Acetaldehyde accumulation suppresses Kupffer cell release of TNF-Alpha and modifies acute hepatic inflammation in rats.

abstract：BACKGROUND:The model for end-stage liver disease (MELD) is useful for assessing the recipients of liver transplants, namely, deceased-donor transplantation. The application of MELD for living donor liver transplantation (LDLT) is under investigation. Thus, the aim of this study was to analyze the impact of the MELD sco...

journal_title：Journal of gastroenterology

authors： Kogure T,Ueno Y,Kawagishi N,Kanno N,Yamagiwa Y,Fukushima K,Satomi S,Shimosegawa T

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Musashi-1 (Msi-1) is a RNA-binding protein, known as a putative marker of intestinal stem cells (ISCs). However, little is known about the function of Msi-1 within human intestinal epithelial cells (IECs). Thus, the present study aimed to clarify the role of Msi-1 in differentiation and proliferation of IECs...

journal_title：Journal of gastroenterology

authors： Murayama M,Okamoto R,Tsuchiya K,Akiyama J,Nakamura T,Sakamoto N,Kanai T,Watanabe M

更新日期：2009-01-01 00:00:00

abstract：:Asia has intermediate-to-high prevalence and high morbidity of hepatitis B virus (HBV) infection. The use of guideline-recommended nucleos(t)ide analogs with high barrier to resistance, such as entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF), is one of the key interventions for cu...

journal_title：Journal of gastroenterology

authors： Charlton MR,Alam A,Shukla A,Dashtseren B,Lesmana CRA,Duger D,Payawal DA,Duy Cuong D,Jargalsaikhan G,Cua IHY,Sollano JD,Singh KR,Madan K,Win KM,Kyi KP,Tun KS,Salih M,Rastogi M,Saraf N,Thuy PTT,Hien PTD,Gani RA,

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a common cancer type in China. In this study, we aimed to develop aneuploidy markers for diagnosis and prognosis of ESCC. METHODS:Chromosomal aneuploidies were detected in 493 primary tumors and 61 precancerous lesions by fluorescence in situ hybridization with c...

journal_title：Journal of gastroenterology

authors： Hao JJ,Yao HQ,Dai GY,Kang W,Jia XM,Xu X,Cai Y,Zhan QM,Wang GQ,Wang MR

更新日期：2015-02-01 00:00:00

abstract：:IL-22 is a relatively new cytokine that is characterized by several unique biological properties. In the intestines, the effect of IL-22 is restricted mainly to non-lymphoid cells such as epithelial cells. Interestingly, the expression pattern and major cellular source of IL-22 have distinct difference between large a...

journal_title：Journal of gastroenterology

authors： Mizoguchi A,Yano A,Himuro H,Ezaki Y,Sadanaga T,Mizoguchi E

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Superior mesenteric artery syndrome (SMAS) is caused by compression of the third part of the duodenum between the superior mesenteric artery and the aorta. It occurs most frequently in patients with rapid weight loss. METHODS:We report two young patients, who each presented with a longstanding history of po...

journal_title：Journal of gastroenterology

authors： Lippl F,Hannig C,Weiss W,Allescher HD,Classen M,Kurjak M

更新日期：2002-01-01 00:00:00

abstract：:Soft drinks containing dietary fiber are popular in Japan. There seem to be two types, one containing polydextrose and the other, oligosaccharide. These beverages are claimed to be useful for constipation or obesity, but data are scanty. We examined four such fiber-containing beverages [Fibe-mini Otsuka Pharmaceutical...

journal_title：Journal of gastroenterology

authors： Kondo T,Nakae Y

更新日期：1996-10-01 00:00:00

abstract：:Fulminant hepatic failure (FHF) usually has a fatal prognosis without liver transplantation. We describe the case of a woman who developed FHF, and was evaluated as a candidate for liver transplantation, but who was cured without transplantation through intensive medical care that included glucagon-insulin therapy, me...

journal_title：Journal of gastroenterology

authors： Masuhara M,Yagawa T,Aoyagi M,Suzuki C,Sakaguchi E,Segawa M,Hironaka K,Kayano K,Tamura F,Seguchi M,Soejima Y,Murakami F,Sakaida I,Tateishi A,Fukumoto Y,Okita K

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:In Japan, there are few studies of long-term (more than 1 month) interferon (IFN) therapy for chronic hepatitis B (CHB). In this retrospective study, we investigated the efficacy and predictors of response to 6-month IFN therapy. METHODS:We analyzed 66 Japanese patients with CHB who were treated with IFN fo...

journal_title：Journal of gastroenterology

authors： Suzuki F,Arase Y,Akuta N,Tsubota A,Suzuki Y,Sezaki H,Hosaka T,Someya T,Kobayashi M,Saitoh S,Ikeda K,Kobayashi M,Matsuda M,Satoh J,Kumada H

更新日期：2004-10-01 00:00:00

abstract：:Involvement of the gastroduodenum is extremely rare in Crohn's disease. For obstructing duodenal Crohn's disease, bypass procedures have traditionally been selected. However, more recently, strictureplasty has become an acceptable surgical option. We treated two Crohn's disease patients with short proximal duodenal st...

journal_title：Journal of gastroenterology

authors： Takesue Y,Yokoyama T,Akagi S,Ohge H,Murakami Y,Imamura Y,Uemura K,Kanehiro T,Matsuura Y

更新日期：2000-12-01 00:00:00

abstract：:A 21-year-old man with diarrhea and edema was admitted to our hospital and diagnosed with protein-losing enteropathy caused by primary intestinal lymphangiectasia. He was placed, in turn, on a low-fat diet, an elemental diet, and, subsequently, fasting therapy with total parenteral nutrition (TPN) support. However, hi...

journal_title：Journal of gastroenterology

authors： Kuroiwa G,Takayama T,Sato Y,Takahashi Y,Fujita T,Nobuoka A,Kukitsu T,Kato J,Sakamaki S,Niitsu Y

更新日期：2001-02-01 00:00:00

abstract：:We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonograp...

journal_title：Journal of gastroenterology

authors： Murakami T,Imai A,Nakamura H,Tsuda K,Kanai T,Wakasa K

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:The dynamic change in gastric emptying on a minute-by-minute basis (gastric velocity) is evaluated by the 13C-octanoate breath test with deconvolution analysis. However, deconvolution is impractical, because it requires dual experiments to obtain 13CO2 excretion profiles following intraduodenal and oral admi...

journal_title：Journal of gastroenterology

authors： Sanaka M,Yamamoto T,Osaki Y,Kuyama Y

更新日期：2006-07-01 00:00:00

abstract：:We report a case of primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap syndrome with concurrent idiopathic thrombocytopenic purpura (ITP) and Hashimoto's disease with positivity for anticentromere antibody. The patient was a 64-year-old woman with symptoms of jaundice and general fatigue. About 30 year...

journal_title：Journal of gastroenterology

authors： Arakawa Y,Amaki S,Miyakawa H,Sakai T,Gotou I,Tanaka N,Moriyama M,Iwasaki A,Sugitani M,Arakawa Y

更新日期：2004-01-01 00:00:00

abstract：:Neuroendocrine tumors (NETs) [carcinoids, pancreatic neuroendocrine tumors (pNETs)] are becoming an increasing clinical problem because not only are they increasing in frequency, but they can frequently present with advanced disease that requires diagnostic and treatment approaches different from those used in the neo...

journal_title：Journal of gastroenterology

authors： Ito T,Igarashi H,Jensen RT

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:We carried out this study to evaluate the association between regulatory T cells (Treg) and prognosis and progression after cryoablation in patients with hepatitis-B virus-related hepatocellular carcinoma. METHODS:Peripheral Treg frequency in 111 patients with hepatocellular carcinoma (HCC) was detected by ...

journal_title：Journal of gastroenterology

authors： Zhou L,Fu JL,Lu YY,Fu BY,Wang CP,An LJ,Wang XZ,Zeng Z,Zhou CB,Yang YP,Wang FS

更新日期：2010-09-01 00:00:00

abstract：:To evaluate the diagnostic utility of blood biochemical parameters in assessing degree of hepatic fibrosis, serum levels of aminoterminal type III procollagen peptide (P III P), type IV collagen (IV-collagen), 7S domain of type IV collagen (7S-collagen), and hyaluronan (HA) were measured in 54 patients with chronic vi...

journal_title：Journal of gastroenterology

authors： Takamatsu S,Nakabayashi H,Okamoto Y,Nakano H

更新日期：1997-06-01 00:00:00

abstract：:We estimated the levels of free sialic acid and sialylated oligosaccharides excreted in the urine of normal donors (n = 10) and patients with gastric cancer (n = 6) and colorectal cancer (n = 4). The total sialic acid level in cancer patients was similar to that in normal donors. However, the ratios of glycosidically ...

journal_title：Journal of gastroenterology

authors： Shimada I,Shoji M,Futatsuya R,Katoh T,Kominato Y,Sakamoto T,Fujikura T

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Although it is less frequently encountered, mesenteric vein occlusion poses as important a problem as mesenteric artery occlusion. The energy metabolism of intestinal tissue during venous occlusion and reperfusion was studied. METHODS:Male Wistar rats were studied in four groups of 17 animals each. Intestin...

journal_title：Journal of gastroenterology

authors： Kimura M,Kataoka M,Kuwabara Y,Sato A,Sugiura M,Fujii Y

更新日期：2003-01-01 00:00:00

abstract：:Electronic endoscopy, developed in 1983, enables the endoscopic image to be transmitted through electric signals that can be easily processed by computer. An electronic endoscope is composed of three vital parts, i.e., a charge-coupled device (CCD) that converts the image to electric signals, a video processor that co...

journal_title：Journal of gastroenterology

authors： Fujino MA,Morozumi A,Nakamura T,Kojima Y,Kawai T,Sato T,Kubo K,Ohtsuka H,Otaka M,Yamamoto Y

更新日期：1994-07-01 00:00:00

abstract：:In this study, we used magnetic resonance (MR) imaging to measure portal blood flow in 12 healthy controls and 17 cirrhotics while they were breath-holding after inspiration and after expiration. We then compared the results with measurements made during normal respiration in the healthy controls and cirrhotics. Blood...

journal_title：Journal of gastroenterology

authors： Sugano S,Yamamoto K,Sasao K,Watanabe M

更新日期：1999-10-01 00:00:00

abstract：:Small bowel transit time (SBTT) in 15 young and 13 elderly women was assessed by measuring breath hydrogen concentrations after they had consumed a solid test meal. The meal consisted of 200 g cooked rice, 50 ml miso (made from fermented soy bean curd) soup, a boiled egg, and 95.5 g of cooked soy beans with mixed vege...

journal_title：Journal of gastroenterology

authors： Kagaya M,Iwata N,Toda Y,Nakae Y,Kondo T

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:The search is on to find more effective drug regimens for patients with severe ulcerative colitis, as conventional drugs such as sulfasalazine and its congeners fail to prevent relapse in a significant number of patients. Azathioprine has also been reported to be useful as a steroid-sparing drug in patients ...

journal_title：Journal of gastroenterology

authors： Sood A,Kaushal V,Midha V,Bhatia KL,Sood N,Malhotra V

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Intestinal Behçet's disease (BD) is very rare, and epidemiologic data regarding BD are scarce. Moreover, there have been no population-based studies focusing on intestinal BD. We conducted a nationwide population-based study to examine the incidence and clinical course of Korean patients with intestinal BD. ...

journal_title：Journal of gastroenterology

authors： Han M,Jung YS,Kim WH,Cheon JH,Park S

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Vedolizumab is a gut-selective humanized antibody that binds the α4β7 integrin. We evaluated efficacy and safety of vedolizumab in Japanese patients with moderate-to-severe Crohn's disease (CD). METHODS:In this Phase 3, double-blind study (NCT02038920), 157 patients were randomized to receive intravenous ve...

journal_title：Journal of gastroenterology

authors： Watanabe K,Motoya S,Ogata H,Kanai T,Matsui T,Suzuki Y,Shikamura M,Sugiura K,Oda K,Hori T,Araki T,Watanabe M,Hibi T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Interferon (IFN)-based therapy has been reported to reduce the liver-related mortality rate in patients with chronic hepatitis C virus (HCV) infection. However, predictors of survival and causes of death, including non-liver-related causes, have not been sufficiently investigated in chronic HCV patients who ...

journal_title：Journal of gastroenterology

authors： Tada T,Kumada T,Toyoda H,Kiriyama S,Tanikawa M,Hisanaga Y,Kanamori A,Kitabatake S,Yama T,Tanaka J

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Hepatic steatosis is frequently observed in subjects with metabolic syndrome (MS). In type 2 diabetics, it is independently associated with cardiovascular diseases. In order to confirm and extend this finding, a large group of patients with risk factors for atherosclerosis was studied. METHODS:Carotid atherosc...

journal_title：Journal of gastroenterology

authors： Carallo C,Mancuso G,Mauro G,Laghi F,Madafferi B,Irace C,Gnasso A,Scavelli F,Dell'Aquila F,Bartone M,Gullo F,Ferraro M,Spagnuolo V,Belmonte M,Ferrara A,Silvano Rotondaro A,Brandolino N,Parasporo F,Scopelliti F

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Studies on the risk of osteoporotic fractures related to the use of proton pump inhibitors (PPIs) have been inconsistent. One recent cohort study reported that there was an interaction between PPIs and bisphosphonates (BPs). Thus we performed a case-control study aimed at evaluating the risk of hip fractures...

journal_title：Journal of gastroenterology

authors： Lee J,Youn K,Choi NK,Lee JH,Kang D,Song HJ,Park BJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:In elderly patients with superficial esophageal squamous cell carcinoma (ESCC), the optimal treatment strategy after non-curative endoscopic submucosal dissection (ESD) remains unclear. We aimed to evaluate the validity of additional treatments after non-curative ESD and post-ESD survival predictors in elder...

journal_title：Journal of gastroenterology

authors： Nakajo K,Abe S,Oda I,Ishihara R,Tanaka M,Yoshio T,Katada C,Yano T

更新日期：2019-10-01 00:00:00

abstract：:We present a patient with complication of huge hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL) for pancreatic lithotripsy. The hematoma measured 78-110mm. Angiography showed a subcapsular hematoma, rather than a hematoma in the liver. In the arterial phase, the distal end of the small v...

journal_title：Journal of gastroenterology

authors： Hirata N,Kushida Y,Ohguri T,Wakasugi S,Kojima T,Fujita R

更新日期：1999-12-01 00:00:00