Abstract:
:Endoscopic biliary drainage (EBD) for unresectable hepatocellular carcinoma (HCC) associated with obstructive jaundice remains controversial because of the short survival of these patients. To evaluate the effectiveness of this procedure, we retrospectively studied 18 patients who had unresectable HCC with obstructive jaundice and underwent EBD with polyethylene stents, over a 10-year period. Nine patients with tumor thrombus involving the first branches of the portal vein or portal trunk (Vp3) formed group A and the other 9 (Vp0-Vp2) formed group B. The serum albumin level and serum total bililubin level differed significantly between the two groups (P < 0.05 and P < 0.005. Student's t-test), but prothrombin time did not. The obstructive jaundice was mainly caused by direct tumor invasion in 6 patients from group A and 3 from group B, by blood clots and/or tumor fragments in 2 patients from group A and 3 from group B, by the tumor protruding into the common hepatic duct in 2 patients from group B. and by tumor compression of the common bile duct in 1 patient from each group. Drainage was successful in 4 patients (44%) from group A and in all 9 patients (100%) from group B. Among the 5 patients with unsuccessful drainage in group A, 4 had obstruction of both the left and right hepatic ducts and 3 had multiple tumors in both lobes. The mean survival time (mean +/- SD) after EBD was 47 +/- 44 days in group A and 181 +/- 70 days in group B. In group A. the average survival time was only 85 days in the 4 patients with successful drainage. However, an improvement in the quality of life after EBD was observed in one-third of the Vp3 patients and in all of the Vp0-Vp2 patients. In summary, satisfactory palliation is possible with successful EBD, but this is difficult in most patients with Vp3 portal thrombus, direct tumor invasion involving both hepatic ducts, and multiple tumors in both lobes. It is important to determine the site, extent, and nature of the obstruction, as well as liver function and the presence of portal thrombus, before performing EBD.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Matsueda K,Yamamoto H,Umeoka F,Ueki T,Matsumura T,Tezen T,Doi Idoi
10.1007/s005350170125subject
Has Abstractpub_date
2001-03-01 00:00:00pages
173-80issue
3eissn
0944-1174issn
1435-5922journal_volume
36pub_type
杂志文章abstract::We used positron emission tomography with 2-deoxy-2-[(18)F]fluoro- d-glucose (FDG-PET) in the diagnosis of two cases of malignant intraductal papillary mucinous tumor (IPMT) of the pancreas. A 56-year-old man and a 72-year-old man, both with tumors in the pancreatic head, were referred to Akita University Medical Cent...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-003-1230-8
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:We recently reported that the presence of a papillary adenocarcinoma (pap) component was an independent risk factor for lymphatic involvement in endoscopically resected early gastric cancer (EGC). This study aimed to investigate the potential association between the presence of a pap component in EGC and lym...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-014-0991-6
更新日期:2015-04-01 00:00:00
abstract::The effect of nifedipine administration (10 mg) on esophageal acid exposure time was investigated in 11 non-reflux esophagitis (non-RE) patients and 11 grade C (Los Angeles classification) reflux esophagitis (RE) patients. In each subject, esophageal pH monitoring was performed, with the subject in the supine position...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050008
更新日期:2000-01-01 00:00:00
abstract::We simultaneously recorded gastric emptying of radio-opaque markers (ROMs) and monitored serial changes in plasma acetaminophen (AAP) levels to demonstrate the relationship between the ROM and the AAP methods, and we investigated the effect of a single intravenous dose of erythromycin (EM) on gastric emptying in healt...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02936948
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy is the current standard of care for patients with chronic hepatitis C. Determining precisely the risk of serious adverse events (SAEs) and mortality from a single study is rather difficult because of the infrequency of such events. The aim of this s...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1007/s00535-012-0631-y
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Rice extract has been shown to protect gastric mucosa from stress-induced damage. In this study, the antibiotic effect and the anti-inflammatory effect of orally administered aqueous rice extract on Helicobacter pylori infection and H. pylori-induced gastritis, respectively, in Mongolian gerbils were investi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-005-1570-7
更新日期:2005-05-01 00:00:00
abstract::Duodenal gastrinoma is recognized as a relatively common cause of Zollinger-Ellison syndrome, but its clinical and biological features are not well known. Here we report a case of duodenal gastrinoma with lymph node metastasis which was confirmed by pathology examinations. Hypergastrinemia and gastric acid hypersecret...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050163
更新日期:1998-10-01 00:00:00
abstract::Depletion of goblet cells (the main mucin-producing cells in the colon) is one of the most reliable histological characteristics of ulcerative colitis, whereas a major symptom of this disease is bloody diarrhea containing a large amount of mucus. The discrepancy between these phenomena was investigated in a time-cours...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050245
更新日期:1999-04-01 00:00:00
abstract::The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for the test. The test ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050092
更新日期:1998-06-01 00:00:00
abstract::An extremely rare case of malignant schwannoma of the esophagus with lymph node metastasis is reported. A 49-year-old woman was found to have an abnormal shadow on a chest X-ray film taken during an annual checkup. Upper gastrointestinal series showed extrinsic pressure on the middle thoracic esophagus, without a muco...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s005350170020
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to elucidate the role of nuclear factor kappaB (NF-kappaB) in the development of gastric ischemia-reperfusion (GI-R) injury and in mediating the effects of angiotensin II (Ang II) in the paraventricular nucleus (PVN) on GI-R injury. METHODS:GI-R injury was induced in rats by cl...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-008-2217-2
更新日期:2008-01-01 00:00:00
abstract::Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is the most frequent complication of ERCP. Several meta-analyses have examined the effects of protease inhibitors (gabexate mesilate, ulinastatin, and nafamostat mesilate) and non-steroidal anti-inflammatory drugs (NSAIDs) on post-ERCP pancreatiti...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00535-013-0834-x
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Superior mesenteric artery syndrome (SMAS) is caused by compression of the third part of the duodenum between the superior mesenteric artery and the aorta. It occurs most frequently in patients with rapid weight loss. METHODS:We report two young patients, who each presented with a longstanding history of po...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350200101
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Evidence suggests that rates of gastroesophageal reflux disease are increasing in the Asia-Pacific region, where patients tend to have predominantly non-erosive reflux disease as opposed to erosive (reflux) esophagitis. At present, data for the responsiveness of non-erosive reflux disease to proton pump inhi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00535-011-0402-1
更新日期:2011-07-01 00:00:00
abstract::We aimed to determine the safety and feasibility of an alternative postoperative oral intake protocol for Japanese patients who had had oncological colorectal surgery, with the goal of shortening the length of postoperative stay to the same level as that in Western countries. The subjects of the study were 42 consecut...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350070075
更新日期:2000-01-01 00:00:00
abstract::Using commercial quantitative assays, quantitative hepatitis B surface antigen (qHBsAg) has improved our understanding and management of chronic hepatitis B (CHB). The HBsAg level is highest in the immune tolerance phase, starts to decline during the immune clearance phase, and decreases slowly but progressively after...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-012-0668-y
更新日期:2013-01-01 00:00:00
abstract::Perianal fistulae are frequently seen complications in Crohn's disease. Although surgical procedures such as Seton's method have been devised, many patients still suffer from fistulae that are resistant to conventional therapy. We administered oral adsorbent to a patient with disease Crohn's who had a complicated peri...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350050349
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND/AIMS:King's College Hospital (KCH) criteria and the model for end-stage liver disease (MELD) score are useful and widely-employed prognostic markers for acute liver failure (ALF). We previously reported that liver atrophy is an important prognostic factor for ALF. The aim of the present study was to assess t...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-009-0045-7
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Gene therapy is a promising therapeutic method but is severely hampered due to its lack of an ideal delivery system. Therefore, in this study, a nonviral and magnetic resonance imaging (MRI) visible vector, polyethylene glycol-grafted polyethylenimine and superparamagnetic iron oxide nanoparticles (PEG-g-PEI...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0713-x
更新日期:2013-07-01 00:00:00
abstract::The gastrointestinal epithelium is a unique model for the study of mammalian stem cells. Not only does it have a highly stereotypical organization, its remarkable rate of self-renewal provides a daily readout of stem cell activity. The past decade has seen a major investment in developing technologies dedicated to rev...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s00535-011-0424-8
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Linked color imaging (LCI) increases the visibility of early gastric cancers, which may be associated with characteristic findings including background purple mucosae. These lesions are found in areas of chronic gastritis and surrounding mucosa. The aim of this study is to objectively characterize these lesi...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-018-1515-6
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Autoimmune pancreatitis (AIP) is considered to be a pancreatic lesion of IgG4-related systemic disease, but about 20% of AIP patients do not have elevated serum IgG4 levels. This study aimed to clarify the pathophysiology of AIP patients without elevated serum IgG4 levels. METHODS:Fifty-eight AIP patients w...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-010-0317-2
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the impact of age on esophageal sensation, and to determine whether esophageal mechanosensitivity and chemosensitivity are correlated in healthy Japanese subjects. METHODS:To evaluate chemosensitivity, a catheter was inserted and placed 10 cm above the upper border of th...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-012-0665-1
更新日期:2013-03-01 00:00:00
abstract::As an increase in gastroesophageal reflux disease (GERD) has been reported in Japan, and public interest in GERD has been increasing, the Japanese Society of Gastroenterology published the Evidence-based Clinical Practice Guidelines for GERD (1st edition) in 2009. Six years have passed since its publication, and there...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,实务指引,评审
doi:10.1007/s00535-016-1227-8
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Fulminant non-A, non-B, non-C hepatitis has a high mortality rate, making the identification of its causative agent imperative. Cytomegalovirus, Epstein-Barr virus, human herpesvirus-6, and herpes simplex virus are all members of the herpesviridae family that are associated with fatal hepatic failure. We inv...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s005350200081
更新日期:2002-01-01 00:00:00
abstract::A new triple therapy using a proton pump inhibitor and two antibiotics shows high efficiency against Helicobacter pylori infection. The aim of this study was to determine the optimal dose and duration of lansoprazole (LA) administration in combination with amoxicillin (AMPC) and metronidazole (MNZ). A total of 91 pati...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::We report a rare case of massive and recurrent bleeding from ileal varices in a patient with hepatitis C virus-positive liver cirrhosis. A 66-year old woman, who had undergone laparotomy and blood transfusion 36 years before (because of an extrauterine pregnancy) and endoscopic sclerotherapy for esophageal varices 1 y...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1007/s005350050255
更新日期:1999-04-01 00:00:00
abstract::The requirement for well spread out chromosomes for the cytogenetic analysis of primary gastrointestinal tumors led us to develop new techniques. These techniques involved two main procedures: (1) preliminary incubation with culture medium in the presence of collagenase, Dispase, and colcemid, for 3 h, and (2) treatme...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02355049
更新日期:1996-08-01 00:00:00
abstract::We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonograp...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02355038
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:The purpose of our study was to evaluate the long-term outcome and complications of balloon-occluded retrograde transvenous obliteration (B-RTO) in patients with hemorrhage from gastric fundal varices. METHODS:Thirty-four consecutive patients with bleeding from gastric varices who were treated with B-RTO we...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/s00535-007-2077-1
更新日期:2007-08-01 00:00:00