55pub_type
杂志文章abstract::Prevention of human diseases has become a major focus of biomedical investigators around the world. Our current screening and treatment regimens for colorectal cancer are not effective, as indicated by the fact that this disease is the second leading cause of death from cancer in the United States. Recently published ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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abstract::This paper describes a program of research undertaken by the Inflammatory Bowel Disease Study Group at the Royal Free Hospital School of Medicine. The Group has tested the hypothesis that the primary pathological abnormality in Crohn's disease is in the mesenteric blood supply. The first experiments involved microcorr...
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pub_type: 杂志文章,评审
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abstract:BACKGROUND:Inflammatory bowel disease affects the quality of a patient's life in many ways, but no validated instrument for measuring disease-specific quality of life in these patients is available in Japan. We developed a Japanese version of the Inflammatory Bowel Disease Questionnaire (IBDQ), together with the author...
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更新日期:1995-08-01 00:00:00
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更新日期:2008-01-01 00:00:00
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doi:10.1007/s005350300046
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章,评审
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abstract:BACKGROUND:The T-helper (Th)1 immune reaction is essential for the eradication of hepatitis C virus (HCV) during interferon (IFN) therapy in patients with chronic hepatitis C. Osteopontin is a cytokine crucial for the initiation of the Th1 response. Recently, we identified four single-nucleotide polymorphisms (SNPs) in...
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更新日期:2011-02-01 00:00:00
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更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:In Japan, generally, patients with chronic hepatitis C are aged. The aim of this study was to investigate the effect of interferon (IFN) therapy on the mortality of chronic hepatitis C patients over age 60. METHODS:Seven-hundred and seven patients with histologically proven chronic hepatitis C were enrolled...
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pub_type: 杂志文章,多中心研究
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更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Efficacy and safety of interferon induction therapy alone or in combination with ribavirin or ribavirin plus amantadine were evaluated in chronic hepatitis C patients who were nonresponders to primary antiviral treatment. METHODS:The study was designed to have 225 HCV nonresponder patients, but at an interi...
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Autoimmune pancreatitis (AIP) is considered to be a pancreatic lesion of IgG4-related systemic disease, but about 20% of AIP patients do not have elevated serum IgG4 levels. This study aimed to clarify the pathophysiology of AIP patients without elevated serum IgG4 levels. METHODS:Fifty-eight AIP patients w...
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doi:10.1007/s00535-010-0317-2
更新日期:2011-01-01 00:00:00
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更新日期:2015-04-01 00:00:00
abstract::A case of Dieulafoy's vascular malformation of the jejunum treated by laparoscopic surgery is described. The patient was a 31-year-old-woman who had complained of melena and had severe anemia needing blood transfusion. Angiography revealed microaneurysms and hypervascularity of the jejunum in the area between the firs...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-003-1305-6
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Loss of imprinting (LOI) of the insulin-like growth factor 2 (IGF2) is an early event in the development of colorectal cancer (CRC). Whether LOI of IGF2 denotes a molecular or clinical cancer subgroup is currently unknown. METHODS:Tumor biopsies and paired normal mucosa from 399 patients with extensive clin...
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pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00