Abstract:
BACKGROUND:Anemia of inflammation, commonly observed in patients with chronic diseases, is associated with decreased serum iron. Hepcidin, mainly produced by hepatocytes in a STAT3- and/or SMAD-dependent manner, is involved in iron homeostasis. What remains to be established is whether or not the hepatic IL-6/STAT3 signal has a role in anemia of inflammation in vivo. METHODS:Turpentine oil was subcutaneously injected into wild-type mice or hepatocyte-specific STAT3-deficient mice (L-STAT3KO) to induce inflammation. RESULTS:Turpentine injection increased serum IL-6 levels. It activated liver STAT3 in wild-type mice, but not in L-STAT3KO mice. In chronic inflammation, wild-type mice showed decreased serum iron levels and anemia with up-regulation of hepcidin levels in the liver. In contrast, L-STAT3KO mice showed no increase in hepatic hepcidin levels or anemia. CONCLUSIONS:Liver STAT3 is critically involved in the development of anemia of inflammation via the expression of hepcidin. The liver regulates anemia of inflammation through STAT3 signaling.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Sakamori R,Takehara T,Tatsumi T,Shigekawa M,Hikita H,Hiramatsu N,Kanto T,Hayashi Ndoi
10.1007/s00535-009-0159-ysubject
Has Abstractpub_date
2010-02-01 00:00:00pages
244-8issue
2eissn
0944-1174issn
1435-5922journal_volume
45pub_type
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