DNA methylation as a marker for the past and future.

abstract：:Black liver is a common finding in Dubin-Johnson syndrome (DJS), which is caused by the lack of multidrug resistance-associated protein 2 (MRP2). Impaired excretion of epinephrine metabolites is believed to be a cause of black liver in DJS. Recently, we experienced a patient with black liver whose serum bilirubin leve...

journal_title：Journal of gastroenterology

authors： Kobayashi Y,Ishihara T,Wada M,Kajihara S,Araki J,Mifuji R,Itani T,Kuroda M,Urawa F,Kaito M,Adachi Y

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effect of P.g infection on risk of progression to NASH. M...

journal_title：Journal of gastroenterology

authors： Nakahara T,Hyogo H,Ono A,Nagaoki Y,Kawaoka T,Miki D,Tsuge M,Hiraga N,Hayes CN,Hiramatsu A,Imamura M,Kawakami Y,Aikata H,Ochi H,Abe-Chayama H,Furusho H,Shintani T,Kurihara H,Miyauchi M,Takata T,Arihiro K,Chayama

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Polymorphisms in the gene for interleukin 1beta (IL-1B) have been found to increase the risks of gastric cancer and its precursors in response to Helicobacter pylori infection in white populations. however, there has been no independent confirmation of the role of IL-1B markers in gastric cancer patients fro...

journal_title：Journal of gastroenterology

authors： Lee KA,Ki CS,Kim HJ,Sohn KM,Kim JW,Kang WK,Rhee JC,Song SY,Sohn TS

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:In patients with hepatitis C virus (HCV)-genotype 1b and a high virus load, of more than 1 Meq/ml by the DNA probe assay, the clearance of HCV-RNA was achieved in only 10% with a 6-month interferon (IFN) course. We therefore assessed the efficacy of prolonged IFN therapy in patients with HCV-genotype 1b and ...

journal_title：Journal of gastroenterology

authors： Arase Y,Ikeda K,Tsubota A,Suzuki Y,Saitoh S,Kobayashi M,Kobayashi M,Suzuki F,Akuta N,Someya T,Kumada H

更新日期：2003-01-01 00:00:00

abstract：:Focal nodular hyperplasia (FNH) of the liver is a rare benign lesion that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Currently, the natural history of the disease remains largely unknown. We present a patient with FNH of the liver who was followed up for 4 years. A 22-yea...

journal_title：Journal of gastroenterology

authors： Ohmoto K,Honda T,Hirokawa M,Mitsui Y,Iguchi Y,Kuboki M,Yamamoto S

更新日期：2002-01-01 00:00:00

abstract：:To evaluate the diagnostic utility of blood biochemical parameters in assessing degree of hepatic fibrosis, serum levels of aminoterminal type III procollagen peptide (P III P), type IV collagen (IV-collagen), 7S domain of type IV collagen (7S-collagen), and hyaluronan (HA) were measured in 54 patients with chronic vi...

journal_title：Journal of gastroenterology

authors： Takamatsu S,Nakabayashi H,Okamoto Y,Nakano H

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Because of the wide overlap between the groups, patients with reflux esophagitis (RE) cannot be distinguished from healthy subjects by basal lower esophageal sphincter (LES) pressure. The LES has radial asymmetry, with maximum pressure on the left side. It has been noted that one directional LES pressure, de...

journal_title：Journal of gastroenterology

authors： Iwakiri K,Hayashi Y,Kotoyori M,Sugiura T,Kawakami A,Sakamoto C

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Although balloon-occluded retrograde transvenous obliteration (BRTO) is often selected to treat gastric varices caused by portal hypertension, data comparing BRTO and splenectomy with gastric devascularization (Sp + Dev) are limited. METHODS:From January 2009 to February 2018, 100 patients with gastric vari...

journal_title：Journal of gastroenterology

authors： Oshita K,Ohira M,Honmyo N,Kobayashi T,Murakami E,Aikata H,Baba Y,Kawano R,Awai K,Chayama K,Ohdan H

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Heartburn is a common symptom with great impact on quality of life and on the economy. An approach that helps to alleviate patients' symptoms, decrease the burden on the economy, and improve longterm outcome is needed. Step-down therapy, starting with the proton pump inhibitor lansoprazole, seems to achieve ...

journal_title：Journal of gastroenterology

authors： Abu Farsakh N

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Drug resistance in colorectal cancers is assumed to be mediated by changes in the expression of microRNAs, but the specific identities and roles of microRNAs are largely unclear. We examined the effect of 5-fluorouracil (5-FU) resistance on microRNA expression. METHODS:Two types of 5-FU-resistant colon canc...

journal_title：Journal of gastroenterology

authors： Kurokawa K,Tanahashi T,Iima T,Yamamoto Y,Akaike Y,Nishida K,Masuda K,Kuwano Y,Murakami Y,Fukushima M,Rokutan K

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The efficacy, safety, and pharmacokinetics of the combination of three direct-acting antiviral (DAA) agents (adafosbuvir [also known as AL-335], odalasvir, and simeprevir) were investigated in DAA treatment-naïve Japanese patients with genotype (GT)1 or GT2 chronic hepatitis C virus (HCV) infection, with or ...

journal_title：Journal of gastroenterology

authors： Takehara T,Chayama K,Kurosaki M,Yatsuhashi H,Tanaka Y,Hiramatsu N,Sakamoto N,Asahina Y,Nozaki A,Nakano T,Hagiwara Y,Shimizu H,Yoshida H,Huang Y,Biermer M,Vijgen L,Hayashi N

更新日期：2020-06-01 00:00:00

abstract：:Depletion of goblet cells (the main mucin-producing cells in the colon) is one of the most reliable histological characteristics of ulcerative colitis, whereas a major symptom of this disease is bloody diarrhea containing a large amount of mucus. The discrepancy between these phenomena was investigated in a time-cours...

journal_title：Journal of gastroenterology

authors： Nakano S,Ohara S,Kubota T,Saigenji K,Hotta K

更新日期：1999-04-01 00:00:00

abstract：:In a pilot study of direct dissolution therapy of gallstones with methyl tert-butyl ether (MTBE), endoscopic transpapillary catheterization in the gallbladder (ETCG) was performed. Complete dissolution was seen in 8 out of 12 (66%) patients and partial dissolution was seen in 2 (16%) patients. In one of the 8 complete...

journal_title：Journal of gastroenterology

authors： Uchida N,Nakatsu T,Hirabayashi S,Minami A,Fukuma H,Ezaki T,Morshed SA,Fuke C,Ameno K,Ijiri I

更新日期：1994-08-01 00:00:00

abstract：:The present study was carried out to examine the effects of submucosal administration of endothelin on gastric mucosal integrity in rats. Injection of endothelin-3 into the submucosal space of the stomach induced gastric mucosal damage dose-dependently and site-specifically. The gastric injury was localized only at th...

journal_title：Journal of gastroenterology

authors： Watanabe Y,Okumura T,Harada K,Kohgo Y

更新日期：1997-04-01 00:00:00

abstract：:Primary sclerosing cholangitis is very rare in Japan. The aim of the present study was to identify the characteristics of such patients in Japan. A questionnaire was sent to the members of the Japanese Society of Gastroenterology and responses for 192 cases were analyzed. There was male predominancy (61%), and two pea...

journal_title：Journal of gastroenterology

authors： Takikawa H,Manabe T

更新日期：1997-02-01 00:00:00

abstract：:We report a 74-year-old man with triple synchronous cancers occurring in the gallbladder, common bile duct, and pancreas. The patient had consulted a nearby physician because of epigastralgia and icterus. On September 30, 1997, the patient was admitted to our department for further evaluation and treatment. Abdominal ...

journal_title：Journal of gastroenterology

authors： Sato K,Maekawa T,Yabuki K,Tamasaki Y,Maekawa H,Kudo K,Sengoku H,Kawa I,Wada R,Matsumoto M

更新日期：2003-01-01 00:00:00

abstract：:Inflammatory cells in the gastric epithelium and direct cell damage are important effects of H. pylori infection in causing gastroduodenal diseases. The aim of this study was to determine whether H. Pylori possessing the cagA gene and vacuolating cytotoxin activity (cagA+/tox+) has these toxigenicities. The detection ...

journal_title：Journal of gastroenterology

authors： Kodama K,Fujioka T,Ito A,Kodama R,Nasu M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:We investigated the effects of rabeprazole compared with those of omeprazole on enterochromaffin-like cells and parietal cells in rats. METHODS:Rabeprazole or omeprazole was administered for 7 days by intraperitoneal injection (100 mg/kg or 20mg/kg once a day) and the serum gastrin concentration, the antral...

journal_title：Journal of gastroenterology

authors： Tari A,Kawano M,Kodama K,Yonei Y,Okahara S,Haruma K,Sumii K,Kajiyama G

更新日期：2002-01-01 00:00:00

abstract：:A 27-year-old woman with a 9-year history of ulcerative colitis involving the entire colon was admitted to our hospital in August 1992 because of bloody stools and left lower abdominal pain. She had been treated with sulfasalazine since 1983 and the colitis had been clinically quiescent or mild for 7 years. She had al...

journal_title：Journal of gastroenterology

authors： Seo M,Okada M,Osamura S,Hara S,Umeno T,Maeshiro K,Yamada Y,Yuh K

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Nocturnal administration of branched-chain amino acid (BCAA) granules improves serum albumin levels in patients with cirrhosis. However, it is unclear whether or not this administration method can improve the patients' quality of life (QOL). In this study, we aimed to investigate the efficacy of BCAA granule...

journal_title：Journal of gastroenterology

authors： Hidaka H,Nakazawa T,Kutsukake S,Yamazaki Y,Aoki I,Nakano S,Asaba N,Minamino T,Takada J,Tanaka Y,Okuwaki Y,Watanabe M,Shibuya A,Koizumi W

更新日期：2013-02-01 00:00:00

abstract：:The incidence and prevalence of primary biliary cirrhosis show wide geographic differences. The frequency of this disease in Japan is lower than in Northern Europe. To elucidate the immunoreactivity of serum with enzymes of the 2-oxo-acid dehydrogenase complex (2-OADC) and the M2 mitochondrial antigenic complex in Jap...

journal_title：Journal of gastroenterology

authors： Omagari K,Rowley MJ,Jois JA,Feeney SJ,Komatsu K,Maeda T,Onishi S,Yamazaki K,Suzuki K,Galperin C,Mackay IR

更新日期：1996-02-01 00:00:00

abstract：:An association of hidradenitis suppurativa with Crohn's disease is supported by previous repent. We here report a patient with hidradenitis suppurativa who subsequently developed peripheral arthritis, sacroiliitis, and Crohn's disease. A significant attenuation of bowel, cutaneous, and joint symptoms was achieved afte...

journal_title：Journal of gastroenterology

authors： Roussomoustakaki M,Dimoulios P,Chatzicostas C,Kritikos HD,Romanos J,Panayiotides JG,Kouroumalis EA

更新日期：2003-01-01 00:00:00

abstract：:Our objective was to determine whether the prevalence of vacuolating cytotoxin production differed among Helicobacter pylori isolates obtained from patients with chronic gastritis, gastric ulcer, or duodenal ulcer. We examined the vacuolating cytotoxin production of 114 clinical H. pylori isolates in rabbit gastic epi...

journal_title：Journal of gastroenterology

authors： Kodama K,Fujioka T,Ito A,Kubota T,Murakami K,Nasu M

更新日期：1996-11-01 00:00:00

abstract：:Involvement of the gastroduodenum is extremely rare in Crohn's disease. For obstructing duodenal Crohn's disease, bypass procedures have traditionally been selected. However, more recently, strictureplasty has become an acceptable surgical option. We treated two Crohn's disease patients with short proximal duodenal st...

journal_title：Journal of gastroenterology

authors： Takesue Y,Yokoyama T,Akagi S,Ohge H,Murakami Y,Imamura Y,Uemura K,Kanehiro T,Matsuura Y

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Depth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. However, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the ...

journal_title：Journal of gastroenterology

authors： Kitajima K,Fujimori T,Fujii S,Takeda J,Ohkura Y,Kawamata H,Kumamoto T,Ishiguro S,Kato Y,Shimoda T,Iwashita A,Ajioka Y,Watanabe H,Watanabe T,Muto T,Nagasako K

更新日期：2004-06-01 00:00:00

abstract：:Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and non-lymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients wit...

journal_title：Journal of gastroenterology

authors： Malaguarnera M,Di Fazio I,Romeo MA,Restuccia S,Laurino A,Trovato BA

更新日期：1997-04-01 00:00:00

abstract：:We present a patient with complication of huge hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL) for pancreatic lithotripsy. The hematoma measured 78-110mm. Angiography showed a subcapsular hematoma, rather than a hematoma in the liver. In the arterial phase, the distal end of the small v...

journal_title：Journal of gastroenterology

authors： Hirata N,Kushida Y,Ohguri T,Wakasugi S,Kojima T,Fujita R

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:The (13)C-urea breath test (UBT) is a simple breath test for the diagnosis of Helicobacter pylori infection, but several factors have been reported to affect the results of this test. In this study, the effects of the antiulcer drugs used in Japan on the results of UBT were determined. METHODS:The subjects ...

journal_title：Journal of gastroenterology

authors： Murakami K,Sato R,Okimoto T,Watanabe K,Nasu M,Fujioka T,Kodama M,Kagawa J

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Experimental evidence and clinical studies suggest that the renin-angiotensin system and its inhibitors may play a role in regulating the mechanisms of liver fibrosis development. The present study aimed to verify whether carriage of specific angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) all...

journal_title：Journal of gastroenterology

authors： Fabris C,Toniutto P,Bitetto D,Minisini R,Fornasiere E,Smirne C,Pirisi M

更新日期：2007-07-01 00:00:00

abstract：:Duodenal gastrinoma is recognized as a relatively common cause of Zollinger-Ellison syndrome, but its clinical and biological features are not well known. Here we report a case of duodenal gastrinoma with lymph node metastasis which was confirmed by pathology examinations. Hypergastrinemia and gastric acid hypersecret...

journal_title：Journal of gastroenterology

authors： Takasu A,Shimosegawa T,Fukudo S,Asakura T,Uchi M,Kimura K,Kashimura J,Satoh K,Koizumi M,Sasaki I,Hongo M,Suzuki T,Toyota T

更新日期：1998-10-01 00:00:00