Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT.

Abstract:

BACKGROUND:We aimed to evaluate gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the detection of hepatocellular carcinomas (HCCs) and dysplastic nodules (DNs) compared with dynamic multi-detector row computed tomography (MDCT), and to discriminate between HCCs and DNs. METHODS:Eighty-six nodules diagnosed as HCC or DNs were retrospectively investigated. Gd-EOB-DTPA-enhanced MRI and dynamic MDCT were compared with respect to their diagnostic ability for hypervascular HCCs and detection sensitivity for hypovascular tumors. The ability of hepatobiliary images of Gd-EOB-DTPA-enhanced MRI to discriminate between these nodules was assessed. We also calculated the EOB enhancement ratio of the tumors. RESULTS:For hypervascular HCCs, the diagnostic ability of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of MDCT for tumors less than 2 cm (p = 0.048). There was no difference in the detection of hypervascular HCCs between hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI (43/45: 96%) and dynamic MDCT (40/45: 89%), whereas the detection sensitivity of hypovascular tumors by Gd-EOB-DTPA-enhanced MRI was significantly higher than that by dynamic MDCT (39/41: 95% vs. 25/41: 61%, p = 0.001). EOB enhancement ratios were decreased in parallel with the degree of differentiation in DNs and HCCs, although there was no difference between DNs and hypovascular well-differentiated HCCs. CONCLUSION:The diagnostic ability of Gd-EOB-DTPA-enhanced MRI for hypervascular HCCs less than 2 cm was significantly higher than that of MDCT. For hypovascular tumors, the detection sensitivity of hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of dynamic Gd-EOB-DTPA-enhanced MRI and dynamic MDCT. It was difficult to distinguish between DNs and hypovascular well-differentiated HCCs based on the EOB enhancement ratio.

journal_name

J Gastroenterol

authors

Inoue T,Kudo M,Komuta M,Hayaishi S,Ueda T,Takita M,Kitai S,Hatanaka K,Yada N,Hagiwara S,Chung H,Sakurai T,Ueshima K,Sakamoto M,Maenishi O,Hyodo T,Okada M,Kumano S,Murakami T

doi

10.1007/s00535-012-0571-6

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1036-47

issue

9

eissn

0944-1174

issn

1435-5922

journal_volume

47

pub_type

杂志文章
  • Hepatic vascular side effects of styrene maleic acid neocarzinostatin in the treatment of hepatocellular carcinoma.

    abstract::Styrene-maleic acid neocarzinostatin (SMANCS) sometimes causes hepatic vascular side effects, including arterial stricture, obstruction, and arterio-portal shunt. A total of 128 intra-arterial SMANCS injection treatments, performed for 89 patients with hepatocellular carcinoma, were analyzed to determine the relations...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050360

    authors: Ikeda K,Saitoh S,Kobayashi M,Suzuki Y,Suzuki F,Tsubota A,Arase Y,Chayama K,Murashima N,Kumada H

    更新日期:2000-01-01 00:00:00

  • Clinical evaluation of 3D-CT cholangiography for preoperative examination in laparoscopic cholecystectomy.

    abstract::Three-dimensional-computed tomography (3D-CT) cholangiography is a 3D shaded surface display image of the biliary tract obtained by using helical CT after intravenous cholangiography or cholangiography per percutaneous transhepatic cholangio-drainage tube. We investigated whether 3D-CT cholangiography could provide a ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050225

    authors: Kinami S,Yao T,Kurachi M,Ishizaki Y

    更新日期:1999-02-01 00:00:00

  • Role of endogenous substance P in ethanol-induced mucosal damage in the rat stomach.

    abstract::To determine the role of endogenous substance P in ethanol-induced mucosal damage, two experiments were performed. In the first experiment, the stomachs of anesthetized rats were doubly cannulated and gastric damage was induced with 5ml of 30% ethanol in the gastric lumen. The damage was ameliorated by pretreatment wi...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02355018

    authors: Hayashi H,Nishiyama K,Majima M,Katori M,Saigenji K

    更新日期:1996-06-01 00:00:00

  • Factors affecting in-hospital mortality in patients with lower gastrointestinal tract bleeding: a retrospective study using a national database in Japan.

    abstract:BACKGROUND:Bleeding of the lower gastrointestinal tract requires hospitalization and can cause in-hospital death in the most serious cases; however, only a few studies have evaluated in-hospital death from bleeding of the lower gastrointestinal tract. The aim of this study was to investigate the in-hospital mortality o...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00535-014-0994-3

    authors: Niikura R,Yasunaga H,Yamaji Y,Horiguchi H,Fushimi K,Yamada A,Hirata Y,Koike K

    更新日期:2015-05-01 00:00:00

  • Adverse effects of sulfasalazine and treatment of ulcerative colitis with mesalazine.

    abstract::We investigated the adverse effects of sulfasalazine in the treatment of inflammatory bowel disease in Japan. In our first survey, adverse effects were observed in 52 out of 751 patients with ulcerative colitis (6.9%) and in 8 out of 221 patients with Crohn's disease (3.6%); i.e., such effects were observed in 60 out ...

    journal_title:Journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Nakajima H,Munakata A,Yoshida Y

    更新日期:1995-11-01 00:00:00

  • Current status of preoperative biliary drainage.

    abstract::Preoperative biliary drainage (PBD) has been thought to be preferable regardless of the site of biliary strictures, e.g., distal or proximal strictures because PBD by endoscopy or interventional radiology decreases postoperative mortality and morbidity rates. However, recently, several studies have revealed that PBD s...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-015-1096-6

    authors: Umeda J,Itoi T

    更新日期:2015-09-01 00:00:00

  • Ciliated foregut cyst in cirrhotic liver.

    abstract::We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonograp...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02355038

    authors: Murakami T,Imai A,Nakamura H,Tsuda K,Kanai T,Wakasa K

    更新日期:1996-06-01 00:00:00

  • Genetic characteristics of inflammatory bowel disease in a Japanese population.

    abstract:BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japan...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-015-1135-3

    authors: Fuyuno Y,Yamazaki K,Takahashi A,Esaki M,Kawaguchi T,Takazoe M,Matsumoto T,Matsui T,Tanaka H,Motoya S,Suzuki Y,Kiyohara Y,Kitazono T,Kubo M

    更新日期:2016-07-01 00:00:00

  • Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus.

    abstract:BACKGROUND:The Japan Society of Diabetes Mellitus reported that the leading cause of death in patients with diabetes mellitus (DM) was chronic liver disease; however, there are limited studies investigating the cause of liver injury in these patients. Our study aimed to clarify the clinicopathological features of liver...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00535-012-0653-5

    authors: Shima T,Uto H,Ueki K,Takamura T,Kohgo Y,Kawata S,Yasui K,Park H,Nakamura N,Nakatou T,Tanaka N,Umemura A,Mizuno M,Tanaka J,Okanoue T

    更新日期:2013-04-01 00:00:00

  • Cowden's disease with a defined genetic alteration--chromosomal duplication at 15q11-q13.

    abstract::Cowden's disease, multiple hamartoma syndrome, is a dominantly inherited disorder characterized by multiple hamartomas of ectodermal, endodermal, and mesodermal origin and also by a high incidence of malignant tumors. Despite many efforts to identify the genetic alterations responsible for the syndrome, the molecular ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02934124

    authors: Suzuki T,Ichinose M,Matsubara Y,Yahagi N,Kurokawa K,Fukamachi H,Miki K

    更新日期:1997-10-01 00:00:00

  • Therapy of metastatic pancreatic neuroendocrine tumors (pNETs): recent insights and advances.

    abstract::Neuroendocrine tumors (NETs) [carcinoids, pancreatic neuroendocrine tumors (pNETs)] are becoming an increasing clinical problem because not only are they increasing in frequency, but they can frequently present with advanced disease that requires diagnostic and treatment approaches different from those used in the neo...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-012-0642-8

    authors: Ito T,Igarashi H,Jensen RT

    更新日期:2012-09-01 00:00:00

  • Efficacy of clarithromycin in eradicating Helicobacter pylori.

    abstract::We reviewed reports on the efficacy of clarithromycin in eradicating Helicobacter pylori. Reports on dual and 1-week triple therapy that included clarithromycin were analyzed to assess the eradication rates of H. pylori infection. Dual therapy with clarithromycin and a proton pump inhibitor achieved eradication rates ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Satoh K,Kimura K,Takimoto T,Kihira K,Taniguchi Y,Saifuku K

    更新日期:1996-11-01 00:00:00

  • Overexpression of apelin receptor (APJ/AGTRL1) on hepatic stellate cells and sinusoidal angiogenesis in human cirrhotic liver.

    abstract:BACKGROUND:The apelin receptor (APJ) is related to angiotensin-like-receptor 1 (AGTRL1). This study was designed to elucidate the in vivo localization and changes of APJ in cirrhotic liver, and the in vitro changes of APJ expression in cultured hepatic stellate cells (HSCs) and capillarized sinusoidal endothelial cells...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-010-0296-3

    authors: Yokomori H,Oda M,Yoshimura K,Machida S,Kaneko F,Hibi T

    更新日期:2011-02-01 00:00:00

  • Intestinal microflora as a therapeutic target in inflammatory bowel disease.

    abstract::Although the causes of inflammatory bowel disease (IBD) remain incompletely understood, increasing evidence implicates intestinal microflora in the pathogenesis of these disorders. Alteration of intestinal flora therefore may offer a plausible therapeutic approach. Although recent data support a potential therapeutic ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/BF03326418

    authors: Mitsuyama K,Toyonaga A,Sata M

    更新日期:2002-11-01 00:00:00

  • Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan.

    abstract:BACKGROUND:There have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan. METHODS:We examined the epidemiology of GEP-NETs [pancreatic endocrine tumors (PETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005 using a nationwide stratified random sa...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-009-0194-8

    authors: Ito T,Sasano H,Tanaka M,Osamura RY,Sasaki I,Kimura W,Takano K,Obara T,Ishibashi M,Nakao K,Doi R,Shimatsu A,Nishida T,Komoto I,Hirata Y,Nakamura K,Igarashi H,Jensen RT,Wiedenmann B,Imamura M

    更新日期:2010-02-01 00:00:00

  • The efficacy of nocturnal administration of branched-chain amino acid granules to improve quality of life in patients with cirrhosis.

    abstract:BACKGROUND:Nocturnal administration of branched-chain amino acid (BCAA) granules improves serum albumin levels in patients with cirrhosis. However, it is unclear whether or not this administration method can improve the patients' quality of life (QOL). In this study, we aimed to investigate the efficacy of BCAA granule...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00535-012-0632-x

    authors: Hidaka H,Nakazawa T,Kutsukake S,Yamazaki Y,Aoki I,Nakano S,Asaba N,Minamino T,Takada J,Tanaka Y,Okuwaki Y,Watanabe M,Shibuya A,Koizumi W

    更新日期:2013-02-01 00:00:00

  • Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p.

    abstract:BACKGROUND:Circular RNAs (circRNAs) act as vital regulators of gene expression in a variety of cancers. However, the role of circRNAs in gastric cancer (GC) remains largely unexplored. Herein, we identified that circTMEM87A sponges miR-142-5p to promote GC progression through up-regulating ULK1 expression. METHODS:The...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-020-01744-1

    authors: Wang H,Sun G,Xu P,Lv J,Zhang X,Zhang L,Wang S,Cao J,Xia Y,Xuan Z,Li B,Huang X,Jiang T,Fang L,Xu Z

    更新日期:2020-11-06 00:00:00

  • Nonrotation of the midgut with appendiceal mucocele in an adult.

    abstract::Nonrotation of the midgut in adults and appendiceal mucocele are both rare pathological conditions. We report here the first case of nonrotation of the midgut associated with appendiceal mucocele. The patient was a 51-year-old man admitted to hospital with ileus. An upper gastrointestinal series and a barium enema rev...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350170153

    authors: Kawashima K,Ishihara S,Amano K,Hirakawa K,Adachi K,Fukuda R,Sumi S,Watanabe M,Kinoshita Y

    更新日期:2001-01-01 00:00:00

  • Value of post-vascular phase (Kupffer imaging) by contrast-enhanced ultrasonography using Sonazoid in the detection of hepatocellular carcinoma.

    abstract:BACKGROUND:We evaluated the sensitivity and specificity of post-vascular phase (Kupffer imaging) by contrast-enhanced ultrasonography (CEUS) using perflubutane microbubbles (Sonazoid) in comparison with conventional B-mode ultrasonography (US) for the detection of hepatocellular carcinoma (HCC) nodules. METHODS:A tota...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-011-0512-9

    authors: Goto E,Masuzaki R,Tateishi R,Kondo Y,Imamura J,Goto T,Ikeda H,Akahane M,Shiina S,Omata M,Yoshida H,Koike K

    更新日期:2012-04-01 00:00:00

  • A case of AIDS-related hepatic Kaposi's sarcoma.

    abstract::In Japan, Kaposi's sarcoma (KS) is a very rare neoplasm. However, it does occur as one of the complications in patients with acquired immunodeficiency syndrome (AIDS). AIDS-related KS commonly involves the skin, lymph nodes, and gastrointestinal tract. Hepatic KS is sometimes observed in AIDS patients at autopsy, but ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02348677

    authors: Tanaka T,Masuda G,Takechi A,Kobayashi H,Tanaka S,Koike M,Hattori N

    更新日期:1995-04-01 00:00:00

  • JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study.

    abstract:BACKGROUND:The efficacy, safety, and pharmacokinetics of the combination of three direct-acting antiviral (DAA) agents (adafosbuvir [also known as AL-335], odalasvir, and simeprevir) were investigated in DAA treatment-naïve Japanese patients with genotype (GT)1 or GT2 chronic hepatitis C virus (HCV) infection, with or ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-020-01672-0

    authors: Takehara T,Chayama K,Kurosaki M,Yatsuhashi H,Tanaka Y,Hiramatsu N,Sakamoto N,Asahina Y,Nozaki A,Nakano T,Hagiwara Y,Shimizu H,Yoshida H,Huang Y,Biermer M,Vijgen L,Hayashi N

    更新日期:2020-06-01 00:00:00

  • Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in industrialized countries worldwide, and has become a serious public health issue not only in Western countries but also in many Asian countries including Japan. Within the wide spectrum of NAFLD, nonalcoholic steato...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,实务指引

    doi:10.1007/s00535-015-1050-7

    authors: Watanabe S,Hashimoto E,Ikejima K,Uto H,Ono M,Sumida Y,Seike M,Takei Y,Takehara T,Tokushige K,Nakajima A,Yoneda M,Saibara T,Shiota G,Sakaida I,Nakamuta M,Mizuta T,Tsubouchi H,Sugano K,Shimosegawa T,Japanese Society

    更新日期:2015-04-01 00:00:00

  • Dieulafoy's vascular malformation of the jejunum: first case report of laparoscopic treatment.

    abstract::A case of Dieulafoy's vascular malformation of the jejunum treated by laparoscopic surgery is described. The patient was a 31-year-old-woman who had complained of melena and had severe anemia needing blood transfusion. Angiography revealed microaneurysms and hypervascularity of the jejunum in the area between the firs...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-003-1305-6

    authors: Mino A,Ogawa Y,Ishikawa T,Uchima Y,Yamazaki M,Nakamura S,Yukawa T,Matsumoto T,Arakawa T,Hirakawa K

    更新日期:2004-01-01 00:00:00

  • IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis.

    abstract:BACKGROUND:In the respiratory mucosa, interleukin (IL)-33, has been shown to enhance T helper 2 (TH2)-type responses through the master regulatory gene GATA-3. IL-33 is upregulated in ulcerative colitis (UC), and the aim was to assess if IL-33 holds a similar key position in the shaping of the immune response in experi...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-014-0982-7

    authors: Seidelin JB,Coskun M,Kvist PH,Holm TL,Holgersen K,Nielsen OH

    更新日期:2015-02-01 00:00:00

  • Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer.

    abstract:BACKGROUND:Better diagnosis of metastatic disease has been pursued by oncologists: however, many of the tumor markers have been still controversial. Our purpose was to estimate the usefulness of soluble E-selectin and its ligand sialyl Lewis A for more accurate diagnosis as a combined tumor marker for metastases in col...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350170004

    authors: Ito K,Ye CL,Hibi K,Mitsuoka C,Kannagi R,Hidemura K,Ando H,Kasai Y,Akiyama S,Nakao A

    更新日期:2001-12-01 00:00:00

  • Effect of arterial administration of a high molecular weight anti-tumor agent, styrene maleic acid neocarzinostatin, for multiple small liver cancer--a pilot study.

    abstract::To assess the efficacy of the zinostatin derivative, the anti-tumor agent, styrene-maleic acid neocarzinostatin, in treating multiple small liver cancers, 29 patients with multiple hepatocellular carcinoma of 3 cm or less in diameter were treated with intraarterial injections of this high molecular weight agent, mixed...

    journal_title:Journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02934092

    authors: Ikeda K,Saitoh S,Suzuki Y,Tsubota A,Koida I,Kobayashi M,Arase Y,Chayama K,Murashima N,Kumada H

    更新日期:1997-08-01 00:00:00

  • Strain differences in the induction of intestinal metaplasia by X-irradiation in rats.

    abstract::Strain differences in the susceptibility of rats to induction of intestinal metaplasia by X-irradiation were examined. The gastric regions of 5-week-old males of five inbred strains of rats (F344/NSlc, Copenhagen, Buffalo/NacJcl, and ACI/NHos) and three strains of randomly bred rats (HOS:Donryu, Slc:Wistar, Slc:SD) we...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02934483

    authors: Watanabe H,Fujimoto N,Masaoka Y,Ohtaki M,Ito A

    更新日期:1997-06-01 00:00:00

  • Endoscopic diagnosis and treatment of esophageal adenocarcinoma: introduction of Japan Esophageal Society classification of Barrett's esophagus.

    abstract::Endoscopic surveillance of Barrett's esophagus has become a foundation of the management of esophageal adenocarcinoma (EAC). Surveillance for Barrett's esophagus commonly involves periodic upper endoscopy with biopsies of suspicious areas and random four-quadrant biopsies. However, targeted biopsies using narrow-band ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-018-1491-x

    authors: Ishihara R,Goda K,Oyama T

    更新日期:2019-01-01 00:00:00

  • Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: the STEATO Study.

    abstract:PURPOSE:Hepatic steatosis is frequently observed in subjects with metabolic syndrome (MS). In type 2 diabetics, it is independently associated with cardiovascular diseases. In order to confirm and extend this finding, a large group of patients with risk factors for atherosclerosis was studied. METHODS:Carotid atherosc...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-009-0125-8

    authors: Carallo C,Mancuso G,Mauro G,Laghi F,Madafferi B,Irace C,Gnasso A,Scavelli F,Dell'Aquila F,Bartone M,Gullo F,Ferraro M,Spagnuolo V,Belmonte M,Ferrara A,Silvano Rotondaro A,Brandolino N,Parasporo F,Scopelliti F

    更新日期:2009-01-01 00:00:00

  • The minimum pressure of the lower esophageal sphincter, determined by the rapid pull-through method, is an index of severe reflux esophagitis.

    abstract:BACKGROUND:Because of the wide overlap between the groups, patients with reflux esophagitis (RE) cannot be distinguished from healthy subjects by basal lower esophageal sphincter (LES) pressure. The LES has radial asymmetry, with maximum pressure on the left side. It has been noted that one directional LES pressure, de...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-003-1355-9

    authors: Iwakiri K,Hayashi Y,Kotoyori M,Sugiura T,Kawakami A,Sakamoto C

    更新日期:2004-07-01 00:00:00