Abstract:
:Hepatitis C virus (HCV) infection is responsible for more than a half of the cases of chronic viral hepatitis in Japan. About 20% of patients who are chronically infected with the virus develop cirrhosis about 20-30 years after the infection, with hepatocellular carcinoma developing in about 5% of patients a year. The only drug that effectively reduces the virus is interferon, but complete eradication of the virus can be obtained in only 30%-40% of treated patients. Reevaluation of the predictive factors to eradicate the virus by 24-week interferon therapy showed that the genotype other than 1b, a low virus load, and multiple amino acid substitutions in the interferon sensitivity determining region (ISDR) of genotype 1b are statistically significant predictive factors. Amino acid substitution in the PePHD domain of the E2 protein was rare and was unrelated with the outcome of interferon therapy. The fluctuation of the virus titer measured by branched DNA during a 2-year observation period was less that 10-fold in most patients, and amino acid substitutions in the ISDR were rare in such patients, suggesting that one point measurement of these parameters may be useful to select candidates for interferon therapy. A comparison of patients treated with interferon and untreated patients from the viewpoint of cancer prevention showed only a slight decrease in the risk of treated patients developing hepatocellular carcinoma. However, patients who showed normal alanine amino-transaminase (ALT) irrespective of virus clearance showed a significantly reduced risk of liver carcinogenesis. Similarly, a retrospective study to evaluate the long-term preventive effect of glycyrrhizin on hepatocellular carcinoma development showed that the therapy was effective in lowering the ALT value and in preventing liver carcinogenesis.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Chayama Kdoi
10.1007/BF02990103subject
Has Abstractpub_date
2002-01-01 00:00:00pages
69-73eissn
0944-1174issn
1435-5922journal_volume
37 Suppl 13pub_type
杂志文章abstract:BACKGROUND:In Japan, generally, patients with chronic hepatitis C are aged. The aim of this study was to investigate the effect of interferon (IFN) therapy on the mortality of chronic hepatitis C patients over age 60. METHODS:Seven-hundred and seven patients with histologically proven chronic hepatitis C were enrolled...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00535-004-1448-0
更新日期:2004-11-01 00:00:00
abstract::An association between macrovascular thrombosis and idiopathic inflammatory bowel disease has been described, although very few well-documented cases have been published. We report on a 39-year-old woman who presented with right hemifacial and upper limb edema that was shown to be due to an extensive right brachioceph...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350300046
更新日期:2003-01-01 00:00:00
abstract::We reviewed reports on the efficacy of clarithromycin in eradicating Helicobacter pylori. Reports on dual and 1-week triple therapy that included clarithromycin were analyzed to assess the eradication rates of H. pylori infection. Dual therapy with clarithromycin and a proton pump inhibitor achieved eradication rates ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Endoscopic transpapillary brush cytology and forceps biopsy are widely used for the pathological diagnosis of suspected malignant biliary strictures (MBS). However, the sensitivity of these methods remains insufficient, and it can be difficult to confirm the diagnosis. We aimed to evaluate the diagnostic abi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-011-0404-z
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:This study examined the association of cholelithiasis post-cholecystectomy with subsequent cancers and evaluated the risk of cancer in patients with both cholelithiasis and cholecystectomy. METHODS:The Taiwanese National Health Insurance Research Database was used to identify 15545 newly diagnosed cholelith...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-013-0846-6
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Thrombocytopenia represents an obstacle for invasive procedures in chronic liver disease (CLD) patients. We aimed to estimate the appropriate dose and evaluate the efficacy and safety of lusutrombopag for the treatment of thrombocytopenia before percutaneous liver radiofrequency ablation (RFA) for primary he...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00535-018-1499-2
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Intestinal Behçet's disease (BD) is very rare, and epidemiologic data regarding BD are scarce. Moreover, there have been no population-based studies focusing on intestinal BD. We conducted a nationwide population-based study to examine the incidence and clinical course of Korean patients with intestinal BD. ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-016-1300-3
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Subepithelial myofibroblasts (SEMFs) play a role in extracellular matrix (ECM) metabolism in the colon. In this study, we investigated the effects of interleukin (IL)-17, IL-1beta, and tumor necrosis factor (TNF)-alpha on matrix metalloproteinase (MMP)-3 secretion in colonic SEMFs. METHODS:MMP-3 secretion a...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-002-1101-8
更新日期:2003-01-01 00:00:00
abstract::A 59-year-old woman presented with consciousness disturbance with flapping tremor. Laboratory examinations revealed normal liver functions, and imaging studies, ultrasonography, magnetic resonance imaging, and angiography, showed portal vein aneurysm communicating from the portal vein to the hepatic vein, splenomegaly...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/BF02349649
更新日期:1995-12-01 00:00:00
abstract::The effect of nifedipine administration (10 mg) on esophageal acid exposure time was investigated in 11 non-reflux esophagitis (non-RE) patients and 11 grade C (Los Angeles classification) reflux esophagitis (RE) patients. In each subject, esophageal pH monitoring was performed, with the subject in the supine position...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050008
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:We evaluated the sensitivity and specificity of post-vascular phase (Kupffer imaging) by contrast-enhanced ultrasonography (CEUS) using perflubutane microbubbles (Sonazoid) in comparison with conventional B-mode ultrasonography (US) for the detection of hepatocellular carcinoma (HCC) nodules. METHODS:A tota...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-011-0512-9
更新日期:2012-04-01 00:00:00
abstract::Acute and chronic pancreatitises are gastrointestinal inflammatory diseases, the incidence of which is increasing worldwide. Most (~ 80%) acute pancreatitis (AP) patients have mild disease, and about 20% have severe disease, which causes multiple organ failure and has a high mortality rate. Chronic pancreatitis (CP) i...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-018-1500-0
更新日期:2019-02-01 00:00:00
abstract::The histopathological changes due to chronic Helicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication of H. pylori on nonulcer dyspepsia, the long-term ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/BF02990094
更新日期:2002-01-01 00:00:00
abstract::The clinical significance of small intestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains under-appreciated. It occurs with greater frequency than the damage caused by these drugs in the upper gastrointestinal tract, but is much more difficult to diagnose and treat. Although the pathogenesis...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-014-1032-1
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a common cancer type in China. In this study, we aimed to develop aneuploidy markers for diagnosis and prognosis of ESCC. METHODS:Chromosomal aneuploidies were detected in 493 primary tumors and 61 precancerous lesions by fluorescence in situ hybridization with c...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-014-0961-z
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Musashi-1 (Msi-1) is a RNA-binding protein, known as a putative marker of intestinal stem cells (ISCs). However, little is known about the function of Msi-1 within human intestinal epithelial cells (IECs). Thus, the present study aimed to clarify the role of Msi-1 in differentiation and proliferation of IECs...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-008-2284-4
更新日期:2009-01-01 00:00:00
abstract::An extremely rare case of malignant schwannoma of the esophagus with lymph node metastasis is reported. A 49-year-old woman was found to have an abnormal shadow on a chest X-ray film taken during an annual checkup. Upper gastrointestinal series showed extrinsic pressure on the middle thoracic esophagus, without a muco...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s005350170020
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Studies on the risk of osteoporotic fractures related to the use of proton pump inhibitors (PPIs) have been inconsistent. One recent cohort study reported that there was an interaction between PPIs and bisphosphonates (BPs). Thus we performed a case-control study aimed at evaluating the risk of hip fractures...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0722-9
更新日期:2013-09-01 00:00:00
abstract::Inflammatory cells in the gastric epithelium and direct cell damage are important effects of H. pylori infection in causing gastroduodenal diseases. The aim of this study was to determine whether H. Pylori possessing the cagA gene and vacuolating cytotoxin activity (cagA+/tox+) has these toxigenicities. The detection ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Circular RNAs (circRNAs) act as vital regulators of gene expression in a variety of cancers. However, the role of circRNAs in gastric cancer (GC) remains largely unexplored. Herein, we identified that circTMEM87A sponges miR-142-5p to promote GC progression through up-regulating ULK1 expression. METHODS:The...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-020-01744-1
更新日期:2020-11-06 00:00:00
abstract:BACKGROUND:High serum immunoglobulin G4 (IgG4) levels and IgG4-positive plasma cell infiltration are characteristic of type 1 autoimmune pancreatitis (AIP). It is unclear whether innate immunity is a cause of type 1 AIP; the possible involvement of microbial infection has been suggested in its pathogenesis. To clarify ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-014-0977-4
更新日期:2015-04-01 00:00:00
abstract::A case of life-threatening lower gastrointestinal hemorrhage from Crohn's disease is reported. Several promising studies have recently been published that describe superselective embolization for the treatment of massive lower gastrointestinal hemorrhage in patients with bleeding colonic diverticular disease and angio...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-005-1714-9
更新日期:2005-12-01 00:00:00
abstract::Nonrotation of the midgut in adults and appendiceal mucocele are both rare pathological conditions. We report here the first case of nonrotation of the midgut associated with appendiceal mucocele. The patient was a 51-year-old man admitted to hospital with ileus. An upper gastrointestinal series and a barium enema rev...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350170153
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Primary biliary cirrhosis (PBC) is histopathologically characterized by chronic nonsuppurative destructive cholangitis and ductopenia of interlobular bile ducts. Bile duct injury is also often encountered in chronic viral hepatitis (CVH) and in autoimmune hepatitis (AIH). METHODS:In this study, we performed...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-004-1514-7
更新日期:2005-02-01 00:00:00
abstract::Positron emission tomography (PET) is widely available and its application with 2-[(18)F] fluoro-2-deoxy-D-glucose ((18)F-FDG) in oncology has become one of the standard imaging modalities in diagnosing and staging of tumors, and monitoring the therapeutic efficacy in hepatic malignancies. Recently, investigators have...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-013-0790-5
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Gastric marker mucins (MUC5AC and MUC6) and intestinal marker molecules (MUC2 and CD10) have been used to determine the cell lineage of epithelial cell of gastric carcinoma (GC). METHODS:To clarify the characteristics of Epstein-Barr virus (EBV)-associated GC, 18 cases were immunohistochemically evaluated a...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-006-1841-y
更新日期:2006-08-01 00:00:00
abstract::Gastrointestinal symptoms such as abdominal pain, dyspepsia, and diarrhea are relatively nonspecific and a common cause for seeking medical attention. To date, it is challenging for physicians to differentiate between functional and organic gastrointestinal conditions and it involves the use of serological and endosco...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-016-1182-4
更新日期:2016-05-01 00:00:00
abstract::The localization and distribution of gamma delta T cell receptor (TCR)-positive cells (gamma delta T cells) in hepatocellular carcinoma capsules was investigated immunohistochemically at both light and electron microscopic levels. Most of the mononuclear cells infiltrating the tumor capsules were CD3-positive. Togethe...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02347508
更新日期:1995-06-01 00:00:00
abstract::A retrospective long-term endoscopic follow-up study was designed to examine atrophic changes in the gastric mucosa over time in Helicobacter pylori-positive patients. Over a period of 8-17 years (mean, 13.4 years) 22 subjects (5 men, 17 women, mean age, 55 years) without localized gastroduodenal lesions underwent ser...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF01213291
更新日期:1997-02-01 00:00:00
abstract::A case of heterotopic gastric mucosa in the fundus of the gallbladder is reported. A 23-year-old man, who had been healthy and asymptomatic, visited our hospital because of abnormal findings in a liver enzyme test given during a routine health screening. Ultrasonography demonstrated a highly echogenic polypoid mass in...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02347576
更新日期:1995-08-01 00:00:00