Abstract:
BACKGROUND:High serum immunoglobulin G4 (IgG4) levels and IgG4-positive plasma cell infiltration are characteristic of type 1 autoimmune pancreatitis (AIP). It is unclear whether innate immunity is a cause of type 1 AIP; the possible involvement of microbial infection has been suggested in its pathogenesis. To clarify the pathogenesis of type 1 AIP, we investigated Toll-like receptors (TLRs) in type 1 AIP patients. METHODS:We studied nine cases of type 1 AIP with ten cases of alcoholic chronic pancreatitis (ACP) and three of the samples from non-tumorous lesion of neuroendocrine tumor (NET) as control subjects. We counted the number of TLR1-11-positive cells immunohistochemically stained with anti-TLR1-11 antibodies. To identify TLR-positive cells in pancreata from type 1 AIP patients, we used a double-immunofluorescence method and counted the numbers of identifiable CD68-, CD163-, CD123-, and CD20-positive cells. RESULTS:In type 1 AIP, TLR7 (8.815 ± 1.755), TLR8 (3.852 ± 1.489), and TLR10 (3.852 ± 0.921) were highly expressed. Only the ratio of TLR7 per monocyte was significantly higher in type 1 AIP (0.053 ± 0.012) than in ACP (0.007 ± 0.004; p < 0.01) and non-tumorous lesion of NET (0.000 ± 0.000; p < 0.01). In type 1 AIP, the CD163 to TLR7 ratio (0.789 ± 0.031) was significantly higher both than that of CD123 to TLR7 ratio (0.034 ± 0.006; p < 0.001) and CD20 to TLR7 ratio (0.029 ± 0.010; p < 0.001). CONCLUSIONS:TLR7 might be key pattern-recognition receptors involved in the development of type 1 AIP.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Fukui Y,Uchida K,Sakaguchi Y,Fukui T,Nishio A,Shikata N,Sakaida N,Uemura Y,Satoi S,Okazaki Kdoi
10.1007/s00535-014-0977-4subject
Has Abstractpub_date
2015-04-01 00:00:00pages
435-44issue
4eissn
0944-1174issn
1435-5922journal_volume
50pub_type
杂志文章abstract::Neuroendocrine tumors (NETs) [carcinoids, pancreatic neuroendocrine tumors (pNETs)] are becoming an increasing clinical problem because not only are they increasing in frequency, but they can frequently present with advanced disease that requires diagnostic and treatment approaches different from those used in the neo...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-012-0642-8
更新日期:2012-09-01 00:00:00
abstract::Although stomal varices are a rare complication, bleeding stomal varices often need to be treated owing to symptoms of hypovolemic shock, recurrence of stomal bleeding, or deterioration in the quality of life. Various treatment strategies for the management of bleeding stomal varices have thus far been reported. We re...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-006-1960-5
更新日期:2007-01-01 00:00:00
abstract::To determine the role of endogenous substance P in ethanol-induced mucosal damage, two experiments were performed. In the first experiment, the stomachs of anesthetized rats were doubly cannulated and gastric damage was induced with 5ml of 30% ethanol in the gastric lumen. The damage was ameliorated by pretreatment wi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02355018
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Using cDNA microarray analysis that displays a total of 8734 mouse genes, we have identified 21 known and novel transcripts, including mouse expressed sequence tags (ESTs) that were consistently up- or downregulated in the fundus of wild-type mice and W/W(V) mice, where intramuscular interstitial cells of Ca...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1283-8
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:We recently reported that the presence of a papillary adenocarcinoma (pap) component was an independent risk factor for lymphatic involvement in endoscopically resected early gastric cancer (EGC). This study aimed to investigate the potential association between the presence of a pap component in EGC and lym...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-014-0991-6
更新日期:2015-04-01 00:00:00
abstract::Involvement of the gastroduodenum is extremely rare in Crohn's disease. For obstructing duodenal Crohn's disease, bypass procedures have traditionally been selected. However, more recently, strictureplasty has become an acceptable surgical option. We treated two Crohn's disease patients with short proximal duodenal st...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350070008
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. left-sided colon,' 'colon vs. rectum,' and 'right-sided (right-sided colon) vs. left-sided (left-sided colon and rectum).' This nationwide multicenter ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-020-01706-7
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Liver histology is the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH). Noninvasive, simple, reproducible, and reliable biomarkers are greatly needed to differentiate NASH from nonalcoholic fatty liver disease (NAFLD). METHODS:To construct a scoring system for predicting NASH, 177 Jap...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-010-0305-6
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Efficacy and safety of interferon induction therapy alone or in combination with ribavirin or ribavirin plus amantadine were evaluated in chronic hepatitis C patients who were nonresponders to primary antiviral treatment. METHODS:The study was designed to have 225 HCV nonresponder patients, but at an interi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00535-007-2006-3
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Several small, prospective, open studies suggest that leukocytapheresis might be efficient in patients with steroid-dependent ulcerative colitis (UC). AIM:To evaluate the short- and long-term effectiveness of leukocytapheresis for the management of steroid-dependent UC in clinical practice. METHODS:A Web-b...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-011-0499-2
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Intestinal Behçet's disease (BD) is very rare, and epidemiologic data regarding BD are scarce. Moreover, there have been no population-based studies focusing on intestinal BD. We conducted a nationwide population-based study to examine the incidence and clinical course of Korean patients with intestinal BD. ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-016-1300-3
更新日期:2017-08-01 00:00:00
abstract::We report the coexistence of symptomatic viral, bacterial, and fungal infection of the upper gastrointestinal tract in a heart transplant recipient. Endoscopic findings were normal at all levels but, because of severe symptoms and recent conversion to positive serology for Cytomegalovirus, biopsies were taken. These s...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02358613
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Additional surgical treatment after non-curative endoscopic resection for superficial esophageal cancer should be considered unless the tumor is pathologically proven to be categorized within the absolute indication of endoscopic resection. However, the significance of this treatment strategy has been poorly...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-014-0983-6
更新日期:2015-04-01 00:00:00
abstract::We report a 13-year-old girl who presented with hepatic failure and hemolytic anemia. Laboratory findings showed a normal serum copper level (104 microg/dl), high urinary copper level (2370 microg/dl), and low serum ceruloplasmin level (14.3 microg/dl). Slit-lamp examination revealed Kayser-Fleischer rings on her corn...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-005-1600-5
更新日期:2005-06-01 00:00:00
abstract::Cytosolic phospholipase A2 (PLase A2) is activated by low Ca2+ concentrations and translocates from the cytosol to the cell membrane, releasing arachidonic acid; the arachidonic acid cascade then leads to the production of many inflammatory mediators. The aim of this study, accordingly, was to investigate the role of ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050215
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Vaniprevir is a potent macrocyclic hepatitis C virus (HCV) nonstructural protein 3/4A protease inhibitor. This phase III study evaluated the safety and efficacy of vaniprevir in combination with peginterferon alfa-2b and ribavirin (PR) for 24 weeks compared with PR alone for 48 weeks in treatment-naive Japan...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00535-015-1120-x
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Patients with primary biliary cirrhosis (PBC) exhibit a variety of clinical manifestations and patterns of disease progression. The aim of this study was to identify genetic determinants of PBC progression. METHODS:A total of 52 tag single nucleotide polymorphisms (SNPs) of 11 candidate genes involved in re...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0730-9
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Few epidemiologic studies have examined the role of nutrient intake in the development of pancreatic cancer in Japan. We addressed this association in a population-based case-control study. METHODS:The cases were 109 patients who were newly diagnosed with pancreatic cancer between January 2000 and March 200...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00535-004-1537-0
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Subunit A of coagulation factor XIII (FXIII-A) is important for clot stability and acts in the subsequent wound healing process. Loss of plasma FXIII-A has been reported after surgery, sepsis, and inflammatory conditions. In the intestinal mucosa, FXIII-A is expressed by macrophages and cellular FXIII-A has ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-015-1152-2
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy is the current standard of care for patients with chronic hepatitis C. Determining precisely the risk of serious adverse events (SAEs) and mortality from a single study is rather difficult because of the infrequency of such events. The aim of this s...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1007/s00535-012-0631-y
更新日期:2013-02-01 00:00:00
abstract::We describe a gastric carcinoma cell line that has been maintained in vitro for more than 10 years and retains the capacity to produce a large amount of alpha-fetoprotein. This cell line was isolated from a metastatic lymph node of a 63-year-old male patient with advanced gastric carcinoma (T2N3P0H0M0) who showed high...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02367784
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:We recently reported the real-world changes in the etiologies of liver cirrhosis (LC) based on nationwide survey data and assessed the etiologies of LC with hepatocellular carcinoma (HCC). METHODS:Fifty-five participants from 68 institutions provided data on 23,637 patients with HCC-complicated LC. The chan...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-020-01748-x
更新日期:2020-11-20 00:00:00
abstract:PURPOSE:Recent routine testing for liver function and anti-mitochondrial antibodies has increased the number of newly diagnosed patients with primary biliary cirrhosis (PBC). This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC pat...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-009-0090-2
更新日期:2009-01-01 00:00:00
abstract::Preoperative biliary drainage (PBD) has been thought to be preferable regardless of the site of biliary strictures, e.g., distal or proximal strictures because PBD by endoscopy or interventional radiology decreases postoperative mortality and morbidity rates. However, recently, several studies have revealed that PBD s...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-015-1096-6
更新日期:2015-09-01 00:00:00
abstract::Primary T/natural killer (NK) cell lymphoma of the colon is extremely rare. Despite the advances in histological and immunophenotypic studies, the diagnosis of primary T/NK cell lymphoma of the colon can be delayed because the early symptoms and colonoscopic findings may be very similar to those of inflammatory bowel ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350200158
更新日期:2002-01-01 00:00:00
abstract::Chronic inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer. However, the mechanism underlying the development of colorectal cancers through chronic inflammation is not known. Activation-induced cytidine deaminase (AID) was originally identified as an inducer of so...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-010-0326-1
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:DNA microarray technology has enabled genomewide analysis of gene transcript levels, yielding insight into the molecular nature of liver disease. METHODS:We compared gene expression of liver biopsy specimens in 16 patients with different stages of chronic hepatitis B, five with autoimmune hepatitis (AIH), f...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-008-2237-y
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Little is known about the difference in enhancement patterns of hepatocellular carcinoma (HCC) during multistep hepatocarcinogenesis between the post-vascular phase of Sonazoid-enhanced ultrasonography (SEUS) and hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine (Gd-EOB-DTPA)-enhanced MRI, as...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-013-0859-1
更新日期:2014-06-01 00:00:00
abstract::The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for the test. The test ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050092
更新日期:1998-06-01 00:00:00
abstract::The chemotactic activity of Helicobacter pylori is important for its colonization. H. pylori exhibited chemotactic responses to urea and potassium bicarbonate, which can be supplied from human gastric epithelium. The chemotactic activities of H. pylori in a fluid environment were higher on the urease-positive strain t...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00