Abstract:
:To determine the role of endogenous substance P in ethanol-induced mucosal damage, two experiments were performed. In the first experiment, the stomachs of anesthetized rats were doubly cannulated and gastric damage was induced with 5ml of 30% ethanol in the gastric lumen. The damage was ameliorated by pretreatment with capsaicin (0.16 and 1.6 mM) and spantide (100 mg/kg, i.v.). In the second experiment, the gastric mucosa of these rats was perfused with physiological saline containing pepstatin (10 microliters/ml). Endogenous substance P (SP) in the perfusate was measured by enzyme immunoassay (EIA). The peak SP levels were increased by capsaicin (0.16-1.6 mM) in a concentration-dependent manner. Perfusion with 50% ethanol for 5 min increased the SP levels approximately threefold. Perfusion with 1.6 mM capsaicin, followed by 50% ethanol, reduced the injured area to about one-quarter of the original injured area. The peak SP levels during perfusion with 50% ethanol after pretreatment with 1.6 mM capsaicin did not differ from those observed after vehicle pretreatment (control). The area under the curve for SP release during 50% ethanol perfusion after vehicle perfusion was not reduced by previous perfusion with 1.6 mM capsaicin followed by 50% ethanol, indicating that the prevention of ethanol-induced injury by capsaicin may be due to excess amounts of different neuropeptides released simultaneously.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Hayashi H,Nishiyama K,Majima M,Katori M,Saigenji Kdoi
10.1007/BF02355018subject
Has Abstractpub_date
1996-06-01 00:00:00pages
314-22issue
3eissn
0944-1174issn
1435-5922journal_volume
31pub_type
杂志文章abstract:BACKGROUND AND AIM:Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia. METHODS:Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median age, 1.1 years (rang...
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更新日期:2017-02-01 00:00:00
abstract::We investigated whether extravariceal collateral pattern contributed to the development of portal-hypertensive gastropathy (PHG) before and after sclerotherapy. Ninety-nine patients with cirrhosis and large esophageal varices were examined in this retrospective study. They were divided into four groups according to tr...
journal_title:Journal of gastroenterology
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abstract::In the original publication of the article, the following errors were noted and corrected in this correction. ...
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/BF02347632
更新日期:1996-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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更新日期:1996-02-01 00:00:00
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更新日期:1997-10-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1995-11-01 00:00:00
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更新日期:2008-01-01 00:00:00
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更新日期:1998-08-01 00:00:00
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更新日期:2019-02-01 00:00:00