Nationwide epidemiological survey of chronic pancreatitis in Japan: introduction and validation of the new Japanese diagnostic criteria 2019.

Abstract:

OBJECTIVES:To provide updated clinico-epidemiological information on chronic pancreatitis (CP) in Japan. METHODS:We conducted a two-stage nationwide epidemiological survey; the number of CP patients was estimated in the first-stage survey, and their clinical features were examined in the second-stage survey. We surveyed patients with CP who had visited hospitals in 2016 and were diagnosed according to the Japanese diagnostic criteria 2009 (DC2009). Furthermore, we validated the new Japanese diagnostic criteria (DC2019) in patients with early CP diagnosed according to DC2009. RESULTS:The number of patients with definite/probable CP in 2016 was 56,520 (prevalence, 44.5 per 100,000 persons), and that of early CP was 4470 (prevalence, 3.5 per 100,000 persons). We obtained detailed clinical information of 2150 patients with definite/probable CP and 249 patients with early CP. Compared with the early CP cases, the definite/probable CP cases had higher proportions of male (4.8 vs. 1.3), alcohol-related etiology (72.0% vs. 45.8%), smoking history (69.6% vs. 41.0%), diabetes mellitus (42.3% vs. 19.3%), and past history of acute pancreatitis (AP) (50.4% vs. 22.1%). Among the patients with early CP diagnosed according to DC2009, 93 (37.3%) were diagnosed with early CP according to DC2019, but the diagnosis of the remaining 156 (62.7%) patients was downgraded. Alcohol-related etiology, smoking history, early disease onset, and past history of AP were associated with the maintenance of early CP diagnosis in DC2019. CONCLUSION:We clarified the current status of CP in Japan. Further validation studies are warranted to clarify the diagnostic utility of DC2019.

journal_name

J Gastroenterol

authors

Masamune A,Kikuta K,Kume K,Hamada S,Tsuji I,Takeyama Y,Shimosegawa T,Okazaki K,Japan Pancreas Society.

doi

10.1007/s00535-020-01704-9

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1062-1071

issue

11

eissn

0944-1174

issn

1435-5922

pii

10.1007/s00535-020-01704-9

journal_volume

55

pub_type

杂志文章
  • Heterotopic gastric mucosa of the gallbladder.

    abstract::A case of heterotopic gastric mucosa in the fundus of the gallbladder is reported. A 23-year-old man, who had been healthy and asymptomatic, visited our hospital because of abnormal findings in a liver enzyme test given during a routine health screening. Ultrasonography demonstrated a highly echogenic polypoid mass in...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02347576

    authors: Uchiyama S,Imai S,Suzuki T,Arita A,Takeda K,Sujino H,Kameda H

    更新日期:1995-08-01 00:00:00

  • Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study.

    abstract:BACKGROUND:Depth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. However, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00535-004-1339-4

    authors: Kitajima K,Fujimori T,Fujii S,Takeda J,Ohkura Y,Kawamata H,Kumamoto T,Ishiguro S,Kato Y,Shimoda T,Iwashita A,Ajioka Y,Watanabe H,Watanabe T,Muto T,Nagasako K

    更新日期:2004-06-01 00:00:00

  • Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease.

    abstract:BACKGROUND:Abrogating tolerance is a critical step in the pathogenesis of Crohn's disease (CD). T cell-anergy is one of the main mechanisms of tolerance and is regulated by the gene related to anergy in lymphocytes (GRAIL). This study investigated the expressions and regulation of GRAIL in CD and murine colitis models....

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-013-0923-x

    authors: Mukai A,Iijima H,Hiyama S,Fujii H,Shinzaki S,Inoue T,Shiraishi E,Kawai S,Araki M,Hayashi Y,Kondo J,Mizushima T,Kanto T,Egawa S,Nishida T,Tsujii M,Takehara T

    更新日期:2014-12-01 00:00:00

  • Gallstones, a cholecystectomy, chronic pancreatitis, and the risk of subsequent pancreatic cancer in diabetic patients: a population-based cohort study.

    abstract:BACKGROUND:The causal association between diabetes and pancreatic cancer remains unclear in Asian populations. This study examined whether gallstones, a cholecystectomy, chronic pancreatitis and the treatment of antidiabetic agents affect the risk of subsequent pancreatic cancer for patients with diabetes in a Taiwanes...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-012-0674-0

    authors: Lai HC,Tsai IJ,Chen PC,Muo CH,Chou JW,Peng CY,Lai SW,Sung FC,Lyu SY,Morisky DE

    更新日期:2013-06-01 00:00:00

  • Pu'erh tea extract-mediated protection against hepatosteatosis and insulin resistance in mice with diet-induced obesity is associated with the induction of de novo lipogenesis in visceral adipose tissue.

    abstract:BACKGROUND:White adipose tissue (WAT) is important for the maintenance of metabolic homeostasis, and metabolic syndrome is sometimes associated with WAT dysfunction in humans and animals. WAT reportedly plays a key, beneficial role in the maintenance of glucose and lipid homeostasis during de novo lipogenesis (DNL). Pu...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-017-1332-3

    authors: Cai X,Hayashi S,Fang C,Hao S,Wang X,Nishiguchi S,Tsutsui H,Sheng J

    更新日期:2017-12-01 00:00:00

  • Recurrence of hepatocellular carcinoma 102 months after successful eradication and removal of membranous obstruction of the inferior vena cava.

    abstract::We report a 54-year-old Japanese woman who developed liver tumors 102 months after hepatic resection for hepatocellular carcinoma (HCC) and percutaneous transluminal angioplasty (PTA) for membranous obstruction of the inferior vena cava (MOVC), which is one form of Budd-Chiari syndrome. In the present admission workup...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-004-1365-2

    authors: Takamura M,Ichida T,Yokoyama J,Matsuda Y,Nomoto M,Aoyagi Y

    更新日期:2004-07-01 00:00:00

  • Partial normalization of pubertal timing in female mice with DSS colitis treated with anti-TNF-α antibody.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) and resultant colitis occurring prior to puberty are frequently associated with delayed puberty and losses of growth and bone mineralization. Some of this delay may be due to colonic inflammation and associated systemic inflammation. To date no treatments for IBD have been sh...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-012-0542-y

    authors: Deboer MD,Steinman J,Li Y

    更新日期:2012-06-01 00:00:00

  • Ciliated foregut cyst in cirrhotic liver.

    abstract::We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonograp...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02355038

    authors: Murakami T,Imai A,Nakamura H,Tsuda K,Kanai T,Wakasa K

    更新日期:1996-06-01 00:00:00

  • Introduction of an examination and treatment for Helicobacter pylori infection in high school health screening.

    abstract:BACKGROUND:Recently, a significant relationship between gastric cancer and Helicobacter pylori infection has been proven. The purpose of this study was to elucidate the actual conditions of H. pylori infection in Japanese teenagers. METHODS:The study subjects were students at a certain high school between 2007 and 200...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-011-0450-6

    authors: Akamatsu T,Ichikawa S,Okudaira S,Yokosawa S,Iwaya Y,Suga T,Ota H,Tanaka E

    更新日期:2011-12-01 00:00:00

  • Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer.

    abstract:BACKGROUND:Better diagnosis of metastatic disease has been pursued by oncologists: however, many of the tumor markers have been still controversial. Our purpose was to estimate the usefulness of soluble E-selectin and its ligand sialyl Lewis A for more accurate diagnosis as a combined tumor marker for metastases in col...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350170004

    authors: Ito K,Ye CL,Hibi K,Mitsuoka C,Kannagi R,Hidemura K,Ando H,Kasai Y,Akiyama S,Nakao A

    更新日期:2001-12-01 00:00:00

  • Sex-related influence of angiotensin-converting enzyme polymorphisms on fibrosis progression due to recurrent hepatitis C after liver transplantation.

    abstract:BACKGROUND:Experimental evidence and clinical studies suggest that the renin-angiotensin system and its inhibitors may play a role in regulating the mechanisms of liver fibrosis development. The present study aimed to verify whether carriage of specific angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) all...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-007-2040-1

    authors: Fabris C,Toniutto P,Bitetto D,Minisini R,Fornasiere E,Smirne C,Pirisi M

    更新日期:2007-07-01 00:00:00

  • Granular cell tumor occurring in the sigmoid colon treated by endoscopic mucosal resection using a transparent cap (EMR-C).

    abstract::A case of granular cell tumor occurring in the sigmoid colon is reported. The patient, a 56-year-old man, visited our hospital for further evaluation of occult blood in his stool. Endoscopic examination revealed a yellowish, hemispheric submucosal tumor (SMT) with redness, about 6 mm in diameter, in the sigmoid colon....

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s005350300068

    authors: Endo S,Hirasaki S,Doi T,Endo H,Nishina T,Moriwaki T,Nakauchi M,Masumoto T,Tanimizu M,Hyodo I

    更新日期:2003-01-01 00:00:00

  • Treatment of bleeding stomal varices by balloon-occluded retrograde transvenous obliteration.

    abstract::Although stomal varices are a rare complication, bleeding stomal varices often need to be treated owing to symptoms of hypovolemic shock, recurrence of stomal bleeding, or deterioration in the quality of life. Various treatment strategies for the management of bleeding stomal varices have thus far been reported. We re...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-006-1960-5

    authors: Minami S,Okada K,Matsuo M,Kamohara Y,Sakamoto I,Kanematsu T

    更新日期:2007-01-01 00:00:00

  • Randomized, parallel, double-blind comparison of the ulcer-healing effects of ilaprazole and omeprazole in the treatment of gastric and duodenal ulcers.

    abstract:PURPOSE:Ilaprazole (IY-81149) is a new proton-pump inhibitor (PPI) not previously studied in human patients with ulcer disease. This study evaluated and compared it with a reference PPI, omeprazole, in the treatment of gastric and duodenal ulcers. METHODS:This was a double-blind, parallel, randomized study. Patients a...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00535-009-0072-4

    authors: Ho KY,Kuan A,Zaño F,Goh KL,Mahachai V,Kim DY,Yoon HM

    更新日期:2009-01-01 00:00:00

  • A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease.

    abstract::Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases such as inflammatory bowel disease (IBD). The development of next-generation sequencing technology allows th...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-015-1084-x

    authors: Kanai T,Mikami Y,Hayashi A

    更新日期:2015-09-01 00:00:00

  • Current status of preoperative biliary drainage.

    abstract::Preoperative biliary drainage (PBD) has been thought to be preferable regardless of the site of biliary strictures, e.g., distal or proximal strictures because PBD by endoscopy or interventional radiology decreases postoperative mortality and morbidity rates. However, recently, several studies have revealed that PBD s...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-015-1096-6

    authors: Umeda J,Itoi T

    更新日期:2015-09-01 00:00:00

  • A randomized controlled trial of lusutrombopag in Japanese patients with chronic liver disease undergoing radiofrequency ablation.

    abstract:BACKGROUND:Thrombocytopenia represents an obstacle for invasive procedures in chronic liver disease (CLD) patients. We aimed to estimate the appropriate dose and evaluate the efficacy and safety of lusutrombopag for the treatment of thrombocytopenia before percutaneous liver radiofrequency ablation (RFA) for primary he...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00535-018-1499-2

    authors: Tateishi R,Seike M,Kudo M,Tamai H,Kawazoe S,Katsube T,Ochiai T,Fukuhara T,Kano T,Tanaka K,Kurokawa M,Yamamoto K,Osaki Y,Izumi N,Imawari M

    更新日期:2019-02-01 00:00:00

  • Clinical impact of a newly developed capsule endoscope: usefulness of a real-time image viewer for gastric transit abnormality.

    abstract:BACKGROUND:A new capsule endoscope has been developed by Olympus Medical Systems. The visualization and usefulness of its real-time image viewer for gastric transit abnormality were evaluated by using this new device. METHODS:Thirty-seven consecutive patients were enrolled. In cases of gastric transit abnormality (gas...

    journal_title:Journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00535-007-2140-y

    authors: Ogata H,Kumai K,Imaeda H,Aiura K,Hisamatsu T,Okamoto S,Iwao Y,Sugino Y,Kitajima M,Hibi T

    更新日期:2008-01-01 00:00:00

  • Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers.

    abstract:BACKGROUND AND AIMS:Insulin-like growth factor (IGF)-I receptor (IGF-IR) signaling plays important parts in both the tumorigenicity and progression of digestive/gastrointestinal malignancies. In this study, we sought to test the effectiveness of a practical approach to blocking IGF-IR signaling using RNA interference d...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-009-0151-6

    authors: Wang Y,Adachi Y,Imsumran A,Yamamoto H,Piao W,Li H,Ii M,Arimura Y,Park MY,Kim D,Lee CT,Carbone DP,Imai K,Shinomura Y

    更新日期:2010-02-01 00:00:00

  • NS5A resistance-associated variants undermine the effectiveness of ledipasvir and sofosbuvir for cirrhotic patients infected with HCV genotype 1b.

    abstract:BACKGROUND:Little real-world cohort data has been reported for Asians who have received interferon-free regimens with sofosbuvir (SOF) for chronic hepatitis C virus (HCV) infection. We evaluated the effectiveness and safety in clinical practice of ledipasvir (LDV) plus SOF for Japanese patients infected with HCV genoty...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00535-016-1290-1

    authors: Ogawa E,Furusyo N,Nomura H,Dohmen K,Higashi N,Takahashi K,Kawano A,Azuma K,Satoh T,Nakamuta M,Koyanagi T,Kato M,Shimoda S,Kajiwara E,Hayashi J,Kyushu University Liver Disease Study (KULDS) Group.

    更新日期:2017-07-01 00:00:00

  • The beneficial effect of azathioprine on maintenance of remission in severe ulcerative colitis.

    abstract:BACKGROUND:The search is on to find more effective drug regimens for patients with severe ulcerative colitis, as conventional drugs such as sulfasalazine and its congeners fail to prevent relapse in a significant number of patients. Azathioprine has also been reported to be useful as a steroid-sparing drug in patients ...

    journal_title:Journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s005350200034

    authors: Sood A,Kaushal V,Midha V,Bhatia KL,Sood N,Malhotra V

    更新日期:2002-01-01 00:00:00

  • Fibrogenesis serum markers in patients with chronic hepatitis C treated with alpha-IFN.

    abstract::The correlation between therapeutic response and liver fibrogenesis was studied in serum and liver specimens taken from 31 patients treated with alpha-interferon (IFN) (14 sustained responders and 17 non-responders) for chronic hepatitis C. Serum samples, collected before therapy, and at further 6-month intervals over...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050272

    authors: Fabris P,Marranconi F,Bozzola L,Biasin MR,De Lazzari F,Plebani M,Benedetti P,Tositti G,Pellizzer G,Stecca C,de Lalla F

    更新日期:1999-06-01 00:00:00

  • T cell cytotoxicity of autologous and allogeneic lymphocytes in a patient with Crohn's disease.

    abstract::We report a 27-year-old male with Crohn's disease (CD) of the small and large intestine, whose peripheral blood lymphocytes (PBL) showed increased cell-mediated cytotoxicity (CTL). Autologous and allogeneic effector cells from PBL and intestinal lymph nodes (LN) were isolated on a Ficoll-Hypaque gradient. Colonic cell...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02361237

    authors: Okazaki K,Yokoyama Y,Yamamoto Y,Kobayashi M,Araki K,Ogata T

    更新日期:1994-08-01 00:00:00

  • Pancreatic regeneration after ethionine-induced acute pancreatitis in rats lacking pancreatic CCK-A receptor gene expression.

    abstract:BACKGROUND:We examined the effects of cholecystokinin (CCK) on the development of ethionine-induced pancreatitis and pancreatic recovery. We used Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model lacking pancreatic CCK-A receptor gene expression. METHODS:Ethionine-induced pancreatitis was induced in the 7-week-o...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-003-1120-0

    authors: Sato T,Niikawa J,Usui I,Imamura T,Yoshida H,Tanaka S,Mitamura K

    更新日期:2003-01-01 00:00:00

  • Prognostic impact of primary tumor location in Stage III colorectal cancer-right-sided colon versus left-sided colon versus rectum: a nationwide multicenter retrospective study.

    abstract:BACKGROUND:Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. left-sided colon,' 'colon vs. rectum,' and 'right-sided (right-sided colon) vs. left-sided (left-sided colon and rectum).' This nationwide multicenter ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-020-01706-7

    authors: Shida D,Inoue M,Tanabe T,Moritani K,Tsukamoto S,Yamauchi S,Sugihara K,Kanemitsu Y

    更新日期:2020-10-01 00:00:00

  • Eradication therapy of Helicobacter pylori. A review. Report from a workshop organized by the Swedish and Norwegian Medical Products Agencies, September 1995.

    abstract::An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all were involved in the fina...

    journal_title:Journal of gastroenterology

    pub_type:

    doi:

    authors: Unge P

    更新日期:1998-01-01 00:00:00

  • Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evaluated using cycling-probe real-time PCR combined with direct sequencing.

    abstract:BACKGROUND:Dual oral therapy with daclatasvir plus asunaprevir yielded an SVR rate of 85% among patients with genotype 1b HCV. Treatment failure mainly occurred in patients with pre-existing HCV with NS5A-Y93H mutation. The significance of the mutation was evaluated. METHODS:The percent of serum NS5A-Y93H strains rela...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-015-1106-8

    authors: Uchida Y,Kouyama J,Naiki K,Sugawara K,Ando S,Nakao M,Motoya D,Inao M,Imai Y,Nakayama N,Mochida S

    更新日期:2016-03-01 00:00:00

  • Distribution of ghrelin-immunoreactive cells in human gastric mucosa: comparison with that of parietal cells.

    abstract:BACKGROUND:Ghrelin is a novel 28-amino-acid peptide isolated from rat and human stomach. This peptide is an endogenous ligand for the growth hormone secretagogue receptor and stimulates the release of growth hormones. Although the principal site of ghrelin synthesis has been reported to be in the stomach, there have be...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-004-1550-3

    authors: Tanaka-Shintani M,Watanabe M

    更新日期:2005-04-01 00:00:00

  • Incidence and clinical outcomes of intestinal Behçet's disease in Korea, 2011-2014: a nationwide population-based study.

    abstract:BACKGROUND:Intestinal Behçet's disease (BD) is very rare, and epidemiologic data regarding BD are scarce. Moreover, there have been no population-based studies focusing on intestinal BD. We conducted a nationwide population-based study to examine the incidence and clinical course of Korean patients with intestinal BD. ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-016-1300-3

    authors: Han M,Jung YS,Kim WH,Cheon JH,Park S

    更新日期:2017-08-01 00:00:00

  • Comparison of standard-dose and low-dose gemcitabine regimens in pancreatic adenocarcinoma patients: a prospective randomized trial.

    abstract:BACKGROUND:A prospective, randomized study was performed to determine whether gemcitabine infusion at a low dose (250 mg/m2) is comparable or superior to the standard-dose infusion (1000 mg/m2) in terms of the survival period, clinical benefit, and frequency of adverse effects in patients with advanced pancreatic adeno...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00535-005-1724-7

    authors: Sakamoto H,Kitano M,Suetomi Y,Takeyama Y,Ohyanagi H,Nakai T,Yasuda C,Kudo M

    更新日期:2006-01-01 00:00:00