Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV) often recurs after surgical or medical treatment. METHODS:Eighty consecutive patients with HBV-positive cirrhosis and HCC who underwent potentially curative ablation for HCC were analyzed. Eleven patients received long-term interferon (IFN) th...

journal_title：Journal of gastroenterology

authors： Someya T,Ikeda K,Saitoh S,Kobayashi M,Hosaka T,Sezaki H,Akuta N,Suzuki F,Suzuki Y,Arase Y,Kumada H

更新日期：2006-12-01 00:00:00

abstract：:Neuroendocrine tumors (NETs) [carcinoids, pancreatic neuroendocrine tumors (pNETs)] are becoming an increasing clinical problem because not only are they increasing in frequency, but they can frequently present with advanced disease that requires diagnostic and treatment approaches different from those used in the neo...

journal_title：Journal of gastroenterology

authors： Ito T,Igarashi H,Jensen RT

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The remnant stomach corresponds to the gastric cardia, but is exposed to a completely different environment. The present study was performed to investigate the role of Epstein-Barr virus (EBV) infection in patients with gastric remnant carcinoma (GRC). METHODS:Clinicopathological features, gastritis, and in...

journal_title：Journal of gastroenterology

authors： Kaizaki Y,Hosokawa O,Sakurai S,Fukayama M

更新日期：2005-06-01 00:00:00

abstract：:Nonrotation of the midgut in adults and appendiceal mucocele are both rare pathological conditions. We report here the first case of nonrotation of the midgut associated with appendiceal mucocele. The patient was a 51-year-old man admitted to hospital with ileus. An upper gastrointestinal series and a barium enema rev...

journal_title：Journal of gastroenterology

authors： Kawashima K,Ishihara S,Amano K,Hirakawa K,Adachi K,Fukuda R,Sumi S,Watanabe M,Kinoshita Y

更新日期：2001-01-01 00:00:00

abstract：:Inflammatory cells in the gastric epithelium and direct cell damage are important effects of H. pylori infection in causing gastroduodenal diseases. The aim of this study was to determine whether H. Pylori possessing the cagA gene and vacuolating cytotoxin activity (cagA+/tox+) has these toxigenicities. The detection ...

journal_title：Journal of gastroenterology

authors： Kodama K,Fujioka T,Ito A,Kodama R,Nasu M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori induces chronic inflammation and intestinal metaplasia (IM) through genetic and epigenetic changes and activation of intracellular signaling pathways that contribute to gastric carcinogenesis. However, the precise mechanism of IM in gastric carcinogenesis has not been fully elucidated. We...

journal_title：Journal of gastroenterology

authors： Sue S,Shibata W,Kameta E,Sato T,Ishii Y,Kaneko H,Miwa H,Sasaki T,Tamura T,Kondo M,Maeda S

更新日期：2016-10-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) findings in three patients with primary anorectal malignant melanoma are described. Two patients had melanotic and one had amelanotic anorectal melanoma. The findings of MRI with a pelvic coil and an endorectal coil were consistent with pathologic findings. MRI with a pelvic coil demon...

journal_title：Journal of gastroenterology

authors： Matsuoka H,Nakamura A,Iwamoto K,Sugiyama M,Hachiya J,Atomi Y,Masaki T

更新日期：2005-08-01 00:00:00

abstract：:Asia has intermediate-to-high prevalence and high morbidity of hepatitis B virus (HBV) infection. The use of guideline-recommended nucleos(t)ide analogs with high barrier to resistance, such as entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF), is one of the key interventions for cu...

journal_title：Journal of gastroenterology

authors： Charlton MR,Alam A,Shukla A,Dashtseren B,Lesmana CRA,Duger D,Payawal DA,Duy Cuong D,Jargalsaikhan G,Cua IHY,Sollano JD,Singh KR,Madan K,Win KM,Kyi KP,Tun KS,Salih M,Rastogi M,Saraf N,Thuy PTT,Hien PTD,Gani RA,

更新日期：2020-09-01 00:00:00

abstract：:A patient with familial adenomatous polyposis (FAP) presented with a relapsing attack of acute pancreatitis. Evaluation using computed tomography, ultrasonography, and duodenoscopy revealed an ampullary adenoma, which was classified as Spigelman's stage III according to Spigelman's criteria. The patient underwent a py...

journal_title：Journal of gastroenterology

authors： Murakami Y,Uemura K,Hayashidani Y,Sudo T,Sueda T

更新日期：2006-08-01 00:00:00

abstract：:An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all were involved in the fina...

journal_title：Journal of gastroenterology

authors： Unge P

更新日期：1998-01-01 00:00:00

abstract：:Cytosolic phospholipase A2 (PLase A2) is activated by low Ca2+ concentrations and translocates from the cytosol to the cell membrane, releasing arachidonic acid; the arachidonic acid cascade then leads to the production of many inflammatory mediators. The aim of this study, accordingly, was to investigate the role of ...

journal_title：Journal of gastroenterology

authors： Morita H,Nakanishi K,Dohi T,Yasugi E,Oshima M

更新日期：1999-02-01 00:00:00

abstract：:Focal nodular hyperplasia (FNH) of the liver is a rare benign lesion that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Currently, the natural history of the disease remains largely unknown. We present a patient with FNH of the liver who was followed up for 4 years. A 22-yea...

journal_title：Journal of gastroenterology

authors： Ohmoto K,Honda T,Hirokawa M,Mitsui Y,Iguchi Y,Kuboki M,Yamamoto S

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Vedolizumab is a gut-selective humanized antibody that binds the α4β7 integrin. We evaluated efficacy and safety of vedolizumab in Japanese patients with moderate-to-severe Crohn's disease (CD). METHODS:In this Phase 3, double-blind study (NCT02038920), 157 patients were randomized to receive intravenous ve...

journal_title：Journal of gastroenterology

authors： Watanabe K,Motoya S,Ogata H,Kanai T,Matsui T,Suzuki Y,Shikamura M,Sugiura K,Oda K,Hori T,Araki T,Watanabe M,Hibi T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Photodynamic therapy (PDT) has not been reported for human hepatoma, because cancer cells only weakly take up the photosensitizer. Indocyanine green (ICG) is a photosensitizer normally excreted into the bile, and bile excretion is impaired in human hepatomas. We examined whether human hepatoma cell lines pre...

journal_title：Journal of gastroenterology

authors： Kaneko J,Inagaki Y,Ishizawa T,Gao J,Tang W,Aoki T,Sakamoto Y,Hasegawa K,Sugawara Y,Kokudo N

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In Japan, there are few studies of long-term (more than 1 month) interferon (IFN) therapy for chronic hepatitis B (CHB). In this retrospective study, we investigated the efficacy and predictors of response to 6-month IFN therapy. METHODS:We analyzed 66 Japanese patients with CHB who were treated with IFN fo...

journal_title：Journal of gastroenterology

authors： Suzuki F,Arase Y,Akuta N,Tsubota A,Suzuki Y,Sezaki H,Hosaka T,Someya T,Kobayashi M,Saitoh S,Ikeda K,Kobayashi M,Matsuda M,Satoh J,Kumada H

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Fatty liver is an important clinical feature not only in alcoholic and non-alcoholic fatty liver diseases, but in other chronic liver diseases as well. Our aim was to elucidate the effect and relationship between habitual alcohol intake and obesity in the development of fatty liver disease. METHODS:We enrol...

journal_title：Journal of gastroenterology

authors： Takahashi H,Ono M,Hyogo H,Tsuji C,Kitajima Y,Ono N,Eguchi T,Fujimoto K,Chayama K,Saibara T,Anzai K,Eguchi Y

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:In Japan, generally, patients with chronic hepatitis C are aged. The aim of this study was to investigate the effect of interferon (IFN) therapy on the mortality of chronic hepatitis C patients over age 60. METHODS:Seven-hundred and seven patients with histologically proven chronic hepatitis C were enrolled...

journal_title：Journal of gastroenterology

authors： Imai Y,Kasahara A,Tanaka H,Okanoue T,Hiramatsu N,Tsubouchi H,Yoshioka K,Kawata S,Tanaka E,Hino K,Hayashi K,Tamura S,Itoh Y,Sasaki Y,Kiyosawa K,Kakumu S,Okita K,Hayashi N

更新日期：2004-11-01 00:00:00

abstract：:One complication of choledochal cyst in adulthood is the development of secondary carcinoma, usually well-differentiated adenocarcinoma. We report a case of extrahepatic bile duct carcinoma associated with choledochal cyst and presenting predominantly sarcomatous features. The patient was a 52-year-old female who pres...

journal_title：Journal of gastroenterology

authors： Nonomura A,Mizukami Y,Matsubara F,Ueda H

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Gastric marker mucins (MUC5AC and MUC6) and intestinal marker molecules (MUC2 and CD10) have been used to determine the cell lineage of epithelial cell of gastric carcinoma (GC). METHODS:To clarify the characteristics of Epstein-Barr virus (EBV)-associated GC, 18 cases were immunohistochemically evaluated a...

journal_title：Journal of gastroenterology

authors： Barua RR,Uozaki H,Chong JM,Ushiku T,Hino R,Chang MS,Nagai H,Fukayama M

更新日期：2006-08-01 00:00:00

abstract：:Preoperative biliary drainage (PBD) has been thought to be preferable regardless of the site of biliary strictures, e.g., distal or proximal strictures because PBD by endoscopy or interventional radiology decreases postoperative mortality and morbidity rates. However, recently, several studies have revealed that PBD s...

journal_title：Journal of gastroenterology

authors： Umeda J,Itoi T

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:It remains unknown whether the Rome III criteria can exclude organic colonic lesions prior to the diagnosis of irritable bowel syndrome (IBS). We evaluated the colonoscopy results of patients meeting the Rome III criteria for the diagnosis of IBS to determine the presence of organic colonic lesions. METHODS...

journal_title：Journal of gastroenterology

authors： Ishihara S,Yashima K,Kushiyama Y,Izumi A,Kawashima K,Fujishiro H,Kojo H,Komazawa Y,Hamamoto T,Yamamoto T,Sasaki Y,Shimizu T,Okamoto E,Yoshimura T,Furuta K,Noguchi N,Tanaka H,Murawaki Y,Kinoshita Y

更新日期：2012-10-01 00:00:00

abstract：:Electronic endoscopy, developed in 1983, enables the endoscopic image to be transmitted through electric signals that can be easily processed by computer. An electronic endoscope is composed of three vital parts, i.e., a charge-coupled device (CCD) that converts the image to electric signals, a video processor that co...

journal_title：Journal of gastroenterology

authors： Fujino MA,Morozumi A,Nakamura T,Kojima Y,Kawai T,Sato T,Kubo K,Ohtsuka H,Otaka M,Yamamoto Y

更新日期：1994-07-01 00:00:00

abstract：:The purpose of the present study was to elucidate the effect of hepatic reflow following ischemia on the remnant liver after hepatectomy with occluded hepatic blood inflow in dogs with obstructive jaundice. When 40% hepatectomy was performed with 10-min occlusion of hepatic blood inflow in dogs with obstructive jaundi...

journal_title：Journal of gastroenterology

authors： Ogura Y,Takagi K,Kawarada Y,Mizumoto R

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:There have only been a few prospective studies investigating risk factors associated with the development of hepatocellular carcinoma (HCC) among chronic hepatitis B patients all over the world, and no study has been conducted in Japanese population. METHODS:A population-based cohort consisting of 19393 sub...

journal_title：Journal of gastroenterology

authors： Kusakabe A,Tanaka Y,Inoue M,Kurbanov F,Tatematsu K,Nojiri S,Joh T,Tsugane S,Mizokami M

更新日期：2011-01-01 00:00:00

abstract：:Both reflex and sensory mechanisms control the function of the stomach, and disturbances in these mechanisms may explain the pathophysiology of disorders of gastric function. The objective of this report is to perform a literature-based critical analysis of new, relevant or conflicting information on gastric sensitivi...

journal_title：Journal of gastroenterology

authors： Azpiroz F,Feinle-Bisset C,Grundy D,Tack J

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:Recent routine testing for liver function and anti-mitochondrial antibodies has increased the number of newly diagnosed patients with primary biliary cirrhosis (PBC). This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC pat...

journal_title：Journal of gastroenterology

authors： Kubota J,Ikeda F,Terada R,Kobashi H,Fujioka S,Okamoto R,Baba S,Morimoto Y,Ando M,Makino Y,Taniguchi H,Yasunaka T,Miyake Y,Iwasaki Y,Yamamoto K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Liver histology is the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH). Noninvasive, simple, reproducible, and reliable biomarkers are greatly needed to differentiate NASH from nonalcoholic fatty liver disease (NAFLD). METHODS:To construct a scoring system for predicting NASH, 177 Jap...

journal_title：Journal of gastroenterology

authors： Sumida Y,Yoneda M,Hyogo H,Yamaguchi K,Ono M,Fujii H,Eguchi Y,Suzuki Y,Imai S,Kanemasa K,Fujita K,Chayama K,Yasui K,Saibara T,Kawada N,Fujimoto K,Kohgo Y,Okanoue T,Japan Study Group of Nonalcoholic Fatty Liver Disease

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Vaniprevir is a potent macrocyclic hepatitis C virus (HCV) nonstructural protein 3/4A protease inhibitor. This phase III study evaluated the safety and efficacy of vaniprevir in combination with peginterferon alfa-2b and ribavirin (PR) for 24 weeks compared with PR alone for 48 weeks in treatment-naive Japan...

journal_title：Journal of gastroenterology

authors： Hayashi N,Nakamuta M,Takehara T,Kumada H,Takase A,Howe AY,Ludmerer SW,Mobashery N

更新日期：2016-04-01 00:00:00

abstract：:We assessed the influence of epidermal growth factor (EGF) and insulin on gastric epithelial restoration in vitro. Rabbit gastric epithelial cells were cultured and formed a complete monolayer cell sheet in 2 days. We created a wound (1.8 +/- 0.05 mm2) by denuding an area of cells, and EGF (0.1-30 ng/ml) and/or insuli...

journal_title：Journal of gastroenterology

authors： Maehiro K,Watanabe S,Hirose M,Iwazaki R,Miwa H,Sato N

更新日期：1997-10-01 00:00:00

abstract：:Eosinophilic esophagitis (EE) is a rarely diagnosed condition involving eosinophilic infiltration of the esophageal mucosa. Here we present a case of EE in a 69-year-old Japanese man, who presented with abdominal pain, appetite loss, and a history of bronchial asthma. Laboratory findings included peripheral eosinophil...

journal_title：Journal of gastroenterology

authors： Furuta K,Adachi K,Kowari K,Mishima Y,Imaoka H,Kadota C,Koshino K,Miyake T,Kadowaki Y,Furuta K,Kazumori H,Sato S,Ishihara S,Amano Y,Honda M,Kinoshita Y

更新日期：2006-07-01 00:00:00