Effect of nifedipine administration (10 mg) on esophageal acid exposure time.

abstract：:We report a case of primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap syndrome with concurrent idiopathic thrombocytopenic purpura (ITP) and Hashimoto's disease with positivity for anticentromere antibody. The patient was a 64-year-old woman with symptoms of jaundice and general fatigue. About 30 year...

journal_title：Journal of gastroenterology

authors： Arakawa Y,Amaki S,Miyakawa H,Sakai T,Gotou I,Tanaka N,Moriyama M,Iwasaki A,Sugitani M,Arakawa Y

更新日期：2004-01-01 00:00:00

abstract：:This study aimed to investigate sex differences in relation to hepatitis B e antigen (HBeAg) and serum alanine aminotransferase (ALT) levels in chronic asymptomatic hepatitis B virus (HBV) infection. HBeAg and ALT level were determined in 636 asymptomatic hepatitis B surface antigen carriers. There was no significant ...

journal_title：Journal of gastroenterology

authors： Tsai JF,Chuang LY,Jeng JE,Ho MS,Lin ZY,Hsieh MY,Wang LY,Tsai JH

更新日期：2000-01-01 00:00:00

abstract：:Diagnosis of chronic pancreatitis in its early stage is an extremely difficult task. If the genetic predispositions are identified, it may help make possible the earlier diagnosis of chronic pancreatitis or the detection of patients at risk. There are two major hypotheses about the pathogenesis of chronic pancreatitis...

journal_title：Journal of gastroenterology

authors： Naruse S,Fujiki K,Ishiguro H

更新日期：2007-01-01 00:00:00

abstract：:To determine the role of endogenous substance P in ethanol-induced mucosal damage, two experiments were performed. In the first experiment, the stomachs of anesthetized rats were doubly cannulated and gastric damage was induced with 5ml of 30% ethanol in the gastric lumen. The damage was ameliorated by pretreatment wi...

journal_title：Journal of gastroenterology

authors： Hayashi H,Nishiyama K,Majima M,Katori M,Saigenji K

更新日期：1996-06-01 00:00:00

abstract：:We present herein a case of a 75-year-old Japanese man who had developed a pancreatic abscess 7 years after a longitudinal pancreatojejunostomy for chronic pancreatitis. The patient, a heavy drinker of alcohol, underwent surgical decompression of a ductal obstruction to relieve persistent abdominal pain due to severel...

journal_title：Journal of gastroenterology

authors： Suzuki A,Matsunaga T,Aoki S,Hirayama T,Nakagawa N,Shibata K,Yabana T,Kawasaki H,Takasaka H,Sasaki K,Katsuramaki T,Mukaiya M,Hirata K,Imai K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:A new capsule endoscope has been developed by Olympus Medical Systems. The visualization and usefulness of its real-time image viewer for gastric transit abnormality were evaluated by using this new device. METHODS:Thirty-seven consecutive patients were enrolled. In cases of gastric transit abnormality (gas...

journal_title：Journal of gastroenterology

authors： Ogata H,Kumai K,Imaeda H,Aiura K,Hisamatsu T,Okamoto S,Iwao Y,Sugino Y,Kitajima M,Hibi T

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) occurs in chronic hepatitis B (CH-B) patients even after treatment with nucleos(t)ide analogues (NAs) by a mechanism involving an association between the oncogenic factors of integrated HBV and liver fibrosis. An association has been demonstrated between advanced chronic liver ...

journal_title：Journal of gastroenterology

authors： Kawaguchi K,Honda M,Ohta H,Terashima T,Shimakami T,Arai K,Yamashita T,Sakai Y,Yamashita T,Mizukoshi E,Komura T,Unoura M,Kaneko S

更新日期：2018-06-01 00:00:00

abstract：:CYFRA 21-1 is a fragment of cytokeratin 19 (CK 19). Four patients with large intrahepatic (or peripheral) cholangiocarcinoma (CC) and high serum levels of CYFRA 21-1 (normal, < or = 2 ng/ml) are reported. CYFRA 21-1 levels exceeded 9 ng/ml in all 4 patients. Carcinoembryonic antigen (CEA), was high in 1 (CEA; normal r...

journal_title：Journal of gastroenterology

authors： Kashihara T,Ohki A,Kobayashi T,Sato T,Nishizawa H,Ogawa K,Tako H,Kawakami F,Tsuji M,Tamaoka K

更新日期：1998-06-01 00:00:00

abstract：:The histopathological changes due to chronic Helicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication of H. pylori on nonulcer dyspepsia, the long-term ...

journal_title：Journal of gastroenterology

authors： Franceschi F,Genta RM,Sepulveda AR

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:There have only been a few prospective studies investigating risk factors associated with the development of hepatocellular carcinoma (HCC) among chronic hepatitis B patients all over the world, and no study has been conducted in Japanese population. METHODS:A population-based cohort consisting of 19393 sub...

journal_title：Journal of gastroenterology

authors： Kusakabe A,Tanaka Y,Inoue M,Kurbanov F,Tatematsu K,Nojiri S,Joh T,Tsugane S,Mizokami M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Efficacy and safety of interferon induction therapy alone or in combination with ribavirin or ribavirin plus amantadine were evaluated in chronic hepatitis C patients who were nonresponders to primary antiviral treatment. METHODS:The study was designed to have 225 HCV nonresponder patients, but at an interi...

journal_title：Journal of gastroenterology

authors： Gramenzi A,Andreone P,Cursaro C,Verucchi G,Boccia S,Giacomoni PL,Galli S,Furlini G,Biselli M,Lorenzini S,Attard L,Bonvicini F,Bernardi M

更新日期：2007-05-01 00:00:00

abstract：:From its pattern of metastasis and recurrence, gastric carcinoma can be recognized as a slow-growing malignancy whose local control is still the most important part of treatment. With application of asymptomatic population screening and awareness of the high risk of this disease among the general population in Japan, ...

journal_title：Journal of gastroenterology

authors： Sasako M

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Little real-world cohort data has been reported for Asians who have received interferon-free regimens with sofosbuvir (SOF) for chronic hepatitis C virus (HCV) infection. We evaluated the effectiveness and safety in clinical practice of ledipasvir (LDV) plus SOF for Japanese patients infected with HCV genoty...

journal_title：Journal of gastroenterology

authors： Ogawa E,Furusyo N,Nomura H,Dohmen K,Higashi N,Takahashi K,Kawano A,Azuma K,Satoh T,Nakamuta M,Koyanagi T,Kato M,Shimoda S,Kajiwara E,Hayashi J,Kyushu University Liver Disease Study (KULDS) Group.

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Nocturnal administration of branched-chain amino acid (BCAA) granules improves serum albumin levels in patients with cirrhosis. However, it is unclear whether or not this administration method can improve the patients' quality of life (QOL). In this study, we aimed to investigate the efficacy of BCAA granule...

journal_title：Journal of gastroenterology

authors： Hidaka H,Nakazawa T,Kutsukake S,Yamazaki Y,Aoki I,Nakano S,Asaba N,Minamino T,Takada J,Tanaka Y,Okuwaki Y,Watanabe M,Shibuya A,Koizumi W

更新日期：2013-02-01 00:00:00

abstract：:We report a case of pancreas head carcinoma associated with fat replacement of the body and tail. A 68-year-old man presented with obstructive jaundice and was admitted to our hospital. Ultrasonography and computed tomography showed pancreas head tumor with a neighboring cystic lesion and fatty replacement of parenchy...

journal_title：Journal of gastroenterology

authors： Toyama N,Kamiyama H,Suminaga Y,Namai K,Ota M,Konishi F

更新日期：2004-01-01 00:00:00

abstract：:Inflammatory cells in the gastric epithelium and direct cell damage are important effects of H. pylori infection in causing gastroduodenal diseases. The aim of this study was to determine whether H. Pylori possessing the cagA gene and vacuolating cytotoxin activity (cagA+/tox+) has these toxigenicities. The detection ...

journal_title：Journal of gastroenterology

authors： Kodama K,Fujioka T,Ito A,Kodama R,Nasu M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) consists of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH); the latter progresses to liver cirrhosis and hepatocellular carcinoma. Discriminating NASH from NAFL typically involves liver biopsy. The mechanism of NASH progression is unclear but ...

journal_title：Journal of gastroenterology

authors： Kado A,Tsutsumi T,Enooku K,Fujinaga H,Ikeuchi K,Okushin K,Moriya K,Yotsuyanagi H,Koike K

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The Japan Society of Diabetes Mellitus reported that the leading cause of death in patients with diabetes mellitus (DM) was chronic liver disease; however, there are limited studies investigating the cause of liver injury in these patients. Our study aimed to clarify the clinicopathological features of liver...

journal_title：Journal of gastroenterology

authors： Shima T,Uto H,Ueki K,Takamura T,Kohgo Y,Kawata S,Yasui K,Park H,Nakamura N,Nakatou T,Tanaka N,Umemura A,Mizuno M,Tanaka J,Okanoue T

更新日期：2013-04-01 00:00:00

abstract：:The proliferative activity of serrated adenomas of the large intestine was determined by examining proliferating cell nuclear antigen (PCNA). The PCNA labeling index, determined by visual inspection, and the PCNA area rate, determined with the newly developed image processor for analytical pathology (IPAP), of serrate...

journal_title：Journal of gastroenterology

authors： Fujishima N

更新日期：1996-04-01 00:00:00

abstract：:A new triple therapy using a proton pump inhibitor and two antibiotics shows high efficiency against Helicobacter pylori infection. The aim of this study was to determine the optimal dose and duration of lansoprazole (LA) administration in combination with amoxicillin (AMPC) and metronidazole (MNZ). A total of 91 pati...

journal_title：Journal of gastroenterology

authors： Nishikawa K,Sugiyama T,Ishizuka J,Kudo T,Komatsu Y,Katagiri M,Sukegawa M,Kagaya H,Kudo M,Kato M,Takeda H,Toyota J,Asaka M

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Histamine participates in the immune regulation of several gastrointestinal diseases. However, the effect of histamine on intestinal intraepithelial lymphocytes (IELs), the front line of the intestinal mucosal immune system, is not well understood. We examined whether histamine has a direct effect on cytokin...

journal_title：Journal of gastroenterology

authors： Takagaki K,Osawa S,Horio Y,Yamada T,Hamaya Y,Takayanagi Y,Furuta T,Hishida A,Ikuma M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:In Japan, generally, patients with chronic hepatitis C are aged. The aim of this study was to investigate the effect of interferon (IFN) therapy on the mortality of chronic hepatitis C patients over age 60. METHODS:Seven-hundred and seven patients with histologically proven chronic hepatitis C were enrolled...

journal_title：Journal of gastroenterology

authors： Imai Y,Kasahara A,Tanaka H,Okanoue T,Hiramatsu N,Tsubouchi H,Yoshioka K,Kawata S,Tanaka E,Hino K,Hayashi K,Tamura S,Itoh Y,Sasaki Y,Kiyosawa K,Kakumu S,Okita K,Hayashi N

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:In acute pancreatitis, pancreatic phospholipase A(2) (PLA2) in the circulating blood hydrolyzes phospholipids contained in plasma lipoproteins, liberating eicosanoid precursors that are subsequently converted to various eicosanoids. The pathophysiological significance of eicosanoid synthesis via this pathway...

journal_title：Journal of gastroenterology

authors： Motoyoshi M,Sugiyama M,Atomi Y,Kimura W,Nagawa H

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Heartburn is a common symptom with great impact on quality of life and on the economy. An approach that helps to alleviate patients' symptoms, decrease the burden on the economy, and improve longterm outcome is needed. Step-down therapy, starting with the proton pump inhibitor lansoprazole, seems to achieve ...

journal_title：Journal of gastroenterology

authors： Abu Farsakh N

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Recent routine testing for liver function and anti-mitochondrial antibodies has increased the number of newly diagnosed patients with primary biliary cirrhosis (PBC). This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC pat...

journal_title：Journal of gastroenterology

authors： Kubota J,Ikeda F,Terada R,Kobashi H,Fujioka S,Okamoto R,Baba S,Morimoto Y,Ando M,Makino Y,Taniguchi H,Yasunaka T,Miyake Y,Iwasaki Y,Yamamoto K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:In recent years in Japan, the rate of clarithromycin (CAM) resistance in Helicobacter pylori has risen to around 30%, and the eradication rate with triple therapy [proton pump inhibitor + amoxicillin (AMPC) + CAM] has been trending downward to around 70%. In 2007, rabeprazole (RPZ)-based triple therapy (RPZ ...

journal_title：Journal of gastroenterology

authors： Fujioka T,Aoyama N,Sakai K,Miwa Y,Kudo M,Kawashima J,Matsubara Y,Miwa J,Yakabi K

更新日期：2012-03-01 00:00:00

abstract：:We report a case of living-related partial liver transplantation for decompensated hepatitis B without reactivation of hepatitis B in the following 30 months, and we analyze the factors that indicate a favorable prognosis for transplantation. The 42-year-old female patient received continuously administered lamivudine...

journal_title：Journal of gastroenterology

authors： Hasegawa K,Hashimoto E,Kanai N,Ogawa M,Naritomi T,Taniai M,Takasaki K,Hayashi N

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:It is suggested that nonalcoholic fatty liver disease (NAFLD), including nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH), can be associated with insomnia and gastro-esophageal reflux disease (GERD). The relationship between GERD and insomnia in subjects with biopsy-proven NAFLD was in...

journal_title：Journal of gastroenterology

authors： Taketani H,Sumida Y,Tanaka S,Imajo K,Yoneda M,Hyogo H,Ono M,Fujii H,Eguchi Y,Kanemasa K,Chayama K,Itoh Y,Yoshikawa T,Saibara T,Fujimoto K,Nakajima A,Japan Study Group of NAFLD.

更新日期：2014-07-01 00:00:00

abstract：:We describe a gastric carcinoma cell line that has been maintained in vitro for more than 10 years and retains the capacity to produce a large amount of alpha-fetoprotein. This cell line was isolated from a metastatic lymph node of a 63-year-old male patient with advanced gastric carcinoma (T2N3P0H0M0) who showed high...

journal_title：Journal of gastroenterology

authors： Sekiguchi M,Fujii Y,Saito A,Suzuki T,Shiroko Y,Nakamura H,Hasumi K

更新日期：1995-10-01 00:00:00

abstract：:Black liver is a common finding in Dubin-Johnson syndrome (DJS), which is caused by the lack of multidrug resistance-associated protein 2 (MRP2). Impaired excretion of epinephrine metabolites is believed to be a cause of black liver in DJS. Recently, we experienced a patient with black liver whose serum bilirubin leve...

journal_title：Journal of gastroenterology

authors： Kobayashi Y,Ishihara T,Wada M,Kajihara S,Araki J,Mifuji R,Itani T,Kuroda M,Urawa F,Kaito M,Adachi Y

更新日期：2004-09-01 00:00:00