当前位置： SCI文献检索 > JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Nuclear cyclin D1 overexpression is a critical event associated with cell proliferation and invasive growth in gallbladder carcinogenesis.

Nuclear cyclin D1 overexpression is a critical event associated with cell proliferation and invasive growth in gallbladder carcinogenesis.

Abstract：

:Cyclin D1 overexpression is remarkably frequent in several human carcinomas and is believed to be a critical event in oncogenesis. We examined cyclin D1 expression, p53 expression, and the Ki-67 labeling index by immunostaining in human gallbladder mucosa in conditions varying from normal to malignant tissue. We also examined K-ras codon 12 mutations in these tissues with a two-step polymerase chain reaction. Nuclear cyclin D1 overexpression was observed in 48% of carcinomas occurring independently of adenoma, but not in adenomas, carcinomas arising in adenomas, or nonneoplastic lesions. Cytoplasmic cyclin D1 overexpression was observed in about 15% of abnormal specimens, irrespective of the type of epithelial abnormality. Carcinomas showing nuclear cyclin D1 overexpression had significantly higher Ki-67 labeling indexes than those with no overexpression. Moderately to poorly differentiated adenocarcinomas showed a higher incidence of nuclear cyclin D1 overexpression than papillary to well differentiated carcinomas. Specimens with cyclin D1 overexpression showed a high incidence of lymph permeation, venous permeation, and lymph node metastasis. We conclude that nuclear cyclin D1 overexpression is a critical event importantly associated with cell proliferation and invasive growth in gallbladder carcinogenesis, and that cyclin D1 immunostaining may become a useful marker for evaluating gallbladder carcinomas.

journal_name

J Gastroenterol

journal_title

Journal of gastroenterology

authors

Itoi T,Shinohara Y,Takeda K,Nakamura K,Takei K,Sanada J,Horibe T,Saito T,Kasuya K,Ebihara Y

doi

10.1007/s005350050027

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

142-9

issue

2

eissn

0944-1174

issn

1435-5922

journal_volume

35

pub_type

杂志文章

相关文献

JOURNAL OF GASTROENTEROLOGY文献大全
  • Epstein-Barr virus-associated gastric carcinoma in the remnant stomach: de novo and metachronous gastric remnant carcinoma.

    abstract：BACKGROUND:The remnant stomach corresponds to the gastric cardia, but is exposed to a completely different environment. The present study was performed to investigate the role of Epstein-Barr virus (EBV) infection in patients with gastric remnant carcinoma (GRC). METHODS:Clinicopathological features, gastritis, and in...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-005-1590-3

    authors： Kaizaki Y,Hosokawa O,Sakurai S,Fukayama M

    更新日期：2005-06-01 00:00:00

  • Images of Sonazoid-enhanced ultrasonography in multistep hepatocarcinogenesis: comparison with Gd-EOB-DTPA-enhanced MRI.

    abstract：BACKGROUND:Little is known about the difference in enhancement patterns of hepatocellular carcinoma (HCC) during multistep hepatocarcinogenesis between the post-vascular phase of Sonazoid-enhanced ultrasonography (SEUS) and hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine (Gd-EOB-DTPA)-enhanced MRI, as...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-013-0859-1

    authors： Ohama H,Imai Y,Nakashima O,Kogita S,Takamura M,Hori M,Seki Y,Sawai Y,Igura T,Fukuda K,Makino Y,Morimoto O,Ohsawa M,Sakamoto M,Murakami T

    更新日期：2014-06-01 00:00:00

  • Hypertension as a paraneoplastic syndrome in hepatocellular carcinoma.

    abstract：:We report a 66-year-old man with hepatocellular carcinoma who was positive for hepatitis B surface antigen, and was hospitalized because of hypoglycemia and hypertension. His plasma renin activity was normal (2.3 ng/ml per h), but concentrations of angiotensin I (>2500 pg/ml) and II (86 pg/ml) were high. Increased ang...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s005350050309

    authors： Arai H,Saitoh S,Matsumoto T,Makita F,Mitsugi S,Yuasa K,Takagi H,Mori M

    更新日期：1999-08-01 00:00:00

  • Sex differences in relation to serum hepatitis B e antigen and alanine aminotransferase levels among asymptomatic hepatitis B surface antigen carriers.

    abstract：:This study aimed to investigate sex differences in relation to hepatitis B e antigen (HBeAg) and serum alanine aminotransferase (ALT) levels in chronic asymptomatic hepatitis B virus (HBV) infection. HBeAg and ALT level were determined in 636 asymptomatic hepatitis B surface antigen carriers. There was no significant ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350070048

    authors： Tsai JF,Chuang LY,Jeng JE,Ho MS,Lin ZY,Hsieh MY,Wang LY,Tsai JH

    更新日期：2000-01-01 00:00:00

  • Color Doppler endoscopic ultrasonography in identifying groups at a high-risk of recurrence of esophageal varices after endoscopic treatment.

    abstract：BACKGROUND:Our preliminary study indicated that either a high hepatofugal flow velocity in the left gastric vein (LGV) or an anterior branch dominant pattern seen under color Doppler EUS (CD-EUS) were possible contributing risk factors for variceal recurrence after endoscopic treatment. However, the sample size was too...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-006-1992-x

    authors： Kuramochi A,Imazu H,Kakutani H,Uchiyama Y,Hino S,Urashima M

    更新日期：2007-03-01 00:00:00

  • Dieulafoy's vascular malformation of the jejunum: first case report of laparoscopic treatment.

    abstract：:A case of Dieulafoy's vascular malformation of the jejunum treated by laparoscopic surgery is described. The patient was a 31-year-old-woman who had complained of melena and had severe anemia needing blood transfusion. Angiography revealed microaneurysms and hypervascularity of the jejunum in the area between the firs...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s00535-003-1305-6

    authors： Mino A,Ogawa Y,Ishikawa T,Uchima Y,Yamazaki M,Nakamura S,Yukawa T,Matsumoto T,Arakawa T,Hirakawa K

    更新日期：2004-01-01 00:00:00

  • Possible involvement of Toll-like receptor 7 in the development of type 1 autoimmune pancreatitis.

    abstract：BACKGROUND:High serum immunoglobulin G4 (IgG4) levels and IgG4-positive plasma cell infiltration are characteristic of type 1 autoimmune pancreatitis (AIP). It is unclear whether innate immunity is a cause of type 1 AIP; the possible involvement of microbial infection has been suggested in its pathogenesis. To clarify ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-014-0977-4

    authors： Fukui Y,Uchida K,Sakaguchi Y,Fukui T,Nishio A,Shikata N,Sakaida N,Uemura Y,Satoi S,Okazaki K

    更新日期：2015-04-01 00:00:00

  • Effects of transjugular intrahepatic portosystemic shunt on changes in the small bowel mucosa of cirrhotic patients with portal hypertension.

    abstract：BACKGROUND:The introduction of capsule endoscopy (CE) has facilitated the detection of mucosal changes in the small bowel, and such mucosal changes have been noted in cirrhotic patients with portal hypertension; these changes are described as portal hypertensive enteropathy. The aim of this study was to assess the effe...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-012-0660-6

    authors： Matsushita Y,Narahara Y,Fujimori S,Kanazawa H,Itokawa N,Fukuda T,Takahashi Y,Kondo C,Kidokoro H,Atsukawa M,Nakatsuka K,Sakamoto C

    更新日期：2013-05-01 00:00:00

  • Quantification of Helicobacter pylori infection: Simple and rapid 13C-urea breath test in Taiwan.

    abstract：:The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for the test. The test ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050092

    authors： Wang WM,Lee SC,Ding HJ,Jan CM,Chen LT,Wu DC,Liu CS,Peng CF,Chen YW,Huang YF,Chen CY

    更新日期：1998-06-01 00:00:00

  • Meta-analysis: mortality and serious adverse events of peginterferon plus ribavirin therapy for chronic hepatitis C.

    abstract：BACKGROUND:Pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy is the current standard of care for patients with chronic hepatitis C. Determining precisely the risk of serious adverse events (SAEs) and mortality from a single study is rather difficult because of the infrequency of such events. The aim of this s...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00535-012-0631-y

    authors： Minami T,Kishikawa T,Sato M,Tateishi R,Yoshida H,Koike K

    更新日期：2013-02-01 00:00:00

  • Portal venous blood flow while breath-holding after inspiration or expiration and during normal respiration in controls and cirrhotics.

    abstract：:In this study, we used magnetic resonance (MR) imaging to measure portal blood flow in 12 healthy controls and 17 cirrhotics while they were breath-holding after inspiration and after expiration. We then compared the results with measurements made during normal respiration in the healthy controls and cirrhotics. Blood...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050381

    authors： Sugano S,Yamamoto K,Sasao K,Watanabe M

    更新日期：1999-10-01 00:00:00

  • Photodynamic therapy for human hepatoma-cell-line tumors utilizing biliary excretion properties of indocyanine green.

    abstract：BACKGROUND:Photodynamic therapy (PDT) has not been reported for human hepatoma, because cancer cells only weakly take up the photosensitizer. Indocyanine green (ICG) is a photosensitizer normally excreted into the bile, and bile excretion is impaired in human hepatomas. We examined whether human hepatoma cell lines pre...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-013-0775-4

    authors： Kaneko J,Inagaki Y,Ishizawa T,Gao J,Tang W,Aoki T,Sakamoto Y,Hasegawa K,Sugawara Y,Kokudo N

    更新日期：2014-01-01 00:00:00

  • Prevalence of organic colonic lesions in patients meeting Rome III criteria for diagnosis of IBS: a prospective multi-center study utilizing colonoscopy.

    abstract：BACKGROUND:It remains unknown whether the Rome III criteria can exclude organic colonic lesions prior to the diagnosis of irritable bowel syndrome (IBS). We evaluated the colonoscopy results of patients meeting the Rome III criteria for the diagnosis of IBS to determine the presence of organic colonic lesions. METHODS...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00535-012-0573-4

    authors： Ishihara S,Yashima K,Kushiyama Y,Izumi A,Kawashima K,Fujishiro H,Kojo H,Komazawa Y,Hamamoto T,Yamamoto T,Sasaki Y,Shimizu T,Okamoto E,Yoshimura T,Furuta K,Noguchi N,Tanaka H,Murawaki Y,Kinoshita Y

    更新日期：2012-10-01 00:00:00

  • Long-term outcomes after treatment for pedunculated-type T1 colorectal carcinoma: a multicenter retrospective cohort study.

    abstract：BACKGROUND:The risk for lymph node metastasis and the prognostic significance of pedunculated-type T1 colorectal carcinomas (CRCs) require further study. We aimed to assess the validity of the 2014 Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines based on long-term outcomes of pedunculated-type T1...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00535-015-1144-2

    authors： Asayama N,Oka S,Tanaka S,Nagata S,Furudoi A,Kuwai T,Onogawa S,Tamura T,Kanao H,Hiraga Y,Okanobu H,Kuwabara T,Kunihiro M,Mukai S,Goto E,Shimamoto F,Chayama K

    更新日期：2016-07-01 00:00:00

  • Percutaneous ultrasound-guided radiofrequency ablation of hepatocellular carcinoma with artificially induced pleural effusion and ascites.

    abstract：BACKGROUND:Ultrasound-guided procedures are sometimes of limited use because the tumor is located under the diaphragm or near the surface of the liver. We investigated the safety and efficacy of radiofrequency ablation (RFA) with artificial pleural effusion and/or artificial ascites. METHODS:Between January 2002 and M...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-006-1949-0

    authors： Uehara T,Hirooka M,Ishida K,Hiraoka A,Kumagi T,Kisaka Y,Hiasa Y,Onji M

    更新日期：2007-04-01 00:00:00

  • The comparative effects of single intravenous doses of omeprazole and famotidine on intragastric pH.

    abstract：BACKGROUND:The ideal medication for the treatment of acid-related diseases, for example, hemorrhagic ulcers and stress-related gastric bleeding, should have a rapid onset of action to promote hemostasis and alleviate symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion afte...

    journal_title：Journal of gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00535-003-1240-6

    authors： Abe Y,Inamori M,Togawa J,Kikuchi T,Muramatsu K,Chiguchi G,Kawamura H,Kobayashi N,Kirikoshi H,Sakaguchi T,Takamura T,Nakajima A,Ueno N,Sekihara H

    更新日期：2004-01-01 00:00:00

  • Primary sclerosing cholangitis in Japan--analysis of 192 cases.

    abstract：:Primary sclerosing cholangitis is very rare in Japan. The aim of the present study was to identify the characteristics of such patients in Japan. A questionnaire was sent to the members of the Japanese Society of Gastroenterology and responses for 192 cases were analyzed. There was male predominancy (61%), and two pea...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF01213311

    authors： Takikawa H,Manabe T

    更新日期：1997-02-01 00:00:00

  • Chemotherapy for metastatic gastric cancer: past, present, and future.

    abstract：:Despite the numerous efforts of randomized studies on advanced gastric cancer, no globally accepted standard regimen has yet been established. Two triplet regimens have already demonstrated significant survival prolongation in Western studies. However, the benefit seems to be marginal, and these regimens may be replac...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s00535-008-2177-6

    authors： Ohtsu A

    更新日期：2008-01-01 00:00:00

  • Loss of diurnal variation in ornithine decarboxylase and apoptosis in small intestine of Mongolian gerbils.

    abstract：:The aim of this study was to examine the diurnal variations in ornithine decarboxylase (ODC) activity and apoptosis in the small intestinal mucosa of Mongolian gerbils. First, the feeding, drinking, and ambulatory patterns of the gerbils were recorded. The results indicated that Mongolian gerbils lost diurnal cyclicit...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350070088

    authors： Kashiwagi Y,Fujimoto K,Iwakiri R,Yoshida T,Noda T,Aw TY,Niho Y,Sakata T

    更新日期：2000-01-01 00:00:00

  • Clinical significance of a papillary adenocarcinoma component in early gastric cancer: a single-center retrospective analysis of 628 surgically resected early gastric cancers.

    abstract：BACKGROUND:We recently reported that the presence of a papillary adenocarcinoma (pap) component was an independent risk factor for lymphatic involvement in endoscopically resected early gastric cancer (EGC). This study aimed to investigate the potential association between the presence of a pap component in EGC and lym...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-014-0991-6

    authors： Sekiguchi M,Kushima R,Oda I,Suzuki H,Taniguchi H,Sekine S,Fukagawa T,Katai H

    更新日期：2015-04-01 00:00:00

  • Effect of arterial administration of a high molecular weight anti-tumor agent, styrene maleic acid neocarzinostatin, for multiple small liver cancer--a pilot study.

    abstract：:To assess the efficacy of the zinostatin derivative, the anti-tumor agent, styrene-maleic acid neocarzinostatin, in treating multiple small liver cancers, 29 patients with multiple hepatocellular carcinoma of 3 cm or less in diameter were treated with intraarterial injections of this high molecular weight agent, mixed...

    journal_title：Journal of gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02934092

    authors： Ikeda K,Saitoh S,Suzuki Y,Tsubota A,Koida I,Kobayashi M,Arase Y,Chayama K,Murashima N,Kumada H

    更新日期：1997-08-01 00:00:00

  • The pathogenesis of Crohn's disease.

    abstract：:This paper describes a program of research undertaken by the Inflammatory Bowel Disease Study Group at the Royal Free Hospital School of Medicine. The Group has tested the hypothesis that the primary pathological abnormality in Crohn's disease is in the mesenteric blood supply. The first experiments involved microcorr...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：

    authors： Pounder RE

    更新日期：1994-07-01 00:00:00

  • Assessment of the gastric emptying velocity by the 13C-octanoate breath test: deconvolution versus a Wagner-Nelson analysis.

    abstract：BACKGROUND:The dynamic change in gastric emptying on a minute-by-minute basis (gastric velocity) is evaluated by the 13C-octanoate breath test with deconvolution analysis. However, deconvolution is impractical, because it requires dual experiments to obtain 13CO2 excretion profiles following intraduodenal and oral admi...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-006-1814-1

    authors： Sanaka M,Yamamoto T,Osaki Y,Kuyama Y

    更新日期：2006-07-01 00:00:00

  • Significance of modes of adherence in esophageal Candida albicans.

    abstract：:Although esophageal candidiasis is the most common form of Candida infection in the gastro-intestinal tract, little attention has been directed toward determining the mechanism of its infection. We have already clarified the existence of four modes of adherence of Candida albicans to the esophagus; attachment, subepit...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF01229065

    authors： Hoshika K,Mine H

    更新日期：1994-02-01 00:00:00

  • Gallstones, a cholecystectomy, chronic pancreatitis, and the risk of subsequent pancreatic cancer in diabetic patients: a population-based cohort study.

    abstract：BACKGROUND:The causal association between diabetes and pancreatic cancer remains unclear in Asian populations. This study examined whether gallstones, a cholecystectomy, chronic pancreatitis and the treatment of antidiabetic agents affect the risk of subsequent pancreatic cancer for patients with diabetes in a Taiwanes...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-012-0674-0

    authors： Lai HC,Tsai IJ,Chen PC,Muo CH,Chou JW,Peng CY,Lai SW,Sung FC,Lyu SY,Morisky DE

    更新日期：2013-06-01 00:00:00

  • Pyloric antral inhibition of gastrin release.

    abstract：:Inconsistencies and omissions in current explanations for the well known depressions of gastric acid secretion and blood gastrin levels following acidification by antral stimulants are discussed. Evidence is presented which favors a reciprocal sensitivity relationship between the fundic mucosa and the antral G cells, ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02347632

    authors： Magee DF

    更新日期：1996-10-01 00:00:00

  • Influence of anti-ulcer drugs used in Japan on the result of (13)C-urea breath test for the diagnosis of Helicobacter pylori infection.

    abstract：BACKGROUND:The (13)C-urea breath test (UBT) is a simple breath test for the diagnosis of Helicobacter pylori infection, but several factors have been reported to affect the results of this test. In this study, the effects of the antiulcer drugs used in Japan on the results of UBT were determined. METHODS:The subjects ...

    journal_title：Journal of gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00535-003-1176-x

    authors： Murakami K,Sato R,Okimoto T,Watanabe K,Nasu M,Fujioka T,Kodama M,Kagawa J

    更新日期：2003-01-01 00:00:00

  • Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study.

    abstract：BACKGROUND:Few studies have investigated measures to prevent small bowel injuries induced by aspirin. Our aim was to evaluate the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use. METHODS:Thirty-five patients who took low-dose enteric-coated aspirin 100 mg daily (for mo...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00535-011-0410-1

    authors： Endo H,Higurashi T,Hosono K,Sakai E,Sekino Y,Iida H,Sakamoto Y,Koide T,Takahashi H,Yoneda M,Tokoro C,Inamori M,Abe Y,Nakajima A

    更新日期：2011-07-01 00:00:00

  • Different concentrations of various radiopharmaceuticals in the two main liver lobes: a preliminary study in clinical patients.

    abstract：BACKGROUND:At clinical scintigraphic examinations of the abdomen using single photon emission computed tomography (SPECT), we have observed a different distribution between the left and right main liver lobes of various radiopharmaceuticals. This was studied retrospectively in clinical patients. METHODS:Examinations w...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-005-1617-9

    authors： Jacobsson H,Jonas E,Hellström PM,Larsson SA

    更新日期：2005-07-01 00:00:00

  • Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs).

    abstract：BACKGROUND:Recently, the novel gene DOG1 has been found to be overexpressed in most gastrointestinal stromal tumors (GISTs) specifically within the field of soft tissue tumors. DOG1 might play a role in development of GISTs and have potential as a diagnostic marker and therapeutic target, but the biological function an...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-008-2195-4

    authors： Miwa S,Nakajima T,Murai Y,Takano Y,Sugiyama T

    更新日期：2008-01-01 00:00:00