Abstract:
BACKGROUND:The model for end-stage liver disease (MELD) is useful for assessing the recipients of liver transplants, namely, deceased-donor transplantation. The application of MELD for living donor liver transplantation (LDLT) is under investigation. Thus, the aim of this study was to analyze the impact of the MELD score in LDLT in Japan. METHODS:Seventeen adult cases of LDLT during 2001 to 2005 were enrolled. Indications for LDLT were primary biliary cirrhosis, seven; liver cirrhosis, two; hepatocellular carcinoma (HCC), three; metabolic liver disease, one; primary sclerosing cholangitis, two; Caroli's disease, one; and biliary atresia, one. Total medical charges during the operative periods were retrospectively evaluated. The united network of organ sharing (UNOS) modified was obtained using preoperative clinical data. RESULTS:The average medical expense of the 17 cases was approximately 97,901 US dollar. The UNOS-modified MELD score was 22.1. A statistically significant positive correlation was found between the MELD score and medical expense (P = 0.0086, rho = 0.657), and between the MELD score and the length of stay in the intensive care unit (ICU) (P = 0.0396, rho = 0.515). The cause of the liver disease leading to transplantation was not related to MELD score, medical expense, or length of ICU stay. CONCLUSIONS:Although not originally designed for the application to LDLT, the MELD score is useful for predicting medical expenses in LDLT. Similar to those of deceased-donor liver transplantation, the disadvantage of high medical expenses associated with a high MELD score allow consideration of an earlier elective operation in suitable cases.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Kogure T,Ueno Y,Kawagishi N,Kanno N,Yamagiwa Y,Fukushima K,Satomi S,Shimosegawa Tdoi
10.1007/s00535-006-1887-xsubject
Has Abstractpub_date
2006-10-01 00:00:00pages
1005-10issue
10eissn
0944-1174issn
1435-5922journal_volume
41pub_type
杂志文章abstract::This study was conducted to determine and compare serum trace metal levels in viral hepatitis-associated chronic liver disease. Of 98 patients aged 43 (+/- 13) [mean (+/- SD)] years, 83 (85%) were seropositive for hepatitis B surface antigen (HBsAg) and 15 (15%) were seropositive for anti-hepatitis C virus (HCV). Twen...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Evidence suggests that rates of gastroesophageal reflux disease are increasing in the Asia-Pacific region, where patients tend to have predominantly non-erosive reflux disease as opposed to erosive (reflux) esophagitis. At present, data for the responsiveness of non-erosive reflux disease to proton pump inhi...
journal_title:Journal of gastroenterology
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abstract:BACKGROUND:Physical inactivity is a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). "Hybrid training", a training that involves both voluntary and electrical muscle contractions, causes beneficial alterations in muscles even after short durations of exercise. The aim of this study was to i...
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abstract:BACKGROUND:Gene therapy is a promising therapeutic method but is severely hampered due to its lack of an ideal delivery system. Therefore, in this study, a nonviral and magnetic resonance imaging (MRI) visible vector, polyethylene glycol-grafted polyethylenimine and superparamagnetic iron oxide nanoparticles (PEG-g-PEI...
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abstract::Depletion of goblet cells (the main mucin-producing cells in the colon) is one of the most reliable histological characteristics of ulcerative colitis, whereas a major symptom of this disease is bloody diarrhea containing a large amount of mucus. The discrepancy between these phenomena was investigated in a time-cours...
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journal_title:Journal of gastroenterology
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abstract:BACKGROUND AND AIMS:The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effect of P.g infection on risk of progression to NASH. M...
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更新日期:2018-02-01 00:00:00
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更新日期:2011-05-01 00:00:00
abstract::Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases such as inflammatory bowel disease (IBD). The development of next-generation sequencing technology allows th...
journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2016-02-01 00:00:00
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更新日期:1996-10-01 00:00:00
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更新日期:2015-04-01 00:00:00
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abstract:PURPOSE:The abnormal expression of several genes is involved in the development of colorectal tumors. The aim of this study was to examine the expression of KAI1, CAR, and Smad4, which has been associated with the progression of other cancers. METHODS:We examined 12 adenomas, 38 primary carcinomas, 10 liver metastases...
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1995-04-01 00:00:00
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更新日期:2002-01-01 00:00:00
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更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章,评审
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abstract:BACKGROUND:This study aimed to develop a model to predict the development of severe anemia during pegylated interferon alpha-2b plus ribavirin combination therapy. METHODS:Data were collected from 1081 genotype 1b chronic hepatitis C patients who were treated at 6 hospitals in Japan. These patients were randomly assig...
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pub_type: 杂志文章
doi:10.1007/s00535-011-0412-z
更新日期:2011-09-01 00:00:00
abstract::Little data are available regarding the effects of hepatitis virus serostatus and the severity of coexisting chronic inflammation on intrahepatic recurrence after hepatectomy for hepatocellular carcinoma (HCC). We investigated the extent to which these factors modified the prognosis of hepatectomized patients. A total...
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