Abstract:
BACKGROUND:We recently reported that the presence of a papillary adenocarcinoma (pap) component was an independent risk factor for lymphatic involvement in endoscopically resected early gastric cancer (EGC). This study aimed to investigate the potential association between the presence of a pap component in EGC and lymph node metastasis (LNM). METHODS:In order to evaluate the association between LNM and clinicopathological features, including a pap component, we reviewed 628 surgically resected EGCs at our institution between 2009 and 2012. Clinicopathological features included age, gender, tumor location, macroscopic type, tumor size, histological type, depth, ulcerative findings, and lymphatic and venous involvement. In addition, the association between clinicopathological features and lymphatic involvement was also evaluated. RESULTS:LNM was observed in 52 cases (8.3%). Univariate analyses revealed a significant correlation between a pap component and LNM as well as tumor size, depth, macroscopic type, a poorly differentiated adenocarcinoma component, and lymphatic and venous involvement. The percentage of positive LNM among the EGC cases with a pap component was significantly higher than in those without the component (18.2 vs. 7.3%, P = 0.010). Via multivariate analyses lymphatic involvement was identified as the strongest risk factor for LNM [odds ratio (OR) 14.1] and a pap component was revealed as an independent risk factor for lymphatic involvement (OR 3.1). CONCLUSION:Our study revealed that EGC cases with a pap component were at higher risk of lymphatic involvement and showed a higher percentage of positive LNM. More attention should be paid to a pap component in EGC.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Sekiguchi M,Kushima R,Oda I,Suzuki H,Taniguchi H,Sekine S,Fukagawa T,Katai Hdoi
10.1007/s00535-014-0991-6subject
Has Abstractpub_date
2015-04-01 00:00:00pages
424-34issue
4eissn
0944-1174issn
1435-5922journal_volume
50pub_type
杂志文章abstract::The present study was carried out to examine the effects of submucosal administration of endothelin on gastric mucosal integrity in rats. Injection of endothelin-3 into the submucosal space of the stomach induced gastric mucosal damage dose-dependently and site-specifically. The gastric injury was localized only at th...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02936360
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abstract::To study the appropriate period for formalin fixation in order to detect p53 abnormalities in formalin-fixed tissue, we used seven surgically resected human colorectal cancer specimens. The immunohistochemical reactivity of p53 immunostaining and amplification of DNA by polymerase chain reaction (PCR) of the p53 gene ...
journal_title:Journal of gastroenterology
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更新日期:2010-02-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-01-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050163
更新日期:1998-10-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of gastroenterology
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pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00535-010-0326-1
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF02347576
更新日期:1995-08-01 00:00:00