Abstract:
PURPOSE:Single nucleotide polymorphisms (SNPs) of the adiponectin gene have been reported to be associated with insulin resistance and the prevalence of type-2 diabetes. We investigated the SNPs of adiponectin in non-alcoholic fatty liver disease (NAFLD) patients. METHODS:One hundred nineteen patients histologically diagnosed as having NAFLD and 115 control subjects were examined. Adiponectin SNP sites were investigated at +45 of exon 2 and at +276 of intron 2; these sites have been thought to be associated with diabetes or insulin resistance. RESULTS:Regarding the +276 SNP, the frequency of G/G tended to be higher in NAFLD patients than in controls, but not significantly. Among females only, however, the G/G frequency was significantly higher in NAFLD patients. As for the +45 SNP, in the severe fibrosis group, the frequency of G/G homozygotes was significantly higher than that in the mild fibrosis group, and G/G homozygotes of the +45 SNP proved by multivariate analysis to be an independent factor in severe fibrosis. In NAFLD patients with adiponectin +45 G/G, homeostasis model assessment-insulin resistance was significantly higher than in NAFLD patients without adiponectin +45 G/G. CONCLUSION:Adiponectin SNPs were found to be associated with the progression of liver fibrosis and insulin resistance, suggesting that adiponectin SNPs might play roles in the occurrence and progression of NAFLD.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Tokushige K,Hashimoto E,Noto H,Yatsuji S,Taniai M,Torii N,Shiratori Kdoi
10.1007/s00535-009-0085-zsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
976-82issue
9eissn
0944-1174issn
1435-5922journal_volume
44pub_type
杂志文章abstract::The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for the test. The test ...
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pub_type: 杂志文章,评审
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
doi:
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journal_title:Journal of gastroenterology
pub_type: 杂志文章
doi:10.1007/BF02355069
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abstract::To evaluate the diagnostic utility of blood biochemical parameters in assessing degree of hepatic fibrosis, serum levels of aminoterminal type III procollagen peptide (P III P), type IV collagen (IV-collagen), 7S domain of type IV collagen (7S-collagen), and hyaluronan (HA) were measured in 54 patients with chronic vi...
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pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章,评审
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