Abstract:
:Gastrointestinal symptoms such as abdominal pain, dyspepsia, and diarrhea are relatively nonspecific and a common cause for seeking medical attention. To date, it is challenging for physicians to differentiate between functional and organic gastrointestinal conditions and it involves the use of serological and endoscopic techniques. Therefore, a simple, noninvasive, inexpensive, and effective test would be of utmost importance in clinical practice. Fecal calprotectin (FC) is considered to be a reliable biomarker that fulfills these criteria. FC can detect intestinal inflammation, and its level correlates well with macroscopic and histological inflammation as detected by colonoscopy and biopsies, respectively. FC has a decent diagnostic accuracy for differentiating organic diseases and functional disorders because of its excellent negative predictive value in ruling out inflammatory bowel disease (IBD) in symptomatic undiagnosed patients. There is accumulating evidence that FC has been effectively used to monitor the natural course of IBD, to predict relapse, and to see the response to treatment. This novel biomarker has the ability to assess mucosal healing (MH), which is a therapeutic goal in IBD management. A literature search was carried out using PubMed with the keywords FC, IBD, intestinal inflammation, and MH. In our review, we provide an overview of the utility and scope of FC as a biomarker in patients with IBD as well as undiagnosed patients with lower gastrointestinal symptoms.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Ikhtaire S,Shajib MS,Reinisch W,Khan WIdoi
10.1007/s00535-016-1182-4subject
Has Abstractpub_date
2016-05-01 00:00:00pages
434-46issue
5eissn
0944-1174issn
1435-5922pii
10.1007/s00535-016-1182-4journal_volume
51pub_type
杂志文章,评审abstract:BACKGROUND:The levels of serum HER2 extracellular domain (ECD) are highly correlated with tissue HER2 status in metastatic gastric cancer (AGC). We sought to explore whether serum HER2 ECD could predict the efficacy of trastuzumab-treated HER2-positive AGC. MATERIALS AND METHODS:From 2011 to 2013, trastuzumab-treated ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-015-1046-3
更新日期:2015-09-01 00:00:00
abstract::We report a case of gastric neuroendocrine (NE) carcinoma associated with chronic atrophic gastritis type A (CAG/A) or reversed atrophic type gastritis. A 9 x 6 cm tumor was resected from the stomach to control pain in a 55-year-old Japanese woman with peritoneal dissemination and metastatic tumors of the liver and ov...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02934114
更新日期:1997-10-01 00:00:00
abstract::Depletion of goblet cells (the main mucin-producing cells in the colon) is one of the most reliable histological characteristics of ulcerative colitis, whereas a major symptom of this disease is bloody diarrhea containing a large amount of mucus. The discrepancy between these phenomena was investigated in a time-cours...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050245
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Given the well-documented adverse side effects of sorafenib, many sorafenib-treated patients may need the reduced initial dose of the compound, and an alternative sorafenib-based therapy, which exerts similar clinical benefit, is anticipated. An angiostatic therapy with sorafenib is considered one of the pro...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-013-0906-y
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Infection with Helicobacter pylori is the main risk factor for development of gastric cancer. CD44 overexpression, especially that of variant 9 (CD44v9), has also been implicated in the local inflammatory response and metaplasia-carcinoma sequence in human stomach. We recently identified miR-328 as one of th...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-014-1019-y
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:In patients with hepatitis C virus (HCV)-genotype 1b and a high virus load, of more than 1 Meq/ml by the DNA probe assay, the clearance of HCV-RNA was achieved in only 10% with a 6-month interferon (IFN) course. We therefore assessed the efficacy of prolonged IFN therapy in patients with HCV-genotype 1b and ...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s005350300026
更新日期:2003-01-01 00:00:00
abstract::The present study was carried out to examine the effects of submucosal administration of endothelin on gastric mucosal integrity in rats. Injection of endothelin-3 into the submucosal space of the stomach induced gastric mucosal damage dose-dependently and site-specifically. The gastric injury was localized only at th...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02936360
更新日期:1997-04-01 00:00:00
abstract::Ulcerative colitis is a chronic inflammatory disease of colonic mucosa in which the pathogenesis of any immunological disorders would likely be related. Various circulating autoantibodies have been reported in patients with ulcerative colitis, although their possible roles in this disease process have not yet been cla...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF03326407
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Catechin, a polyphenol contained in tea (a cup of tea contains approximately 0.1% [w/v] catechin), has various physiological effects. The aim of this study was to investigate the mechanism of the inhibitory effect of catechin on gastric mucosal lesions. METHODS:We studied the effect of catechin on gastric m...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350200004
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Autoimmune pancreatitis (AIP) is considered to be a pancreatic lesion of IgG4-related systemic disease, but about 20% of AIP patients do not have elevated serum IgG4 levels. This study aimed to clarify the pathophysiology of AIP patients without elevated serum IgG4 levels. METHODS:Fifty-eight AIP patients w...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-010-0317-2
更新日期:2011-01-01 00:00:00
abstract::The aim of this study was to examine the diurnal variations in ornithine decarboxylase (ODC) activity and apoptosis in the small intestinal mucosa of Mongolian gerbils. First, the feeding, drinking, and ambulatory patterns of the gerbils were recorded. The results indicated that Mongolian gerbils lost diurnal cyclicit...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350070088
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The apelin receptor (APJ) is related to angiotensin-like-receptor 1 (AGTRL1). This study was designed to elucidate the in vivo localization and changes of APJ in cirrhotic liver, and the in vitro changes of APJ expression in cultured hepatic stellate cells (HSCs) and capillarized sinusoidal endothelial cells...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-010-0296-3
更新日期:2011-02-01 00:00:00
abstract::Human glucagonoma cells were isolated and maintained in vitro. Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels. Atropine abolished the stimulatory e...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02349291
更新日期:1994-12-01 00:00:00
abstract::Two hundred and three patients with Crohn's disease seen at Kyushu University, Fukuoka University, and their affiliated centers from 1973 to 1988 were followed for 4.4 +/- 3.2 years (mean +/- SD), to evaluate the prognosis relative to life span and surgery. Cumulative survival rate and cumulative operation rate were c...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究
doi:
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:The risk for lymph node metastasis and the prognostic significance of pedunculated-type T1 colorectal carcinomas (CRCs) require further study. We aimed to assess the validity of the 2014 Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines based on long-term outcomes of pedunculated-type T1...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00535-015-1144-2
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Few studies have investigated the association between smoking and ultrasonographically diagnosed gallbladder (GB) disease, and their results were uncertain. This study was conducted to examine the association between smoking and drinking and GB diseases. METHODS:A total of 9,947 subjects (age, 30-69 years; ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350200066
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Innate immunity mechanisms have been shown to play a paramount role in organ transplantation. Our aim was to investigate the hypothesis that activation of the interferon system may affect clinically relevant outcomes, such as acute rejection and/or early fibrosis progression, after liver transplantation. ME...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-011-0440-8
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Although it is less frequently encountered, mesenteric vein occlusion poses as important a problem as mesenteric artery occlusion. The energy metabolism of intestinal tissue during venous occlusion and reperfusion was studied. METHODS:Male Wistar rats were studied in four groups of 17 animals each. Intestin...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1160-5
更新日期:2003-01-01 00:00:00
abstract::Because most gastric cancers develop from a background of Helicobacter pylori-infected gastric mucosa, H. pylori plays an important role in gastric carcinogenesis. Therefore, eradication of H. pylori may inhibit the incidence of gastric cancers. In experimental studies, H. pylori eradication has proved to act as a pro...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-006-1928-5
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Linked color imaging (LCI) increases the visibility of early gastric cancers, which may be associated with characteristic findings including background purple mucosae. These lesions are found in areas of chronic gastritis and surrounding mucosa. The aim of this study is to objectively characterize these lesi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-018-1515-6
更新日期:2019-05-01 00:00:00
abstract::The role of the tumor stroma in carcinogenesis and cancer progression have been documented for a long time. However, the molecules and mechanisms involved have not been understood precisely. Recently, various mediators involved in the communication between the tumor epithelium and stroma and their roles have been reve...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-008-2321-3
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:A prospective, randomized study was performed to determine whether gemcitabine infusion at a low dose (250 mg/m2) is comparable or superior to the standard-dose infusion (1000 mg/m2) in terms of the survival period, clinical benefit, and frequency of adverse effects in patients with advanced pancreatic adeno...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00535-005-1724-7
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:In Japan, there are few studies of long-term (more than 1 month) interferon (IFN) therapy for chronic hepatitis B (CHB). In this retrospective study, we investigated the efficacy and predictors of response to 6-month IFN therapy. METHODS:We analyzed 66 Japanese patients with CHB who were treated with IFN fo...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-004-1430-x
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether leptin and insulin resistance (IR) showed differences between steatotic patients with and without elevated serum transaminases. METHODS:The study included 32 patients with fatty liver and high serum transaminase level (group I), 31 patients with fatty liver and...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-002-1084-5
更新日期:2003-01-01 00:00:00
abstract::Cyclin D1 overexpression is remarkably frequent in several human carcinomas and is believed to be a critical event in oncogenesis. We examined cyclin D1 expression, p53 expression, and the Ki-67 labeling index by immunostaining in human gallbladder mucosa in conditions varying from normal to malignant tissue. We also ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050027
更新日期:2000-01-01 00:00:00
abstract::Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and non-lymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients wit...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02936370
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to elucidate the role of nuclear factor kappaB (NF-kappaB) in the development of gastric ischemia-reperfusion (GI-R) injury and in mediating the effects of angiotensin II (Ang II) in the paraventricular nucleus (PVN) on GI-R injury. METHODS:GI-R injury was induced in rats by cl...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-008-2217-2
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Infection with Helicobacter pylori has been associated with chronic idiopathic urticaria (CIU). The aim of this study was to investigate the efficacy of H. pylori eradication in the treatment of patients with CIU. METHODS:Fifty patients with CIU (16 men and 34 women; age 25-75 years) and 100 sex- and age-ma...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-004-1397-7
更新日期:2004-09-01 00:00:00
abstract::We investigated the effect of intravenous infusions of the therapeutically available amino acid solutions Moripron and Morihepamin (Roussel Morishita, Osaka, Japan) on gallbladder contraction and cholecystokinin (CCK) release in healthy male volunteers. Plasma CCK levels were measured by radioimmunoassay, using the an...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02355059
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:There are substantial differences in inflammatory bowel disease (IBD) genetics depending on the populations examined. We aimed to identify Japanese population-specific or true culprit susceptibility genes through a meta-analysis of past genetic studies of Japanese IBD. METHODS:For this study, we reviewed 2,...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00535-013-0866-2
更新日期:2014-08-01 00:00:00