Epidemiological study of ulcerative colitis in Japan: incidence and familial occurrence. The Epidemiology Group of the Research Committee of Inflammatory Bowel Disease in Japan.

abstract：BACKGROUND:This study aimed to develop a model to predict the development of severe anemia during pegylated interferon alpha-2b plus ribavirin combination therapy. METHODS:Data were collected from 1081 genotype 1b chronic hepatitis C patients who were treated at 6 hospitals in Japan. These patients were randomly assig...

journal_title：Journal of gastroenterology

authors： Hiramatsu N,Kurosaki M,Sakamoto N,Iwasaki M,Sakamoto M,Suzuki Y,Sugauchi F,Tamori A,Kakinnuma S,Matsuura K,Izumi N

更新日期：2011-09-01 00:00:00

abstract：:A case of life-threatening lower gastrointestinal hemorrhage from Crohn's disease is reported. Several promising studies have recently been published that describe superselective embolization for the treatment of massive lower gastrointestinal hemorrhage in patients with bleeding colonic diverticular disease and angio...

journal_title：Journal of gastroenterology

authors： Kazama Y,Watanabe T,Akahane M,Yoshioka N,Ohtomo K,Nagawa H

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Only a few studies have longitudinally evaluated whether fatty pancreas increases the risk of type-2 diabetes (T2D), and their results were inconsistent. Fatty pancreas is closely linked to overweight and obesity, but previous studies did not exclude overweight or obese individuals. Therefore, in this cohort...

journal_title：Journal of gastroenterology

authors： Yamazaki H,Tauchi S,Wang J,Dohke M,Hanawa N,Kodama Y,Katanuma A,Saisho Y,Kamitani T,Fukuhara S,Yamamoto Y

更新日期：2020-07-01 00:00:00

abstract：:We reviewed reports on the efficacy of clarithromycin in eradicating Helicobacter pylori. Reports on dual and 1-week triple therapy that included clarithromycin were analyzed to assess the eradication rates of H. pylori infection. Dual therapy with clarithromycin and a proton pump inhibitor achieved eradication rates ...

journal_title：Journal of gastroenterology

authors： Satoh K,Kimura K,Takimoto T,Kihira K,Taniguchi Y,Saifuku K

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:At present, squamous cell carcinoma accounts for most esophageal cancers in Japan; however, there is concern that the incidence of esophageal adenocarcinoma in Japan is increasing in comparison to Western countries. Akita Prefecture, with a population of 1 million, has the highest rate of esophageal cancer-a...

journal_title：Journal of gastroenterology

authors： Koizumi S,Motoyama S,Iijima K

更新日期：2018-07-01 00:00:00

abstract：:Although polycystic liver disease (PLD) is known to be associated with autosomal dominant polycystic kidney disease, a finding of PLD with pancreatic ductal adenocarcinoma is extremely rare. We have experienced one such case of a ductal adenocarcinoma of the pancreas in a patient with Potter type III cystic disease of...

journal_title：Journal of gastroenterology

authors： Sakurai Y,Shoji M,Matsubara T,Ochiai M,Funabiki T,Urano M,Mizoguchi Y,Fuwa N

更新日期：2001-06-01 00:00:00

abstract：:An extremely rare case of malignant schwannoma of the esophagus with lymph node metastasis is reported. A 49-year-old woman was found to have an abnormal shadow on a chest X-ray film taken during an annual checkup. Upper gastrointestinal series showed extrinsic pressure on the middle thoracic esophagus, without a muco...

journal_title：Journal of gastroenterology

authors： Murase K,Hino A,Ozeki Y,Karagiri Y,Onitsuka A,Sugie S

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japan...

journal_title：Journal of gastroenterology

authors： Fuyuno Y,Yamazaki K,Takahashi A,Esaki M,Kawaguchi T,Takazoe M,Matsumoto T,Matsui T,Tanaka H,Motoya S,Suzuki Y,Kiyohara Y,Kitazono T,Kubo M

更新日期：2016-07-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) could be curable by "immune rest" and correction of the genetic predisposition inherent in allogeneic hematopoietic stem cell transplantation. However, balancing risks against benefits remains challenging. The application of mesenchymal stem cells (MSCs) serving as a site-regulated "dr...

journal_title：Journal of gastroenterology

authors： Nagaishi K,Arimura Y,Fujimiya M

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:We investigated the effects of rabeprazole compared with those of omeprazole on enterochromaffin-like cells and parietal cells in rats. METHODS:Rabeprazole or omeprazole was administered for 7 days by intraperitoneal injection (100 mg/kg or 20mg/kg once a day) and the serum gastrin concentration, the antral...

journal_title：Journal of gastroenterology

authors： Tari A,Kawano M,Kodama K,Yonei Y,Okahara S,Haruma K,Sumii K,Kajiyama G

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Few studies have investigated the association between smoking and ultrasonographically diagnosed gallbladder (GB) disease, and their results were uncertain. This study was conducted to examine the association between smoking and drinking and GB diseases. METHODS:A total of 9,947 subjects (age, 30-69 years; ...

journal_title：Journal of gastroenterology

authors： Okamoto M,Yamagata Z,Takeda Y,Yoda Y,Kobayashi K,Fujino MA

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Recently, guidelines for the treatment and prevention of ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs) were established. This study investigated the association between the current adherence to the guidelines and the incidence of gastric mucosal lesions caused by NSAIDs. METHODS:This study...

journal_title：Journal of gastroenterology

authors： Tsumura H,Fujita T,Tamura I,Morita Y,Yoshida M,Toyonaga T,Mukai H,Inokuchi H,Kutsumi H,Azuma T

更新日期：2010-09-01 00:00:00

abstract：:We report a 27-year-old male with Crohn's disease (CD) of the small and large intestine, whose peripheral blood lymphocytes (PBL) showed increased cell-mediated cytotoxicity (CTL). Autologous and allogeneic effector cells from PBL and intestinal lymph nodes (LN) were isolated on a Ficoll-Hypaque gradient. Colonic cell...

journal_title：Journal of gastroenterology

authors： Okazaki K,Yokoyama Y,Yamamoto Y,Kobayashi M,Araki K,Ogata T

更新日期：1994-08-01 00:00:00

abstract：:We treated a patient with a mechanical ileus resulting from encasement of a loop of the small intestine by the great omentum, caused by abnormal adhesion. Apart from its occurrence postoperatively with laparotomy, strangulation of small intestine into the omentum is very rare, and its occurrence without underlying dis...

journal_title：Journal of gastroenterology

authors： Kimura H,Earashi M,Konishi K,Tsuneda A,Tazawa K,Inoue T,Maeda K,Yabushita K,Kuroda Y,Tsuji M,Miwa A

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Catechin, a polyphenol contained in tea (a cup of tea contains approximately 0.1% [w/v] catechin), has various physiological effects. The aim of this study was to investigate the mechanism of the inhibitory effect of catechin on gastric mucosal lesions. METHODS:We studied the effect of catechin on gastric m...

journal_title：Journal of gastroenterology

authors： Sato H,Matsui T,Arakawa Y

更新日期：2002-01-01 00:00:00

abstract：:We investigated the effect of intravenous infusions of the therapeutically available amino acid solutions Moripron and Morihepamin (Roussel Morishita, Osaka, Japan) on gallbladder contraction and cholecystokinin (CCK) release in healthy male volunteers. Plasma CCK levels were measured by radioimmunoassay, using the an...

journal_title：Journal of gastroenterology

authors： Shirohara H,Tabaru A,Otsuki M

更新日期：1996-08-01 00:00:00

abstract：:Fulminant hepatic failure (FHF) usually has a fatal prognosis without liver transplantation. We describe the case of a woman who developed FHF, and was evaluated as a candidate for liver transplantation, but who was cured without transplantation through intensive medical care that included glucagon-insulin therapy, me...

journal_title：Journal of gastroenterology

authors： Masuhara M,Yagawa T,Aoyagi M,Suzuki C,Sakaguchi E,Segawa M,Hironaka K,Kayano K,Tamura F,Seguchi M,Soejima Y,Murakami F,Sakaida I,Tateishi A,Fukumoto Y,Okita K

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:In Japan, generally, patients with chronic hepatitis C are aged. The aim of this study was to investigate the effect of interferon (IFN) therapy on the mortality of chronic hepatitis C patients over age 60. METHODS:Seven-hundred and seven patients with histologically proven chronic hepatitis C were enrolled...

journal_title：Journal of gastroenterology

authors： Imai Y,Kasahara A,Tanaka H,Okanoue T,Hiramatsu N,Tsubouchi H,Yoshioka K,Kawata S,Tanaka E,Hino K,Hayashi K,Tamura S,Itoh Y,Sasaki Y,Kiyosawa K,Kakumu S,Okita K,Hayashi N

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Anemia of inflammation, commonly observed in patients with chronic diseases, is associated with decreased serum iron. Hepcidin, mainly produced by hepatocytes in a STAT3- and/or SMAD-dependent manner, is involved in iron homeostasis. What remains to be established is whether or not the hepatic IL-6/STAT3 sig...

journal_title：Journal of gastroenterology

authors： Sakamori R,Takehara T,Tatsumi T,Shigekawa M,Hikita H,Hiramatsu N,Kanto T,Hayashi N

更新日期：2010-02-01 00:00:00

abstract：:A retrospective long-term endoscopic follow-up study was designed to examine atrophic changes in the gastric mucosa over time in Helicobacter pylori-positive patients. Over a period of 8-17 years (mean, 13.4 years) 22 subjects (5 men, 17 women, mean age, 55 years) without localized gastroduodenal lesions underwent ser...

journal_title：Journal of gastroenterology

authors： Sakaki N,Arakawa T,Katou H,Momma K,Egawa N,Kamisawa T,Yamada Y,Tu Y,Ishikawa C,Ishiwata J

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Additional surgical treatment after non-curative endoscopic resection for superficial esophageal cancer should be considered unless the tumor is pathologically proven to be categorized within the absolute indication of endoscopic resection. However, the significance of this treatment strategy has been poorly...

journal_title：Journal of gastroenterology

authors： Saeki H,Watanabe M,Mine S,Shigaki H,Oya S,Ishiyama A,Tsuchida T,Fujisaki J,Baba H,Maehara Y,Sano T

更新日期：2015-04-01 00:00:00

abstract：:There have been numerous reports that mucinous cystadenoma of the pancreas can transform to mucinous cystadenocarcinoma after cystenterostomy, but few authors have reported morphological changes long after cystenterostomy for mucinous cystadenoma. A 41-year-old Japanese woman had undergone cystgastrostomy at a nearby ...

journal_title：Journal of gastroenterology

authors： Masatsugu T,Yamaguchi K,Arima T,Chijiiwa K,Tanaka M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Once-daily, orally administered, co-formulated glecaprevir (NS3/4A protease inhibitor) and pibrentasvir (NS5A inhibitor) (G/P) demonstrated pangenotypic activity and high sustained virologic response (SVR) rates in studies outside Japan. Here we report safety and efficacy in a subset of Japanese patients wit...

journal_title：Journal of gastroenterology

authors： Kumada H,Watanabe T,Suzuki F,Ikeda K,Sato K,Toyoda H,Atsukawa M,Ido A,Takaki A,Enomoto N,Kato K,Alves K,Burroughs M,Redman R,Pugatch D,Pilot-Matias TJ,Krishnan P,Oberoi RK,Xie W,Chayama K

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Patients with primary biliary cirrhosis (PBC) exhibit a variety of clinical manifestations and patterns of disease progression. The aim of this study was to identify genetic determinants of PBC progression. METHODS:A total of 52 tag single nucleotide polymorphisms (SNPs) of 11 candidate genes involved in re...

journal_title：Journal of gastroenterology

authors： Inamine T,Higa S,Noguchi F,Kondo S,Omagari K,Yatsuhashi H,Tsukamoto K,Nakamura M

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in tumor invasion and metastasis, being inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs). In this study, we examined the expression of MMP-2, MMP-9, membrane-type 1 (MT1)-MMP, TIMP-1,...

journal_title：Journal of gastroenterology

authors： Shim KN,Jung SA,Joo YH,Yoo K

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Primary biliary cirrhosis (PBC) is histopathologically characterized by chronic nonsuppurative destructive cholangitis and ductopenia of interlobular bile ducts. Bile duct injury is also often encountered in chronic viral hepatitis (CVH) and in autoimmune hepatitis (AIH). METHODS:In this study, we performed...

journal_title：Journal of gastroenterology

authors： Zen Y,Harada K,Sasaki M,Tsuneyama K,Matsui K,Haratake J,Sakisaka S,Maeyama S,Yamamoto K,Nakano M,Shimamatsu K,Kage M,Kurose N,Uchiyama A,Kaizaki Y,Toda G,Nakanuma Y

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) has been shown to affect the progression of various inflammatory disorders, including pancreatitis. To investigate the role of MCP-1 in acute pancreatitis and to seek possible therapeutic means, we evaluated the effect of a plasmid expression vector containing a dom...

journal_title：Journal of gastroenterology

authors： Ishibashi T,Zhao H,Kawabe K,Oono T,Egashira K,Suzuki K,Nawata H,Takayanagi R,Ito T

更新日期：2008-01-01 00:00:00

abstract：:The present study was carried out to examine the effects of submucosal administration of endothelin on gastric mucosal integrity in rats. Injection of endothelin-3 into the submucosal space of the stomach induced gastric mucosal damage dose-dependently and site-specifically. The gastric injury was localized only at th...

journal_title：Journal of gastroenterology

authors： Watanabe Y,Okumura T,Harada K,Kohgo Y

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:An optimal surveillance program is important to prevent advanced colorectal neoplasm. In this context, we have evaluated the cumulative risk of high-risk adenoma (HRA) or colorectal cancer (CRC) according to surveillance interval time after polypectomy. In addition, we assessed risk factors for late surveill...

journal_title：Journal of gastroenterology

authors： Tae CH,Moon CM,Kim SE,Jung SA,Eun CS,Park JJ,Seo GS,Cha JM,Park SC,Chun J,Lee HJ,Jung Y,Kim JO,Joo YE,Park DI

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:This study examined the association of cholelithiasis post-cholecystectomy with subsequent cancers and evaluated the risk of cancer in patients with both cholelithiasis and cholecystectomy. METHODS:The Taiwanese National Health Insurance Research Database was used to identify 15545 newly diagnosed cholelith...

journal_title：Journal of gastroenterology

authors： Chen YK,Yeh JH,Lin CL,Peng CL,Sung FC,Hwang IM,Kao CH

更新日期：2014-05-01 00:00:00