Acetylcholine regulates glucagon secretion from human glucagonoma cells.

abstract：:Strain differences in the susceptibility of rats to induction of intestinal metaplasia by X-irradiation were examined. The gastric regions of 5-week-old males of five inbred strains of rats (F344/NSlc, Copenhagen, Buffalo/NacJcl, and ACI/NHos) and three strains of randomly bred rats (HOS:Donryu, Slc:Wistar, Slc:SD) we...

journal_title：Journal of gastroenterology

authors： Watanabe H,Fujimoto N,Masaoka Y,Ohtaki M,Ito A

更新日期：1997-06-01 00:00:00

abstract：:Class II antigens are strongly expressed on the inflamed colonic epithelium in inflammatory bowel disease. However, the mechanism of this epithelial class II antigen induction is not fully understood. Increased activities of interferon (IFN)gamma, tumor necrosis factor (TNF)alpha, and interleukin (IL)2 have been shown...

journal_title：Journal of gastroenterology

authors： Horie Y,Chiba M,Suzuki T,Kudo T,Kamata A,Iizuka M,Masamune O

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in tumor invasion and metastasis, being inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs). In this study, we examined the expression of MMP-2, MMP-9, membrane-type 1 (MT1)-MMP, TIMP-1,...

journal_title：Journal of gastroenterology

authors： Shim KN,Jung SA,Joo YH,Yoo K

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Studies on the risk of osteoporotic fractures related to the use of proton pump inhibitors (PPIs) have been inconsistent. One recent cohort study reported that there was an interaction between PPIs and bisphosphonates (BPs). Thus we performed a case-control study aimed at evaluating the risk of hip fractures...

journal_title：Journal of gastroenterology

authors： Lee J,Youn K,Choi NK,Lee JH,Kang D,Song HJ,Park BJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Long-term nucleos(t)ide analogue (NA) therapy for chronic hepatitis B (CHB) patients has been reported to reduce the risk of hepatocellular carcinoma (HCC) development. However, survival rates and causes of death in CHB patients either treated or not treated with NA therapy are unclear. Therefore, we investi...

journal_title：Journal of gastroenterology

authors： Tada T,Kumada T,Toyoda H,Kiriyama S,Tanikawa M,Hisanaga Y,Kanamori A,Kitabtake S,Ito T

更新日期：2015-07-01 00:00:00

abstract：:Three-dimensional-computed tomography (3D-CT) cholangiography is a 3D shaded surface display image of the biliary tract obtained by using helical CT after intravenous cholangiography or cholangiography per percutaneous transhepatic cholangio-drainage tube. We investigated whether 3D-CT cholangiography could provide a ...

journal_title：Journal of gastroenterology

authors： Kinami S,Yao T,Kurachi M,Ishizaki Y

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:Recently, guidelines for the treatment and prevention of ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs) were established. This study investigated the association between the current adherence to the guidelines and the incidence of gastric mucosal lesions caused by NSAIDs. METHODS:This study...

journal_title：Journal of gastroenterology

authors： Tsumura H,Fujita T,Tamura I,Morita Y,Yoshida M,Toyonaga T,Mukai H,Inokuchi H,Kutsumi H,Azuma T

更新日期：2010-09-01 00:00:00

abstract：:Pyogenic granulomas represent the aquisition of vasodilative granulation tissue in the skin or mucosa. They are extremely rare in the alimentary tract, other than in the oral cavity. Here, we report a case of pyogenic granuloma arising from the gastric mucosa. An 82-year-old man was admitted to our hospital because of...

journal_title：Journal of gastroenterology

authors： Kusakabe A,Kato H,Hayashi K,Igami T,Hasegawa H,Tsuzuki T,Ueda R,Mizokami M

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:The abnormal expression of several genes is involved in the development of colorectal tumors. The aim of this study was to examine the expression of KAI1, CAR, and Smad4, which has been associated with the progression of other cancers. METHODS:We examined 12 adenomas, 38 primary carcinomas, 10 liver metastases...

journal_title：Journal of gastroenterology

authors： Mikami T,Ookawa K,Shimoyama T,Fukuda S,Saito H,Munakata A

更新日期：2001-07-01 00:00:00

abstract：:We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonograp...

journal_title：Journal of gastroenterology

authors： Murakami T,Imai A,Nakamura H,Tsuda K,Kanai T,Wakasa K

更新日期：1996-06-01 00:00:00

abstract：:Epidemiological studies of ulcerative colitis (UC) have been conducted once every year since 1973 in Japan. The number of participating hospitals in 1429 and they are distributed throughout Japan. A total number of 10819 patients diagnosed with UC have been registered, including 197 patients with a positive family his...

journal_title：Journal of gastroenterology

authors： Kitahora T,Utsunomiya T,Yokota A

更新日期：1995-11-01 00:00:00

abstract：:This study was conducted to determine and compare serum trace metal levels in viral hepatitis-associated chronic liver disease. Of 98 patients aged 43 (+/- 13) [mean (+/- SD)] years, 83 (85%) were seropositive for hepatitis B surface antigen (HBsAg) and 15 (15%) were seropositive for anti-hepatitis C virus (HCV). Twen...

journal_title：Journal of gastroenterology

authors： Pramoolsinsap C,Promvanit N,Komindr S,Lerdverasirikul P,Srianujata S

更新日期：1994-10-01 00:00:00

abstract：:We report a rare case of massive and recurrent bleeding from ileal varices in a patient with hepatitis C virus-positive liver cirrhosis. A 66-year old woman, who had undergone laparotomy and blood transfusion 36 years before (because of an extrauterine pregnancy) and endoscopic sclerotherapy for esophageal varices 1 y...

journal_title：Journal of gastroenterology

authors： Ohtani T,Kajiwara E,Suzuki N,Kawasaki A,Sadoshima S,Sakata H,Sasaguri Y,Onoyama K

更新日期：1999-04-01 00:00:00

abstract：:A case of life-threatening lower gastrointestinal hemorrhage from Crohn's disease is reported. Several promising studies have recently been published that describe superselective embolization for the treatment of massive lower gastrointestinal hemorrhage in patients with bleeding colonic diverticular disease and angio...

journal_title：Journal of gastroenterology

authors： Kazama Y,Watanabe T,Akahane M,Yoshioka N,Ohtomo K,Nagawa H

更新日期：2005-12-01 00:00:00

abstract：:The localization and distribution of gamma delta T cell receptor (TCR)-positive cells (gamma delta T cells) in hepatocellular carcinoma capsules was investigated immunohistochemically at both light and electron microscopic levels. Most of the mononuclear cells infiltrating the tumor capsules were CD3-positive. Togethe...

journal_title：Journal of gastroenterology

authors： Chin K,Morise K,Kanayama K,Nagura H

更新日期：1995-06-01 00:00:00

abstract：:Fulminant hepatic failure (FHF) usually has a fatal prognosis without liver transplantation. We describe the case of a woman who developed FHF, and was evaluated as a candidate for liver transplantation, but who was cured without transplantation through intensive medical care that included glucagon-insulin therapy, me...

journal_title：Journal of gastroenterology

authors： Masuhara M,Yagawa T,Aoyagi M,Suzuki C,Sakaguchi E,Segawa M,Hironaka K,Kayano K,Tamura F,Seguchi M,Soejima Y,Murakami F,Sakaida I,Tateishi A,Fukumoto Y,Okita K

更新日期：2001-05-01 00:00:00

abstract：:In vivo progression to malignancy is characterized by the switch to an angiogenic phenotype. The angiogenic switch is a critical control point for tumor expansion. The ability of a tumor to become neovascularized permits rapid expansion of tumor growth and increases the likelihood of metastases. The genetic alteration...

journal_title：Journal of gastroenterology

authors： Tanaka S,Sugimachi K,Yamashita Y,Shirabe K,Shimada M,Wands JR,Sugimachi K

更新日期：2003-03-01 00:00:00

abstract：:We report a case of living-related partial liver transplantation for decompensated hepatitis B without reactivation of hepatitis B in the following 30 months, and we analyze the factors that indicate a favorable prognosis for transplantation. The 42-year-old female patient received continuously administered lamivudine...

journal_title：Journal of gastroenterology

authors： Hasegawa K,Hashimoto E,Kanai N,Ogawa M,Naritomi T,Taniai M,Takasaki K,Hayashi N

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The ideal medication for the treatment of acid-related diseases, for example, hemorrhagic ulcers and stress-related gastric bleeding, should have a rapid onset of action to promote hemostasis and alleviate symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion afte...

journal_title：Journal of gastroenterology

authors： Abe Y,Inamori M,Togawa J,Kikuchi T,Muramatsu K,Chiguchi G,Kawamura H,Kobayashi N,Kirikoshi H,Sakaguchi T,Takamura T,Nakajima A,Ueno N,Sekihara H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Vedolizumab is a gut-selective humanized antibody that binds the α4β7 integrin. We evaluated efficacy and safety of vedolizumab in Japanese patients with moderate-to-severe Crohn's disease (CD). METHODS:In this Phase 3, double-blind study (NCT02038920), 157 patients were randomized to receive intravenous ve...

journal_title：Journal of gastroenterology

authors： Watanabe K,Motoya S,Ogata H,Kanai T,Matsui T,Suzuki Y,Shikamura M,Sugiura K,Oda K,Hori T,Araki T,Watanabe M,Hibi T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The virologic impact of adding interferon to antiviral nucleoside therapy was studied in Japanese patients having perinatally transmitted hepatitis B virus (HBV) genotype C. METHODS:Sixty-four patients including 41 positive for hepatitis B e antigen (HBeAg) were assigned to receive either (1) a combination ...

journal_title：Journal of gastroenterology

authors： Yuki N,Nagaoka T,Nukui K,Omura M,Hikiji K,Kato M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Few studies have investigated the association between smoking and ultrasonographically diagnosed gallbladder (GB) disease, and their results were uncertain. This study was conducted to examine the association between smoking and drinking and GB diseases. METHODS:A total of 9,947 subjects (age, 30-69 years; ...

journal_title：Journal of gastroenterology

authors： Okamoto M,Yamagata Z,Takeda Y,Yoda Y,Kobayashi K,Fujino MA

更新日期：2002-01-01 00:00:00

abstract：:A retrospective long-term endoscopic follow-up study was designed to examine atrophic changes in the gastric mucosa over time in Helicobacter pylori-positive patients. Over a period of 8-17 years (mean, 13.4 years) 22 subjects (5 men, 17 women, mean age, 55 years) without localized gastroduodenal lesions underwent ser...

journal_title：Journal of gastroenterology

authors： Sakaki N,Arakawa T,Katou H,Momma K,Egawa N,Kamisawa T,Yamada Y,Tu Y,Ishikawa C,Ishiwata J

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Peristaltic reflex does not fully explain the polarity of peristalsis. In the distal colon, we propose that the balance of circular muscle contraction proximal and distal to the pellet is a local reflex that predicts polarity of peristalsis. METHODS:Guinea pig distal colon segments were harvested, and fecal...

journal_title：Journal of gastroenterology

authors： Gribovskaja-Rupp I,Kwak JM,Takahashi T,Ludwig K

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Contrast-enhanced echocardiography (CEE) using agitated saline can detect intrapulmonary vasodilatation (IPVD) in patients with hepatopulmonary syndrome (HPS). We estimated the pulmonary transit time of erythrocytes (PTT) by CEE, using microbubbles, and studied its relationship to arterial oxygenation in chr...

journal_title：Journal of gastroenterology

authors： Katsuta Y,Honma H,Zhang XJ,Ohsuga M,Komeichi H,Shimizu S,Katoh Y,Miura H,Satomura K,Aramaki T,Takano T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Recently, a significant relationship between gastric cancer and Helicobacter pylori infection has been proven. The purpose of this study was to elucidate the actual conditions of H. pylori infection in Japanese teenagers. METHODS:The study subjects were students at a certain high school between 2007 and 200...

journal_title：Journal of gastroenterology

authors： Akamatsu T,Ichikawa S,Okudaira S,Yokosawa S,Iwaya Y,Suga T,Ota H,Tanaka E

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:In elderly patients with superficial esophageal squamous cell carcinoma (ESCC), the optimal treatment strategy after non-curative endoscopic submucosal dissection (ESD) remains unclear. We aimed to evaluate the validity of additional treatments after non-curative ESD and post-ESD survival predictors in elder...

journal_title：Journal of gastroenterology

authors： Nakajo K,Abe S,Oda I,Ishihara R,Tanaka M,Yoshio T,Katada C,Yano T

更新日期：2019-10-01 00:00:00

abstract：:A 59-year-old woman presented with consciousness disturbance with flapping tremor. Laboratory examinations revealed normal liver functions, and imaging studies, ultrasonography, magnetic resonance imaging, and angiography, showed portal vein aneurysm communicating from the portal vein to the hepatic vein, splenomegaly...

journal_title：Journal of gastroenterology

authors： Hanatate F,Matsuoka H,Mizuno Y,Kitamura T

更新日期：1995-12-01 00:00:00

abstract：:Small bowel transit time (SBTT) in 15 young and 13 elderly women was assessed by measuring breath hydrogen concentrations after they had consumed a solid test meal. The meal consisted of 200 g cooked rice, 50 ml miso (made from fermented soy bean curd) soup, a boiled egg, and 95.5 g of cooked soy beans with mixed vege...

journal_title：Journal of gastroenterology

authors： Kagaya M,Iwata N,Toda Y,Nakae Y,Kondo T

更新日期：1997-08-01 00:00:00

abstract：:To investigate autonomic nervous function during upper gastrointestinal endoscopy, we analyzed R-R interval variability from electrocardiograms obtained during endoscopy. Holter electrocardiogram recordings were made before and after premedication, and during endoscopy. Time- and frequency-domain analyses of heart rat...

journal_title：Journal of gastroenterology

authors： Hayashi T,Nomura M,Honda H,Tezuka K,Torisu R,Takeuchi Y,Nakaya Y,Ito S

更新日期：2000-01-01 00:00:00