Serum trace metals in chronic viral hepatitis and hepatocellular carcinoma in Thailand.


:This study was conducted to determine and compare serum trace metal levels in viral hepatitis-associated chronic liver disease. Of 98 patients aged 43 (+/- 13) [mean (+/- SD)] years, 83 (85%) were seropositive for hepatitis B surface antigen (HBsAg) and 15 (15%) were seropositive for anti-hepatitis C virus (HCV). Twenty-five patients had chronic persistent hepatitis, 32 chronic active hepatitis, 21 post-necrotic cirrhosis, and 20 hepatocellular carcinoma. Determination of fasting serum trace metal levels (zinc, copper, calcium, magnesium, and phosphorus) was performed after the patients had been on a 2-day diet containing 10-12 mg zinc/day. Compared to healthy volunteers (n = 30), serum zinc levels were significantly decreased in patients with chronic active hepatitis, cirrhosis, and hepatocellular carcinoma (P < or = 0.0001), and copper levels were significantly elevated only in patients with hepatocellular carcinoma (P < 0.0001). The overall serum levels of calcium, magnesium, and phosphorus were within normal ranges, and levels of calcium and magnesium correlated with serum zinc (P = 0.01-0.03). Serum zinc levels correlated with bilirubin, albumin, and cholesterol (P = 0.0004 < or = 0.0001), but not with daily urinary zinc excretion. Serum copper levels correlated with alkaline phosphatase and gamma-glutamyltransferase (P = 0.008-0.0001). These results suggested that changes in liver cell pathology compounded by functional impairment may alter the metabolism of trace metals, in particular, zinc and copper. The possible relationship of these changes to the pathogenesis of chronic liver disease is discussed.


J Gastroenterol


Pramoolsinsap C,Promvanit N,Komindr S,Lerdverasirikul P,Srianujata S




Has Abstract


1994-10-01 00:00:00












  • Surgical management of cystic hepatic neoplasms.

    abstract:BACKGROUND:The clinicopathologic features of cystic neoplasms of the liver, such as cystadenoma and cystadenocarcinoma, are poorly defined because these lesions are extremely rare. METHODS:Clinicopathologic findings in six patients who underwent surgery for a cystic hepatic neoplasm were reviewed retrospectively to de...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Hai S,Hirohashi K,Uenishi T,Yamamoto T,Shuto T,Tanaka H,Kubo S,Tanaka S,Kinoshita H

    更新日期:2003-01-01 00:00:00

  • Effectiveness of endoscopic biliary drainage for unresectable hepatocellular carcinoma associated with obstructive jaundice.

    abstract::Endoscopic biliary drainage (EBD) for unresectable hepatocellular carcinoma (HCC) associated with obstructive jaundice remains controversial because of the short survival of these patients. To evaluate the effectiveness of this procedure, we retrospectively studied 18 patients who had unresectable HCC with obstructive...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Matsueda K,Yamamoto H,Umeoka F,Ueki T,Matsumura T,Tezen T,Doi I

    更新日期:2001-03-01 00:00:00

  • Efficacy of 6-month interferon therapy in chronic hepatitis B virus infection in Japan.

    abstract:BACKGROUND:In Japan, there are few studies of long-term (more than 1 month) interferon (IFN) therapy for chronic hepatitis B (CHB). In this retrospective study, we investigated the efficacy and predictors of response to 6-month IFN therapy. METHODS:We analyzed 66 Japanese patients with CHB who were treated with IFN fo...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Suzuki F,Arase Y,Akuta N,Tsubota A,Suzuki Y,Sezaki H,Hosaka T,Someya T,Kobayashi M,Saitoh S,Ikeda K,Kobayashi M,Matsuda M,Satoh J,Kumada H

    更新日期:2004-10-01 00:00:00

  • Association of the interleukin-1 beta genetic polymorphism and gastric cancer risk in Japanese.

    abstract:BACKGROUND:Helicobacter pylori infection is associated not only with gastroduodenal ulcers but with the development of gastric cancer. Interleukin-1 beta (IL-1 beta) is a potent inhibitor of gastric secretion. The -31 C-to-T base transition in the intron of this gene has been reported to be involved in carcinogenic cha...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Kato S,Onda M,Yamada S,Matsuda N,Tokunaga A,Matsukura N

    更新日期:2001-10-01 00:00:00

  • Resection depth and layer of cold snare polypectomy versus endoscopic mucosal resection.

    abstract:BACKGROUND:Cold snare polypectomy (CSP) has not undergone sufficient histopathological evaluation. This study aimed to clarify the histopathological features of CSP specimens, including resection depth and layer, as compared with endoscopic mucosal resection (EMR). METHODS:Polyps were recruited retrospectively. Sessil...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Ito A,Suga T,Ota H,Tateiwa N,Matsumoto A,Tanaka E

    更新日期:2018-11-01 00:00:00

  • Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.

    abstract:BACKGROUND:Neutrophil elastase (NE) is a major secretory product from activated neutrophils and a major contributor to tissue destruction. However, little is known about the pathogenic contribution of NE to ulcerative colitis (UC). This study was designed to investigate the contribution of NE by measuring NE activity i...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Morohoshi Y,Matsuoka K,Chinen H,Kamada N,Sato T,Hisamatsu T,Okamoto S,Inoue N,Takaishi H,Ogata H,Iwao Y,Hibi T

    更新日期:2006-04-01 00:00:00

  • Treatment of bleeding stomal varices by balloon-occluded retrograde transvenous obliteration.

    abstract::Although stomal varices are a rare complication, bleeding stomal varices often need to be treated owing to symptoms of hypovolemic shock, recurrence of stomal bleeding, or deterioration in the quality of life. Various treatment strategies for the management of bleeding stomal varices have thus far been reported. We re...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Minami S,Okada K,Matsuo M,Kamohara Y,Sakamoto I,Kanematsu T

    更新日期:2007-01-01 00:00:00

  • Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.

    abstract::Because most gastric cancers develop from a background of Helicobacter pylori-infected gastric mucosa, H. pylori plays an important role in gastric carcinogenesis. Therefore, eradication of H. pylori may inhibit the incidence of gastric cancers. In experimental studies, H. pylori eradication has proved to act as a pro...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Kato M,Asaka M,Ono S,Nakagawa M,Nakagawa S,Shimizu Y,Chuma M,Kawakami H,Komatsu Y,Hige S,Takeda H

    更新日期:2007-01-01 00:00:00

  • Endoscopic characterization of the small bowel in patients with portal hypertension evaluated by double balloon endoscopy.

    abstract:BACKGROUND:The endoscopic abnormalities present in the small bowel (SB) of patients with portal hypertension (PH) are not well understood. This study sought to evaluate endoscopic findings of the SB in patients with PH by double balloon endoscopy (DBE). METHODS:We evaluated the endoscopic findings of SB in 15 patients...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Kodama M,Uto H,Numata M,Hori T,Murayama T,Sasaki F,Tsubouchi N,Ido A,Shimoda K,Tsubouchi H

    更新日期:2008-01-01 00:00:00

  • Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study.

    abstract:BACKGROUND:Vaniprevir is a potent macrocyclic hepatitis C virus (HCV) nonstructural protein 3/4A protease inhibitor. This phase III study evaluated the safety and efficacy of vaniprevir in combination with peginterferon alfa-2b and ribavirin (PR) for 24 weeks compared with PR alone for 48 weeks in treatment-naive Japan...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Hayashi N,Nakamuta M,Takehara T,Kumada H,Takase A,Howe AY,Ludmerer SW,Mobashery N

    更新日期:2016-04-01 00:00:00

  • An experimental study of gastric mucosal blood flow in endotoxemia of the rat, with special reference to the vagus nerve and EDRF.

    abstract::Gastric mucosal lesions are an important complication in endotoxemia. In order to define the role played by the vagus nerve and endothelial-derived relaxing factor (EDRF) in gastric mucosal blood flow, an investigation was carried out on four groups of rats: a control group; a group given lipopolysaccharide (LPS, 5 mg...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Sakano T,Itoh K,Tanaka M,Arakawa Y,Matsuo Y

    更新日期:1995-02-01 00:00:00

  • Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer.

    abstract:BACKGROUND:Matrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in tumor invasion and metastasis, being inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs). In this study, we examined the expression of MMP-2, MMP-9, membrane-type 1 (MT1)-MMP, TIMP-1,...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Shim KN,Jung SA,Joo YH,Yoo K

    更新日期:2007-02-01 00:00:00

  • Study of hemodynamic changes in portal systemic shunts and their relation to variceal relapse after endoscopic variceal ligation combined with ethanol sclerotherapy.

    abstract:BACKGROUND:Among the factors influencing variceal relapse after endoscopic treatment, portal hemodynamic changes, especially in portal systemic shunts, could be the most important factor because hemodynamics are directly related to the development of esophageal varices. We aimed to clarify the influence of endoscopic t...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Ito K,Matsutani S,Maruyama H,Akiike T,Nomoto H,Suzuki T,Fukuzawa T,Mizumoto H,Saisho H

    更新日期:2006-02-01 00:00:00

  • Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p.

    abstract:BACKGROUND:Circular RNAs (circRNAs) act as vital regulators of gene expression in a variety of cancers. However, the role of circRNAs in gastric cancer (GC) remains largely unexplored. Herein, we identified that circTMEM87A sponges miR-142-5p to promote GC progression through up-regulating ULK1 expression. METHODS:The...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang H,Sun G,Xu P,Lv J,Zhang X,Zhang L,Wang S,Cao J,Xia Y,Xuan Z,Li B,Huang X,Jiang T,Fang L,Xu Z

    更新日期:2020-11-06 00:00:00

  • Current status of preoperative biliary drainage.

    abstract::Preoperative biliary drainage (PBD) has been thought to be preferable regardless of the site of biliary strictures, e.g., distal or proximal strictures because PBD by endoscopy or interventional radiology decreases postoperative mortality and morbidity rates. However, recently, several studies have revealed that PBD s...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Umeda J,Itoi T

    更新日期:2015-09-01 00:00:00

  • Kupffer phase image of Sonazoid-enhanced US is useful in predicting a hypervascularization of non-hypervascular hypointense hepatic lesions detected on Gd-EOB-DTPA-enhanced MRI: a multicenter retrospective study.

    abstract:BACKGROUND:It remains unknown whether Kupffer-phase images in Sonazoid-enhanced ultrasonography (US) can be used to predict hypervascularization of borderline lesions. Therefore, we aimed to clarify whether Kupffer-phase images in Sonazoid-enhanced ultrasonography can predict subsequent hypervascularization in hypovasc...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Inoue T,Hyodo T,Korenaga K,Murakami T,Imai Y,Higaki A,Suda T,Takano T,Miyoshi K,Koda M,Tanaka H,Iijima H,Ochi H,Hirooka M,Numata K,Kudo M

    更新日期:2016-02-01 00:00:00

  • Strangulation ileus resulting from encasement of a loop of the small intestine by the great omentum, caused by abnormal adhesion.

    abstract::We treated a patient with a mechanical ileus resulting from encasement of a loop of the small intestine by the great omentum, caused by abnormal adhesion. Apart from its occurrence postoperatively with laparotomy, strangulation of small intestine into the omentum is very rare, and its occurrence without underlying dis...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Kimura H,Earashi M,Konishi K,Tsuneda A,Tazawa K,Inoue T,Maeda K,Yabushita K,Kuroda Y,Tsuji M,Miwa A

    更新日期:1996-10-01 00:00:00

  • Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study.

    abstract:BACKGROUND:We recently reported the efficacy of indigo naturalis (IN) in patients with active ulcerative colitis (UC) in a randomized controlled trial (INDIGO study). However, few studies have been conducted to investigate whether IN is effective even in treatment-refractory cases, such as in those with steroid depende...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Naganuma M,Sugimoto S,Fukuda T,Mitsuyama K,Kobayashi T,Yoshimura N,Ohi H,Tanaka S,Andoh A,Ohmiya N,Saigusa K,Yamamoto T,Morohoshi Y,Ichikawa H,Matsuoka K,Hisamatsu T,Watanabe K,Mizuno S,Abe T,Suzuki Y,Kanai T,IN

    更新日期:2020-02-01 00:00:00

  • Brachiocephalic vein thrombosis associated with Crohn's disease.

    abstract::An association between macrovascular thrombosis and idiopathic inflammatory bowel disease has been described, although very few well-documented cases have been published. We report on a 39-year-old woman who presented with right hemifacial and upper limb edema that was shown to be due to an extensive right brachioceph...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Ribeiro JM,Rebocho L,Lucas MB,Campos P,Victorino RM

    更新日期:2003-01-01 00:00:00

  • Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H(2)-receptor knockout.

    abstract:BACKGROUND:Ghrelin, an appetite-promoting peptide secreted from the stomach, is reported to enhance preprandial acid output, possibly through stimulation of the cephalic phase. The present study was designed to clarify the dynamics of ghrelin in H(2) receptor (H(2)R)-null mice by genetic H(2)R knockout. METHODS:Fiftee...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Arakawa M,Suzuki H,Minegishi Y,Fukushima Y,Masaoka T,Ishikawa T,Hosoda H,Kangawa K,Hibi T

    更新日期:2007-09-01 00:00:00

  • Effect of age and correlation between esophageal visceral chemosensitivity and mechanosensitivity in healthy Japanese subjects.

    abstract:BACKGROUND:The aim of this study was to examine the impact of age on esophageal sensation, and to determine whether esophageal mechanosensitivity and chemosensitivity are correlated in healthy Japanese subjects. METHODS:To evaluate chemosensitivity, a catheter was inserted and placed 10 cm above the upper border of th...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Yamasaki T,Oshima T,Tomita T,Kondo T,Toyoshima F,Sakurai J,Fukui H,Matsumoto T,Watari J,Miwa H

    更新日期:2013-03-01 00:00:00

  • Treatment outcomes after splenectomy with gastric devascularization or balloon-occluded retrograde transvenous obliteration for gastric varices: a propensity score-weighted analysis from a single institution.

    abstract:BACKGROUND:Although balloon-occluded retrograde transvenous obliteration (BRTO) is often selected to treat gastric varices caused by portal hypertension, data comparing BRTO and splenectomy with gastric devascularization (Sp + Dev) are limited. METHODS:From January 2009 to February 2018, 100 patients with gastric vari...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Oshita K,Ohira M,Honmyo N,Kobayashi T,Murakami E,Aikata H,Baba Y,Kawano R,Awai K,Chayama K,Ohdan H

    更新日期:2020-09-01 00:00:00

  • Intestinal microflora as a therapeutic target in inflammatory bowel disease.

    abstract::Although the causes of inflammatory bowel disease (IBD) remain incompletely understood, increasing evidence implicates intestinal microflora in the pathogenesis of these disorders. Alteration of intestinal flora therefore may offer a plausible therapeutic approach. Although recent data support a potential therapeutic ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Mitsuyama K,Toyonaga A,Sata M

    更新日期:2002-11-01 00:00:00

  • Real-time energy metabolism of intestine during arterial versus venous occlusion in the rat.

    abstract:BACKGROUND:Although it is less frequently encountered, mesenteric vein occlusion poses as important a problem as mesenteric artery occlusion. The energy metabolism of intestinal tissue during venous occlusion and reperfusion was studied. METHODS:Male Wistar rats were studied in four groups of 17 animals each. Intestin...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Kimura M,Kataoka M,Kuwabara Y,Sato A,Sugiura M,Fujii Y

    更新日期:2003-01-01 00:00:00

  • EUS-FNA for suspected malignant biliary strictures after negative endoscopic transpapillary brush cytology and forceps biopsy.

    abstract:BACKGROUND:Endoscopic transpapillary brush cytology and forceps biopsy are widely used for the pathological diagnosis of suspected malignant biliary strictures (MBS). However, the sensitivity of these methods remains insufficient, and it can be difficult to confirm the diagnosis. We aimed to evaluate the diagnostic abi...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Ohshima Y,Yasuda I,Kawakami H,Kuwatani M,Mukai T,Iwashita T,Doi S,Nakashima M,Hirose Y,Asaka M,Moriwaki H

    更新日期:2011-07-01 00:00:00

  • Interleukin 10 inhibits interferon gamma- and tumor necrosis factor alpha-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon.

    abstract:BACKGROUND:NADPH oxidase 1 (Nox1) is preferentially expressed in the colon, but its functional role is not fully understood. This study was designed to elucidate a potential role of Nox1 in inflammation of the colon. METHODS:Superoxide production by T84 cells was measured by the cytochrome c method. Protein and mRNA l...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Kamizato M,Nishida K,Masuda K,Takeo K,Yamamoto Y,Kawai T,Teshima-Kondo S,Tanahashi T,Rokutan K

    更新日期:2009-01-01 00:00:00

  • Anorectal malignant melanoma: preoperative usefulness of magnetic resonance imaging.

    abstract::Magnetic resonance imaging (MRI) findings in three patients with primary anorectal malignant melanoma are described. Two patients had melanotic and one had amelanotic anorectal melanoma. The findings of MRI with a pelvic coil and an endorectal coil were consistent with pathologic findings. MRI with a pelvic coil demon...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Matsuoka H,Nakamura A,Iwamoto K,Sugiyama M,Hachiya J,Atomi Y,Masaki T

    更新日期:2005-08-01 00:00:00

  • Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers.

    abstract::Chronic inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer. However, the mechanism underlying the development of colorectal cancers through chronic inflammation is not known. Activation-induced cytidine deaminase (AID) was originally identified as an inducer of so...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Endo Y,Marusawa H,Chiba T

    更新日期:2011-01-01 00:00:00

  • Integrated analysis of circRNAs and mRNAs expression profile revealed the involvement of hsa_circ_0007919 in the pathogenesis of ulcerative colitis.

    abstract:BACKGROUND:Ulcerative colitis (UC) is characterized by chronic inflammation in the colon and epigenetic factors underlying the occurrence. Circular RNAs (circRNAs) have been under intensive focus due to the circular construct and gene-regulating functions. However, the changes and roles of circRNAs in UC remain unknown...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang T,Chen N,Ren W,Liu F,Gao F,Ye L,Han Y,Zhang Y,Liu Y

    更新日期:2019-09-01 00:00:00

  • Histological evaluation of obliterative phlebitis for the diagnosis of autoimmune pancreatitis.

    abstract:BACKGROUND:Obliterative phlebitis is a useful pathological finding for the diagnosis of lymphoplasmacytic sclerosing pancreatitis (LPSP), or type 1 autoimmune pancreatitis. The present study evaluated histological findings of obliterative phlebitis, including the significance of adding Elastica van Gieson stain (EVG) i...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章


    authors: Miyabe K,Notohara K,Nakazawa T,Hayashi K,Naitoh I,Okumura F,Shimizu S,Yoshida M,Yamashita H,Takahashi S,Ohara H,Joh T

    更新日期:2014-04-01 00:00:00