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Long-term outcome of autoimmune pancreatitis.

Abstract：

PURPOSE:Autoimmune pancreatitis (AIP) is a unique form of pancreatitis and can be complicated with various extrapancreatic lesions. Little is known about the long-term clinical course of AIP. Here we aimed to document the clinical course of AIP. METHODS:For this study, we recruited 21 patients, averaging 66.5 years in age (range, 19-84 years) and observed them at a mean interval of 40.8 months (range, 18-130 months). Three of the patients were also diagnosed with retroperitoneal fibrosis, 3 had sialoadenitis, 2 had chronic thyroiditis, 1 had interstitial nephritis, and 1 had interstitial pneumonia. Three of the patients underwent surgical therapy, 12 patients received methylprednisolone (PSL) treatment, and the 6 remaining patients received no treatment. RESULTS:Enlargement of the pancreas was attenuated in all the PSL-treated patients. Seven of the 21 patients showed pancreatic atrophy, of whom 2 were non-PSL-treated patients. Three patients developed chronic pancreatitis. One patient was diagnosed with pancreatic cancer after 50 months of PSL therapy. CONCLUSIONS:As with chronic pancreatitis patients, AIP patients should be observed closely for abnormality in pancreatic function.

journal_name

J Gastroenterol

journal_title

Journal of gastroenterology

authors

Uchida K,Yazumi S,Nishio A,Kusuda T,Koyabu M,Fukata M,Miyoshi H,Sakaguchi Y,Fukui T,Matsushita M,Takaoka M,Okazaki K

doi

10.1007/s00535-009-0049-3

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

726-32

issue

7

eissn

0944-1174

issn

1435-5922

journal_volume

44

pub_type

杂志文章

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