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Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease.

Abstract：

BACKGROUND AND AIMS:The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effect of P.g infection on risk of progression to NASH. METHODS:(1) Serum IgG antibody titers against P.g fimbriae (fimA) in 200 biopsy-proven NAFLD patients were measured by ELISA and compared with histological findings. (2) C57BL/6J mice were fed a control diet (CD) or high-fat diet (HFD) with or without P.g-odontogenic infection and analyzed histologically. Mouse livers were analyzed using CE-TOFMS and LC-TOFMS. RESULTS:(1) A significant correlation between fibrosis progression and antibody titers against P.g possessing fimA type 4 was identified (P = 0.0081). Multivariate analysis identified older age and type 4 P.g-positivity as risk factors for advanced fibrosis. (2) Fibrosis and steatosis were more severe in HFD P.g(+) mice compared with HFD P.g(-) mice. In metabolome analysis, fatty acid metabolism was significantly disrupted with HFD in P.g-infected mouse livers. Monounsaturated/saturated fatty acid ratios were significantly higher in the HFD P.g(+) group than in the HFD P.g(-) group (P < 0.05). Moreover, expression levels of SCD1 and ELOVL6 were significantly reduced. CONCLUSIONS:These results suggest that P.g infection is an important risk factor for pathological progression in NAFLD. Increase in the monounsaturated/saturated fatty acid ratio may be an important change that facilitates progression of NAFLD.

journal_name

J Gastroenterol

journal_title

Journal of gastroenterology

authors

Nakahara T,Hyogo H,Ono A,Nagaoki Y,Kawaoka T,Miki D,Tsuge M,Hiraga N,Hayes CN,Hiramatsu A,Imamura M,Kawakami Y,Aikata H,Ochi H,Abe-Chayama H,Furusho H,Shintani T,Kurihara H,Miyauchi M,Takata T,Arihiro K,Chayama

doi

10.1007/s00535-017-1368-4

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

269-280

issue

2

eissn

0944-1174

issn

1435-5922

pii

10.1007/s00535-017-1368-4

journal_volume

53

pub_type

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