Blocking of monocyte chemoattractant protein-1 (MCP-1) activity attenuates the severity of acute pancreatitis in rats.

abstract：BACKGROUND:Primary biliary cirrhosis (PBC) is histopathologically characterized by chronic nonsuppurative destructive cholangitis and ductopenia of interlobular bile ducts. Bile duct injury is also often encountered in chronic viral hepatitis (CVH) and in autoimmune hepatitis (AIH). METHODS:In this study, we performed...

journal_title：Journal of gastroenterology

authors： Zen Y,Harada K,Sasaki M,Tsuneyama K,Matsui K,Haratake J,Sakisaka S,Maeyama S,Yamamoto K,Nakano M,Shimamatsu K,Kage M,Kurose N,Uchiyama A,Kaizaki Y,Toda G,Nakanuma Y

更新日期：2005-02-01 00:00:00

abstract：:Small bowel transit time (SBTT) in 15 young and 13 elderly women was assessed by measuring breath hydrogen concentrations after they had consumed a solid test meal. The meal consisted of 200 g cooked rice, 50 ml miso (made from fermented soy bean curd) soup, a boiled egg, and 95.5 g of cooked soy beans with mixed vege...

journal_title：Journal of gastroenterology

authors： Kagaya M,Iwata N,Toda Y,Nakae Y,Kondo T

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Whether mucosal inflammation affects gastric motility in patients with functional dyspepsia (FD) is controversial. Few reports discuss gastric motility in relation to histologic gastritis. We examined the relation between gastric motility and histologic gastritis in Japanese patients with FD. METHODS:Subjec...

journal_title：Journal of gastroenterology

authors： Matsumoto Y,Ito M,Kamino D,Tanaka S,Haruma K,Chayama K

更新日期：2008-01-01 00:00:00

abstract：:In our hospital, 83 patients with colorectal cancer underwent the immunologic fecal occult blood test (IFOBT). The positive rate for IFOBT in all patients was 87%. Colon cancers more proximal than the transverse colon were 100% positive. Carcinomas of the ulcerative type showed a significantly higher positive rate tha...

journal_title：Journal of gastroenterology

authors： Iida Y,Munemoto Y,Miura S,Kasahara Y,Saito H,Mitsui T,Asada Y,Fukuoka K,Toya D,Tanaka N

更新日期：1995-04-01 00:00:00

abstract：:An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all were involved in the fina...

journal_title：Journal of gastroenterology

authors： Unge P

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:We aimed to evaluate gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the detection of hepatocellular carcinomas (HCCs) and dysplastic nodules (DNs) compared with dynamic multi-detector row computed tomography (MDCT), and to discriminate ...

journal_title：Journal of gastroenterology

authors： Inoue T,Kudo M,Komuta M,Hayaishi S,Ueda T,Takita M,Kitai S,Hatanaka K,Yada N,Hagiwara S,Chung H,Sakurai T,Ueshima K,Sakamoto M,Maenishi O,Hyodo T,Okada M,Kumano S,Murakami T

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Acute liver failure is a potentially fatal disease of various etiologies for which liver transplantation is the only known curative treatment. Although the decision-making on transplantation is largely dependent on the severity of liver injury (based on predicting a fatal outcome), a statistical analysis to ...

journal_title：Journal of gastroenterology

authors： Mawatari S,Moriuchi A,Ohba F,Kawano T,Oda K,Takikawa Y,Takikawa H,Ido A,Tsubouchi H

更新日期：2018-07-01 00:00:00

abstract：:IL-22 is a relatively new cytokine that is characterized by several unique biological properties. In the intestines, the effect of IL-22 is restricted mainly to non-lymphoid cells such as epithelial cells. Interestingly, the expression pattern and major cellular source of IL-22 have distinct difference between large a...

journal_title：Journal of gastroenterology

authors： Mizoguchi A,Yano A,Himuro H,Ezaki Y,Sadanaga T,Mizoguchi E

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:There have only been a few prospective studies investigating risk factors associated with the development of hepatocellular carcinoma (HCC) among chronic hepatitis B patients all over the world, and no study has been conducted in Japanese population. METHODS:A population-based cohort consisting of 19393 sub...

journal_title：Journal of gastroenterology

authors： Kusakabe A,Tanaka Y,Inoue M,Kurbanov F,Tatematsu K,Nojiri S,Joh T,Tsugane S,Mizokami M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Experimental evidence and clinical studies suggest that the renin-angiotensin system and its inhibitors may play a role in regulating the mechanisms of liver fibrosis development. The present study aimed to verify whether carriage of specific angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) all...

journal_title：Journal of gastroenterology

authors： Fabris C,Toniutto P,Bitetto D,Minisini R,Fornasiere E,Smirne C,Pirisi M

更新日期：2007-07-01 00:00:00

abstract：:We investigated the adverse effects of sulfasalazine in the treatment of inflammatory bowel disease in Japan. In our first survey, adverse effects were observed in 52 out of 751 patients with ulcerative colitis (6.9%) and in 8 out of 221 patients with Crohn's disease (3.6%); i.e., such effects were observed in 60 out ...

journal_title：Journal of gastroenterology

authors： Nakajima H,Munakata A,Yoshida Y

更新日期：1995-11-01 00:00:00

abstract：:Progressive familial intrahepatic cholestasis (PFIC) syndromes are characterized by defects in transporters of conjugated bile acids into the bile canaliculus. Three genes (ATP8B1, ABCB11, ABCB4) are associated with the different forms, but no easy genotype-phenotype correlations help in the prioritization for gene te...

journal_title：Journal of gastroenterology

authors： Nobili V,Di Giandomenico S,Francalanci P,Callea F,Marcellini M,Santorelli FM

更新日期：2006-06-01 00:00:00

abstract：:We report a rare case of gallbladder cancer associated with a common bile duct neuroma, and a cystic liver lesion with histologic findings similar to an inflammatory pseudotumor, in a patient who had had no previous abdominal surgery. The patient was a 62-year-old man whose major complaint was fever. Ultrasonography a...

journal_title：Journal of gastroenterology

authors： Akiyama T,Saito H,Kiriyama M,Tomita F,Kosaka T,Kita I,Takashima S,Matsunou H

更新日期：1995-06-01 00:00:00

abstract：:CYFRA 21-1 is a fragment of cytokeratin 19 (CK 19). Four patients with large intrahepatic (or peripheral) cholangiocarcinoma (CC) and high serum levels of CYFRA 21-1 (normal, < or = 2 ng/ml) are reported. CYFRA 21-1 levels exceeded 9 ng/ml in all 4 patients. Carcinoembryonic antigen (CEA), was high in 1 (CEA; normal r...

journal_title：Journal of gastroenterology

authors： Kashihara T,Ohki A,Kobayashi T,Sato T,Nishizawa H,Ogawa K,Tako H,Kawakami F,Tsuji M,Tamaoka K

更新日期：1998-06-01 00:00:00

abstract：:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is the most frequent complication of ERCP. Several meta-analyses have examined the effects of protease inhibitors (gabexate mesilate, ulinastatin, and nafamostat mesilate) and non-steroidal anti-inflammatory drugs (NSAIDs) on post-ERCP pancreatiti...

journal_title：Journal of gastroenterology

authors： Yuhara H,Ogawa M,Kawaguchi Y,Igarashi M,Shimosegawa T,Mine T

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:There are substantial differences in inflammatory bowel disease (IBD) genetics depending on the populations examined. We aimed to identify Japanese population-specific or true culprit susceptibility genes through a meta-analysis of past genetic studies of Japanese IBD. METHODS:For this study, we reviewed 2,...

journal_title：Journal of gastroenterology

authors： Arimura Y,Isshiki H,Onodera K,Nagaishi K,Yamashita K,Sonoda T,Matsumoto T,Takahashi A,Takazoe M,Yamazaki K,Kubo M,Fujimiya M,Imai K,Shinomura Y

更新日期：2014-08-01 00:00:00

abstract：:Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases such as inflammatory bowel disease (IBD). The development of next-generation sequencing technology allows th...

journal_title：Journal of gastroenterology

authors： Kanai T,Mikami Y,Hayashi A

更新日期：2015-09-01 00:00:00

abstract：:One complication of choledochal cyst in adulthood is the development of secondary carcinoma, usually well-differentiated adenocarcinoma. We report a case of extrahepatic bile duct carcinoma associated with choledochal cyst and presenting predominantly sarcomatous features. The patient was a 52-year-old female who pres...

journal_title：Journal of gastroenterology

authors： Nonomura A,Mizukami Y,Matsubara F,Ueda H

更新日期：1994-10-01 00:00:00

abstract：:We report a rare case of massive and recurrent bleeding from ileal varices in a patient with hepatitis C virus-positive liver cirrhosis. A 66-year old woman, who had undergone laparotomy and blood transfusion 36 years before (because of an extrauterine pregnancy) and endoscopic sclerotherapy for esophageal varices 1 y...

journal_title：Journal of gastroenterology

authors： Ohtani T,Kajiwara E,Suzuki N,Kawasaki A,Sadoshima S,Sakata H,Sasaguri Y,Onoyama K

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Subunit A of coagulation factor XIII (FXIII-A) is important for clot stability and acts in the subsequent wound healing process. Loss of plasma FXIII-A has been reported after surgery, sepsis, and inflammatory conditions. In the intestinal mucosa, FXIII-A is expressed by macrophages and cellular FXIII-A has ...

journal_title：Journal of gastroenterology

authors： Soendergaard C,Kvist PH,Seidelin JB,Pelzer H,Nielsen OH

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Bleeding of the lower gastrointestinal tract requires hospitalization and can cause in-hospital death in the most serious cases; however, only a few studies have evaluated in-hospital death from bleeding of the lower gastrointestinal tract. The aim of this study was to investigate the in-hospital mortality o...

journal_title：Journal of gastroenterology

authors： Niikura R,Yasunaga H,Yamaji Y,Horiguchi H,Fushimi K,Yamada A,Hirata Y,Koike K

更新日期：2015-05-01 00:00:00

abstract：:Focal nodular hyperplasia (FNH) is a benign lesion of the liver which usually presents with one or two localizations. We report a patient with history of resection of a biliary cyst, and who had been taking oral contraceptives for the past 18 years, who had multiple localizations of FNH (more than 30 lesions). The lar...

journal_title：Journal of gastroenterology

authors： Colle I,de Beeck BO,Hoorens A,Hautekeete M

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Liver cirrhosis affects the results of many of the traditional techniques currently used to evaluate nutritional status. Our aim was to compare the traditional two-compartment model (subjective global assessment and anthropometry and blood tests) of nutritional assessment with a multicompartmental model (bod...

journal_title：Journal of gastroenterology

authors： Figueiredo FA,Perez RM,Freitas MM,Kondo M

更新日期：2006-05-01 00:00:00

abstract：:The localization and distribution of gamma delta T cell receptor (TCR)-positive cells (gamma delta T cells) in hepatocellular carcinoma capsules was investigated immunohistochemically at both light and electron microscopic levels. Most of the mononuclear cells infiltrating the tumor capsules were CD3-positive. Togethe...

journal_title：Journal of gastroenterology

authors： Chin K,Morise K,Kanayama K,Nagura H

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:In the respiratory mucosa, interleukin (IL)-33, has been shown to enhance T helper 2 (TH2)-type responses through the master regulatory gene GATA-3. IL-33 is upregulated in ulcerative colitis (UC), and the aim was to assess if IL-33 holds a similar key position in the shaping of the immune response in experi...

journal_title：Journal of gastroenterology

authors： Seidelin JB,Coskun M,Kvist PH,Holm TL,Holgersen K,Nielsen OH

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) occurs in chronic hepatitis B (CH-B) patients even after treatment with nucleos(t)ide analogues (NAs) by a mechanism involving an association between the oncogenic factors of integrated HBV and liver fibrosis. An association has been demonstrated between advanced chronic liver ...

journal_title：Journal of gastroenterology

authors： Kawaguchi K,Honda M,Ohta H,Terashima T,Shimakami T,Arai K,Yamashita T,Sakai Y,Yamashita T,Mizukoshi E,Komura T,Unoura M,Kaneko S

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Abrogating tolerance is a critical step in the pathogenesis of Crohn's disease (CD). T cell-anergy is one of the main mechanisms of tolerance and is regulated by the gene related to anergy in lymphocytes (GRAIL). This study investigated the expressions and regulation of GRAIL in CD and murine colitis models....

journal_title：Journal of gastroenterology

authors： Mukai A,Iijima H,Hiyama S,Fujii H,Shinzaki S,Inoue T,Shiraishi E,Kawai S,Araki M,Hayashi Y,Kondo J,Mizushima T,Kanto T,Egawa S,Nishida T,Tsujii M,Takehara T

更新日期：2014-12-01 00:00:00

abstract：:Several components of the gastrointestinal tract including the esophagogastric junction (EGJ) show circumferential asymmetry in the formation of pathological lesions, which is caused by the morphological and functional asymmetry of the gastrointestinal tract. Pressure in the lower esophageal sphincter (LES) is higher ...

journal_title：Journal of gastroenterology

authors： Kinoshita Y,Furuta K,Adachi K,Amano Y

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Superior mesenteric artery syndrome (SMAS) is caused by compression of the third part of the duodenum between the superior mesenteric artery and the aorta. It occurs most frequently in patients with rapid weight loss. METHODS:We report two young patients, who each presented with a longstanding history of po...

journal_title：Journal of gastroenterology

authors： Lippl F,Hannig C,Weiss W,Allescher HD,Classen M,Kurjak M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:In patients with hepatitis C virus (HCV)-genotype 1b and a high virus load, of more than 1 Meq/ml by the DNA probe assay, the clearance of HCV-RNA was achieved in only 10% with a 6-month interferon (IFN) course. We therefore assessed the efficacy of prolonged IFN therapy in patients with HCV-genotype 1b and ...

journal_title：Journal of gastroenterology

authors： Arase Y,Ikeda K,Tsubota A,Suzuki Y,Saitoh S,Kobayashi M,Kobayashi M,Suzuki F,Akuta N,Someya T,Kumada H

更新日期：2003-01-01 00:00:00