Action of endothelins on hepatic stellate cells.

abstract：:Hepatitis C virus (HCV) infection is responsible for more than a half of the cases of chronic viral hepatitis in Japan. About 20% of patients who are chronically infected with the virus develop cirrhosis about 20-30 years after the infection, with hepatocellular carcinoma developing in about 5% of patients a year. The...

journal_title：Journal of gastroenterology

authors： Chayama K

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Recently, guidelines for the treatment and prevention of ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs) were established. This study investigated the association between the current adherence to the guidelines and the incidence of gastric mucosal lesions caused by NSAIDs. METHODS:This study...

journal_title：Journal of gastroenterology

authors： Tsumura H,Fujita T,Tamura I,Morita Y,Yoshida M,Toyonaga T,Mukai H,Inokuchi H,Kutsumi H,Azuma T

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Drug resistance in colorectal cancers is assumed to be mediated by changes in the expression of microRNAs, but the specific identities and roles of microRNAs are largely unclear. We examined the effect of 5-fluorouracil (5-FU) resistance on microRNA expression. METHODS:Two types of 5-FU-resistant colon canc...

journal_title：Journal of gastroenterology

authors： Kurokawa K,Tanahashi T,Iima T,Yamamoto Y,Akaike Y,Nishida K,Masuda K,Kuwano Y,Murakami Y,Fukushima M,Rokutan K

更新日期：2012-08-01 00:00:00

abstract：:To study the appropriate period for formalin fixation in order to detect p53 abnormalities in formalin-fixed tissue, we used seven surgically resected human colorectal cancer specimens. The immunohistochemical reactivity of p53 immunostaining and amplification of DNA by polymerase chain reaction (PCR) of the p53 gene ...

journal_title：Journal of gastroenterology

authors： Matsubayashi H,Watanabe H,Nishikura K,Ajioka Y,Maejima T,Kijima H,Saitoh T

更新日期：1998-10-01 00:00:00

abstract：:The clinical significance of small intestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains under-appreciated. It occurs with greater frequency than the damage caused by these drugs in the upper gastrointestinal tract, but is much more difficult to diagnose and treat. Although the pathogenesis...

journal_title：Journal of gastroenterology

authors： Syer SD,Blackler RW,Martin R,de Palma G,Rossi L,Verdu E,Bercik P,Surette MG,Aucouturier A,Langella P,Wallace JL

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Primary biliary cirrhosis (PBC) is histopathologically characterized by chronic nonsuppurative destructive cholangitis and ductopenia of interlobular bile ducts. Bile duct injury is also often encountered in chronic viral hepatitis (CVH) and in autoimmune hepatitis (AIH). METHODS:In this study, we performed...

journal_title：Journal of gastroenterology

authors： Zen Y,Harada K,Sasaki M,Tsuneyama K,Matsui K,Haratake J,Sakisaka S,Maeyama S,Yamamoto K,Nakano M,Shimamatsu K,Kage M,Kurose N,Uchiyama A,Kaizaki Y,Toda G,Nakanuma Y

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Little real-world cohort data has been reported for Asians who have received interferon-free regimens with sofosbuvir (SOF) for chronic hepatitis C virus (HCV) infection. We evaluated the effectiveness and safety in clinical practice of ledipasvir (LDV) plus SOF for Japanese patients infected with HCV genoty...

journal_title：Journal of gastroenterology

authors： Ogawa E,Furusyo N,Nomura H,Dohmen K,Higashi N,Takahashi K,Kawano A,Azuma K,Satoh T,Nakamuta M,Koyanagi T,Kato M,Shimoda S,Kajiwara E,Hayashi J,Kyushu University Liver Disease Study (KULDS) Group.

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The (13)C-urea breath test (UBT) is a simple breath test for the diagnosis of Helicobacter pylori infection, but several factors have been reported to affect the results of this test. In this study, the effects of the antiulcer drugs used in Japan on the results of UBT were determined. METHODS:The subjects ...

journal_title：Journal of gastroenterology

authors： Murakami K,Sato R,Okimoto T,Watanabe K,Nasu M,Fujioka T,Kodama M,Kagawa J

更新日期：2003-01-01 00:00:00

abstract：:Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases such as inflammatory bowel disease (IBD). The development of next-generation sequencing technology allows th...

journal_title：Journal of gastroenterology

authors： Kanai T,Mikami Y,Hayashi A

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The introduction of capsule endoscopy (CE) has facilitated the detection of mucosal changes in the small bowel, and such mucosal changes have been noted in cirrhotic patients with portal hypertension; these changes are described as portal hypertensive enteropathy. The aim of this study was to assess the effe...

journal_title：Journal of gastroenterology

authors： Matsushita Y,Narahara Y,Fujimori S,Kanazawa H,Itokawa N,Fukuda T,Takahashi Y,Kondo C,Kidokoro H,Atsukawa M,Nakatsuka K,Sakamoto C

更新日期：2013-05-01 00:00:00

abstract：:Human glucagonoma cells were isolated and maintained in vitro. Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels. Atropine abolished the stimulatory e...

journal_title：Journal of gastroenterology

authors： Funakoshi A,Yasunami Y,Ryu S,Shinozaki H,Jimi A,Ikeda S

更新日期：1994-12-01 00:00:00

abstract：:An extremely rare case of malignant schwannoma of the esophagus with lymph node metastasis is reported. A 49-year-old woman was found to have an abnormal shadow on a chest X-ray film taken during an annual checkup. Upper gastrointestinal series showed extrinsic pressure on the middle thoracic esophagus, without a muco...

journal_title：Journal of gastroenterology

authors： Murase K,Hino A,Ozeki Y,Karagiri Y,Onitsuka A,Sugie S

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:The ideal medication for the treatment of acid-related diseases, for example, hemorrhagic ulcers and stress-related gastric bleeding, should have a rapid onset of action to promote hemostasis and alleviate symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion afte...

journal_title：Journal of gastroenterology

authors： Abe Y,Inamori M,Togawa J,Kikuchi T,Muramatsu K,Chiguchi G,Kawamura H,Kobayashi N,Kirikoshi H,Sakaguchi T,Takamura T,Nakajima A,Ueno N,Sekihara H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Several small, prospective, open studies suggest that leukocytapheresis might be efficient in patients with steroid-dependent ulcerative colitis (UC). AIM:To evaluate the short- and long-term effectiveness of leukocytapheresis for the management of steroid-dependent UC in clinical practice. METHODS:A Web-b...

journal_title：Journal of gastroenterology

authors： Cabriada JL,Domènech E,Ibargoyen N,Hernández V,Clofent J,Ginard D,Gutiérrez-Ibarluzea I,Hinojosa J

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Linked color imaging (LCI) increases the visibility of early gastric cancers, which may be associated with characteristic findings including background purple mucosae. These lesions are found in areas of chronic gastritis and surrounding mucosa. The aim of this study is to objectively characterize these lesi...

journal_title：Journal of gastroenterology

authors： Fukuda H,Miura Y,Osawa H,Takezawa T,Ino Y,Okada M,Khurelbaatar T,Lefor AK,Yamamoto H

更新日期：2019-05-01 00:00:00

abstract：:Although stomal varices are a rare complication, bleeding stomal varices often need to be treated owing to symptoms of hypovolemic shock, recurrence of stomal bleeding, or deterioration in the quality of life. Various treatment strategies for the management of bleeding stomal varices have thus far been reported. We re...

journal_title：Journal of gastroenterology

authors： Minami S,Okada K,Matsuo M,Kamohara Y,Sakamoto I,Kanematsu T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Liver histology is the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH). Noninvasive, simple, reproducible, and reliable biomarkers are greatly needed to differentiate NASH from nonalcoholic fatty liver disease (NAFLD). METHODS:To construct a scoring system for predicting NASH, 177 Jap...

journal_title：Journal of gastroenterology

authors： Sumida Y,Yoneda M,Hyogo H,Yamaguchi K,Ono M,Fujii H,Eguchi Y,Suzuki Y,Imai S,Kanemasa K,Fujita K,Chayama K,Yasui K,Saibara T,Kawada N,Fujimoto K,Kohgo Y,Okanoue T,Japan Study Group of Nonalcoholic Fatty Liver Disease

更新日期：2011-02-01 00:00:00

abstract：:We report a 54-year-old Japanese woman who developed liver tumors 102 months after hepatic resection for hepatocellular carcinoma (HCC) and percutaneous transluminal angioplasty (PTA) for membranous obstruction of the inferior vena cava (MOVC), which is one form of Budd-Chiari syndrome. In the present admission workup...

journal_title：Journal of gastroenterology

authors： Takamura M,Ichida T,Yokoyama J,Matsuda Y,Nomoto M,Aoyagi Y

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:The risk for lymph node metastasis and the prognostic significance of pedunculated-type T1 colorectal carcinomas (CRCs) require further study. We aimed to assess the validity of the 2014 Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines based on long-term outcomes of pedunculated-type T1...

journal_title：Journal of gastroenterology

authors： Asayama N,Oka S,Tanaka S,Nagata S,Furudoi A,Kuwai T,Onogawa S,Tamura T,Kanao H,Hiraga Y,Okanobu H,Kuwabara T,Kunihiro M,Mukai S,Goto E,Shimamoto F,Chayama K

更新日期：2016-07-01 00:00:00

abstract：:We present a patient with complication of huge hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL) for pancreatic lithotripsy. The hematoma measured 78-110mm. Angiography showed a subcapsular hematoma, rather than a hematoma in the liver. In the arterial phase, the distal end of the small v...

journal_title：Journal of gastroenterology

authors： Hirata N,Kushida Y,Ohguri T,Wakasugi S,Kojima T,Fujita R

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:There have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan. METHODS:We examined the epidemiology of GEP-NETs [pancreatic endocrine tumors (PETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005 using a nationwide stratified random sa...

journal_title：Journal of gastroenterology

authors： Ito T,Sasano H,Tanaka M,Osamura RY,Sasaki I,Kimura W,Takano K,Obara T,Ishibashi M,Nakao K,Doi R,Shimatsu A,Nishida T,Komoto I,Hirata Y,Nakamura K,Igarashi H,Jensen RT,Wiedenmann B,Imamura M

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japan...

journal_title：Journal of gastroenterology

authors： Fuyuno Y,Yamazaki K,Takahashi A,Esaki M,Kawaguchi T,Takazoe M,Matsumoto T,Matsui T,Tanaka H,Motoya S,Suzuki Y,Kiyohara Y,Kitazono T,Kubo M

更新日期：2016-07-01 00:00:00

abstract：:The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for the test. The test ...

journal_title：Journal of gastroenterology

authors： Wang WM,Lee SC,Ding HJ,Jan CM,Chen LT,Wu DC,Liu CS,Peng CF,Chen YW,Huang YF,Chen CY

更新日期：1998-06-01 00:00:00

abstract：:To investigate autonomic nervous function during upper gastrointestinal endoscopy, we analyzed R-R interval variability from electrocardiograms obtained during endoscopy. Holter electrocardiogram recordings were made before and after premedication, and during endoscopy. Time- and frequency-domain analyses of heart rat...

journal_title：Journal of gastroenterology

authors： Hayashi T,Nomura M,Honda H,Tezuka K,Torisu R,Takeuchi Y,Nakaya Y,Ito S

更新日期：2000-01-01 00:00:00

abstract：:We reviewed reports on the efficacy of clarithromycin in eradicating Helicobacter pylori. Reports on dual and 1-week triple therapy that included clarithromycin were analyzed to assess the eradication rates of H. pylori infection. Dual therapy with clarithromycin and a proton pump inhibitor achieved eradication rates ...

journal_title：Journal of gastroenterology

authors： Satoh K,Kimura K,Takimoto T,Kihira K,Taniguchi Y,Saifuku K

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Depth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. However, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the ...

journal_title：Journal of gastroenterology

authors： Kitajima K,Fujimori T,Fujii S,Takeda J,Ohkura Y,Kawamata H,Kumamoto T,Ishiguro S,Kato Y,Shimoda T,Iwashita A,Ajioka Y,Watanabe H,Watanabe T,Muto T,Nagasako K

更新日期：2004-06-01 00:00:00

abstract：:The chemotactic activity of Helicobacter pylori is important for its colonization. H. pylori exhibited chemotactic responses to urea and potassium bicarbonate, which can be supplied from human gastric epithelium. The chemotactic activities of H. pylori in a fluid environment were higher on the urease-positive strain t...

journal_title：Journal of gastroenterology

authors： Yoshiyama H,Nakamura H,Kimoto M,Okita K,Nakazawa T

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Adiponectin has been shown to have suppressive effects on tumor development, but the expression of adiponectin receptors in tumor tissue has not been fully elucidated. The purpose of this study was to quantitatively evaluate the expression of two adiponectin receptors, AdipoR1 and AdipoR2, in gastric cancer ...

journal_title：Journal of gastroenterology

authors： Otani K,Kitayama J,Kamei T,Soma D,Miyato H,Yamauchi T,Kadowaki T,Nagawa H

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:To provide updated clinico-epidemiological information on chronic pancreatitis (CP) in Japan. METHODS:We conducted a two-stage nationwide epidemiological survey; the number of CP patients was estimated in the first-stage survey, and their clinical features were examined in the second-stage survey. We survey...

journal_title：Journal of gastroenterology

authors： Masamune A,Kikuta K,Kume K,Hamada S,Tsuji I,Takeyama Y,Shimosegawa T,Okazaki K,Japan Pancreas Society.

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Vaniprevir is a potent macrocyclic hepatitis C virus (HCV) nonstructural protein 3/4A protease inhibitor. This phase III study evaluated the safety and efficacy of vaniprevir in combination with peginterferon alfa-2b and ribavirin (PR) for 24 weeks compared with PR alone for 48 weeks in treatment-naive Japan...

journal_title：Journal of gastroenterology

authors： Hayashi N,Nakamuta M,Takehara T,Kumada H,Takase A,Howe AY,Ludmerer SW,Mobashery N

更新日期：2016-04-01 00:00:00