Abstract:
:The role of the tumor stroma in carcinogenesis and cancer progression have been documented for a long time. However, the molecules and mechanisms involved have not been understood precisely. Recently, various mediators involved in the communication between the tumor epithelium and stroma and their roles have been revealed by utilizing new technology such as array analysis, laser capture sampling, and genetically altered mice. Moreover, accumulating evidence indicates that some cells in the tumor stroma are derived from the bone marrow (BM). While some of these BM-derived cells are well-known players in inflammation, as exemplified by macrophages, other types of BM-derived cells have been described only recently and are still poorly characterized. In this review, I focus on the latter class of BM-derived cells in colon carcinogenesis, with reference to similar cells in other types of cancer as well. Studies of these myeloid cells should help us understand the inflammation and immune response from a broader perspective as the body's reaction to pathogenic insults.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Taketo MMdoi
10.1007/s00535-008-2321-3subject
Has Abstractpub_date
2009-01-01 00:00:00pages
93-102issue
2eissn
0944-1174issn
1435-5922journal_volume
44pub_type
杂志文章,评审abstract:BACKGROUND:Because of the wide overlap between the groups, patients with reflux esophagitis (RE) cannot be distinguished from healthy subjects by basal lower esophageal sphincter (LES) pressure. The LES has radial asymmetry, with maximum pressure on the left side. It has been noted that one directional LES pressure, de...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1355-9
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Mucosal breaks induced by gastroesophageal reflux of gastric contents were more frequently found on the right anterior wall of the lower esophagus. Bleeding from esophageal varices may be also derived from gastroesophageal reflux. The circumferential location of the ruptured esophageal varices was evaluated ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-008-2232-3
更新日期:2008-01-01 00:00:00
abstract::Fulminant hepatic failure (FHF) usually has a fatal prognosis without liver transplantation. We describe the case of a woman who developed FHF, and was evaluated as a candidate for liver transplantation, but who was cured without transplantation through intensive medical care that included glucagon-insulin therapy, me...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350170103
更新日期:2001-05-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in industrialized countries worldwide, and has become a serious public health issue not only in Western countries but also in many Asian countries including Japan. Within the wide spectrum of NAFLD, nonalcoholic steato...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,实务指引
doi:10.1007/s00535-015-1050-7
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Using cDNA microarray analysis that displays a total of 8734 mouse genes, we have identified 21 known and novel transcripts, including mouse expressed sequence tags (ESTs) that were consistently up- or downregulated in the fundus of wild-type mice and W/W(V) mice, where intramuscular interstitial cells of Ca...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1283-8
更新日期:2004-01-01 00:00:00
abstract::To investigate autonomic nervous function during upper gastrointestinal endoscopy, we analyzed R-R interval variability from electrocardiograms obtained during endoscopy. Holter electrocardiogram recordings were made before and after premedication, and during endoscopy. Time- and frequency-domain analyses of heart rat...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s005350070018
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The virologic impact of adding interferon to antiviral nucleoside therapy was studied in Japanese patients having perinatally transmitted hepatitis B virus (HBV) genotype C. METHODS:Sixty-four patients including 41 positive for hepatitis B e antigen (HBeAg) were assigned to receive either (1) a combination ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00535-008-2174-9
更新日期:2008-01-01 00:00:00
abstract::Helicobacter pylori infection has been found to decrease the expression of antral somatostatin and to increase the release of the acid-stimulating hormone gastrin. The reversal of these changes in gut hormones by the eradication of H. pylori, and in-vivo and in-vitro studies in animals either infected with H. pylori o...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s005350200000
更新日期:2002-01-01 00:00:00
abstract::Human glucagonoma cells were isolated and maintained in vitro. Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels. Atropine abolished the stimulatory e...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02349291
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:As biopsy sites may miss coexisting gastric mucosal high grade neoplasia (HGN) foci, making a diagnosis of gastric mucosal low grade neoplasia (LGN) based only on forceps biopsy specimens can be inaccurate. Therefore, to achieve an accurate diagnosis, endoscopic mucosal resection (EMR) of the entire lesion i...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-010-0289-2
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) occurs in chronic hepatitis B (CH-B) patients even after treatment with nucleos(t)ide analogues (NAs) by a mechanism involving an association between the oncogenic factors of integrated HBV and liver fibrosis. An association has been demonstrated between advanced chronic liver ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-017-1386-2
更新日期:2018-06-01 00:00:00
abstract::Primary T/natural killer (NK) cell lymphoma of the colon is extremely rare. Despite the advances in histological and immunophenotypic studies, the diagnosis of primary T/NK cell lymphoma of the colon can be delayed because the early symptoms and colonoscopic findings may be very similar to those of inflammatory bowel ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350200158
更新日期:2002-01-01 00:00:00
abstract::Three-dimensional-computed tomography (3D-CT) cholangiography is a 3D shaded surface display image of the biliary tract obtained by using helical CT after intravenous cholangiography or cholangiography per percutaneous transhepatic cholangio-drainage tube. We investigated whether 3D-CT cholangiography could provide a ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050225
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:NADPH oxidase 1 (Nox1) is preferentially expressed in the colon, but its functional role is not fully understood. This study was designed to elucidate a potential role of Nox1 in inflammation of the colon. METHODS:Superoxide production by T84 cells was measured by the cytochrome c method. Protein and mRNA l...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-009-0119-6
更新日期:2009-01-01 00:00:00
abstract::In vivo progression to malignancy is characterized by the switch to an angiogenic phenotype. The angiogenic switch is a critical control point for tumor expansion. The ability of a tumor to become neovascularized permits rapid expansion of tumor growth and increases the likelihood of metastases. The genetic alteration...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the impact of age on esophageal sensation, and to determine whether esophageal mechanosensitivity and chemosensitivity are correlated in healthy Japanese subjects. METHODS:To evaluate chemosensitivity, a catheter was inserted and placed 10 cm above the upper border of th...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0665-1
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:To further clarify the clinico-epidemiological features of autoimmune pancreatitis (AIP) in Japan, we conducted the fourth nationwide epidemiological survey. METHODS:This study consisted of two stage surveys; the number of AIP patients was estimated by the first survey and their clinical features were asses...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-019-01658-7
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Abrogating tolerance is a critical step in the pathogenesis of Crohn's disease (CD). T cell-anergy is one of the main mechanisms of tolerance and is regulated by the gene related to anergy in lymphocytes (GRAIL). This study investigated the expressions and regulation of GRAIL in CD and murine colitis models....
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-013-0923-x
更新日期:2014-12-01 00:00:00
abstract::Reducing the incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) is the key ultimate goal set in essentially all treatment guidelines. There has been solid evidence supporting the relationship between serum hepatitis B virus (HBV) DNA level and risk of HCC. Antiviral treatment with o...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-020-01726-3
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori infection is associated not only with gastroduodenal ulcers but with the development of gastric cancer. Interleukin-1 beta (IL-1 beta) is a potent inhibitor of gastric secretion. The -31 C-to-T base transition in the intron of this gene has been reported to be involved in carcinogenic cha...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350170033
更新日期:2001-10-01 00:00:00
abstract::We reviewed reports on the efficacy of clarithromycin in eradicating Helicobacter pylori. Reports on dual and 1-week triple therapy that included clarithromycin were analyzed to assess the eradication rates of H. pylori infection. Dual therapy with clarithromycin and a proton pump inhibitor achieved eradication rates ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:1996-11-01 00:00:00
abstract::An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all were involved in the fina...
journal_title:Journal of gastroenterology
pub_type:
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Linked color imaging (LCI) increases the visibility of early gastric cancers, which may be associated with characteristic findings including background purple mucosae. These lesions are found in areas of chronic gastritis and surrounding mucosa. The aim of this study is to objectively characterize these lesi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-018-1515-6
更新日期:2019-05-01 00:00:00
abstract::A 69-year-old woman was admitted to our hospital with fever and abdominal pain in the epigastric region. Abdominal ultrasonography demonstrated a well-defined hypoechoic mass in the epigastric region with encasement of the left hepatic lobe and stomach. Computed tomography confirmed a low-density mass, 20 cm in diamet...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-003-1203-y
更新日期:2003-01-01 00:00:00
abstract::In this study, we used magnetic resonance (MR) imaging to measure portal blood flow in 12 healthy controls and 17 cirrhotics while they were breath-holding after inspiration and after expiration. We then compared the results with measurements made during normal respiration in the healthy controls and cirrhotics. Blood...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050381
更新日期:1999-10-01 00:00:00
abstract::We simultaneously recorded gastric emptying of radio-opaque markers (ROMs) and monitored serial changes in plasma acetaminophen (AAP) levels to demonstrate the relationship between the ROM and the AAP methods, and we investigated the effect of a single intravenous dose of erythromycin (EM) on gastric emptying in healt...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02936948
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Corticosteroid therapy has been commonly administered to patients with acute liver injury (ALI)/acute liver failure (ALF) in Japan to prevent the development of hepatic encephalopathy, but the appropriate timing to start corticosteroid therapy has not been determined and optimal response evaluation of the th...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-017-1306-5
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The dynamic change in gastric emptying on a minute-by-minute basis (gastric velocity) is evaluated by the 13C-octanoate breath test with deconvolution analysis. However, deconvolution is impractical, because it requires dual experiments to obtain 13CO2 excretion profiles following intraduodenal and oral admi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-006-1814-1
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Angiogenesis is essential for gastric ulcer healing. Recent results suggest that vascular endothelial growth factor receptor 1 (VEGFR1), which binds to VEGF, promotes angiogenesis. In the present study, we investigated the role of VEGFR1 signaling in gastric ulcer healing and angiogenesis. METHODS:Gastric u...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-013-0869-z
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Recently, the novel gene DOG1 has been found to be overexpressed in most gastrointestinal stromal tumors (GISTs) specifically within the field of soft tissue tumors. DOG1 might play a role in development of GISTs and have potential as a diagnostic marker and therapeutic target, but the biological function an...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-008-2195-4
更新日期:2008-01-01 00:00:00