当前位置： SCI文献检索 > JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Immunoreactivity of antimitochondrial autoantibodies in Japanese patients with primary biliary cirrhosis.

Immunoreactivity of antimitochondrial autoantibodies in Japanese patients with primary biliary cirrhosis.

Abstract：

:The incidence and prevalence of primary biliary cirrhosis show wide geographic differences. The frequency of this disease in Japan is lower than in Northern Europe. To elucidate the immunoreactivity of serum with enzymes of the 2-oxo-acid dehydrogenase complex (2-OADC) and the M2 mitochondrial antigenic complex in Japanese patients, we examined sera from 107 patients with primary biliary cirrhosis from three geographically different regions of Japan. The sera were assayed by immunofluorescence on frozen tissue sections, immunoblotting on bovine heart mitochondria and recombinant E2 subunit of branched chain oxo-acid dehydrogenase complex (BCOADC-E2), ELISA using recombinant E2 subunit of human pyruvate dehydrogenase complex (PDC-E2) and purified porcine 2-oxoglutarate dehydrogenase complex (OGDC), and enzyme inhibition assay using procine PDC and OGDC. Of the 107 sera, 95 (88%) reacted by immunofluorescence, 102 (95%) by immunoblotting with at least one of the M2 autoantigens, although only 78 (73%) reacted with PDC-E2; 72 (67%) by ELISA with PDC-E2; and 81 (76%) with PDC by the enzyme inhibition assay. Thus, the frequency of reactivity with PDC-E2 by all assays was lower for Japanese than the reported frequency for Caucasian patients with primary biliary cirrhosis, whereas the frequency of reactivity by immunoblotting and ELISA against 2-OADC enzymes other than PDC was relatively higher. The relative frequency of reactivity of autoantibodies to the M2 autoantigens was similar for the three different regions of Japan. The different autoantibody profiles for Japanese and Caucasian patients with primary biliary cirrhosis point to immunogenetic and environmental determinants of this disease, which should provide new insights into its autoimmune origins.

journal_name

J Gastroenterol

journal_title

Journal of gastroenterology

authors

Omagari K,Rowley MJ,Jois JA,Feeney SJ,Komatsu K,Maeda T,Onishi S,Yamazaki K,Suzuki K,Galperin C,Mackay IR

doi

10.1007/BF01211188

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

61-8

issue

1

eissn

0944-1174

issn

1435-5922

journal_volume

31

pub_type

杂志文章

相关文献

JOURNAL OF GASTROENTEROLOGY文献大全
  • Malignant schwannoma of the esophagus with lymph node metastasis: literature review of schwannoma of the esophagus.

    abstract：:An extremely rare case of malignant schwannoma of the esophagus with lymph node metastasis is reported. A 49-year-old woman was found to have an abnormal shadow on a chest X-ray film taken during an annual checkup. Upper gastrointestinal series showed extrinsic pressure on the middle thoracic esophagus, without a muco...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s005350170020

    authors： Murase K,Hino A,Ozeki Y,Karagiri Y,Onitsuka A,Sugie S

    更新日期：2001-11-01 00:00:00

  • Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study.

    abstract：BACKGROUND:Physical inactivity is a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). "Hybrid training", a training that involves both voluntary and electrical muscle contractions, causes beneficial alterations in muscles even after short durations of exercise. The aim of this study was to i...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-011-0378-x

    authors： Kawaguchi T,Shiba N,Maeda T,Matsugaki T,Takano Y,Itou M,Sakata M,Taniguchi E,Nagata K,Sata M

    更新日期：2011-06-01 00:00:00

  • Sex differences in relation to serum hepatitis B e antigen and alanine aminotransferase levels among asymptomatic hepatitis B surface antigen carriers.

    abstract：:This study aimed to investigate sex differences in relation to hepatitis B e antigen (HBeAg) and serum alanine aminotransferase (ALT) levels in chronic asymptomatic hepatitis B virus (HBV) infection. HBeAg and ALT level were determined in 636 asymptomatic hepatitis B surface antigen carriers. There was no significant ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350070048

    authors： Tsai JF,Chuang LY,Jeng JE,Ho MS,Lin ZY,Hsieh MY,Wang LY,Tsai JH

    更新日期：2000-01-01 00:00:00

  • Treatment outcomes after splenectomy with gastric devascularization or balloon-occluded retrograde transvenous obliteration for gastric varices: a propensity score-weighted analysis from a single institution.

    abstract：BACKGROUND:Although balloon-occluded retrograde transvenous obliteration (BRTO) is often selected to treat gastric varices caused by portal hypertension, data comparing BRTO and splenectomy with gastric devascularization (Sp + Dev) are limited. METHODS:From January 2009 to February 2018, 100 patients with gastric vari...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-020-01693-9

    authors： Oshita K,Ohira M,Honmyo N,Kobayashi T,Murakami E,Aikata H,Baba Y,Kawano R,Awai K,Chayama K,Ohdan H

    更新日期：2020-09-01 00:00:00

  • Impairment of chemical clearance and mucosal integrity distinguishes hypersensitive esophagus from functional heartburn.

    abstract：BACKGROUND:Hypersensitive esophagus (HE) is defined by endoscopy-negative heartburn with a normal acid exposure time but positive symptom association probability (SAP) and/or symptom index (SI) on impedance-pH monitoring, and proton pump inhibitor (PPI) responsiveness. Functional heartburn (FH) is distinguished by nega...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00535-016-1226-9

    authors： Frazzoni M,de Bortoli N,Frazzoni L,Furnari M,Martinucci I,Tolone S,Farioli A,Marchi S,Fuccio L,Savarino V,Savarino E

    更新日期：2017-04-01 00:00:00

  • Pharmacologic prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis: protease inhibitors and NSAIDs in a meta-analysis.

    abstract：:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is the most frequent complication of ERCP. Several meta-analyses have examined the effects of protease inhibitors (gabexate mesilate, ulinastatin, and nafamostat mesilate) and non-steroidal anti-inflammatory drugs (NSAIDs) on post-ERCP pancreatiti...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00535-013-0834-x

    authors： Yuhara H,Ogawa M,Kawaguchi Y,Igarashi M,Shimosegawa T,Mine T

    更新日期：2014-03-01 00:00:00

  • Intrahepatic cholangiocarcinoma with increased serum CYFRA 21-1 level.

    abstract：:CYFRA 21-1 is a fragment of cytokeratin 19 (CK 19). Four patients with large intrahepatic (or peripheral) cholangiocarcinoma (CC) and high serum levels of CYFRA 21-1 (normal, < or = 2 ng/ml) are reported. CYFRA 21-1 levels exceeded 9 ng/ml in all 4 patients. Carcinoembryonic antigen (CEA), was high in 1 (CEA; normal r...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050112

    authors： Kashihara T,Ohki A,Kobayashi T,Sato T,Nishizawa H,Ogawa K,Tako H,Kawakami F,Tsuji M,Tamaoka K

    更新日期：1998-06-01 00:00:00

  • A population-based case-control study: proton pump inhibition and risk of hip fracture by use of bisphosphonate.

    abstract：BACKGROUND:Studies on the risk of osteoporotic fractures related to the use of proton pump inhibitors (PPIs) have been inconsistent. One recent cohort study reported that there was an interaction between PPIs and bisphosphonates (BPs). Thus we performed a case-control study aimed at evaluating the risk of hip fractures...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-012-0722-9

    authors： Lee J,Youn K,Choi NK,Lee JH,Kang D,Song HJ,Park BJ

    更新日期：2013-09-01 00:00:00

  • The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury.

    abstract：BACKGROUND:Acute liver failure is a potentially fatal disease of various etiologies for which liver transplantation is the only known curative treatment. Although the decision-making on transplantation is largely dependent on the severity of liver injury (based on predicting a fatal outcome), a statistical analysis to ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-017-1421-3

    authors： Mawatari S,Moriuchi A,Ohba F,Kawano T,Oda K,Takikawa Y,Takikawa H,Ido A,Tsubouchi H

    更新日期：2018-07-01 00:00:00

  • Nitric oxide regulates polarity of guinea pig distal colon pellet propagation and circular muscle motor response.

    abstract：BACKGROUND:Peristaltic reflex does not fully explain the polarity of peristalsis. In the distal colon, we propose that the balance of circular muscle contraction proximal and distal to the pellet is a local reflex that predicts polarity of peristalsis. METHODS:Guinea pig distal colon segments were harvested, and fecal...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-013-0842-x

    authors： Gribovskaja-Rupp I,Kwak JM,Takahashi T,Ludwig K

    更新日期：2014-05-01 00:00:00

  • Prevalence of organic colonic lesions in patients meeting Rome III criteria for diagnosis of IBS: a prospective multi-center study utilizing colonoscopy.

    abstract：BACKGROUND:It remains unknown whether the Rome III criteria can exclude organic colonic lesions prior to the diagnosis of irritable bowel syndrome (IBS). We evaluated the colonoscopy results of patients meeting the Rome III criteria for the diagnosis of IBS to determine the presence of organic colonic lesions. METHODS...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00535-012-0573-4

    authors： Ishihara S,Yashima K,Kushiyama Y,Izumi A,Kawashima K,Fujishiro H,Kojo H,Komazawa Y,Hamamoto T,Yamamoto T,Sasaki Y,Shimizu T,Okamoto E,Yoshimura T,Furuta K,Noguchi N,Tanaka H,Murawaki Y,Kinoshita Y

    更新日期：2012-10-01 00:00:00

  • Interferon lowers tumor recurrence rate after surgical resection or ablation of hepatocellular carcinoma: a pilot study of patients with hepatitis B virus-related cirrhosis.

    abstract：BACKGROUND:Hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV) often recurs after surgical or medical treatment. METHODS:Eighty consecutive patients with HBV-positive cirrhosis and HCC who underwent potentially curative ablation for HCC were analyzed. Eleven patients received long-term interferon (IFN) th...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-006-1912-0

    authors： Someya T,Ikeda K,Saitoh S,Kobayashi M,Hosaka T,Sezaki H,Akuta N,Suzuki F,Suzuki Y,Arase Y,Kumada H

    更新日期：2006-12-01 00:00:00

  • Heterotopic gastric mucosa of the gallbladder.

    abstract：:A case of heterotopic gastric mucosa in the fundus of the gallbladder is reported. A 23-year-old man, who had been healthy and asymptomatic, visited our hospital because of abnormal findings in a liver enzyme test given during a routine health screening. Ultrasonography demonstrated a highly echogenic polypoid mass in...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02347576

    authors： Uchiyama S,Imai S,Suzuki T,Arita A,Takeda K,Sujino H,Kameda H

    更新日期：1995-08-01 00:00:00

  • Multiple focal nodular hyperplasia.

    abstract：:Focal nodular hyperplasia (FNH) is a benign lesion of the liver which usually presents with one or two localizations. We report a patient with history of resection of a biliary cyst, and who had been taking oral contraceptives for the past 18 years, who had multiple localizations of FNH (more than 30 lesions). The lar...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050198

    authors： Colle I,de Beeck BO,Hoorens A,Hautekeete M

    更新日期：1998-12-01 00:00:00

  • DNA methylation as a marker for the past and future.

    abstract：:Aberrant methylation of CpG islands in promoter regions can permanently inactivate tumor-suppressor genes, as mutations and chromosomal abnormalities do. In gastric cancers, CDKN2A, CDH1, and MLH1 are inactivated more frequently by aberrant methylation than by mutations, and novel tumor-suppressor genes inactivated by...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s00535-006-1846-6

    authors： Ushijima T,Nakajima T,Maekita T

    更新日期：2006-05-01 00:00:00

  • Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population.

    abstract：PURPOSE:Recent routine testing for liver function and anti-mitochondrial antibodies has increased the number of newly diagnosed patients with primary biliary cirrhosis (PBC). This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC pat...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-009-0090-2

    authors： Kubota J,Ikeda F,Terada R,Kobashi H,Fujioka S,Okamoto R,Baba S,Morimoto Y,Ando M,Makino Y,Taniguchi H,Yasunaka T,Miyake Y,Iwasaki Y,Yamamoto K

    更新日期：2009-01-01 00:00:00

  • Symptomatic and endoscopic outcome of heartburn 3-4.5 years after starting lansoprazole therapy: a prospective study of 142 patients.

    abstract：BACKGROUND:Heartburn is a common symptom with great impact on quality of life and on the economy. An approach that helps to alleviate patients' symptoms, decrease the burden on the economy, and improve longterm outcome is needed. Step-down therapy, starting with the proton pump inhibitor lansoprazole, seems to achieve ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-003-1194-8

    authors： Abu Farsakh N

    更新日期：2003-01-01 00:00:00

  • Is the incidence of esophageal adenocarcinoma increasing in Japan? Trends from the data of a hospital-based registration system in Akita Prefecture, Japan.

    abstract：BACKGROUND:At present, squamous cell carcinoma accounts for most esophageal cancers in Japan; however, there is concern that the incidence of esophageal adenocarcinoma in Japan is increasing in comparison to Western countries. Akita Prefecture, with a population of 1 million, has the highest rate of esophageal cancer-a...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-017-1412-4

    authors： Koizumi S,Motoyama S,Iijima K

    更新日期：2018-07-01 00:00:00

  • Seroepidemiology of hepatitis C virus infection in hemodialysis patients and the general population in Fukuoka and Okinawa, Japan.

    abstract：:In 1992, a seroepidemiologic study was carried out among hemodialysis patients and the general population in Fukuoka and Okinawa, Japan to determine the presence of hepatitis C virus (HCV) infection and HCV viremia. The markers used were antibody to HCV, determined by second-generation assay (anti-HCV), and HCV RNA, d...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02358365

    authors： Hayashi J,Yoshimura E,Nabeshima A,Kishihara Y,Ikematsu H,Hirata M,Maeda Y,Kashiwagi S

    更新日期：1994-06-01 00:00:00

  • A case of gallbladder cancer associated with a common bile duct neuroma, and a cystic lesion of the liver with histologic findings similar to those of an inflammatory pseudotumor.

    abstract：:We report a rare case of gallbladder cancer associated with a common bile duct neuroma, and a cystic liver lesion with histologic findings similar to an inflammatory pseudotumor, in a patient who had had no previous abdominal surgery. The patient was a 62-year-old man whose major complaint was fever. Ultrasonography a...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02347520

    authors： Akiyama T,Saito H,Kiriyama M,Tomita F,Kosaka T,Kita I,Takashima S,Matsunou H

    更新日期：1995-06-01 00:00:00

  • Intrahepatic gene expression profiles in chronic hepatitis B and autoimmune liver disease.

    abstract：BACKGROUND:DNA microarray technology has enabled genomewide analysis of gene transcript levels, yielding insight into the molecular nature of liver disease. METHODS:We compared gene expression of liver biopsy specimens in 16 patients with different stages of chronic hepatitis B, five with autoimmune hepatitis (AIH), f...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-008-2237-y

    authors： Furuta K,Sato S,Yamauchi T,Ozawa T,Harada M,Kakumu S

    更新日期：2008-01-01 00:00:00

  • Cardiac metastasis from squamous cell carcinoma of gallbladder.

    abstract：:A 65-year-old woman was admitted to our hospital with the diagnosis of gallbladder tumor. Right extended hepatic lobectomy plus lymph node dissection of the hepatoduodenal ligament and left hepaticojejunostomy with Roux-en-Y reconstruction was performed in July, 1993. The gallbladder tumor was histologically proven to...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02936968

    authors： Suganuma M,Marugami Y,Sakurai Y,Ochiai M,Hasegawa S,Imazu H,Matsubara T,Funabiki T,Kuroda M

    更新日期：1997-12-01 00:00:00

  • Efficacy of clarithromycin in eradicating Helicobacter pylori.

    abstract：:We reviewed reports on the efficacy of clarithromycin in eradicating Helicobacter pylori. Reports on dual and 1-week triple therapy that included clarithromycin were analyzed to assess the eradication rates of H. pylori infection. Dual therapy with clarithromycin and a proton pump inhibitor achieved eradication rates ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：

    authors： Satoh K,Kimura K,Takimoto T,Kihira K,Taniguchi Y,Saifuku K

    更新日期：1996-11-01 00:00:00

  • Long-term effects of Helicobacter pylori eradication in Mongolian gerbils.

    abstract：BACKGROUND:In this study, to clarify whether Helicobacter pylori eradication alters the course of the development of gastric mucosal changes in the stomach, we examined the long-term effects of H. pylori eradication on H. pylori-inoculated gerbils. METHODS:A total of 40 H. pylori-inoculated gerbils were randomized and...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350200130

    authors： Hirayama F,Takagi S,Yokoyama Y,Yamamoto K,Iwao E,Haga K

    更新日期：2002-01-01 00:00:00

  • Partial normalization of pubertal timing in female mice with DSS colitis treated with anti-TNF-α antibody.

    abstract：BACKGROUND:Inflammatory bowel disease (IBD) and resultant colitis occurring prior to puberty are frequently associated with delayed puberty and losses of growth and bone mineralization. Some of this delay may be due to colonic inflammation and associated systemic inflammation. To date no treatments for IBD have been sh...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-012-0542-y

    authors： Deboer MD,Steinman J,Li Y

    更新日期：2012-06-01 00:00:00

  • The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease.

    abstract：BACKGROUND:It is suggested that nonalcoholic fatty liver disease (NAFLD), including nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH), can be associated with insomnia and gastro-esophageal reflux disease (GERD). The relationship between GERD and insomnia in subjects with biopsy-proven NAFLD was in...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00535-013-0871-5

    authors： Taketani H,Sumida Y,Tanaka S,Imajo K,Yoneda M,Hyogo H,Ono M,Fujii H,Eguchi Y,Kanemasa K,Chayama K,Itoh Y,Yoshikawa T,Saibara T,Fujimoto K,Nakajima A,Japan Study Group of NAFLD.

    更新日期：2014-07-01 00:00:00

  • Primary CD56+ T/NK cell lymphoma of the colon.

    abstract：:Primary T/natural killer (NK) cell lymphoma of the colon is extremely rare. Despite the advances in histological and immunophenotypic studies, the diagnosis of primary T/NK cell lymphoma of the colon can be delayed because the early symptoms and colonoscopic findings may be very similar to those of inflammatory bowel ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350200158

    authors： Kim HS,Lee DK,Baik SK,Kwon SO,Cho MY,Ko YH

    更新日期：2002-01-01 00:00:00

  • Expression of gap junction protein connexin32 in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.

    abstract：BACKGROUND:The gap junction (GJ) plays important roles in the maintenance of tissue homeostasis, the control of cell growth and differentiation, and the prevention of experimental hepatocarcinogenesis. In this study, we examined the relationship between the expression of the GJ protein connexin (Cx) 32 in 24 human hepa...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-003-1386-2

    authors： Nakashima Y,Ono T,Yamanoi A,El-Assal ON,Kohno H,Nagasue N

    更新日期：2004-08-01 00:00:00

  • A proposed severity classification system for hepatolithiasis based on an analysis of prognostic factors in a Japanese patient cohort.

    abstract：BACKGROUND:Hepatolithiasis frequently results in severe complications. We conducted a cohort study to identify prognostic factors and to establish a hepatolithiasis severity classification system. METHODS:The study cohort comprised 396 patients who were identified through a 1998 nationwide survey and followed up for 1...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-017-1410-6

    authors： Suzuki Y,Mori T,Yokoyama M,Kim S,Momose H,Matsuki R,Kogure M,Abe N,Isayama H,Nakazawa T,Notohara K,Tanaka A,Tsuyuguchi T,Tazuma S,Takikawa H,Sugiyama M

    更新日期：2018-07-01 00:00:00

  • A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis.

    abstract：BACKGROUND/AIMS:King's College Hospital (KCH) criteria and the model for end-stage liver disease (MELD) score are useful and widely-employed prognostic markers for acute liver failure (ALF). We previously reported that liver atrophy is an important prognostic factor for ALF. The aim of the present study was to assess t...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-009-0045-7

    authors： Yamagishi Y,Saito H,Ebinuma H,Kikuchi M,Ojiro K,Kanamori H,Tada S,Horie Y,Kato S,Hibi T

    更新日期：2009-01-01 00:00:00