Gastric acid secretion level modulates the association between Helicobacter pylori infection and low-dose aspirin-induced gastropathy.

abstract：BACKGROUND:In recent years in Japan, the rate of clarithromycin (CAM) resistance in Helicobacter pylori has risen to around 30%, and the eradication rate with triple therapy [proton pump inhibitor + amoxicillin (AMPC) + CAM] has been trending downward to around 70%. In 2007, rabeprazole (RPZ)-based triple therapy (RPZ ...

journal_title：Journal of gastroenterology

authors： Fujioka T,Aoyama N,Sakai K,Miwa Y,Kudo M,Kawashima J,Matsubara Y,Miwa J,Yakabi K

更新日期：2012-03-01 00:00:00

abstract：:Endoscopic surveillance of Barrett's esophagus has become a foundation of the management of esophageal adenocarcinoma (EAC). Surveillance for Barrett's esophagus commonly involves periodic upper endoscopy with biopsies of suspicious areas and random four-quadrant biopsies. However, targeted biopsies using narrow-band ...

journal_title：Journal of gastroenterology

authors： Ishihara R,Goda K,Oyama T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:A prospective, randomized study was performed to determine whether gemcitabine infusion at a low dose (250 mg/m2) is comparable or superior to the standard-dose infusion (1000 mg/m2) in terms of the survival period, clinical benefit, and frequency of adverse effects in patients with advanced pancreatic adeno...

journal_title：Journal of gastroenterology

authors： Sakamoto H,Kitano M,Suetomi Y,Takeyama Y,Ohyanagi H,Nakai T,Yasuda C,Kudo M

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The remnant stomach corresponds to the gastric cardia, but is exposed to a completely different environment. The present study was performed to investigate the role of Epstein-Barr virus (EBV) infection in patients with gastric remnant carcinoma (GRC). METHODS:Clinicopathological features, gastritis, and in...

journal_title：Journal of gastroenterology

authors： Kaizaki Y,Hosokawa O,Sakurai S,Fukayama M

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Neovascularization was shown to be critically involved in the progression of multiple cancers, and treatment approaches targeting tumor-associated neovascularization provide convincing results in recent years in some tumor entities. However, little is known about the tumor-associated neovascularization in hi...

journal_title：Journal of gastroenterology

authors： Thelen A,Scholz A,Benckert C,Schröder M,Weichert W,Wiedenmann B,Neuhaus P,Jonas S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Liver histology is the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH). Noninvasive, simple, reproducible, and reliable biomarkers are greatly needed to differentiate NASH from nonalcoholic fatty liver disease (NAFLD). METHODS:To construct a scoring system for predicting NASH, 177 Jap...

journal_title：Journal of gastroenterology

authors： Sumida Y,Yoneda M,Hyogo H,Yamaguchi K,Ono M,Fujii H,Eguchi Y,Suzuki Y,Imai S,Kanemasa K,Fujita K,Chayama K,Yasui K,Saibara T,Kawada N,Fujimoto K,Kohgo Y,Okanoue T,Japan Study Group of Nonalcoholic Fatty Liver Disease

更新日期：2011-02-01 00:00:00

abstract：:A patient with hepatitis C virus (HCV)-related liver cirrhosis and hepatocellular carcinoma (HCC) was treated successfully with an orthotopic liver transplantation (OLT) followed by interferon therapy. The 36-year-old Japanese man was diagnosed as having liver cirrhosis in 1983. HCC was detected in 1991, and by 1994, ...

journal_title：Journal of gastroenterology

authors： Shibata M,Yanaga K,Morizane T,Yanagawa T,Hirakawa M,Ueno Y,Esquivel CO,Mitamura K

更新日期：2003-01-01 00:00:00

abstract：:Cyclin D1 overexpression is remarkably frequent in several human carcinomas and is believed to be a critical event in oncogenesis. We examined cyclin D1 expression, p53 expression, and the Ki-67 labeling index by immunostaining in human gallbladder mucosa in conditions varying from normal to malignant tissue. We also ...

journal_title：Journal of gastroenterology

authors： Itoi T,Shinohara Y,Takeda K,Nakamura K,Takei K,Sanada J,Horibe T,Saito T,Kasuya K,Ebihara Y

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Whether mucosal inflammation affects gastric motility in patients with functional dyspepsia (FD) is controversial. Few reports discuss gastric motility in relation to histologic gastritis. We examined the relation between gastric motility and histologic gastritis in Japanese patients with FD. METHODS:Subjec...

journal_title：Journal of gastroenterology

authors： Matsumoto Y,Ito M,Kamino D,Tanaka S,Haruma K,Chayama K

更新日期：2008-01-01 00:00:00

abstract：:We report a case of pancreas head carcinoma associated with fat replacement of the body and tail. A 68-year-old man presented with obstructive jaundice and was admitted to our hospital. Ultrasonography and computed tomography showed pancreas head tumor with a neighboring cystic lesion and fatty replacement of parenchy...

journal_title：Journal of gastroenterology

authors： Toyama N,Kamiyama H,Suminaga Y,Namai K,Ota M,Konishi F

更新日期：2004-01-01 00:00:00

abstract：:We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in this country. Although the definition of GERD depends on the individual study, the prevalence of GERD has been increasing since the end of the 1990s. The reasons...

journal_title：Journal of gastroenterology

authors： Fujiwara Y,Arakawa T

更新日期：2009-01-01 00:00:00

abstract：:The clinical significance of the measurement of c-erbB-2 oncogene product was evaluated. The subjects consisted of 404 patients, including 248 with cancer of the digestive organs and 128 with benign digestive diseases. Serum c-erbB-2 protein levels were measured by sandwich immunoenzyme assay. The positive rates of c-...

journal_title：Journal of gastroenterology

authors： Motoo Y,Sawabu N,Yamaguchi Y,Mouri I,Yamakawa O,Watanabe H,Ohta H,Okai T,Makino H

更新日期：1994-10-01 00:00:00

abstract：:The localization and distribution of gamma delta T cell receptor (TCR)-positive cells (gamma delta T cells) in hepatocellular carcinoma capsules was investigated immunohistochemically at both light and electron microscopic levels. Most of the mononuclear cells infiltrating the tumor capsules were CD3-positive. Togethe...

journal_title：Journal of gastroenterology

authors： Chin K,Morise K,Kanayama K,Nagura H

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:The T-helper (Th)1 immune reaction is essential for the eradication of hepatitis C virus (HCV) during interferon (IFN) therapy in patients with chronic hepatitis C. Osteopontin is a cytokine crucial for the initiation of the Th1 response. Recently, we identified four single-nucleotide polymorphisms (SNPs) in...

journal_title：Journal of gastroenterology

authors： Naito M,Matsui A,Inao M,Nagoshi S,Nagano M,Ito N,Egashira T,Hashimoto M,Mishiro S,Mochida S,Fujiwara K

更新日期：2005-04-01 00:00:00

abstract：:Styrene-maleic acid neocarzinostatin (SMANCS) sometimes causes hepatic vascular side effects, including arterial stricture, obstruction, and arterio-portal shunt. A total of 128 intra-arterial SMANCS injection treatments, performed for 89 patients with hepatocellular carcinoma, were analyzed to determine the relations...

journal_title：Journal of gastroenterology

authors： Ikeda K,Saitoh S,Kobayashi M,Suzuki Y,Suzuki F,Tsubota A,Arase Y,Chayama K,Murashima N,Kumada H

更新日期：2000-01-01 00:00:00

abstract：:Focal nodular hyperplasia (FNH) is a benign lesion of the liver which usually presents with one or two localizations. We report a patient with history of resection of a biliary cyst, and who had been taking oral contraceptives for the past 18 years, who had multiple localizations of FNH (more than 30 lesions). The lar...

journal_title：Journal of gastroenterology

authors： Colle I,de Beeck BO,Hoorens A,Hautekeete M

更新日期：1998-12-01 00:00:00

abstract：:Although anemia is one of the signs of colorectal cancer, the relationships between histological findings and hematological findings other than hemoglobin level have not been adequately investigated. We investigated the relationship between hematological findings, serum iron, and histological findings in 358 patients ...

journal_title：Journal of gastroenterology

authors： Sadahiro S,Suzuki T,Tokunaga N,Mukai M,Tajima T,Makuuchi H,Saito T

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Nocturnal administration of branched-chain amino acid (BCAA) granules improves serum albumin levels in patients with cirrhosis. However, it is unclear whether or not this administration method can improve the patients' quality of life (QOL). In this study, we aimed to investigate the efficacy of BCAA granule...

journal_title：Journal of gastroenterology

authors： Hidaka H,Nakazawa T,Kutsukake S,Yamazaki Y,Aoki I,Nakano S,Asaba N,Minamino T,Takada J,Tanaka Y,Okuwaki Y,Watanabe M,Shibuya A,Koizumi W

更新日期：2013-02-01 00:00:00

abstract：:We describe a gastric carcinoma cell line that has been maintained in vitro for more than 10 years and retains the capacity to produce a large amount of alpha-fetoprotein. This cell line was isolated from a metastatic lymph node of a 63-year-old male patient with advanced gastric carcinoma (T2N3P0H0M0) who showed high...

journal_title：Journal of gastroenterology

authors： Sekiguchi M,Fujii Y,Saito A,Suzuki T,Shiroko Y,Nakamura H,Hasumi K

更新日期：1995-10-01 00:00:00

abstract：PURPOSE:Ilaprazole (IY-81149) is a new proton-pump inhibitor (PPI) not previously studied in human patients with ulcer disease. This study evaluated and compared it with a reference PPI, omeprazole, in the treatment of gastric and duodenal ulcers. METHODS:This was a double-blind, parallel, randomized study. Patients a...

journal_title：Journal of gastroenterology

authors： Ho KY,Kuan A,Zaño F,Goh KL,Mahachai V,Kim DY,Yoon HM

更新日期：2009-01-01 00:00:00

abstract：:Anomalous arrangement of the pancreaticobiliary ductal system (AAPB), a congenital anomaly defined as a union of the pancreatic and biliary ducts located outside the duodenal wall, is a newly designated disease entity, and is frequently found in adult patients with gallbladder carcinoma (GBX). In the present study, th...

journal_title：Journal of gastroenterology

authors： Yang Y,Fujii H,Matsumoto Y,Suzuki K,Kawaoi A,Suda K

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Several findings suggest that eosinophilic esophagitis (EoE) is strongly associated with atopy and allergen-driven, Th2-type immune responses, indicating the association of EoE with immune dysregulation. The objective of this study is to ascertain the molecular mechanism involved in EoE disease development a...

journal_title：Journal of gastroenterology

authors： Zafra MP,Cancelliere N,Rodríguez del Río P,Ruiz-García M,Estévez L,Andregnette V,Sánchez-García S,Fiandor A,Collantes E,Sastre J,Quirce S,Ibáñez MD,del Pozo V

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Hypersensitive esophagus (HE) is defined by endoscopy-negative heartburn with a normal acid exposure time but positive symptom association probability (SAP) and/or symptom index (SI) on impedance-pH monitoring, and proton pump inhibitor (PPI) responsiveness. Functional heartburn (FH) is distinguished by nega...

journal_title：Journal of gastroenterology

authors： Frazzoni M,de Bortoli N,Frazzoni L,Furnari M,Martinucci I,Tolone S,Farioli A,Marchi S,Fuccio L,Savarino V,Savarino E

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:Single nucleotide polymorphisms (SNPs) of the adiponectin gene have been reported to be associated with insulin resistance and the prevalence of type-2 diabetes. We investigated the SNPs of adiponectin in non-alcoholic fatty liver disease (NAFLD) patients. METHODS:One hundred nineteen patients histologically d...

journal_title：Journal of gastroenterology

authors： Tokushige K,Hashimoto E,Noto H,Yatsuji S,Taniai M,Torii N,Shiratori K

更新日期：2009-01-01 00:00:00

abstract：:We report a 66-year-old man with hepatocellular carcinoma who was positive for hepatitis B surface antigen, and was hospitalized because of hypoglycemia and hypertension. His plasma renin activity was normal (2.3 ng/ml per h), but concentrations of angiotensin I (>2500 pg/ml) and II (86 pg/ml) were high. Increased ang...

journal_title：Journal of gastroenterology

authors： Arai H,Saitoh S,Matsumoto T,Makita F,Mitsugi S,Yuasa K,Takagi H,Mori M

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:White adipose tissue (WAT) is important for the maintenance of metabolic homeostasis, and metabolic syndrome is sometimes associated with WAT dysfunction in humans and animals. WAT reportedly plays a key, beneficial role in the maintenance of glucose and lipid homeostasis during de novo lipogenesis (DNL). Pu...

journal_title：Journal of gastroenterology

authors： Cai X,Hayashi S,Fang C,Hao S,Wang X,Nishiguchi S,Tsutsui H,Sheng J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Drug resistance in colorectal cancers is assumed to be mediated by changes in the expression of microRNAs, but the specific identities and roles of microRNAs are largely unclear. We examined the effect of 5-fluorouracil (5-FU) resistance on microRNA expression. METHODS:Two types of 5-FU-resistant colon canc...

journal_title：Journal of gastroenterology

authors： Kurokawa K,Tanahashi T,Iima T,Yamamoto Y,Akaike Y,Nishida K,Masuda K,Kuwano Y,Murakami Y,Fukushima M,Rokutan K

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The risk for lymph node metastasis and the prognostic significance of pedunculated-type T1 colorectal carcinomas (CRCs) require further study. We aimed to assess the validity of the 2014 Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines based on long-term outcomes of pedunculated-type T1...

journal_title：Journal of gastroenterology

authors： Asayama N,Oka S,Tanaka S,Nagata S,Furudoi A,Kuwai T,Onogawa S,Tamura T,Kanao H,Hiraga Y,Okanobu H,Kuwabara T,Kunihiro M,Mukai S,Goto E,Shimamoto F,Chayama K

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) consists of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH); the latter progresses to liver cirrhosis and hepatocellular carcinoma. Discriminating NASH from NAFL typically involves liver biopsy. The mechanism of NASH progression is unclear but ...

journal_title：Journal of gastroenterology

authors： Kado A,Tsutsumi T,Enooku K,Fujinaga H,Ikeuchi K,Okushin K,Moriya K,Yotsuyanagi H,Koike K

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Given the well-documented adverse side effects of sorafenib, many sorafenib-treated patients may need the reduced initial dose of the compound, and an alternative sorafenib-based therapy, which exerts similar clinical benefit, is anticipated. An angiostatic therapy with sorafenib is considered one of the pro...

journal_title：Journal of gastroenterology

authors： Yoshiji H,Noguchi R,Namisaki T,Moriya K,Kitade M,Aihara Y,Douhara A,Kawaratani H,Nishimura N,Fukui H

更新日期：2014-10-01 00:00:00