Intrahepatic sarcomatoid cholangiocarcinoma.

Abstract:

:A 69-year-old woman was admitted to our hospital with fever and abdominal pain in the epigastric region. Abdominal ultrasonography demonstrated a well-defined hypoechoic mass in the epigastric region with encasement of the left hepatic lobe and stomach. Computed tomography confirmed a low-density mass, 20 cm in diameter, with enhancing peripheral areas. Angiography revealed the tumor to be hypovascular. After admission, the patient had a persistent fever and anemia that required transfusions of concentrated red blood cells. On the twelfth day after admission, she suffered disseminated intravascular coagulation and underwent an emergency operation. A lateral segmentectomy with dissection of lymph nodes, cholecystectomy, and hemigastrectomy were carried out. The size of the tumor was 22 x 17 x 15 cm. Macroscopically, a cross-section revealed massive necrosis with hemorrhage. Histological examination of the tumor showed a malignant neoplasm with a carcinomatous component and a sarcomatous component, which were partly intermingled. The former consisted of moderately differentiated adenocarcinoma, while the latter consisted of pleomorphic spindle cells. Immunohistochemical examination of the sarcomatous component showed positive staining for vimentin, epithelial membrane antigen, and cytokeratin. The tumor was diagnosed as cholangiocarcinoma with extensive sarcomatous changes, based on these histological and immunohistochemical findings. The patient had an uneventful postoperative course. However, she died 3 months after surgery from dissemination of the carcinoma. The literature on this rare disease is reviewed and discussed.

journal_name

J Gastroenterol

authors

Kaibori M,Kawaguchi Y,Yokoigawa N,Yanagida H,Takai S,Kwon AH,Uemura Y,Kamiyama Y

doi

10.1007/s00535-003-1203-y

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

1097-101

issue

11

eissn

0944-1174

issn

1435-5922

journal_volume

38

pub_type

杂志文章,评审
  • Clinicopathologic studies of immunologic fecal occult blood test for colorectal cancer.

    abstract::In our hospital, 83 patients with colorectal cancer underwent the immunologic fecal occult blood test (IFOBT). The positive rate for IFOBT in all patients was 87%. Colon cancers more proximal than the transverse colon were 100% positive. Carcinomas of the ulcerative type showed a significantly higher positive rate tha...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02348665

    authors: Iida Y,Munemoto Y,Miura S,Kasahara Y,Saito H,Mitsui T,Asada Y,Fukuoka K,Toya D,Tanaka N

    更新日期:1995-04-01 00:00:00

  • A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis.

    abstract:BACKGROUND/AIMS:King's College Hospital (KCH) criteria and the model for end-stage liver disease (MELD) score are useful and widely-employed prognostic markers for acute liver failure (ALF). We previously reported that liver atrophy is an important prognostic factor for ALF. The aim of the present study was to assess t...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-009-0045-7

    authors: Yamagishi Y,Saito H,Ebinuma H,Kikuchi M,Ojiro K,Kanamori H,Tada S,Horie Y,Kato S,Hibi T

    更新日期:2009-01-01 00:00:00

  • Endoscopic characterization of the small bowel in patients with portal hypertension evaluated by double balloon endoscopy.

    abstract:BACKGROUND:The endoscopic abnormalities present in the small bowel (SB) of patients with portal hypertension (PH) are not well understood. This study sought to evaluate endoscopic findings of the SB in patients with PH by double balloon endoscopy (DBE). METHODS:We evaluated the endoscopic findings of SB in 15 patients...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-008-2198-1

    authors: Kodama M,Uto H,Numata M,Hori T,Murayama T,Sasaki F,Tsubouchi N,Ido A,Shimoda K,Tsubouchi H

    更新日期:2008-01-01 00:00:00

  • Characteristics of Japanese inflammatory bowel disease susceptibility loci.

    abstract:BACKGROUND:There are substantial differences in inflammatory bowel disease (IBD) genetics depending on the populations examined. We aimed to identify Japanese population-specific or true culprit susceptibility genes through a meta-analysis of past genetic studies of Japanese IBD. METHODS:For this study, we reviewed 2,...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00535-013-0866-2

    authors: Arimura Y,Isshiki H,Onodera K,Nagaishi K,Yamashita K,Sonoda T,Matsumoto T,Takahashi A,Takazoe M,Yamazaki K,Kubo M,Fujimiya M,Imai K,Shinomura Y

    更新日期:2014-08-01 00:00:00

  • Serum pepsinogen concentrations as a measure of gastric acid secretion in Helicobacter pylori-negative and -positive Japanese subjects.

    abstract:BACKGROUND:Although previous studies have indicated that serum pepsinogen I levels, as well as the pepsinogen I/II ratio, were positively correlated with maximal gastric output, the relationship may be different between Helicobacter pylori-negative and -positive subjects. The aim of this study was to investigate the re...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-005-1677-x

    authors: Iijima K,Sekine H,Koike T,Imatani A,Ohara S,Shimosegawa T

    更新日期:2005-10-01 00:00:00

  • What is reasonable treatment for gastric adenocarcinoma?

    abstract::From its pattern of metastasis and recurrence, gastric carcinoma can be recognized as a slow-growing malignancy whose local control is still the most important part of treatment. With application of asymptomatic population screening and awareness of the high risk of this disease among the general population in Japan, ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Sasako M

    更新日期:2000-01-01 00:00:00

  • Spontaneous passage of a colon cast in the absence of abdominal aneurysm.

    abstract::The spontaneous passage of colon cast from a 76-year-old Japanese female patient is reported. Macroscopically, the colon case was shaped like the airbladder of a fish. Histopathologically, the cast consisted of degenerated colonal mucosa, including glands. No inflammatory reaction was apparent. The patient lacked any ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF01229079

    authors: Yoshiji H,Nakae D,Sugiya R,Mizumoto Y,Tsutsumi M,Hiriguchi K,Yokose Y,Sakurai R,Fukui H,Tsujii T

    更新日期:1994-02-01 00:00:00

  • Comparison of three methods of nutritional assessment in liver cirrhosis: subjective global assessment, traditional nutritional parameters, and body composition analysis.

    abstract:BACKGROUND:Liver cirrhosis affects the results of many of the traditional techniques currently used to evaluate nutritional status. Our aim was to compare the traditional two-compartment model (subjective global assessment and anthropometry and blood tests) of nutritional assessment with a multicompartmental model (bod...

    journal_title:Journal of gastroenterology

    pub_type: 评论,杂志文章

    doi:10.1007/s00535-006-1794-1

    authors: Figueiredo FA,Perez RM,Freitas MM,Kondo M

    更新日期:2006-05-01 00:00:00

  • Impairment of chemical clearance and mucosal integrity distinguishes hypersensitive esophagus from functional heartburn.

    abstract:BACKGROUND:Hypersensitive esophagus (HE) is defined by endoscopy-negative heartburn with a normal acid exposure time but positive symptom association probability (SAP) and/or symptom index (SI) on impedance-pH monitoring, and proton pump inhibitor (PPI) responsiveness. Functional heartburn (FH) is distinguished by nega...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00535-016-1226-9

    authors: Frazzoni M,de Bortoli N,Frazzoni L,Furnari M,Martinucci I,Tolone S,Farioli A,Marchi S,Fuccio L,Savarino V,Savarino E

    更新日期:2017-04-01 00:00:00

  • Histological evaluation of obliterative phlebitis for the diagnosis of autoimmune pancreatitis.

    abstract:BACKGROUND:Obliterative phlebitis is a useful pathological finding for the diagnosis of lymphoplasmacytic sclerosing pancreatitis (LPSP), or type 1 autoimmune pancreatitis. The present study evaluated histological findings of obliterative phlebitis, including the significance of adding Elastica van Gieson stain (EVG) i...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-013-0818-x

    authors: Miyabe K,Notohara K,Nakazawa T,Hayashi K,Naitoh I,Okumura F,Shimizu S,Yoshida M,Yamashita H,Takahashi S,Ohara H,Joh T

    更新日期:2014-04-01 00:00:00

  • Crohn's disease with life-threatening hemorrhage from terminal ileum: successful control by superselective arterial embolization.

    abstract::A case of life-threatening lower gastrointestinal hemorrhage from Crohn's disease is reported. Several promising studies have recently been published that describe superselective embolization for the treatment of massive lower gastrointestinal hemorrhage in patients with bleeding colonic diverticular disease and angio...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-005-1714-9

    authors: Kazama Y,Watanabe T,Akahane M,Yoshioka N,Ohtomo K,Nagawa H

    更新日期:2005-12-01 00:00:00

  • Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in industrialized countries worldwide, and has become a serious public health issue not only in Western countries but also in many Asian countries including Japan. Within the wide spectrum of NAFLD, nonalcoholic steato...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,实务指引

    doi:10.1007/s00535-015-1050-7

    authors: Watanabe S,Hashimoto E,Ikejima K,Uto H,Ono M,Sumida Y,Seike M,Takei Y,Takehara T,Tokushige K,Nakajima A,Yoneda M,Saibara T,Shiota G,Sakaida I,Nakamuta M,Mizuta T,Tsubouchi H,Sugano K,Shimosegawa T,Japanese Society

    更新日期:2015-04-01 00:00:00

  • Toxigenicity of Helicobacter pylori isolates possessing cagA gene and vacuolating cytotoxin.

    abstract::Inflammatory cells in the gastric epithelium and direct cell damage are important effects of H. pylori infection in causing gastroduodenal diseases. The aim of this study was to determine whether H. Pylori possessing the cagA gene and vacuolating cytotoxin activity (cagA+/tox+) has these toxigenicities. The detection ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Kodama K,Fujioka T,Ito A,Kodama R,Nasu M

    更新日期:1998-01-01 00:00:00

  • Epidemiology and clinical characteristics of GERD in the Japanese population.

    abstract::We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in this country. Although the definition of GERD depends on the individual study, the prevalence of GERD has been increasing since the end of the 1990s. The reasons...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-009-0047-5

    authors: Fujiwara Y,Arakawa T

    更新日期:2009-01-01 00:00:00

  • Pyloric antral inhibition of gastrin release.

    abstract::Inconsistencies and omissions in current explanations for the well known depressions of gastric acid secretion and blood gastrin levels following acidification by antral stimulants are discussed. Evidence is presented which favors a reciprocal sensitivity relationship between the fundic mucosa and the antral G cells, ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02347632

    authors: Magee DF

    更新日期:1996-10-01 00:00:00

  • DNA methylation as a marker for the past and future.

    abstract::Aberrant methylation of CpG islands in promoter regions can permanently inactivate tumor-suppressor genes, as mutations and chromosomal abnormalities do. In gastric cancers, CDKN2A, CDH1, and MLH1 are inactivated more frequently by aberrant methylation than by mutations, and novel tumor-suppressor genes inactivated by...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-006-1846-6

    authors: Ushijima T,Nakajima T,Maekita T

    更新日期:2006-05-01 00:00:00

  • Positron emission tomography with 2-deoxy-2-[(18)F] fluoro- d-glucose for diagnosis of intraductal papillary mucinous tumor of the pancreas with parenchymal invasion.

    abstract::We used positron emission tomography with 2-deoxy-2-[(18)F]fluoro- d-glucose (FDG-PET) in the diagnosis of two cases of malignant intraductal papillary mucinous tumor (IPMT) of the pancreas. A 56-year-old man and a 72-year-old man, both with tumors in the pancreatic head, were referred to Akita University Medical Cent...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-003-1230-8

    authors: Yoshioka M,Sato T,Furuya T,Shibata S,Andoh H,Asanuma Y,Hatazawa J,Koyama K

    更新日期:2003-01-01 00:00:00

  • Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs).

    abstract:BACKGROUND:Recently, the novel gene DOG1 has been found to be overexpressed in most gastrointestinal stromal tumors (GISTs) specifically within the field of soft tissue tumors. DOG1 might play a role in development of GISTs and have potential as a diagnostic marker and therapeutic target, but the biological function an...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-008-2195-4

    authors: Miwa S,Nakajima T,Murai Y,Takano Y,Sugiyama T

    更新日期:2008-01-01 00:00:00

  • Serum Mac-2 binding protein glycosylation isomer predicts grade F4 liver fibrosis in patients with biliary atresia.

    abstract:BACKGROUND AND AIM:Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia. METHODS:Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median age, 1.1 years (rang...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-016-1235-8

    authors: Yamada N,Sanada Y,Tashiro M,Hirata Y,Okada N,Ihara Y,Urahashi T,Mizuta K

    更新日期:2017-02-01 00:00:00

  • Expression of vacuolating cytotoxin in clinical isolates of Helicobacter pylori.

    abstract::Our objective was to determine whether the prevalence of vacuolating cytotoxin production differed among Helicobacter pylori isolates obtained from patients with chronic gastritis, gastric ulcer, or duodenal ulcer. We examined the vacuolating cytotoxin production of 114 clinical H. pylori isolates in rabbit gastic epi...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Kodama K,Fujioka T,Ito A,Kubota T,Murakami K,Nasu M

    更新日期:1996-11-01 00:00:00

  • Efficacy of oral adsorbent for treatment of peristomal fistula associated with Crohn's disease.

    abstract::Perianal fistulae are frequently seen complications in Crohn's disease. Although surgical procedures such as Seton's method have been devised, many patients still suffer from fistulae that are resistant to conventional therapy. We administered oral adsorbent to a patient with disease Crohn's who had a complicated peri...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050349

    authors: Tsujikawa T,Araki Y,Makino J,Uda K,Ihara T,Sasaki M,Fujiyama Y,Bamba T

    更新日期:2000-01-01 00:00:00

  • Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease.

    abstract:BACKGROUND:For patients with chronic hepatitis due to hepatitis B virus (HBV), factors predicting hepatocellular carcinoma (HCC) other than high levels of HBV-DNA and alanine aminotransferase (ALT) are needed to prevent HCC development, as many patients with chronic HBV infection fulfill these conditions. The purpose o...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-010-0266-9

    authors: Shoji B,Ikeda F,Fujioka S,Kobashi H,Yasunaka T,Miyake Y,Shiraha H,Takaki A,Nouso K,Iwasaki Y,Yamamoto K

    更新日期:2010-11-01 00:00:00

  • Chromosome spreading techniques for primary gastrointestinal tumors.

    abstract::The requirement for well spread out chromosomes for the cytogenetic analysis of primary gastrointestinal tumors led us to develop new techniques. These techniques involved two main procedures: (1) preliminary incubation with culture medium in the presence of collagenase, Dispase, and colcemid, for 3 h, and (2) treatme...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02355049

    authors: Sasai K,Tanaka R,Kawamura M,Honjo K,Matsunaga N,Nakada T,Homma K,Fujimura H

    更新日期:1996-08-01 00:00:00

  • Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+CXCR4 + cells recruited from bone marrow.

    abstract:BACKGROUND:Angiogenesis is essential for gastric ulcer healing. Recent results suggest that vascular endothelial growth factor receptor 1 (VEGFR1), which binds to VEGF, promotes angiogenesis. In the present study, we investigated the role of VEGFR1 signaling in gastric ulcer healing and angiogenesis. METHODS:Gastric u...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-013-0869-z

    authors: Sato T,Amano H,Ito Y,Eshima K,Minamino T,Ae T,Katada C,Ohno T,Hosono K,Suzuki T,Shibuya M,Koizumi W,Majima M

    更新日期:2014-03-01 00:00:00

  • Dubin-Johnson-like black liver with normal bilirubin level.

    abstract::Black liver is a common finding in Dubin-Johnson syndrome (DJS), which is caused by the lack of multidrug resistance-associated protein 2 (MRP2). Impaired excretion of epinephrine metabolites is believed to be a cause of black liver in DJS. Recently, we experienced a patient with black liver whose serum bilirubin leve...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-004-1406-x

    authors: Kobayashi Y,Ishihara T,Wada M,Kajihara S,Araki J,Mifuji R,Itani T,Kuroda M,Urawa F,Kaito M,Adachi Y

    更新日期:2004-09-01 00:00:00

  • Treatment outcomes after splenectomy with gastric devascularization or balloon-occluded retrograde transvenous obliteration for gastric varices: a propensity score-weighted analysis from a single institution.

    abstract:BACKGROUND:Although balloon-occluded retrograde transvenous obliteration (BRTO) is often selected to treat gastric varices caused by portal hypertension, data comparing BRTO and splenectomy with gastric devascularization (Sp + Dev) are limited. METHODS:From January 2009 to February 2018, 100 patients with gastric vari...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-020-01693-9

    authors: Oshita K,Ohira M,Honmyo N,Kobayashi T,Murakami E,Aikata H,Baba Y,Kawano R,Awai K,Chayama K,Ohdan H

    更新日期:2020-09-01 00:00:00

  • Symptomatic and endoscopic outcome of heartburn 3-4.5 years after starting lansoprazole therapy: a prospective study of 142 patients.

    abstract:BACKGROUND:Heartburn is a common symptom with great impact on quality of life and on the economy. An approach that helps to alleviate patients' symptoms, decrease the burden on the economy, and improve longterm outcome is needed. Step-down therapy, starting with the proton pump inhibitor lansoprazole, seems to achieve ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-003-1194-8

    authors: Abu Farsakh N

    更新日期:2003-01-01 00:00:00

  • Cardiac metastasis from squamous cell carcinoma of gallbladder.

    abstract::A 65-year-old woman was admitted to our hospital with the diagnosis of gallbladder tumor. Right extended hepatic lobectomy plus lymph node dissection of the hepatoduodenal ligament and left hepaticojejunostomy with Roux-en-Y reconstruction was performed in July, 1993. The gallbladder tumor was histologically proven to...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02936968

    authors: Suganuma M,Marugami Y,Sakurai Y,Ochiai M,Hasegawa S,Imazu H,Matsubara T,Funabiki T,Kuroda M

    更新日期:1997-12-01 00:00:00

  • Antibodies against hepatoma-derived growth factor and mucosal repair in ulcerative colitis.

    abstract::Ulcerative colitis is a chronic inflammatory disease of colonic mucosa in which the pathogenesis of any immunological disorders would likely be related. Various circulating autoantibodies have been reported in patients with ulcerative colitis, although their possible roles in this disease process have not yet been cla...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF03326407

    authors: Nakamura H,Yoshida K,Ikegame K,Kishima Y,Uyama H,Enomoto H

    更新日期:2002-11-01 00:00:00

  • Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus.

    abstract:BACKGROUND:Using cDNA microarray analysis that displays a total of 8734 mouse genes, we have identified 21 known and novel transcripts, including mouse expressed sequence tags (ESTs) that were consistently up- or downregulated in the fundus of wild-type mice and W/W(V) mice, where intramuscular interstitial cells of Ca...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-003-1283-8

    authors: Daigo Y,Takayama I,Ward SM,Sanders KM,Fujino MA

    更新日期:2004-01-01 00:00:00