Effect of arterial administration of a high molecular weight anti-tumor agent, styrene maleic acid neocarzinostatin, for multiple small liver cancer--a pilot study.

abstract：:Epidemiological studies of ulcerative colitis (UC) have been conducted once every year since 1973 in Japan. The number of participating hospitals in 1429 and they are distributed throughout Japan. A total number of 10819 patients diagnosed with UC have been registered, including 197 patients with a positive family his...

journal_title：Journal of gastroenterology

authors： Kitahora T,Utsunomiya T,Yokota A

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Only a few studies have longitudinally evaluated whether fatty pancreas increases the risk of type-2 diabetes (T2D), and their results were inconsistent. Fatty pancreas is closely linked to overweight and obesity, but previous studies did not exclude overweight or obese individuals. Therefore, in this cohort...

journal_title：Journal of gastroenterology

authors： Yamazaki H,Tauchi S,Wang J,Dohke M,Hanawa N,Kodama Y,Katanuma A,Saisho Y,Kamitani T,Fukuhara S,Yamamoto Y

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy is the current standard of care for patients with chronic hepatitis C. Determining precisely the risk of serious adverse events (SAEs) and mortality from a single study is rather difficult because of the infrequency of such events. The aim of this s...

journal_title：Journal of gastroenterology

authors： Minami T,Kishikawa T,Sato M,Tateishi R,Yoshida H,Koike K

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japan...

journal_title：Journal of gastroenterology

authors： Fuyuno Y,Yamazaki K,Takahashi A,Esaki M,Kawaguchi T,Takazoe M,Matsumoto T,Matsui T,Tanaka H,Motoya S,Suzuki Y,Kiyohara Y,Kitazono T,Kubo M

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is characterized by chronic inflammation in the colon and epigenetic factors underlying the occurrence. Circular RNAs (circRNAs) have been under intensive focus due to the circular construct and gene-regulating functions. However, the changes and roles of circRNAs in UC remain unknown...

journal_title：Journal of gastroenterology

authors： Wang T,Chen N,Ren W,Liu F,Gao F,Ye L,Han Y,Zhang Y,Liu Y

更新日期：2019-09-01 00:00:00

abstract：:Little data are available regarding the effects of hepatitis virus serostatus and the severity of coexisting chronic inflammation on intrahepatic recurrence after hepatectomy for hepatocellular carcinoma (HCC). We investigated the extent to which these factors modified the prognosis of hepatectomized patients. A total...

journal_title：Journal of gastroenterology

authors： Yamanaka N,Takada M,Tanaka T,Yamanaka J,Yasui C,Ando T,Maeda S,Matsushita K,Okamoto E

更新日期：2000-01-01 00:00:00

abstract：:We describe a gastric carcinoma cell line that has been maintained in vitro for more than 10 years and retains the capacity to produce a large amount of alpha-fetoprotein. This cell line was isolated from a metastatic lymph node of a 63-year-old male patient with advanced gastric carcinoma (T2N3P0H0M0) who showed high...

journal_title：Journal of gastroenterology

authors： Sekiguchi M,Fujii Y,Saito A,Suzuki T,Shiroko Y,Nakamura H,Hasumi K

更新日期：1995-10-01 00:00:00

abstract：:A 69-year-old woman was admitted to Hokuso Shiroi Hospital because of recurrent pain in the lower right side of the abdomen. Small-intestinal cancer was strongly suspected after fluoroscopy of the small intestine. Laparotomy showed advanced cancer of the ileum, of complete annular constrictive type, 9.5 x 5cm in size....

journal_title：Journal of gastroenterology

authors： Amano M,Imai Y,Hashimoto T,Saito Y,Miyaoka M,Kawaguchi M,Saito T

更新日期：1998-06-01 00:00:00

abstract：:Because most gastric cancers develop from a background of Helicobacter pylori-infected gastric mucosa, H. pylori plays an important role in gastric carcinogenesis. Therefore, eradication of H. pylori may inhibit the incidence of gastric cancers. In experimental studies, H. pylori eradication has proved to act as a pro...

journal_title：Journal of gastroenterology

authors： Kato M,Asaka M,Ono S,Nakagawa M,Nakagawa S,Shimizu Y,Chuma M,Kawakami H,Komatsu Y,Hige S,Takeda H

更新日期：2007-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in industrialized countries worldwide, and has become a serious public health issue not only in Western countries but also in many Asian countries including Japan. Within the wide spectrum of NAFLD, nonalcoholic steato...

journal_title：Journal of gastroenterology

authors： Watanabe S,Hashimoto E,Ikejima K,Uto H,Ono M,Sumida Y,Seike M,Takei Y,Takehara T,Tokushige K,Nakajima A,Yoneda M,Saibara T,Shiota G,Sakaida I,Nakamuta M,Mizuta T,Tsubouchi H,Sugano K,Shimosegawa T,Japanese Society

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The efficacy, safety, and pharmacokinetics of the combination of three direct-acting antiviral (DAA) agents (adafosbuvir [also known as AL-335], odalasvir, and simeprevir) were investigated in DAA treatment-naïve Japanese patients with genotype (GT)1 or GT2 chronic hepatitis C virus (HCV) infection, with or ...

journal_title：Journal of gastroenterology

authors： Takehara T,Chayama K,Kurosaki M,Yatsuhashi H,Tanaka Y,Hiramatsu N,Sakamoto N,Asahina Y,Nozaki A,Nakano T,Hagiwara Y,Shimizu H,Yoshida H,Huang Y,Biermer M,Vijgen L,Hayashi N

更新日期：2020-06-01 00:00:00

abstract：:Cytosolic phospholipase A2 (PLase A2) is activated by low Ca2+ concentrations and translocates from the cytosol to the cell membrane, releasing arachidonic acid; the arachidonic acid cascade then leads to the production of many inflammatory mediators. The aim of this study, accordingly, was to investigate the role of ...

journal_title：Journal of gastroenterology

authors： Morita H,Nakanishi K,Dohi T,Yasugi E,Oshima M

更新日期：1999-02-01 00:00:00

abstract：:We report a case of gastric neuroendocrine (NE) carcinoma associated with chronic atrophic gastritis type A (CAG/A) or reversed atrophic type gastritis. A 9 x 6 cm tumor was resected from the stomach to control pain in a 55-year-old Japanese woman with peritoneal dissemination and metastatic tumors of the liver and ov...

journal_title：Journal of gastroenterology

authors： Kaizaki Y,Fujii T,Kawai T,Saito K,Kurihara K,Fukayama M

更新日期：1997-10-01 00:00:00

abstract：:Combined hepatocellular (HCC) and cholangiocellular carcinoma (CCC) (mixed carcinoma) is a rare subtype of primary hepatic carcinoma. We report a case of mixed carcinoma that developed in a non-cirrhotic liver, in a patient who was serologically negative for both hepatitis B and C viruses. A 65-year-old Japanese woman...

journal_title：Journal of gastroenterology

authors： Shiraishi M,Takushi Y,Simoji H,Oshiro T,Shinzato S,Tanigawa N,Kusano T,Muto Y

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Superior mesenteric artery syndrome (SMAS) is caused by compression of the third part of the duodenum between the superior mesenteric artery and the aorta. It occurs most frequently in patients with rapid weight loss. METHODS:We report two young patients, who each presented with a longstanding history of po...

journal_title：Journal of gastroenterology

authors： Lippl F,Hannig C,Weiss W,Allescher HD,Classen M,Kurjak M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:To further clarify the clinico-epidemiological features of autoimmune pancreatitis (AIP) in Japan, we conducted the fourth nationwide epidemiological survey. METHODS:This study consisted of two stage surveys; the number of AIP patients was estimated by the first survey and their clinical features were asses...

journal_title：Journal of gastroenterology

authors： Masamune A,Kikuta K,Hamada S,Tsuji I,Takeyama Y,Shimosegawa T,Okazaki K,Collaborators.

更新日期：2020-04-01 00:00:00

abstract：:Although stomal varices are a rare complication, bleeding stomal varices often need to be treated owing to symptoms of hypovolemic shock, recurrence of stomal bleeding, or deterioration in the quality of life. Various treatment strategies for the management of bleeding stomal varices have thus far been reported. We re...

journal_title：Journal of gastroenterology

authors： Minami S,Okada K,Matsuo M,Kamohara Y,Sakamoto I,Kanematsu T

更新日期：2007-01-01 00:00:00

abstract：:To evaluate the diagnostic utility of blood biochemical parameters in assessing degree of hepatic fibrosis, serum levels of aminoterminal type III procollagen peptide (P III P), type IV collagen (IV-collagen), 7S domain of type IV collagen (7S-collagen), and hyaluronan (HA) were measured in 54 patients with chronic vi...

journal_title：Journal of gastroenterology

authors： Takamatsu S,Nakabayashi H,Okamoto Y,Nakano H

更新日期：1997-06-01 00:00:00

abstract：:A rare case of simple ulcer of the colon in a 7-year-old girl is reported. Simple ulcer is clinically and pathologically recognized as a serious disease linked to intestinal Behcet's disease. Recently, some immunomodulators, such as thalidomide and antitumor necrosis factor monoclonal antibody, have been used to treat...

journal_title：Journal of gastroenterology

authors： Kasahara E,Yamagishi N,Tanaka M,Yashiro K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Hereditary pancreatitis (HP) is a rare cause of chronic pancreatitis. We here report a nationwide survey to clarify the epidemiological, genetic, and clinical features of HP in Japan. METHODS:Target subjects were patients with HP and their family members who had visited selected hospitals between 2005 and 2...

journal_title：Journal of gastroenterology

authors： Masamune A,Kikuta K,Hamada S,Nakano E,Kume K,Inui A,Shimizu T,Takeyama Y,Nio M,Shimosegawa T

更新日期：2018-01-01 00:00:00

abstract：:Progressive familial intrahepatic cholestasis (PFIC) syndromes are characterized by defects in transporters of conjugated bile acids into the bile canaliculus. Three genes (ATP8B1, ABCB11, ABCB4) are associated with the different forms, but no easy genotype-phenotype correlations help in the prioritization for gene te...

journal_title：Journal of gastroenterology

authors： Nobili V,Di Giandomenico S,Francalanci P,Callea F,Marcellini M,Santorelli FM

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Vedolizumab is a gut-selective humanized antibody that binds the α4β7 integrin. We evaluated efficacy and safety of vedolizumab in Japanese patients with moderate-to-severe Crohn's disease (CD). METHODS:In this Phase 3, double-blind study (NCT02038920), 157 patients were randomized to receive intravenous ve...

journal_title：Journal of gastroenterology

authors： Watanabe K,Motoya S,Ogata H,Kanai T,Matsui T,Suzuki Y,Shikamura M,Sugiura K,Oda K,Hori T,Araki T,Watanabe M,Hibi T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Fatty liver is an important clinical feature not only in alcoholic and non-alcoholic fatty liver diseases, but in other chronic liver diseases as well. Our aim was to elucidate the effect and relationship between habitual alcohol intake and obesity in the development of fatty liver disease. METHODS:We enrol...

journal_title：Journal of gastroenterology

authors： Takahashi H,Ono M,Hyogo H,Tsuji C,Kitajima Y,Ono N,Eguchi T,Fujimoto K,Chayama K,Saibara T,Anzai K,Eguchi Y

更新日期：2015-11-01 00:00:00

abstract：:This study aimed to investigate sex differences in relation to hepatitis B e antigen (HBeAg) and serum alanine aminotransferase (ALT) levels in chronic asymptomatic hepatitis B virus (HBV) infection. HBeAg and ALT level were determined in 636 asymptomatic hepatitis B surface antigen carriers. There was no significant ...

journal_title：Journal of gastroenterology

authors： Tsai JF,Chuang LY,Jeng JE,Ho MS,Lin ZY,Hsieh MY,Wang LY,Tsai JH

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:We carried out this study to evaluate recent clinical features of Wilson's disease (WD) with hepatic presentation, especially in terms of age, degree of liver injury, and association with hepatocellular carcinoma (HCC). METHODS:Sixteen patients with hepatic manifestations were diagnosed with WD in the perio...

journal_title：Journal of gastroenterology

authors： Kumagi T,Horiike N,Michitaka K,Hasebe A,Kawai K,Tokumoto Y,Nakanishi S,Furukawa S,Hiasa Y,Matsui H,Kurose K,Matsuura B,Onji M

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Alcohol-related diseases have multiple and varied associations with acetaldehyde, a highly toxic product of ethanol oxidation that accumulates in the absence of active aldehyde dehydrogenase (ALDH). This study was designed to clarify the role of acetaldehyde in liver injury, specifically in vivo and in vitro...

journal_title：Journal of gastroenterology

authors： Nakamura Y,Yokoyama H,Higuchi S,Hara S,Kato S,Ishii H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Once-daily, orally administered, co-formulated glecaprevir (NS3/4A protease inhibitor) and pibrentasvir (NS5A inhibitor) (G/P) demonstrated pangenotypic activity and high sustained virologic response (SVR) rates in studies outside Japan. Here we report safety and efficacy in a subset of Japanese patients wit...

journal_title：Journal of gastroenterology

authors： Kumada H,Watanabe T,Suzuki F,Ikeda K,Sato K,Toyoda H,Atsukawa M,Ido A,Takaki A,Enomoto N,Kato K,Alves K,Burroughs M,Redman R,Pugatch D,Pilot-Matias TJ,Krishnan P,Oberoi RK,Xie W,Chayama K

更新日期：2018-04-01 00:00:00

abstract：:We aimed to determine the safety and feasibility of an alternative postoperative oral intake protocol for Japanese patients who had had oncological colorectal surgery, with the goal of shortening the length of postoperative stay to the same level as that in Western countries. The subjects of the study were 42 consecut...

journal_title：Journal of gastroenterology

authors： Kawamura YJ,Uchida H,Watanabe T,Nagawa H

更新日期：2000-01-01 00:00:00

abstract：:Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases such as inflammatory bowel disease (IBD). The development of next-generation sequencing technology allows th...

journal_title：Journal of gastroenterology

authors： Kanai T,Mikami Y,Hayashi A

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:We investigated the effects of rabeprazole compared with those of omeprazole on enterochromaffin-like cells and parietal cells in rats. METHODS:Rabeprazole or omeprazole was administered for 7 days by intraperitoneal injection (100 mg/kg or 20mg/kg once a day) and the serum gastrin concentration, the antral...

journal_title：Journal of gastroenterology

authors： Tari A,Kawano M,Kodama K,Yonei Y,Okahara S,Haruma K,Sumii K,Kajiyama G

更新日期：2002-01-01 00:00:00