Abstract:
BACKGROUND:Better diagnosis of metastatic disease has been pursued by oncologists: however, many of the tumor markers have been still controversial. Our purpose was to estimate the usefulness of soluble E-selectin and its ligand sialyl Lewis A for more accurate diagnosis as a combined tumor marker for metastases in colorectal cancer. METHODS:E-selectin and sialyl Lewis A, collected from preoperative blood, were measured of its levels in 54 patients with colorectal cancer classified according to Dukes' stage. E-selectin was assayed by enzyme-linked immunosorbent assay, whereas sialyl Lewis A was quantified by enzyme immunoassay using immunoclone kit. RESULTS:The elevation in the level of E-selectin was significantly higher in Dukes' D group than that of healthy volunteers (P < 0.001, Fisher's procedure of least significance test), Dukes' A (P = 0.01), B (P = 0.025) and C (P < 0.01). Significantly higher level of sialyl Lewis A was shown in the group of metastases than that of non-metastases (P < 0.0068. Student's t-test). Paired elevation of E-selectin and sialyl Lewis A was significantly higher in the hematogenous metastases than non-metastases (P < 0.001, Fisher exact test). CONCLUSIONS:These results suggest that E-selectin could play some role in the progress of hematogenous metastases. The elevation of E-selectin alone or both E-selectin and sialyl Lewis A may be one of the useful indexes for more precise diagnosis of hematogenous metastases of human colorectal cancer.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Ito K,Ye CL,Hibi K,Mitsuoka C,Kannagi R,Hidemura K,Ando H,Kasai Y,Akiyama S,Nakao Adoi
10.1007/s005350170004subject
Has Abstractpub_date
2001-12-01 00:00:00pages
823-9issue
12eissn
0944-1174issn
1435-5922journal_volume
36pub_type
杂志文章abstract::5-aminosalicylate is a fundamental treatment for patients with ulcerative colitis with mild-to-moderate disease; however, evidence for 5-aminosalicylate treatment is unclear in some situations. This review discusses the clinical guidelines and previous studies, and highlights the following points: (1) Although rectal ...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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abstract::To study the appropriate period for formalin fixation in order to detect p53 abnormalities in formalin-fixed tissue, we used seven surgically resected human colorectal cancer specimens. The immunohistochemical reactivity of p53 immunostaining and amplification of DNA by polymerase chain reaction (PCR) of the p53 gene ...
journal_title:Journal of gastroenterology
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abstract:BACKGROUND:Fatty liver is an important clinical feature not only in alcoholic and non-alcoholic fatty liver diseases, but in other chronic liver diseases as well. Our aim was to elucidate the effect and relationship between habitual alcohol intake and obesity in the development of fatty liver disease. METHODS:We enrol...
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更新日期:2015-11-01 00:00:00
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abstract:BACKGROUND:Although pancreatic duct guidewire placement (P-GW) for achieving selective biliary cannulation is reported to be effective in patients in whom endoscopic retrograde cholangiopancreatography (ERCP) is difficult, this technique entails a possible increased risk of post-ERCP pancreatitis. We conducted a prospe...
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Percutaneous microwave ablation and radiofrequency ablation are two commonly used modalities for the treatment of hepatocellular carcinoma; however, comparisons of them have not been documented adequately. METHODS:Of 102 patients with biopsy-proved hepatocellular carcinoma, 49 (98 nodules) were treated perc...
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更新日期:2005-11-01 00:00:00
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更新日期:2014-03-01 00:00:00
abstract::We treated a patient with a mechanical ileus resulting from encasement of a loop of the small intestine by the great omentum, caused by abnormal adhesion. Apart from its occurrence postoperatively with laparotomy, strangulation of small intestine into the omentum is very rare, and its occurrence without underlying dis...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2005-02-01 00:00:00
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更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The introduction of capsule endoscopy (CE) has facilitated the detection of mucosal changes in the small bowel, and such mucosal changes have been noted in cirrhotic patients with portal hypertension; these changes are described as portal hypertensive enteropathy. The aim of this study was to assess the effe...
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更新日期:2013-05-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF02355049
更新日期:1996-08-01 00:00:00
abstract::Aberrant methylation of CpG islands in promoter regions can permanently inactivate tumor-suppressor genes, as mutations and chromosomal abnormalities do. In gastric cancers, CDKN2A, CDH1, and MLH1 are inactivated more frequently by aberrant methylation than by mutations, and novel tumor-suppressor genes inactivated by...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:The p53 tumor suppressor protein plays a fundamental role in maintaining genomic integrity through its ability to arrest the cell cycle in G1 and induce apoptosis. The proapoptotic activity of p53 seems to be strictly related to proline-rich regions, homologous to the SH3 binding domain. In the literature, r...
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pub_type: 杂志文章,多中心研究
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更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF01213311
更新日期:1997-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:2013-08-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00