Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+CXCR4 + cells recruited from bone marrow.

abstract：:Eosinophilic esophagitis (EE) is a rarely diagnosed condition involving eosinophilic infiltration of the esophageal mucosa. Here we present a case of EE in a 69-year-old Japanese man, who presented with abdominal pain, appetite loss, and a history of bronchial asthma. Laboratory findings included peripheral eosinophil...

journal_title：Journal of gastroenterology

authors： Furuta K,Adachi K,Kowari K,Mishima Y,Imaoka H,Kadota C,Koshino K,Miyake T,Kadowaki Y,Furuta K,Kazumori H,Sato S,Ishihara S,Amano Y,Honda M,Kinoshita Y

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Recently, the novel gene DOG1 has been found to be overexpressed in most gastrointestinal stromal tumors (GISTs) specifically within the field of soft tissue tumors. DOG1 might play a role in development of GISTs and have potential as a diagnostic marker and therapeutic target, but the biological function an...

journal_title：Journal of gastroenterology

authors： Miwa S,Nakajima T,Murai Y,Takano Y,Sugiyama T

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:It remains unknown whether the Rome III criteria can exclude organic colonic lesions prior to the diagnosis of irritable bowel syndrome (IBS). We evaluated the colonoscopy results of patients meeting the Rome III criteria for the diagnosis of IBS to determine the presence of organic colonic lesions. METHODS...

journal_title：Journal of gastroenterology

authors： Ishihara S,Yashima K,Kushiyama Y,Izumi A,Kawashima K,Fujishiro H,Kojo H,Komazawa Y,Hamamoto T,Yamamoto T,Sasaki Y,Shimizu T,Okamoto E,Yoshimura T,Furuta K,Noguchi N,Tanaka H,Murawaki Y,Kinoshita Y

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to elucidate the role of nuclear factor kappaB (NF-kappaB) in the development of gastric ischemia-reperfusion (GI-R) injury and in mediating the effects of angiotensin II (Ang II) in the paraventricular nucleus (PVN) on GI-R injury. METHODS:GI-R injury was induced in rats by cl...

journal_title：Journal of gastroenterology

authors： Zhang YM,Wei EQ,Hu X,Qiao WL,Shi Y,Xu M,Zhang JF

更新日期：2008-01-01 00:00:00

abstract：:A 69-year-old woman was admitted to our hospital with fever and abdominal pain in the epigastric region. Abdominal ultrasonography demonstrated a well-defined hypoechoic mass in the epigastric region with encasement of the left hepatic lobe and stomach. Computed tomography confirmed a low-density mass, 20 cm in diamet...

journal_title：Journal of gastroenterology

authors： Kaibori M,Kawaguchi Y,Yokoigawa N,Yanagida H,Takai S,Kwon AH,Uemura Y,Kamiyama Y

更新日期：2003-01-01 00:00:00

abstract：:An association between Crohn's disease and gastric cancer has not been clearly defined. A 34-year-old man was referred to our hospital for the evaluation of a gastric lesion and treatment of small-bowel Crohn's disease. We diagnosed the gastric lesion as adenocarcinoma, using endoscopy and histological studies. The pa...

journal_title：Journal of gastroenterology

authors： Ikeuchi H,Kusunoki M,Yamamura T,Nishigami T

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Endoscopic sphincterotomy (ES) is widely performed in patients with common bile duct stones (CBDS). However, the long-term outcomes of patients following ES have not been sufficiently elucidated. Impaired papillary function following ES may result in additional late complications. In contrast, endoscopic pap...

journal_title：Journal of gastroenterology

authors： Doi S,Yasuda I,Mukai T,Iwashita T,Uemura S,Yamauchi T,Nakashima M,Adachi S,Shimizu M,Tomita E,Itoi T,Moriwaki H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease affects the quality of a patient's life in many ways, but no validated instrument for measuring disease-specific quality of life in these patients is available in Japan. We developed a Japanese version of the Inflammatory Bowel Disease Questionnaire (IBDQ), together with the author...

journal_title：Journal of gastroenterology

authors： Hashimoto H,Green J,Iwao Y,Sakurai T,Hibi T,Fukuhara S

更新日期：2003-01-01 00:00:00

abstract：:The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for the test. The test ...

journal_title：Journal of gastroenterology

authors： Wang WM,Lee SC,Ding HJ,Jan CM,Chen LT,Wu DC,Liu CS,Peng CF,Chen YW,Huang YF,Chen CY

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Insulin-like growth factor (IGF)-I receptor (IGF-IR) signaling plays important parts in both the tumorigenicity and progression of digestive/gastrointestinal malignancies. In this study, we sought to test the effectiveness of a practical approach to blocking IGF-IR signaling using RNA interference d...

journal_title：Journal of gastroenterology

authors： Wang Y,Adachi Y,Imsumran A,Yamamoto H,Piao W,Li H,Ii M,Arimura Y,Park MY,Kim D,Lee CT,Carbone DP,Imai K,Shinomura Y

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Depth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. However, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the ...

journal_title：Journal of gastroenterology

authors： Kitajima K,Fujimori T,Fujii S,Takeda J,Ohkura Y,Kawamata H,Kumamoto T,Ishiguro S,Kato Y,Shimoda T,Iwashita A,Ajioka Y,Watanabe H,Watanabe T,Muto T,Nagasako K

更新日期：2004-06-01 00:00:00

abstract：:We measured urokinase-type plasminogen activator (u-PA) plasma levels in patients with various chronic liver diseases, including hepatocellular carcinoma (HCC), also measuring these levels in healthy volunteers. Plasma u-PA levels in the group of patients with decompensated liver cirrhosis (mean modified Pugh score of...

journal_title：Journal of gastroenterology

authors： Sato S,Higashi T,Ouguchi S,Hino N,Tsuji T

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Gene therapy is a promising therapeutic method but is severely hampered due to its lack of an ideal delivery system. Therefore, in this study, a nonviral and magnetic resonance imaging (MRI) visible vector, polyethylene glycol-grafted polyethylenimine and superparamagnetic iron oxide nanoparticles (PEG-g-PEI...

journal_title：Journal of gastroenterology

authors： Chen Y,Lian G,Liao C,Wang W,Zeng L,Qian C,Huang K,Shuai X

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Photodynamic therapy (PDT) has not been reported for human hepatoma, because cancer cells only weakly take up the photosensitizer. Indocyanine green (ICG) is a photosensitizer normally excreted into the bile, and bile excretion is impaired in human hepatomas. We examined whether human hepatoma cell lines pre...

journal_title：Journal of gastroenterology

authors： Kaneko J,Inagaki Y,Ishizawa T,Gao J,Tang W,Aoki T,Sakamoto Y,Hasegawa K,Sugawara Y,Kokudo N

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Few studies have investigated the association between smoking and ultrasonographically diagnosed gallbladder (GB) disease, and their results were uncertain. This study was conducted to examine the association between smoking and drinking and GB diseases. METHODS:A total of 9,947 subjects (age, 30-69 years; ...

journal_title：Journal of gastroenterology

authors： Okamoto M,Yamagata Z,Takeda Y,Yoda Y,Kobayashi K,Fujino MA

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The gap junction (GJ) plays important roles in the maintenance of tissue homeostasis, the control of cell growth and differentiation, and the prevention of experimental hepatocarcinogenesis. In this study, we examined the relationship between the expression of the GJ protein connexin (Cx) 32 in 24 human hepa...

journal_title：Journal of gastroenterology

authors： Nakashima Y,Ono T,Yamanoi A,El-Assal ON,Kohno H,Nagasue N

更新日期：2004-08-01 00:00:00

abstract：:We report a case of Cruveihier-Baumgarten syndrome associated with portal vein thrombosis that developed, slowly during a 2-year period after endoscopic variceal sclerotherapy. The thrombosis led to the disappearance of the venous hum and the dilated abdominal wall veins characteristic of this syndrome. A 73-year-old ...

journal_title：Journal of gastroenterology

authors： Yamakawa O,Ohta H,Watanabe H,Motoo Y,Okai T,Kadoya M,Matsui O,Sawabu N

更新日期：1996-08-01 00:00:00

abstract：:A rare case of simple ulcer of the colon in a 7-year-old girl is reported. Simple ulcer is clinically and pathologically recognized as a serious disease linked to intestinal Behcet's disease. Recently, some immunomodulators, such as thalidomide and antitumor necrosis factor monoclonal antibody, have been used to treat...

journal_title：Journal of gastroenterology

authors： Kasahara E,Yamagishi N,Tanaka M,Yashiro K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Musashi-1 (Msi-1) is a RNA-binding protein, known as a putative marker of intestinal stem cells (ISCs). However, little is known about the function of Msi-1 within human intestinal epithelial cells (IECs). Thus, the present study aimed to clarify the role of Msi-1 in differentiation and proliferation of IECs...

journal_title：Journal of gastroenterology

authors： Murayama M,Okamoto R,Tsuchiya K,Akiyama J,Nakamura T,Sakamoto N,Kanai T,Watanabe M

更新日期：2009-01-01 00:00:00

abstract：:Inconsistencies and omissions in current explanations for the well known depressions of gastric acid secretion and blood gastrin levels following acidification by antral stimulants are discussed. Evidence is presented which favors a reciprocal sensitivity relationship between the fundic mucosa and the antral G cells, ...

journal_title：Journal of gastroenterology

authors： Magee DF

更新日期：1996-10-01 00:00:00

abstract：:Although esophageal candidiasis is the most common form of Candida infection in the gastro-intestinal tract, little attention has been directed toward determining the mechanism of its infection. We have already clarified the existence of four modes of adherence of Candida albicans to the esophagus; attachment, subepit...

journal_title：Journal of gastroenterology

authors： Hoshika K,Mine H

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. left-sided colon,' 'colon vs. rectum,' and 'right-sided (right-sided colon) vs. left-sided (left-sided colon and rectum).' This nationwide multicenter ...

journal_title：Journal of gastroenterology

authors： Shida D,Inoue M,Tanabe T,Moritani K,Tsukamoto S,Yamauchi S,Sugihara K,Kanemitsu Y

更新日期：2020-10-01 00:00:00

abstract：:We used positron emission tomography with 2-deoxy-2-[(18)F]fluoro- d-glucose (FDG-PET) in the diagnosis of two cases of malignant intraductal papillary mucinous tumor (IPMT) of the pancreas. A 56-year-old man and a 72-year-old man, both with tumors in the pancreatic head, were referred to Akita University Medical Cent...

journal_title：Journal of gastroenterology

authors： Yoshioka M,Sato T,Furuya T,Shibata S,Andoh H,Asanuma Y,Hatazawa J,Koyama K

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:In elderly patients with superficial esophageal squamous cell carcinoma (ESCC), the optimal treatment strategy after non-curative endoscopic submucosal dissection (ESD) remains unclear. We aimed to evaluate the validity of additional treatments after non-curative ESD and post-ESD survival predictors in elder...

journal_title：Journal of gastroenterology

authors： Nakajo K,Abe S,Oda I,Ishihara R,Tanaka M,Yoshio T,Katada C,Yano T

更新日期：2019-10-01 00:00:00

abstract：:A case of Dieulafoy's vascular malformation of the jejunum treated by laparoscopic surgery is described. The patient was a 31-year-old-woman who had complained of melena and had severe anemia needing blood transfusion. Angiography revealed microaneurysms and hypervascularity of the jejunum in the area between the firs...

journal_title：Journal of gastroenterology

authors： Mino A,Ogawa Y,Ishikawa T,Uchima Y,Yamazaki M,Nakamura S,Yukawa T,Matsumoto T,Arakawa T,Hirakawa K

更新日期：2004-01-01 00:00:00

abstract：:We report a case of synchronous gas gangrene and spontaneous bacterial peritonitis associated with liver cirrhosis. The patient was a 52-year-old man who was being followed for decompensated liver cirrhosis. He experienced sudden onset lower abdominal pain with distension and pain in the left leg. A bullous lesion, wi...

journal_title：Journal of gastroenterology

authors： Murata K,Shimizu A,Takase K,Nakano T,Tameda Y

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Patients with primary biliary cirrhosis (PBC) exhibit a variety of clinical manifestations and patterns of disease progression. The aim of this study was to identify genetic determinants of PBC progression. METHODS:A total of 52 tag single nucleotide polymorphisms (SNPs) of 11 candidate genes involved in re...

journal_title：Journal of gastroenterology

authors： Inamine T,Higa S,Noguchi F,Kondo S,Omagari K,Yatsuhashi H,Tsukamoto K,Nakamura M

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Dual oral therapy with daclatasvir plus asunaprevir yielded an SVR rate of 85% among patients with genotype 1b HCV. Treatment failure mainly occurred in patients with pre-existing HCV with NS5A-Y93H mutation. The significance of the mutation was evaluated. METHODS:The percent of serum NS5A-Y93H strains rela...

journal_title：Journal of gastroenterology

authors： Uchida Y,Kouyama J,Naiki K,Sugawara K,Ando S,Nakao M,Motoya D,Inao M,Imai Y,Nakayama N,Mochida S

更新日期：2016-03-01 00:00:00

abstract：:Depletion of goblet cells (the main mucin-producing cells in the colon) is one of the most reliable histological characteristics of ulcerative colitis, whereas a major symptom of this disease is bloody diarrhea containing a large amount of mucus. The discrepancy between these phenomena was investigated in a time-cours...

journal_title：Journal of gastroenterology

authors： Nakano S,Ohara S,Kubota T,Saigenji K,Hotta K

更新日期：1999-04-01 00:00:00

abstract：:The spontaneous passage of colon cast from a 76-year-old Japanese female patient is reported. Macroscopically, the colon case was shaped like the airbladder of a fish. Histopathologically, the cast consisted of degenerated colonal mucosa, including glands. No inflammatory reaction was apparent. The patient lacked any ...

journal_title：Journal of gastroenterology

authors： Yoshiji H,Nakae D,Sugiya R,Mizumoto Y,Tsutsumi M,Hiriguchi K,Yokose Y,Sakurai R,Fukui H,Tsujii T

更新日期：1994-02-01 00:00:00