Abstract:
:In recent years autoimmune pancreatitis (AIP) has been established as a special type of chronic pancreatitis. It is characterized by its histopathological and immunological features. The morphological hallmarks are periductal infiltration by lymphocytes and plasma cells, granulocytic epithelial lesions with focal destruction of the duct epithelium, venulitis, and diffuse sclerosis in advanced stages. AIP has therefore also been called lymphoplasmacytic sclerosing pancreatitis, duct-destructive chronic pancreatitis, or sclerosing pancreatitis. AIP most commonly involves the head of the pancreas and the distal bile duct. Occasionally it is mass-forming, and has been described as an inflammatory myofibroblastic tumor. The presence of more than 20 IgG4-positive plasma cells per high-power field is of high specificity for the tissue diagnosis of AIP.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Klöppel G,Sipos B,Zamboni G,Kojima M,Morohoshi Tdoi
10.1007/s00535-007-2048-6subject
Has Abstractpub_date
2007-05-01 00:00:00pages
28-31eissn
0944-1174issn
1435-5922journal_volume
42 Suppl 18pub_type
杂志文章,评审abstract::The effect of nifedipine administration (10 mg) on esophageal acid exposure time was investigated in 11 non-reflux esophagitis (non-RE) patients and 11 grade C (Los Angeles classification) reflux esophagitis (RE) patients. In each subject, esophageal pH monitoring was performed, with the subject in the supine position...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050008
更新日期:2000-01-01 00:00:00
abstract::Cholecystokinin (CCK) receptor antagonists have been reported on have an inhibitory effect on acute experimental pancreatitis, but their long-term administration is also reported to block pancreatic regeneration. We examined whether the short-term administration of KSG-504 (KSG), a synthetic CCK-A receptor antagonist,...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02347566
更新日期:1995-08-01 00:00:00
abstract::A retrospective long-term endoscopic follow-up study was designed to examine atrophic changes in the gastric mucosa over time in Helicobacter pylori-positive patients. Over a period of 8-17 years (mean, 13.4 years) 22 subjects (5 men, 17 women, mean age, 55 years) without localized gastroduodenal lesions underwent ser...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF01213291
更新日期:1997-02-01 00:00:00
abstract::The aim of this study was to examine the diurnal variations in ornithine decarboxylase (ODC) activity and apoptosis in the small intestinal mucosa of Mongolian gerbils. First, the feeding, drinking, and ambulatory patterns of the gerbils were recorded. The results indicated that Mongolian gerbils lost diurnal cyclicit...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350070088
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Acute liver failure is a potentially fatal disease of various etiologies for which liver transplantation is the only known curative treatment. Although the decision-making on transplantation is largely dependent on the severity of liver injury (based on predicting a fatal outcome), a statistical analysis to ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-017-1421-3
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Primary biliary cirrhosis (PBC) is histopathologically characterized by chronic nonsuppurative destructive cholangitis and ductopenia of interlobular bile ducts. Bile duct injury is also often encountered in chronic viral hepatitis (CVH) and in autoimmune hepatitis (AIH). METHODS:In this study, we performed...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-004-1514-7
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:There have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan. METHODS:We examined the epidemiology of GEP-NETs [pancreatic endocrine tumors (PETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005 using a nationwide stratified random sa...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-009-0194-8
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To examine gastric myoelectrical activity in patients with primary biliary cirrhosis (PBC). MATERIALS AND METHODS:The study comprised 11 female PBC patients (average age 53.4 years, range 43-70) and two aged-matched control groups: 11 (53.4 years, range 37-78) healthy women, and 10 female patients with chron...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-009-0009-y
更新日期:2009-01-01 00:00:00
abstract::Focal nodular hyperplasia (FNH) of the liver is a rare benign lesion that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Currently, the natural history of the disease remains largely unknown. We present a patient with FNH of the liver who was followed up for 4 years. A 22-yea...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350200140
更新日期:2002-01-01 00:00:00
abstract::We report a case of pancreas head carcinoma associated with fat replacement of the body and tail. A 68-year-old man presented with obstructive jaundice and was admitted to our hospital. Ultrasonography and computed tomography showed pancreas head tumor with a neighboring cystic lesion and fatty replacement of parenchy...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1250-4
更新日期:2004-01-01 00:00:00
abstract::Changes of hepatic sinusoids are crucial in the pathogenesis of liver cirrhosis and portal hypertension. Liver injury leads to distinct morphological abnormalities such as loss of sinusoidal fenestration, vasoconstriction, and angiogenesis as well as molecular changes. Communication between the two key cells in this h...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-016-1190-4
更新日期:2016-06-01 00:00:00
abstract::In Japan, Kaposi's sarcoma (KS) is a very rare neoplasm. However, it does occur as one of the complications in patients with acquired immunodeficiency syndrome (AIDS). AIDS-related KS commonly involves the skin, lymph nodes, and gastrointestinal tract. Hepatic KS is sometimes observed in AIDS patients at autopsy, but ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02348677
更新日期:1995-04-01 00:00:00
abstract::We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonograp...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02355038
更新日期:1996-06-01 00:00:00
abstract::The requirement for well spread out chromosomes for the cytogenetic analysis of primary gastrointestinal tumors led us to develop new techniques. These techniques involved two main procedures: (1) preliminary incubation with culture medium in the presence of collagenase, Dispase, and colcemid, for 3 h, and (2) treatme...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02355049
更新日期:1996-08-01 00:00:00
abstract::A 21-year-old man with diarrhea and edema was admitted to our hospital and diagnosed with protein-losing enteropathy caused by primary intestinal lymphangiectasia. He was placed, in turn, on a low-fat diet, an elemental diet, and, subsequently, fasting therapy with total parenteral nutrition (TPN) support. However, hi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350170142
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease affects the quality of a patient's life in many ways, but no validated instrument for measuring disease-specific quality of life in these patients is available in Japan. We developed a Japanese version of the Inflammatory Bowel Disease Questionnaire (IBDQ), together with the author...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1220-x
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Infection with Helicobacter pylori is the main risk factor for development of gastric cancer. CD44 overexpression, especially that of variant 9 (CD44v9), has also been implicated in the local inflammatory response and metaplasia-carcinoma sequence in human stomach. We recently identified miR-328 as one of th...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-014-1019-y
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:The remnant stomach corresponds to the gastric cardia, but is exposed to a completely different environment. The present study was performed to investigate the role of Epstein-Barr virus (EBV) infection in patients with gastric remnant carcinoma (GRC). METHODS:Clinicopathological features, gastritis, and in...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-005-1590-3
更新日期:2005-06-01 00:00:00
abstract::In a pilot study of direct dissolution therapy of gallstones with methyl tert-butyl ether (MTBE), endoscopic transpapillary catheterization in the gallbladder (ETCG) was performed. Complete dissolution was seen in 8 out of 12 (66%) patients and partial dissolution was seen in 2 (16%) patients. In one of the 8 complete...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02361248
更新日期:1994-08-01 00:00:00
abstract::From its pattern of metastasis and recurrence, gastric carcinoma can be recognized as a slow-growing malignancy whose local control is still the most important part of treatment. With application of asymptomatic population screening and awareness of the high risk of this disease among the general population in Japan, ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The efficacy, safety, and pharmacokinetics of the combination of three direct-acting antiviral (DAA) agents (adafosbuvir [also known as AL-335], odalasvir, and simeprevir) were investigated in DAA treatment-naïve Japanese patients with genotype (GT)1 or GT2 chronic hepatitis C virus (HCV) infection, with or ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-020-01672-0
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To provide updated clinico-epidemiological information on chronic pancreatitis (CP) in Japan. METHODS:We conducted a two-stage nationwide epidemiological survey; the number of CP patients was estimated in the first-stage survey, and their clinical features were examined in the second-stage survey. We survey...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-020-01704-9
更新日期:2020-11-01 00:00:00
abstract::We report two cirrhotic patients with gastric antral vascular ectasia (GAVE) in whom chronic blood loss presented a major problem. Case 1, a 69-year-old man, had alcoholic liver cirrhosis, and case 2, a 75-year-old woman, had liver cirrhosis associated with hepatitis C virus. The patients required repeated blood trans...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050130
更新日期:1998-08-01 00:00:00
abstract::A 69-year-old woman was admitted to our hospital with fever and abdominal pain in the epigastric region. Abdominal ultrasonography demonstrated a well-defined hypoechoic mass in the epigastric region with encasement of the left hepatic lobe and stomach. Computed tomography confirmed a low-density mass, 20 cm in diamet...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-003-1203-y
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use. METHODS:Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for mo...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00535-011-0410-1
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD) and resultant colitis occurring prior to puberty are frequently associated with delayed puberty and losses of growth and bone mineralization. Some of this delay may be due to colonic inflammation and associated systemic inflammation. To date no treatments for IBD have been sh...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0542-y
更新日期:2012-06-01 00:00:00
abstract::Our objective was to determine whether the prevalence of vacuolating cytotoxin production differed among Helicobacter pylori isolates obtained from patients with chronic gastritis, gastric ulcer, or duodenal ulcer. We examined the vacuolating cytotoxin production of 114 clinical H. pylori isolates in rabbit gastic epi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::A case of life-threatening lower gastrointestinal hemorrhage from Crohn's disease is reported. Several promising studies have recently been published that describe superselective embolization for the treatment of massive lower gastrointestinal hemorrhage in patients with bleeding colonic diverticular disease and angio...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-005-1714-9
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Patients with primary biliary cirrhosis (PBC) exhibit a variety of clinical manifestations and patterns of disease progression. The aim of this study was to identify genetic determinants of PBC progression. METHODS:A total of 52 tag single nucleotide polymorphisms (SNPs) of 11 candidate genes involved in re...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0730-9
更新日期:2013-10-01 00:00:00
abstract::Duodenal gastrinoma is recognized as a relatively common cause of Zollinger-Ellison syndrome, but its clinical and biological features are not well known. Here we report a case of duodenal gastrinoma with lymph node metastasis which was confirmed by pathology examinations. Hypergastrinemia and gastric acid hypersecret...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050163
更新日期:1998-10-01 00:00:00