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The beneficial effect of azathioprine on maintenance of remission in severe ulcerative colitis.

Abstract：

BACKGROUND:The search is on to find more effective drug regimens for patients with severe ulcerative colitis, as conventional drugs such as sulfasalazine and its congeners fail to prevent relapse in a significant number of patients. Azathioprine has also been reported to be useful as a steroid-sparing drug in patients who suffer from frequent relapses. As these drugs when used individually fail to sustain remission in a significant number of patients, we evaluated the combination of these two drugs. METHODS:Thirty-five newly diagnosed patients with severe ulcerative colitis were randomized into two groups; group A (combination therapy) received sulfasalazine and azathioprine, while group B (sulfasalazine monotherapy) received sulfasalazine and placebo. In addition, all the patients received steroids initially to achieve clinical remission. The patients were followed-up for a period of 1 year. The therapeutic outcome was measured by the number of patients who suffered relapse in each group. RESULTS:All the patients completed the 1-year study period. While 4 patients (23.5%) in group A suffered relapse of disease, 10 (55.6%) in group B suffered relapse, the difference being statistically significant. The relapse-free period was also significantly longer in group A. CONCLUSIONS:Combination therapy (sulfasalazine and azathioprine) is more effective than sulfasalazine and placebo in the maintenance of remission in patients with severe ulcerative colitis.

journal_name

J Gastroenterol

journal_title

Journal of gastroenterology

authors

Sood A,Kaushal V,Midha V,Bhatia KL,Sood N,Malhotra V

doi

10.1007/s005350200034

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

270-4

issue

4

eissn

0944-1174

issn

1435-5922

journal_volume

37

pub_type

临床试验,杂志文章,随机对照试验

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