Abstract:
BACKGROUND:Inflammatory bowel disease (IBD) and resultant colitis occurring prior to puberty are frequently associated with delayed puberty and losses of growth and bone mineralization. Some of this delay may be due to colonic inflammation and associated systemic inflammation. To date no treatments for IBD have been shown to normalize the timing of puberty. Our objective in this study was to determine whether there is a normalization of the timing of puberty during treatment of colitis using monoclonal antibodies (abs) to tumor necrosis factor (TNF)-α. METHODS:We induced colitis in 23-day-old C57Bl6 female mice using 3% dextran sodium sulfate (DSS) for 7 days, followed by removal of DSS for an additional 3 days, resulting in 10 days of worsening colitis. DSS-treated mice received either TNF-α ab or Control ab on days 4 and 8 of colitis, while non-colitic Control mice received injections of TNF-α ab (Control + TNF-α ab). All groups were followed for the timing of vaginal opening until day of life 33, when they were euthanized for serum and colon collection. RESULTS:The DSS + TNF-α ab group had lower levels of systemic interleukin (IL)-6 and a partial normalization of the timing of vaginal opening compared to the DSS + Control ab group. There were no differences in weight gain, growth, or colon histological inflammatory scores between the DSS + TNFα ab and DSS + Control ab groups over the course of the experiment. CONCLUSIONS:We conclude that anti-TNF-α ab treatment causes a partial normalization of pubertal timing coincident with decreased systemic inflammation in DSS colitis. These data may have implications regarding growth and bone mineralization outcomes in pediatric IBD.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Deboer MD,Steinman J,Li Ydoi
10.1007/s00535-012-0542-ysubject
Has Abstractpub_date
2012-06-01 00:00:00pages
647-54issue
6eissn
0944-1174issn
1435-5922journal_volume
47pub_type
杂志文章abstract::The present study was carried out to examine the effects of submucosal administration of endothelin on gastric mucosal integrity in rats. Injection of endothelin-3 into the submucosal space of the stomach induced gastric mucosal damage dose-dependently and site-specifically. The gastric injury was localized only at th...
journal_title:Journal of gastroenterology
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of gastroenterology
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doi:
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-011-0385-y
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pub_type: 杂志文章
doi:10.1007/BF02348677
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journal_title:Journal of gastroenterology
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doi:10.1007/s00535-010-0305-6
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02358674
更新日期:1994-04-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0674-0
更新日期:2013-06-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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abstract::Pyogenic granulomas represent the aquisition of vasodilative granulation tissue in the skin or mucosa. They are extremely rare in the alimentary tract, other than in the oral cavity. Here, we report a case of pyogenic granuloma arising from the gastric mucosa. An 82-year-old man was admitted to our hospital because of...
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