Association of genes involved in bile acid synthesis with the progression of primary biliary cirrhosis in Japanese patients.

abstract：:Small bowel transit time (SBTT) in 15 young and 13 elderly women was assessed by measuring breath hydrogen concentrations after they had consumed a solid test meal. The meal consisted of 200 g cooked rice, 50 ml miso (made from fermented soy bean curd) soup, a boiled egg, and 95.5 g of cooked soy beans with mixed vege...

journal_title：Journal of gastroenterology

authors： Kagaya M,Iwata N,Toda Y,Nakae Y,Kondo T

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) has been shown to affect the progression of various inflammatory disorders, including pancreatitis. To investigate the role of MCP-1 in acute pancreatitis and to seek possible therapeutic means, we evaluated the effect of a plasmid expression vector containing a dom...

journal_title：Journal of gastroenterology

authors： Ishibashi T,Zhao H,Kawabe K,Oono T,Egashira K,Suzuki K,Nawata H,Takayanagi R,Ito T

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japan...

journal_title：Journal of gastroenterology

authors： Fuyuno Y,Yamazaki K,Takahashi A,Esaki M,Kawaguchi T,Takazoe M,Matsumoto T,Matsui T,Tanaka H,Motoya S,Suzuki Y,Kiyohara Y,Kitazono T,Kubo M

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Endotoxin modulates esophageal motor function by increasing nitric oxide (NO) production. The aims of this study were to examine inducible nitric oxide synthase (iNOS) induction in the lower esophageal sphincter (LES) of endotoxemic opossums and to investigate the effects of aminoguanidine (AG), a selective ...

journal_title：Journal of gastroenterology

authors： Park H,Clark E,Cullen JJ,Koland JG,Kim MS,Conklin JL

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:There have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan. METHODS:We examined the epidemiology of GEP-NETs [pancreatic endocrine tumors (PETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005 using a nationwide stratified random sa...

journal_title：Journal of gastroenterology

authors： Ito T,Sasano H,Tanaka M,Osamura RY,Sasaki I,Kimura W,Takano K,Obara T,Ishibashi M,Nakao K,Doi R,Shimatsu A,Nishida T,Komoto I,Hirata Y,Nakamura K,Igarashi H,Jensen RT,Wiedenmann B,Imamura M

更新日期：2010-02-01 00:00:00

abstract：:We report a 74-year-old man with triple synchronous cancers occurring in the gallbladder, common bile duct, and pancreas. The patient had consulted a nearby physician because of epigastralgia and icterus. On September 30, 1997, the patient was admitted to our department for further evaluation and treatment. Abdominal ...

journal_title：Journal of gastroenterology

authors： Sato K,Maekawa T,Yabuki K,Tamasaki Y,Maekawa H,Kudo K,Sengoku H,Kawa I,Wada R,Matsumoto M

更新日期：2003-01-01 00:00:00

abstract：:We describe a gastric carcinoma cell line that has been maintained in vitro for more than 10 years and retains the capacity to produce a large amount of alpha-fetoprotein. This cell line was isolated from a metastatic lymph node of a 63-year-old male patient with advanced gastric carcinoma (T2N3P0H0M0) who showed high...

journal_title：Journal of gastroenterology

authors： Sekiguchi M,Fujii Y,Saito A,Suzuki T,Shiroko Y,Nakamura H,Hasumi K

更新日期：1995-10-01 00:00:00

abstract：:Diagnosis of chronic pancreatitis in its early stage is an extremely difficult task. If the genetic predispositions are identified, it may help make possible the earlier diagnosis of chronic pancreatitis or the detection of patients at risk. There are two major hypotheses about the pathogenesis of chronic pancreatitis...

journal_title：Journal of gastroenterology

authors： Naruse S,Fujiki K,Ishiguro H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Catechin, a polyphenol contained in tea (a cup of tea contains approximately 0.1% [w/v] catechin), has various physiological effects. The aim of this study was to investigate the mechanism of the inhibitory effect of catechin on gastric mucosal lesions. METHODS:We studied the effect of catechin on gastric m...

journal_title：Journal of gastroenterology

authors： Sato H,Matsui T,Arakawa Y

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:In Japan, there are few studies of long-term (more than 1 month) interferon (IFN) therapy for chronic hepatitis B (CHB). In this retrospective study, we investigated the efficacy and predictors of response to 6-month IFN therapy. METHODS:We analyzed 66 Japanese patients with CHB who were treated with IFN fo...

journal_title：Journal of gastroenterology

authors： Suzuki F,Arase Y,Akuta N,Tsubota A,Suzuki Y,Sezaki H,Hosaka T,Someya T,Kobayashi M,Saitoh S,Ikeda K,Kobayashi M,Matsuda M,Satoh J,Kumada H

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Nocturnal administration of branched-chain amino acid (BCAA) granules improves serum albumin levels in patients with cirrhosis. However, it is unclear whether or not this administration method can improve the patients' quality of life (QOL). In this study, we aimed to investigate the efficacy of BCAA granule...

journal_title：Journal of gastroenterology

authors： Hidaka H,Nakazawa T,Kutsukake S,Yamazaki Y,Aoki I,Nakano S,Asaba N,Minamino T,Takada J,Tanaka Y,Okuwaki Y,Watanabe M,Shibuya A,Koizumi W

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Abrogating tolerance is a critical step in the pathogenesis of Crohn's disease (CD). T cell-anergy is one of the main mechanisms of tolerance and is regulated by the gene related to anergy in lymphocytes (GRAIL). This study investigated the expressions and regulation of GRAIL in CD and murine colitis models....

journal_title：Journal of gastroenterology

authors： Mukai A,Iijima H,Hiyama S,Fujii H,Shinzaki S,Inoue T,Shiraishi E,Kawai S,Araki M,Hayashi Y,Kondo J,Mizushima T,Kanto T,Egawa S,Nishida T,Tsujii M,Takehara T

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Gene therapy is a promising therapeutic method but is severely hampered due to its lack of an ideal delivery system. Therefore, in this study, a nonviral and magnetic resonance imaging (MRI) visible vector, polyethylene glycol-grafted polyethylenimine and superparamagnetic iron oxide nanoparticles (PEG-g-PEI...

journal_title：Journal of gastroenterology

authors： Chen Y,Lian G,Liao C,Wang W,Zeng L,Qian C,Huang K,Shuai X

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Ghrelin, an appetite-promoting peptide secreted from the stomach, is reported to enhance preprandial acid output, possibly through stimulation of the cephalic phase. The present study was designed to clarify the dynamics of ghrelin in H(2) receptor (H(2)R)-null mice by genetic H(2)R knockout. METHODS:Fiftee...

journal_title：Journal of gastroenterology

authors： Arakawa M,Suzuki H,Minegishi Y,Fukushima Y,Masaoka T,Ishikawa T,Hosoda H,Kangawa K,Hibi T

更新日期：2007-09-01 00:00:00

abstract：:A case of granular cell tumor occurring in the sigmoid colon is reported. The patient, a 56-year-old man, visited our hospital for further evaluation of occult blood in his stool. Endoscopic examination revealed a yellowish, hemispheric submucosal tumor (SMT) with redness, about 6 mm in diameter, in the sigmoid colon....

journal_title：Journal of gastroenterology

authors： Endo S,Hirasaki S,Doi T,Endo H,Nishina T,Moriwaki T,Nakauchi M,Masumoto T,Tanimizu M,Hyodo I

更新日期：2003-01-01 00:00:00

abstract：:In recent years autoimmune pancreatitis (AIP) has been established as a special type of chronic pancreatitis. It is characterized by its histopathological and immunological features. The morphological hallmarks are periductal infiltration by lymphocytes and plasma cells, granulocytic epithelial lesions with focal dest...

journal_title：Journal of gastroenterology

authors： Klöppel G,Sipos B,Zamboni G,Kojima M,Morohoshi T

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Musashi-1 (Msi-1) is a RNA-binding protein, known as a putative marker of intestinal stem cells (ISCs). However, little is known about the function of Msi-1 within human intestinal epithelial cells (IECs). Thus, the present study aimed to clarify the role of Msi-1 in differentiation and proliferation of IECs...

journal_title：Journal of gastroenterology

authors： Murayama M,Okamoto R,Tsuchiya K,Akiyama J,Nakamura T,Sakamoto N,Kanai T,Watanabe M

更新日期：2009-01-01 00:00:00

abstract：:Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and non-lymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients wit...

journal_title：Journal of gastroenterology

authors： Malaguarnera M,Di Fazio I,Romeo MA,Restuccia S,Laurino A,Trovato BA

更新日期：1997-04-01 00:00:00

abstract：:A 21-year-old man with diarrhea and edema was admitted to our hospital and diagnosed with protein-losing enteropathy caused by primary intestinal lymphangiectasia. He was placed, in turn, on a low-fat diet, an elemental diet, and, subsequently, fasting therapy with total parenteral nutrition (TPN) support. However, hi...

journal_title：Journal of gastroenterology

authors： Kuroiwa G,Takayama T,Sato Y,Takahashi Y,Fujita T,Nobuoka A,Kukitsu T,Kato J,Sakamaki S,Niitsu Y

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Endoscopic transpapillary brush cytology and forceps biopsy are widely used for the pathological diagnosis of suspected malignant biliary strictures (MBS). However, the sensitivity of these methods remains insufficient, and it can be difficult to confirm the diagnosis. We aimed to evaluate the diagnostic abi...

journal_title：Journal of gastroenterology

authors： Ohshima Y,Yasuda I,Kawakami H,Kuwatani M,Mukai T,Iwashita T,Doi S,Nakashima M,Hirose Y,Asaka M,Moriwaki H

更新日期：2011-07-01 00:00:00

abstract：:Primary T/natural killer (NK) cell lymphoma of the colon is extremely rare. Despite the advances in histological and immunophenotypic studies, the diagnosis of primary T/NK cell lymphoma of the colon can be delayed because the early symptoms and colonoscopic findings may be very similar to those of inflammatory bowel ...

journal_title：Journal of gastroenterology

authors： Kim HS,Lee DK,Baik SK,Kwon SO,Cho MY,Ko YH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Dual oral therapy with daclatasvir plus asunaprevir yielded an SVR rate of 85% among patients with genotype 1b HCV. Treatment failure mainly occurred in patients with pre-existing HCV with NS5A-Y93H mutation. The significance of the mutation was evaluated. METHODS:The percent of serum NS5A-Y93H strains rela...

journal_title：Journal of gastroenterology

authors： Uchida Y,Kouyama J,Naiki K,Sugawara K,Ando S,Nakao M,Motoya D,Inao M,Imai Y,Nakayama N,Mochida S

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Liver cirrhosis affects the results of many of the traditional techniques currently used to evaluate nutritional status. Our aim was to compare the traditional two-compartment model (subjective global assessment and anthropometry and blood tests) of nutritional assessment with a multicompartmental model (bod...

journal_title：Journal of gastroenterology

authors： Figueiredo FA,Perez RM,Freitas MM,Kondo M

更新日期：2006-05-01 00:00:00

abstract：:The histopathological changes due to chronic Helicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication of H. pylori on nonulcer dyspepsia, the long-term ...

journal_title：Journal of gastroenterology

authors： Franceschi F,Genta RM,Sepulveda AR

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Most studies evaluating visceral sensation measure visceromotor response (VMR) to colorectal distention (CRD). However, CRD itself induces visceral sensitization, and little is known about the detailed characteristics of this response. The present study tried to clarify this question. METHODS:VMR was determ...

journal_title：Journal of gastroenterology

authors： Nozu T,Kumei S,Miyagishi S,Takakusaki K,Okumura T

更新日期：2015-12-01 00:00:00

abstract：:In our hospital, 83 patients with colorectal cancer underwent the immunologic fecal occult blood test (IFOBT). The positive rate for IFOBT in all patients was 87%. Colon cancers more proximal than the transverse colon were 100% positive. Carcinomas of the ulcerative type showed a significantly higher positive rate tha...

journal_title：Journal of gastroenterology

authors： Iida Y,Munemoto Y,Miura S,Kasahara Y,Saito H,Mitsui T,Asada Y,Fukuoka K,Toya D,Tanaka N

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Little real-world cohort data has been reported for Asians who have received interferon-free regimens with sofosbuvir (SOF) for chronic hepatitis C virus (HCV) infection. We evaluated the effectiveness and safety in clinical practice of ledipasvir (LDV) plus SOF for Japanese patients infected with HCV genoty...

journal_title：Journal of gastroenterology

authors： Ogawa E,Furusyo N,Nomura H,Dohmen K,Higashi N,Takahashi K,Kawano A,Azuma K,Satoh T,Nakamuta M,Koyanagi T,Kato M,Shimoda S,Kajiwara E,Hayashi J,Kyushu University Liver Disease Study (KULDS) Group.

更新日期：2017-07-01 00:00:00

abstract：:5-aminosalicylate is a fundamental treatment for patients with ulcerative colitis with mild-to-moderate disease; however, evidence for 5-aminosalicylate treatment is unclear in some situations. This review discusses the clinical guidelines and previous studies, and highlights the following points: (1) Although rectal ...

journal_title：Journal of gastroenterology

authors： Naganuma M

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Physical inactivity is a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). "Hybrid training", a training that involves both voluntary and electrical muscle contractions, causes beneficial alterations in muscles even after short durations of exercise. The aim of this study was to i...

journal_title：Journal of gastroenterology

authors： Kawaguchi T,Shiba N,Maeda T,Matsugaki T,Takano Y,Itou M,Sakata M,Taniguchi E,Nagata K,Sata M

更新日期：2011-06-01 00:00:00

abstract：:An association between macrovascular thrombosis and idiopathic inflammatory bowel disease has been described, although very few well-documented cases have been published. We report on a 39-year-old woman who presented with right hemifacial and upper limb edema that was shown to be due to an extensive right brachioceph...

journal_title：Journal of gastroenterology

authors： Ribeiro JM,Rebocho L,Lucas MB,Campos P,Victorino RM

更新日期：2003-01-01 00:00:00