Abstract:
BACKGROUND:The apelin receptor (APJ) is related to angiotensin-like-receptor 1 (AGTRL1). This study was designed to elucidate the in vivo localization and changes of APJ in cirrhotic liver, and the in vitro changes of APJ expression in cultured hepatic stellate cells (HSCs) and capillarized sinusoidal endothelial cells (SECs) activated by growth factors. METHODS:In vivo studies used control liver samples, cirrhotic liver samples from patients with Child's A cirrhosis undergoing surgical resection (Child-A-LC), and cirrhotic liver samples from autopsied cases of decompensated Child's C cirrhosis (Child-C-LC). Immunohistochemical (IHC), Western blot, laser-capture microdissection (LCM) coupled with reverse transcription -polymerase chain reaction (RT-PCR), and immunoelectron microscopic (IEM) studies for APJ expression were conducted. In vitro examinations used commercial human HSCs and SECs. APJ expression was examined in cultured HSCs activated by growth factors and in capillarized SECs activated by angiogenic factors. RESULTS:The IHC study of liver samples revealed only slight APJ expression in hepatic sinusoids in control liver tissue. In cirrhotic liver (Child-A-LC and Child-C-LC), APJ expression was evident mainly along the sinusoids and on portal fibroblasts in fibrotic septa. Western blot analysis of whole-liver homogenate and LCM-PCR of sinusoids revealed overexpression of APJ in Child-C-LC samples. The results of IEM studies showed that APJ expression was increased significantly on HSCs, but it was sparse on SECs in Child-C-LC tissue. In vitro examination revealed that APJ was overexpressed in cultured HSCs activated by platelet-derived growth factor-β. CONCLUSIONS:Enhanced expression of APJ on HSCs in cirrhosis indicates markedly increased vascular remodeling.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Yokomori H,Oda M,Yoshimura K,Machida S,Kaneko F,Hibi Tdoi
10.1007/s00535-010-0296-3subject
Has Abstractpub_date
2011-02-01 00:00:00pages
222-31issue
2eissn
0944-1174issn
1435-5922journal_volume
46pub_type
杂志文章abstract::We report a case of squamous cell carcinoma (SCC) of the gastric cardia showing submucosal progression with direct invasion of the liver. A 71-year-old man was admitted with dysphagia. Esophagogastroscopy showed a protruding tumor covered with normal gastric mucosa in the anterior wall of the gastric cardia, although ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
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abstract::We investigated the adverse effects of sulfasalazine in the treatment of inflammatory bowel disease in Japan. In our first survey, adverse effects were observed in 52 out of 751 patients with ulcerative colitis (6.9%) and in 8 out of 221 patients with Crohn's disease (3.6%); i.e., such effects were observed in 60 out ...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究
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abstract::Our objective was to determine whether the prevalence of vacuolating cytotoxin production differed among Helicobacter pylori isolates obtained from patients with chronic gastritis, gastric ulcer, or duodenal ulcer. We examined the vacuolating cytotoxin production of 114 clinical H. pylori isolates in rabbit gastic epi...
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abstract::Inflammatory bowel disease (IBD) could be curable by "immune rest" and correction of the genetic predisposition inherent in allogeneic hematopoietic stem cell transplantation. However, balancing risks against benefits remains challenging. The application of mesenchymal stem cells (MSCs) serving as a site-regulated "dr...
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abstract::The histopathological changes due to chronic Helicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication of H. pylori on nonulcer dyspepsia, the long-term ...
journal_title:Journal of gastroenterology
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02355069
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/BF02358623
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pub_type: 杂志文章
doi:10.1007/s00535-007-2126-9
更新日期:2008-01-01 00:00:00
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doi:10.1007/s00535-020-01744-1
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
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doi:10.1007/s00535-009-0151-6
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journal_title:Journal of gastroenterology
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
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doi:10.1007/BF02348677
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