Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: the STEATO Study.

Abstract:

PURPOSE:Hepatic steatosis is frequently observed in subjects with metabolic syndrome (MS). In type 2 diabetics, it is independently associated with cardiovascular diseases. In order to confirm and extend this finding, a large group of patients with risk factors for atherosclerosis was studied. METHODS:Carotid atherosclerosis was investigated by echo-Doppler, and hepatic steatosis by ultrasound and transaminase values. Strict exclusion criteria were chosen in order to avoid secondary forms of fatty liver and interference on transaminase values. RESULTS:Among 970 enrolled patients, about 20% were diabetics, half had MS and 76% presented echographic hepatic steatosis. In multivariate analyses, fatty liver and MS were associated with carotid atherosclerosis [odds ratio (95% confidence intervals) 2.15 (1.27-3.63) and 1.72(1.12-2.64), respectively], whereas HOMA index was not. Aspartate aminotransferase and alanine aminotransferase were not independently associated with carotid atherosclerosis, whereas gamma-glutamyl transferase showed a link with atherosclerosis beyond MS and steatosis presence. The analyses of the 780 non diabetics recruited showed similar results. CONCLUSIONS:The results of the present study demonstrate that hepatic steatosis measured by echography is associated with carotid atherosclerosis in a large population mostly carrying cardiovascular or metabolic risk factors, independently of MS, cardiovascular diseases, diabetes mellitus and/or insulin resistance.

journal_name

J Gastroenterol

authors

Carallo C,Mancuso G,Mauro G,Laghi F,Madafferi B,Irace C,Gnasso A,Scavelli F,Dell'Aquila F,Bartone M,Gullo F,Ferraro M,Spagnuolo V,Belmonte M,Ferrara A,Silvano Rotondaro A,Brandolino N,Parasporo F,Scopelliti F

doi

10.1007/s00535-009-0125-8

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

1156-61

issue

11

eissn

0944-1174

issn

1435-5922

journal_volume

44

pub_type

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