Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers.

abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japan...

journal_title：Journal of gastroenterology

authors： Fuyuno Y,Yamazaki K,Takahashi A,Esaki M,Kawaguchi T,Takazoe M,Matsumoto T,Matsui T,Tanaka H,Motoya S,Suzuki Y,Kiyohara Y,Kitazono T,Kubo M

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:DNA microarray technology has enabled genomewide analysis of gene transcript levels, yielding insight into the molecular nature of liver disease. METHODS:We compared gene expression of liver biopsy specimens in 16 patients with different stages of chronic hepatitis B, five with autoimmune hepatitis (AIH), f...

journal_title：Journal of gastroenterology

authors： Furuta K,Sato S,Yamauchi T,Ozawa T,Harada M,Kakumu S

更新日期：2008-01-01 00:00:00

abstract：:The spontaneous passage of colon cast from a 76-year-old Japanese female patient is reported. Macroscopically, the colon case was shaped like the airbladder of a fish. Histopathologically, the cast consisted of degenerated colonal mucosa, including glands. No inflammatory reaction was apparent. The patient lacked any ...

journal_title：Journal of gastroenterology

authors： Yoshiji H,Nakae D,Sugiya R,Mizumoto Y,Tsutsumi M,Hiriguchi K,Yokose Y,Sakurai R,Fukui H,Tsujii T

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:This study aimed to develop a model to predict the development of severe anemia during pegylated interferon alpha-2b plus ribavirin combination therapy. METHODS:Data were collected from 1081 genotype 1b chronic hepatitis C patients who were treated at 6 hospitals in Japan. These patients were randomly assig...

journal_title：Journal of gastroenterology

authors： Hiramatsu N,Kurosaki M,Sakamoto N,Iwasaki M,Sakamoto M,Suzuki Y,Sugauchi F,Tamori A,Kakinnuma S,Matsuura K,Izumi N

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. left-sided colon,' 'colon vs. rectum,' and 'right-sided (right-sided colon) vs. left-sided (left-sided colon and rectum).' This nationwide multicenter ...

journal_title：Journal of gastroenterology

authors： Shida D,Inoue M,Tanabe T,Moritani K,Tsukamoto S,Yamauchi S,Sugihara K,Kanemitsu Y

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The p53 tumor suppressor protein plays a fundamental role in maintaining genomic integrity through its ability to arrest the cell cycle in G1 and induce apoptosis. The proapoptotic activity of p53 seems to be strictly related to proline-rich regions, homologous to the SH3 binding domain. In the literature, r...

journal_title：Journal of gastroenterology

authors： Vietri MT,Riegler G,Ursillo A,Caserta L,Cioffi M,Molinari AM

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Little real-world cohort data has been reported for Asians who have received interferon-free regimens with sofosbuvir (SOF) for chronic hepatitis C virus (HCV) infection. We evaluated the effectiveness and safety in clinical practice of ledipasvir (LDV) plus SOF for Japanese patients infected with HCV genoty...

journal_title：Journal of gastroenterology

authors： Ogawa E,Furusyo N,Nomura H,Dohmen K,Higashi N,Takahashi K,Kawano A,Azuma K,Satoh T,Nakamuta M,Koyanagi T,Kato M,Shimoda S,Kajiwara E,Hayashi J,Kyushu University Liver Disease Study (KULDS) Group.

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Linked color imaging (LCI) increases the visibility of early gastric cancers, which may be associated with characteristic findings including background purple mucosae. These lesions are found in areas of chronic gastritis and surrounding mucosa. The aim of this study is to objectively characterize these lesi...

journal_title：Journal of gastroenterology

authors： Fukuda H,Miura Y,Osawa H,Takezawa T,Ino Y,Okada M,Khurelbaatar T,Lefor AK,Yamamoto H

更新日期：2019-05-01 00:00:00

abstract：:Adult midgut rotational anomalies are difficult to diagnose. Any symptoms present in adults may be the result of intermittent volvulus of the midgut. Successful outcome of this clinical condition depends on prompt diagnosis and timely surgical intervention. Computed tomography (CT) is useful in early identification of...

journal_title：Journal of gastroenterology

authors： Wang TK,Yeh CH

更新日期：1998-02-01 00:00:00

abstract：:Three-dimensional-computed tomography (3D-CT) cholangiography is a 3D shaded surface display image of the biliary tract obtained by using helical CT after intravenous cholangiography or cholangiography per percutaneous transhepatic cholangio-drainage tube. We investigated whether 3D-CT cholangiography could provide a ...

journal_title：Journal of gastroenterology

authors： Kinami S,Yao T,Kurachi M,Ishizaki Y

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Although it is less frequently encountered, mesenteric vein occlusion poses as important a problem as mesenteric artery occlusion. The energy metabolism of intestinal tissue during venous occlusion and reperfusion was studied. METHODS:Male Wistar rats were studied in four groups of 17 animals each. Intestin...

journal_title：Journal of gastroenterology

authors： Kimura M,Kataoka M,Kuwabara Y,Sato A,Sugiura M,Fujii Y

更新日期：2003-01-01 00:00:00

abstract：:Involvement of the gastroduodenum is extremely rare in Crohn's disease. For obstructing duodenal Crohn's disease, bypass procedures have traditionally been selected. However, more recently, strictureplasty has become an acceptable surgical option. We treated two Crohn's disease patients with short proximal duodenal st...

journal_title：Journal of gastroenterology

authors： Takesue Y,Yokoyama T,Akagi S,Ohge H,Murakami Y,Imamura Y,Uemura K,Kanehiro T,Matsuura Y

更新日期：2000-12-01 00:00:00

abstract：:In a pilot study of direct dissolution therapy of gallstones with methyl tert-butyl ether (MTBE), endoscopic transpapillary catheterization in the gallbladder (ETCG) was performed. Complete dissolution was seen in 8 out of 12 (66%) patients and partial dissolution was seen in 2 (16%) patients. In one of the 8 complete...

journal_title：Journal of gastroenterology

authors： Uchida N,Nakatsu T,Hirabayashi S,Minami A,Fukuma H,Ezaki T,Morshed SA,Fuke C,Ameno K,Ijiri I

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Endoscopic sphincterotomy (ES) is widely performed in patients with common bile duct stones (CBDS). However, the long-term outcomes of patients following ES have not been sufficiently elucidated. Impaired papillary function following ES may result in additional late complications. In contrast, endoscopic pap...

journal_title：Journal of gastroenterology

authors： Doi S,Yasuda I,Mukai T,Iwashita T,Uemura S,Yamauchi T,Nakashima M,Adachi S,Shimizu M,Tomita E,Itoi T,Moriwaki H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Cold snare polypectomy (CSP) has not undergone sufficient histopathological evaluation. This study aimed to clarify the histopathological features of CSP specimens, including resection depth and layer, as compared with endoscopic mucosal resection (EMR). METHODS:Polyps were recruited retrospectively. Sessil...

journal_title：Journal of gastroenterology

authors： Ito A,Suga T,Ota H,Tateiwa N,Matsumoto A,Tanaka E

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Experimental evidence and clinical studies suggest that the renin-angiotensin system and its inhibitors may play a role in regulating the mechanisms of liver fibrosis development. The present study aimed to verify whether carriage of specific angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) all...

journal_title：Journal of gastroenterology

authors： Fabris C,Toniutto P,Bitetto D,Minisini R,Fornasiere E,Smirne C,Pirisi M

更新日期：2007-07-01 00:00:00

abstract：:Cholecystokinin (CCK) receptor antagonists have been reported on have an inhibitory effect on acute experimental pancreatitis, but their long-term administration is also reported to block pancreatic regeneration. We examined whether the short-term administration of KSG-504 (KSG), a synthetic CCK-A receptor antagonist,...

journal_title：Journal of gastroenterology

authors： Okumura Y,Inoue H,Fujiyama Y,Bamba T

更新日期：1995-08-01 00:00:00

abstract：:Primary sclerosing cholangitis is very rare in Japan. The aim of the present study was to identify the characteristics of such patients in Japan. A questionnaire was sent to the members of the Japanese Society of Gastroenterology and responses for 192 cases were analyzed. There was male predominancy (61%), and two pea...

journal_title：Journal of gastroenterology

authors： Takikawa H,Manabe T

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:There have been few reports on hepatocellular carcinoma (HCC) in nonalcoholic steatohepatitis (NASH) and the natural history of NASH. Accordingly, we assessed the clinical features of HCC in NASH, the risk factors for HCC, and natural history of NASH with advanced fibrosis. PATIENTS AND METHODS:There were 3...

journal_title：Journal of gastroenterology

authors： Hashimoto E,Yatsuji S,Tobari M,Taniai M,Torii N,Tokushige K,Shiratori K

更新日期：2009-01-01 00:00:00

abstract：:An association between Crohn's disease and gastric cancer has not been clearly defined. A 34-year-old man was referred to our hospital for the evaluation of a gastric lesion and treatment of small-bowel Crohn's disease. We diagnosed the gastric lesion as adenocarcinoma, using endoscopy and histological studies. The pa...

journal_title：Journal of gastroenterology

authors： Ikeuchi H,Kusunoki M,Yamamura T,Nishigami T

更新日期：2002-01-01 00:00:00

abstract：:Adenocarcinoma of the small intestine is uncommon. Due to this paucity and the lack of specificity of symptoms, patients are usually seen late in the course of their illness, when curative therapy, mainly represented by extensive surgical resection, is unlikely. The authors report a case of primary well-differentiated...

journal_title：Journal of gastroenterology

authors： Koyama S,Araki M,Yuhara K,Murata Y,Fukutomi H,Atake S,Gohongi T,Yuzawa K,Fukao K,Kikuchi M

更新日期：1995-10-01 00:00:00

abstract：:Ulcerative colitis is a chronic inflammatory disease of colonic mucosa in which the pathogenesis of any immunological disorders would likely be related. Various circulating autoantibodies have been reported in patients with ulcerative colitis, although their possible roles in this disease process have not yet been cla...

journal_title：Journal of gastroenterology

authors： Nakamura H,Yoshida K,Ikegame K,Kishima Y,Uyama H,Enomoto H

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:In recent years in Japan, the rate of clarithromycin (CAM) resistance in Helicobacter pylori has risen to around 30%, and the eradication rate with triple therapy [proton pump inhibitor + amoxicillin (AMPC) + CAM] has been trending downward to around 70%. In 2007, rabeprazole (RPZ)-based triple therapy (RPZ ...

journal_title：Journal of gastroenterology

authors： Fujioka T,Aoyama N,Sakai K,Miwa Y,Kudo M,Kawashima J,Matsubara Y,Miwa J,Yakabi K

更新日期：2012-03-01 00:00:00

abstract：:Helicobacter pylori infection has been found to decrease the expression of antral somatostatin and to increase the release of the acid-stimulating hormone gastrin. The reversal of these changes in gut hormones by the eradication of H. pylori, and in-vivo and in-vitro studies in animals either infected with H. pylori o...

journal_title：Journal of gastroenterology

authors： Kaneko H,Konagaya T,Kusugami K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:We carried out this study to evaluate the association between regulatory T cells (Treg) and prognosis and progression after cryoablation in patients with hepatitis-B virus-related hepatocellular carcinoma. METHODS:Peripheral Treg frequency in 111 patients with hepatocellular carcinoma (HCC) was detected by ...

journal_title：Journal of gastroenterology

authors： Zhou L,Fu JL,Lu YY,Fu BY,Wang CP,An LJ,Wang XZ,Zeng Z,Zhou CB,Yang YP,Wang FS

更新日期：2010-09-01 00:00:00

abstract：:Perianal fistulae are frequently seen complications in Crohn's disease. Although surgical procedures such as Seton's method have been devised, many patients still suffer from fistulae that are resistant to conventional therapy. We administered oral adsorbent to a patient with disease Crohn's who had a complicated peri...

journal_title：Journal of gastroenterology

authors： Tsujikawa T,Araki Y,Makino J,Uda K,Ihara T,Sasaki M,Fujiyama Y,Bamba T

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:The ability of serum infliximab level to predict clinical outcome in infliximab therapy in Crohn's disease is unclear. Here, we aimed to clarify the correlation between the timing of loss of response (LOR) to treatment and a decrease in serum infliximab level, and, in addition, to identify an indicator of in...

journal_title：Journal of gastroenterology

authors： Hibi T,Sakuraba A,Watanabe M,Motoya S,Ito H,Sato N,Yoshinari T,Motegi K,Kinouchi Y,Takazoe M,Suzuki Y,Matsumoto T,Kawakami K,Matsumoto T,Hirata I,Tanaka S,Ashida T,Matsui T

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The causal association between diabetes and pancreatic cancer remains unclear in Asian populations. This study examined whether gallstones, a cholecystectomy, chronic pancreatitis and the treatment of antidiabetic agents affect the risk of subsequent pancreatic cancer for patients with diabetes in a Taiwanes...

journal_title：Journal of gastroenterology

authors： Lai HC,Tsai IJ,Chen PC,Muo CH,Chou JW,Peng CY,Lai SW,Sung FC,Lyu SY,Morisky DE

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effect of P.g infection on risk of progression to NASH. M...

journal_title：Journal of gastroenterology

authors： Nakahara T,Hyogo H,Ono A,Nagaoki Y,Kawaoka T,Miki D,Tsuge M,Hiraga N,Hayes CN,Hiramatsu A,Imamura M,Kawakami Y,Aikata H,Ochi H,Abe-Chayama H,Furusho H,Shintani T,Kurihara H,Miyauchi M,Takata T,Arihiro K,Chayama

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is characterized by chronic inflammation in the colon and epigenetic factors underlying the occurrence. Circular RNAs (circRNAs) have been under intensive focus due to the circular construct and gene-regulating functions. However, the changes and roles of circRNAs in UC remain unknown...

journal_title：Journal of gastroenterology

authors： Wang T,Chen N,Ren W,Liu F,Gao F,Ye L,Han Y,Zhang Y,Liu Y

更新日期：2019-09-01 00:00:00