Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells.

abstract：:In a pilot study of direct dissolution therapy of gallstones with methyl tert-butyl ether (MTBE), endoscopic transpapillary catheterization in the gallbladder (ETCG) was performed. Complete dissolution was seen in 8 out of 12 (66%) patients and partial dissolution was seen in 2 (16%) patients. In one of the 8 complete...

journal_title：Journal of gastroenterology

authors： Uchida N,Nakatsu T,Hirabayashi S,Minami A,Fukuma H,Ezaki T,Morshed SA,Fuke C,Ameno K,Ijiri I

更新日期：1994-08-01 00:00:00

abstract：:To assess the efficacy of the zinostatin derivative, the anti-tumor agent, styrene-maleic acid neocarzinostatin, in treating multiple small liver cancers, 29 patients with multiple hepatocellular carcinoma of 3 cm or less in diameter were treated with intraarterial injections of this high molecular weight agent, mixed...

journal_title：Journal of gastroenterology

authors： Ikeda K,Saitoh S,Suzuki Y,Tsubota A,Koida I,Kobayashi M,Arase Y,Chayama K,Murashima N,Kumada H

更新日期：1997-08-01 00:00:00

abstract：:The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for the test. The test ...

journal_title：Journal of gastroenterology

authors： Wang WM,Lee SC,Ding HJ,Jan CM,Chen LT,Wu DC,Liu CS,Peng CF,Chen YW,Huang YF,Chen CY

更新日期：1998-06-01 00:00:00

abstract：:Two hundred and three patients with Crohn's disease seen at Kyushu University, Fukuoka University, and their affiliated centers from 1973 to 1988 were followed for 4.4 +/- 3.2 years (mean +/- SD), to evaluate the prognosis relative to life span and surgery. Cumulative survival rate and cumulative operation rate were c...

journal_title：Journal of gastroenterology

authors： Iida M,Yao T,Okada M

更新日期：1995-11-01 00:00:00

abstract：:A case of life-threatening lower gastrointestinal hemorrhage from Crohn's disease is reported. Several promising studies have recently been published that describe superselective embolization for the treatment of massive lower gastrointestinal hemorrhage in patients with bleeding colonic diverticular disease and angio...

journal_title：Journal of gastroenterology

authors： Kazama Y,Watanabe T,Akahane M,Yoshioka N,Ohtomo K,Nagawa H

更新日期：2005-12-01 00:00:00

abstract：:Styrene-maleic acid neocarzinostatin (SMANCS) sometimes causes hepatic vascular side effects, including arterial stricture, obstruction, and arterio-portal shunt. A total of 128 intra-arterial SMANCS injection treatments, performed for 89 patients with hepatocellular carcinoma, were analyzed to determine the relations...

journal_title：Journal of gastroenterology

authors： Ikeda K,Saitoh S,Kobayashi M,Suzuki Y,Suzuki F,Tsubota A,Arase Y,Chayama K,Murashima N,Kumada H

更新日期：2000-01-01 00:00:00

abstract：:Adenocarcinoma of the small intestine is uncommon. Due to this paucity and the lack of specificity of symptoms, patients are usually seen late in the course of their illness, when curative therapy, mainly represented by extensive surgical resection, is unlikely. The authors report a case of primary well-differentiated...

journal_title：Journal of gastroenterology

authors： Koyama S,Araki M,Yuhara K,Murata Y,Fukutomi H,Atake S,Gohongi T,Yuzawa K,Fukao K,Kikuchi M

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Liver histology is the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH). Noninvasive, simple, reproducible, and reliable biomarkers are greatly needed to differentiate NASH from nonalcoholic fatty liver disease (NAFLD). METHODS:To construct a scoring system for predicting NASH, 177 Jap...

journal_title：Journal of gastroenterology

authors： Sumida Y,Yoneda M,Hyogo H,Yamaguchi K,Ono M,Fujii H,Eguchi Y,Suzuki Y,Imai S,Kanemasa K,Fujita K,Chayama K,Yasui K,Saibara T,Kawada N,Fujimoto K,Kohgo Y,Okanoue T,Japan Study Group of Nonalcoholic Fatty Liver Disease

更新日期：2011-02-01 00:00:00

abstract：:We investigated the effect of intravenous infusions of the therapeutically available amino acid solutions Moripron and Morihepamin (Roussel Morishita, Osaka, Japan) on gallbladder contraction and cholecystokinin (CCK) release in healthy male volunteers. Plasma CCK levels were measured by radioimmunoassay, using the an...

journal_title：Journal of gastroenterology

authors： Shirohara H,Tabaru A,Otsuki M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The introduction of capsule endoscopy (CE) has facilitated the detection of mucosal changes in the small bowel, and such mucosal changes have been noted in cirrhotic patients with portal hypertension; these changes are described as portal hypertensive enteropathy. The aim of this study was to assess the effe...

journal_title：Journal of gastroenterology

authors： Matsushita Y,Narahara Y,Fujimori S,Kanazawa H,Itokawa N,Fukuda T,Takahashi Y,Kondo C,Kidokoro H,Atsukawa M,Nakatsuka K,Sakamoto C

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:Autoimmune pancreatitis (AIP) is a unique form of pancreatitis and can be complicated with various extrapancreatic lesions. Little is known about the long-term clinical course of AIP. Here we aimed to document the clinical course of AIP. METHODS:For this study, we recruited 21 patients, averaging 66.5 years in...

journal_title：Journal of gastroenterology

authors： Uchida K,Yazumi S,Nishio A,Kusuda T,Koyabu M,Fukata M,Miyoshi H,Sakaguchi Y,Fukui T,Matsushita M,Takaoka M,Okazaki K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:We recently reported that the presence of a papillary adenocarcinoma (pap) component was an independent risk factor for lymphatic involvement in endoscopically resected early gastric cancer (EGC). This study aimed to investigate the potential association between the presence of a pap component in EGC and lym...

journal_title：Journal of gastroenterology

authors： Sekiguchi M,Kushima R,Oda I,Suzuki H,Taniguchi H,Sekine S,Fukagawa T,Katai H

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Endoscopic sphincterotomy (ES) is widely performed in patients with common bile duct stones (CBDS). However, the long-term outcomes of patients following ES have not been sufficiently elucidated. Impaired papillary function following ES may result in additional late complications. In contrast, endoscopic pap...

journal_title：Journal of gastroenterology

authors： Doi S,Yasuda I,Mukai T,Iwashita T,Uemura S,Yamauchi T,Nakashima M,Adachi S,Shimizu M,Tomita E,Itoi T,Moriwaki H

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Recent routine testing for liver function and anti-mitochondrial antibodies has increased the number of newly diagnosed patients with primary biliary cirrhosis (PBC). This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC pat...

journal_title：Journal of gastroenterology

authors： Kubota J,Ikeda F,Terada R,Kobashi H,Fujioka S,Okamoto R,Baba S,Morimoto Y,Ando M,Makino Y,Taniguchi H,Yasunaka T,Miyake Y,Iwasaki Y,Yamamoto K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Fulminant non-A, non-B, non-C hepatitis has a high mortality rate, making the identification of its causative agent imperative. Cytomegalovirus, Epstein-Barr virus, human herpesvirus-6, and herpes simplex virus are all members of the herpesviridae family that are associated with fatal hepatic failure. We inv...

journal_title：Journal of gastroenterology

authors： Ishikawa K,Hasegawa K,Naritomi T,Kanai N,Ogawa M,Kato Y,Kobayashi M,Torii N,Hayashi N

更新日期：2002-01-01 00:00:00

abstract：:We report a case of living-related partial liver transplantation for decompensated hepatitis B without reactivation of hepatitis B in the following 30 months, and we analyze the factors that indicate a favorable prognosis for transplantation. The 42-year-old female patient received continuously administered lamivudine...

journal_title：Journal of gastroenterology

authors： Hasegawa K,Hashimoto E,Kanai N,Ogawa M,Naritomi T,Taniai M,Takasaki K,Hayashi N

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Endotoxin modulates esophageal motor function by increasing nitric oxide (NO) production. The aims of this study were to examine inducible nitric oxide synthase (iNOS) induction in the lower esophageal sphincter (LES) of endotoxemic opossums and to investigate the effects of aminoguanidine (AG), a selective ...

journal_title：Journal of gastroenterology

authors： Park H,Clark E,Cullen JJ,Koland JG,Kim MS,Conklin JL

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Once-daily, orally administered, co-formulated glecaprevir (NS3/4A protease inhibitor) and pibrentasvir (NS5A inhibitor) (G/P) demonstrated pangenotypic activity and high sustained virologic response (SVR) rates in studies outside Japan. Here we report safety and efficacy in a subset of Japanese patients wit...

journal_title：Journal of gastroenterology

authors： Kumada H,Watanabe T,Suzuki F,Ikeda K,Sato K,Toyoda H,Atsukawa M,Ido A,Takaki A,Enomoto N,Kato K,Alves K,Burroughs M,Redman R,Pugatch D,Pilot-Matias TJ,Krishnan P,Oberoi RK,Xie W,Chayama K

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The virologic impact of adding interferon to antiviral nucleoside therapy was studied in Japanese patients having perinatally transmitted hepatitis B virus (HBV) genotype C. METHODS:Sixty-four patients including 41 positive for hepatitis B e antigen (HBeAg) were assigned to receive either (1) a combination ...

journal_title：Journal of gastroenterology

authors： Yuki N,Nagaoka T,Nukui K,Omura M,Hikiji K,Kato M

更新日期：2008-01-01 00:00:00

abstract：:Although the causes of inflammatory bowel disease (IBD) remain incompletely understood, increasing evidence implicates intestinal microflora in the pathogenesis of these disorders. Alteration of intestinal flora therefore may offer a plausible therapeutic approach. Although recent data support a potential therapeutic ...

journal_title：Journal of gastroenterology

authors： Mitsuyama K,Toyonaga A,Sata M

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Depth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. However, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the ...

journal_title：Journal of gastroenterology

authors： Kitajima K,Fujimori T,Fujii S,Takeda J,Ohkura Y,Kawamata H,Kumamoto T,Ishiguro S,Kato Y,Shimoda T,Iwashita A,Ajioka Y,Watanabe H,Watanabe T,Muto T,Nagasako K

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Obliterative phlebitis is a useful pathological finding for the diagnosis of lymphoplasmacytic sclerosing pancreatitis (LPSP), or type 1 autoimmune pancreatitis. The present study evaluated histological findings of obliterative phlebitis, including the significance of adding Elastica van Gieson stain (EVG) i...

journal_title：Journal of gastroenterology

authors： Miyabe K,Notohara K,Nakazawa T,Hayashi K,Naitoh I,Okumura F,Shimizu S,Yoshida M,Yamashita H,Takahashi S,Ohara H,Joh T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is associated not only with gastroduodenal ulcers but with the development of gastric cancer. Interleukin-1 beta (IL-1 beta) is a potent inhibitor of gastric secretion. The -31 C-to-T base transition in the intron of this gene has been reported to be involved in carcinogenic cha...

journal_title：Journal of gastroenterology

authors： Kato S,Onda M,Yamada S,Matsuda N,Tokunaga A,Matsukura N

更新日期：2001-10-01 00:00:00

abstract：:Gastrointestinal symptoms such as abdominal pain, dyspepsia, and diarrhea are relatively nonspecific and a common cause for seeking medical attention. To date, it is challenging for physicians to differentiate between functional and organic gastrointestinal conditions and it involves the use of serological and endosco...

journal_title：Journal of gastroenterology

authors： Ikhtaire S,Shajib MS,Reinisch W,Khan WI

更新日期：2016-05-01 00:00:00

abstract：:To elucidate the role played by hepatic sinusoidal cells in the regulation of the circulatory status in the liver, the effect of endothelins (ETs) on primary-cultured stellate cells was examined. Kinetic analysis with 125I-labeled ET-1 revealed that stellate cells have ET receptors with a Kd value of 141 pM and a Bmax...

journal_title：Journal of gastroenterology

authors： Kawada N,Kuroki T,Kobayashi K,Inoue M,Kaneda K,Decker K

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Contrast-enhanced echocardiography (CEE) using agitated saline can detect intrapulmonary vasodilatation (IPVD) in patients with hepatopulmonary syndrome (HPS). We estimated the pulmonary transit time of erythrocytes (PTT) by CEE, using microbubbles, and studied its relationship to arterial oxygenation in chr...

journal_title：Journal of gastroenterology

authors： Katsuta Y,Honma H,Zhang XJ,Ohsuga M,Komeichi H,Shimizu S,Katoh Y,Miura H,Satomura K,Aramaki T,Takano T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Abrogating tolerance is a critical step in the pathogenesis of Crohn's disease (CD). T cell-anergy is one of the main mechanisms of tolerance and is regulated by the gene related to anergy in lymphocytes (GRAIL). This study investigated the expressions and regulation of GRAIL in CD and murine colitis models....

journal_title：Journal of gastroenterology

authors： Mukai A,Iijima H,Hiyama S,Fujii H,Shinzaki S,Inoue T,Shiraishi E,Kawai S,Araki M,Hayashi Y,Kondo J,Mizushima T,Kanto T,Egawa S,Nishida T,Tsujii M,Takehara T

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Neutrophil elastase (NE) is a major secretory product from activated neutrophils and a major contributor to tissue destruction. However, little is known about the pathogenic contribution of NE to ulcerative colitis (UC). This study was designed to investigate the contribution of NE by measuring NE activity i...

journal_title：Journal of gastroenterology

authors： Morohoshi Y,Matsuoka K,Chinen H,Kamada N,Sato T,Hisamatsu T,Okamoto S,Inoue N,Takaishi H,Ogata H,Iwao Y,Hibi T

更新日期：2006-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is responsible for more than a half of the cases of chronic viral hepatitis in Japan. About 20% of patients who are chronically infected with the virus develop cirrhosis about 20-30 years after the infection, with hepatocellular carcinoma developing in about 5% of patients a year. The...

journal_title：Journal of gastroenterology

authors： Chayama K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) and resultant colitis occurring prior to puberty are frequently associated with delayed puberty and losses of growth and bone mineralization. Some of this delay may be due to colonic inflammation and associated systemic inflammation. To date no treatments for IBD have been sh...

journal_title：Journal of gastroenterology

authors： Deboer MD,Steinman J,Li Y

更新日期：2012-06-01 00:00:00